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Concurrent chemoradiotherapy with weekly docetaxel versus cisplatin in the treatment of locoregionally advanced nasopharyngeal carcinoma:a propensity score-matched analysis

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Cancer Communications 2019年第1期39卷 368-378页

作者： Jun-Fang Liao Qun Zhang Xiao-Jing Du Mei lan Shan Liu Yun-Fei Xia Xiu-Yu Cai Wei Luo Department of Radiation Oncology National Cancer Center/Cancer Hospital&Shenzhen HospitalShenzhen 518116GuangdongP.R.China Department of Radiation Oncology The First Affiliated Hospital of Sun Yat-sen UniversityGuangzhou 510080GuangdongP.R.China State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer MedicineSun Yat-sen University Cancer CenterGuangzhou 510060GuangdongP.R.China Department of Radiation Oncology State Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer MedicineSun Yat-sen University Cancer CenterGuangzhou 510060GuangdongP.R.China Department of Radiation Oncology Cancer Hospital Affiliated to School of MedicineChengdu 610041SichuanP.R.China Department of VIP Region Sun Yat-sen University Cancer CenterGuangzhou 510060GuangdongP.R.China

Background:Promising efficacy and manageable toxicity of docetaxel-based concurrent chemoradiotherapy(CCRT)were reported in head and neck *** addition,the effect of CCRT in combination with cisplatin and/or 5-fluorouracil on both locoregionally advanced and metastatic/recurrent nasopharyngeal carcinoma(NPC)was ***,CCRT with docetaxel for locoregionally advanced NPC are not well *** study aimed to compare effectiveness and toxicities of CCRT with weekly docetaxel versus tri-weekly cisplatin for locoregionally advanced ***:Clinical data of patients with locoregionally advanced NPC newly diagnosed between January 2010 and December 2014 receiving CCRT with either weekly docetaxel(15 mg/m2)or tri-weekly cisplatin(80-100 mg/m2)were *** score matching at a 1:1 ratio was performed to balance baseline *** events and survival were compared between the two ***:A total of 962 patients were included as the whole cohort,and 448 patients were matched and were regarded as the matched *** median follow-up duration was 48 months for the whole *** 3-year nodal recurrence-free survival rate was significantly increased for patients treated with docetaxel in both the whole(hazard ratio[HR]=0.37,95%confidence interval[CI]0.19-0.72,P=0.030)and matched cohorts(HR=0.33,95%CI 0.14-0.79,P=0.023).However,no significant differences were observed in overall survival,local recurrence-free survival,and distant metastasis-free survival between the two groups in both *** higher rates of grade 3 radiodermatitis(6.7%vs.1.8%,P=0.001),mucositis(74.5%vs.37.9%,P<0.001),and leucopenia(2.2%vs.11.6%,P<0.001)were observed in the docetaxel group,but any grade of renal injury(1.8%vs.15.1%,P<0.001),vomiting(18.8%vs.88.3%,P<0.001),and ALT elevation(19.2%vs.31.3%,P=0.027)were more common in the cisplatin ***:CCRT with weekly low-dose docetaxel is an effective and tolerable therapeutic reg

关键词： Concurrent chemoradiotherapy Docetaxel Cisplatin Nasopharyngeal carcinoma Propensity score matching Intensity-modulated radiotherapy Overall survival Distant metastasis-free survival Locoregional recurrence-free survival Nodal recurrence-free survival

Structure-Mediated Excitation of Air Plasma and Silicon Plasma Expansion in Femtosecond Laser Pulses Ablation

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Research 2018年第1期2018卷 152-162页

作者： Qingsong Wang lan Jiang Jingya Sun Changji Pan Weina Han Guoyan Wang Feifei Wang Kaihu Zhang Ming Li Yongfeng Lu Laser Micro/Nano Fabrication Laboratory School of Mechanical EngineeringBeijing Institute of TechnologyBeijing 100081China Beijing Engineering Research Center of Applied Laser Technology Institute of Laser EngineeringBeijing University of TechnologyBeijing 100124China Beijing Spacecrafs China Academy of Space TechnologyBeijing 100094China State Key Laboratory of Transient Optics and Photonics Xi’an Institute of Optics and Precision MechanicsChinese Academy of SciencesXi’an 710119China Department of Electrical and Computer Engineering University of Nebraska-LincolnLincolnNE 68588-0511USA

Femtosecond laser-induced surface structures upon multiple pulses irradiation are strongly correlated with the pulse number,which in turn signifcantly afects successive laser-material *** recording the dynamics of femtosecond laser ablation of silicon using time-resolved shadowgraphy,here we present direct visualization of the excitation of air plasma induced by the refected laser during the second pulse *** interaction of the air plasma and silicon plasma is found to enhance the shockwave expansion induced by silicon ablation in the longitudinal direction,showing anisotropic expansion dynamics in diferent *** further demonstrate the vanishing of air plasma as the pulse number increases because of the generation of a rough surface without light focusing *** the scenario,the interaction of air plasma and silicon plasma disappears;the expansion of the silicon plasma and shockwave restores its original characteristic that is dominated by the laser-material *** results show that the excitation of air plasma and the laser-material coupling involved in laser-induced plasma and shockwave expansion are structure mediated and dependent on the pulse number,which is of fundamental importance for deep insight into the nature of laser-material interactions during multiple pulses ablation.

关键词： Femto expansion second

Gastrodin modified polyurethane conduit promotes nerve repair via optimizing Schwann cells function

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Bioactive Materials 2022年第2期7卷 355-367页

作者： Hongcai Yang Qing Li Limei Li Shaochun Chen Yu Zhao Yingrui Hu Lu wang Xiaoqian lan Lianmei Zhong Di Lu Yunnan Key Laboratory of Stem Cell and Regenerative Medicine Department of NeurologyThe First Affiliated HospitalKunming Medical UniversityKunming650500China Yunnan Key Laboratory of Stem Cell and Regenerative Medicine Science and Technology Achievement Incubation CenterKunming Medical UniversityKunming650500China The School of Rehabilitation Kunming Medical UniversityKunming650500China

Peripheral nerve regeneration and functional recovery remain a major clinical *** guidance conduit(NGC)that can regulate biological behavior of Schwann cells(SCs)and facilitate axonal regeneration through microenvironmental remodeling is beneficial for nerve regeneration and functional ***,a main constituent of a Chinese traditional herbal medicine,has been known to display several biological and pharmacological properties,especially antioxidative,anti-inflammatory and nerve ***,polyurethane(PU)NGCs modified by different weight ratio of Gastrodin(0,1 and 5 wt%)were designed for sequential and sustainable drug release,that created a favorable microenvironment for nerve *** scaffold showed suitable pore structure and biocompatibility in vitro,and evidently promoted morphological and functional recovery of regenerated sciatic nerves in *** to the PU and 1% Gastrodin/PU scaffolds,the 5% Gastrodin/PU significantly enhanced the proliferation,migration and myelination of SCs and up-regulated expression of neurotrophic factors,as well as induction of the differentiation of PC12 ***,the obvious anti-inflammatory response was observed in 5% Gastrodin/PU by reduced expression of TNF-α and iNOS,which also evidenced by the few fibrous capsule formation in the subcutaneous *** a construct presented a similarity to autograft in vivo repairing a 10 mm sciatic nerve *** was able to not only boost the regenerated area of nerve and microvascular network,but also facilitate functional axons growth and remyelination,leading to highly improved functional *** findings demonstrate that the 5% Gastrodin/PU NGC efficiently promotes nerve regeneration,indicating their potential for use in peripheral nerve regeneration applications.

关键词： Gastrodin/PU SCs biological behavior Anti-inflammatory Peripheral nerve regeneration

The m6A reader YTHDF2 alleviates the inflammatory response by inhibiting IL-6R/JAK2/STAT1 pathway-mediated high-mobility group box-1 release

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Burns & Trauma 2023年第1期11卷 524-535页

作者： Zhuo Zeng Yingying lan Lijuan Zhang Yu Chen Yali Gong Fangqing Zuo Junda Li Gaoxing Luo Yizhi Peng Zhiqiang Yuan Institute of Burn Research State Key Laboratory of TraumaBurns and Combined InjurySouthwest HospitalArmy Medical University(Third Military Medical University)Chongqing 400038China

Background:Sepsis is a common severe complication in major burn victims and is characterized by a dysregulated systemic response to *** domain family 2(YTHDF2),a wellstudied N6-methyladenosine(m6A)reader that specifically recognizes and binds to m6A-modified transcripts to mediate their degradation,is connected to pathogenic and physiological processes in eukaryotes,but its effect on sepsis is still *** aimed to discover the effects and mechanisms of YTHDF2 in ***:Quantitative reverse transcription-polymerase chain reaction(qRT-PCR)and western blot analyses were used to measure the expression of YTHDF2,the interleukin 6 receptor(IL-6R),high-mobility group box-1(HMGB1),Janus kinase 2(JAK2)and signal transducer and activator of transcription 1(STAT1)under different in vitro ***-linked immunosorbent assays were utilized to evaluate the expression of HMGB1,IL-6,IL-1βand tumor necrosis factor-α.To confirm that YTHDF2 specifically targets IL-6R mRNA,RNA immunoprecipitation and dual-luciferase reporter assays were ***,we utilized a mouse model of lipopolysaccharide(LPS)-induced sepsis to verify the effects of YTHDF2 in ***:According to our findings,YTHDF2 was expressed at a low level in peripheral blood mononuclear cells from septic mice and patients as well as in LPS-induced RAW264.7 *** of YTHDF2 alleviated the inflammatory response by inhibiting HMGB1 release and JAK2/STAT1 signalling in LPS-stimulated ***,YTHDF2 suppressed JAK2/STAT1 signalling by directly recognizing the m6A-modified site in IL-6R and decreasing the stability of IL-6R mRNA,thereby inhibiting HMGB1 *** vivo experiments showed that YTHDF2 played a protective role in septic mice by suppressing the IL-6R/JAK2/STAT1/HMGB1 ***:In summary,these findings demonstrate that YTHDF2 plays an essential role as an inhibitor of inflammation to reduce the release of HMGB1 by inhibiting the IL-6R/J

关键词： YTH domain family 2 high-mobility group box-1 interleukin 6 receptor Janus kinase 2 signal transducer and activator of transcription 1 Inflammation Sepsis

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基于“开阖枢”理论探讨厥阴下利病机证治

陕西中医药大学学报 2025年第1期48卷 51-55页

作者：陈昱琨邓思琦许洁夏蓝舒雯鄢钰郭明章福建中医药大学福建福州350122 福建中医药大学证研究基地福建福州350122

开阖枢理论是中医基础理论的重要组成部分之一,是对六经气化升降出入与三阴三阳胜复进退的高度概括,在指导六经病辨治中具有重要意义。文章基于“开阖枢”中“厥阴为阖”理论内涵的解读分析,依据气血阴阳在厥阴阶段中“阖”的特性,归纳... 详细信息

开阖枢理论是中医基础理论的重要组成部分之一,是对六经气化升降出入与三阴三阳胜复进退的高度概括,在指导六经病辨治中具有重要意义。文章基于“开阖枢”中“厥阴为阖”理论内涵的解读分析,依据气血阴阳在厥阴阶段中“阖”的特性,归纳厥阴下利之病机,从气厥下利、血虚厥利、阴极寒厥下利、阳郁热厥下利与寒热错杂厥利等角度阐发厥阴下利病机证治,以期为临床提供理论参考。

关键词：开阖枢厥阴为阖厥阴下利六经病伤寒论

Association between UCP3 gene polymorphisms and nonalcoholic fatty liver disease in Chinese children

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World Journal of Gastroenterology 2013年第35期19卷 5897-5903页

作者： Yan-Ping Xu Li Liang Chun-Lin Wang Jun-Fen Fu Pei-Ning Liu lan-Qiu Lv Yi-Min Zhu Department of Endocrinology Children’s Hospital of Zhejiang University School of Medicine Department of Pediatrics the First Affiliated Hospital College of Medicine Zhejiang University Department of Child Health Care the Affiliated Yuying Children’s Hospital of Wenzhou Medical University Department of Child Health Care Ningbo Women and Children’s Hospital Department of Epidemiology and Biostatistics Key Laboratory of Reproductive Genetics Ministry of Education Zhejiang University

AIM:To confirm the hypothesis that polymorphisms of the uncoupling protein 3(UCP3)gene are associated with the occurrence of nonalcoholic fatty liver disease(NAFLD).METHODS:A total of 250 NAFLD patients(147 malesand 103 females)and 200 healthy individuals who served as controls(control,109 males and 91 females),aged between 6 and 16 years were enrolled in this *** four non-synonymous single nucleotide polymorphisms(SNPs)in the UCP3 gene polymorphisms of rs1726745,rs3781907,rs11235972 and rs1800849,were genotyped using *** mass index(BMI),waist and hip circumference,blood pressure(BP),fasting blood glucose(FBG),insulin and lipid profiles were measured and B-ultrasound examination was performed in all ***:NAFLD patients showed risk factors for metabolic syndrome:elevated BMI,waist-to-hip ratio,BP,FBG,homeostasis model assessment-estimated insulin resistance,total triglyceride,total cholesterol and low-density lipoprotein-cholesterol,while decreased high-density lipoprotein-cholesterol level compared with the control *** GG genotype distributions of rs11235972 in the NAFLD group differed significantly from that in the control *** found that waist circumference between CC(58.76±6.45 cm)and CT+TT(57.00±5.59 cm),and hip circumference between CC(71.28±7.84 cm)and CT+TT genotypes(69.06±7.75 cm)were significantly different with and without rs1800849 variation(P<0.05).CONCLUSION:A higher prevalence of rs11235972 GG genotype was observed in the NAFLD group compared with the control *** differences were observed for the other ***,there was a significant difference in body height in addition to waist and hip circumference between the CC(mutant type group)and CT+TT group with and without rs1800849 variation.

关键词： Nonalcoholic fatty liver disease Uncoupling protein 3 Single nucleotide polymorphisms

Confinement fluorescence effect of an aggregation-induced emission luminogen in crystalline polymer

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Aggregate

Aggregate 2023年第5期4卷 112-119页

作者： lan Zhou Linlin Zheng Xiaoxiao Yu Mengyue Gao Chengjian Xu Yifan Ge Tianxiang Bai Jin Wen Yanhua Cheng Meifang Zhu State Key Laboratory for Modification of Chemical Fibers and Polymer Materials College of Materials Science and EngineeringDonghua UniversityShanghaiChina

Despite the impressive progress of stimuli-responsive fluorescent materials,little is known about the influence of confinement created by crystalline polymer over the fluorescence properties of fluorescent *** effects of confinement on the fluorescence of an aggregation-induced emission luminogen(AIEgen)are investigated using computational simulations,which reveal that the confined space induces the AIEgens to take a more planar conformation,resulting in a red-shifted emission *** this property,the study is extended to explore the confinement generated by various polymer crystalline forms,and it is shown that different fluorescence colors are *** confinement fluorescence effect is attributed to the different spatial dimensions of the polymer amorphous layer between lamellar crystals where the AIEgens are *** results indicate the immediate association between crystalline structure and fluorescence signals,activating unprecedented photophysical properties of luminescent materials,and also providing the possibility for crystalline structure visualization,it is important for the many polymer crystallization processes occurring in the materials processing.

关键词： aggregation-induced emission confinement fluorescence effect polymer crystalline structure

Assessment of optic nerve and optic tract alterations in patients with orbital space-occupying lesions using probabilistic diffusion tractography

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International Journal of Ophthalmology(English edition) 2019年第8期12卷 1304-1310页

作者： Chun-Nan Wu Shao-Feng Duan Xue-Tao Mu Yi Wang Peng-Yu lan Xiao-Lu Wang Kun-Cheng Li Department of Radiology Xuanwu HospitalCapitalMedical UniversityBeijing100053China Department of Radiology the Third Medical Center ofChinese PLA General HospitalBeijing100039China Division of Nuclear Technology and Applications Institute ofHigh Energy PhysicsChinese Academy of SciencesBeijing100049China Beijing Engineering Research Center of RadiographicTechniques and Equipment Beijing100049China Orbital Disease Institute the Third Medical Center of ChinesePLA General HospitalBeijing100039China Department of Otolaryngology the Third Medical Center ofChinese PLA General HospitalBeijing100039China

AIM: To investigate the diffusion changes in both the optic nerve and optic tract in orbital space-occupying lesion patients with decreased visual acuity, and its clinical significance using probabilistic diffusion tractography(PDT). METHODS: Twenty patients with orbital space-occupying lesions and 25 age-and gender-matched healthy persons were included. All patients and controls underwent routine orbital magnetic resonance imaging and diffusion tensor imaging(DTI), using a 3.0 T magnetic resonance scanner(Trio Tim Siemens). After the image data were preprocessed, each DTI parameters of the optic nerve and optic tract was obtained by PDT, including fractional anisotropy(FA), mean diffusivity(MD), axial diffusivity(AD) and radial diffusivity(RD). The asymmetry index(AI) of each parameter was calculated. Compared the parameters of the affected side optic nerve and ipsilateral optic tract with the contralateral side by paired sample t-test;compared AI of parameters of optic nerve and optic tract between the patient group and the control group by independent sample t-test. Patients were divided into threesubgroups according to the low vision grade standard of WHO, compared the FA and AI of FA between the three subgroups by single factor variance analysis. RESULTS: The affected side optic nerve presented significantly decreased FA, increased MD, AD, and RD values compared to the unaffected side(P0.05). The AIs of the FA value of the optic nerve in the eyesight <0.1 subgroup was significantly higher than that in the other groups(P<0.05). CONCLUSION: FA, MD, AD, and RD of the affected side optic nerve of the orbital space-occupying lesions have significantly chang

关键词： orbital space-occupying lesions decreased vision optic never and optic tract probabilistic diffusion tractography magnetic resonance imaging

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普适终端业务的管理信息建模及实现机制

电子与信息学报 2011年第3期33卷 729-733页

作者：芮兰兰孟洛明邱雪松北京邮电大学网络与交换技术国家重点实验室北京100876

该文针对现有终端管理信息模型无法为普适终端业务提供完整信息支撑的现状,研究普适终端业务对管理信息的需求及其信息建模方法。基于该方法形成了一套通用的普适终端业务管理信息模型。该模型基于分域的组织框架,提供从设备、网络、业... 详细信息

该文针对现有终端管理信息模型无法为普适终端业务提供完整信息支撑的现状,研究普适终端业务对管理信息的需求及其信息建模方法。基于该方法形成了一套通用的普适终端业务管理信息模型。该模型基于分域的组织框架,提供从设备、网络、业务到用户层面的管理信息,展现了各信息间的关系,有效地弥补了现有终端管理信息模型的不足。提出了基于管理信息模型的推理实现智能化、个性化普适终端业务的机制。最后通过一个具体业务接续场景验证了提出的建模方法及业务实现机制。结果表明,该信息模型能够对各种被管资源进行抽象,基于该信息模型可实现异构终端环境下面向用户个性需求的普适终端业务。

关键词：普适终端业务管理信息模型建模方法上下文基于信息模型的推理