检索结果-南通市图书馆

Mn-based cGAS-STING activation for tumor therapy

Chinese Journal of Cancer Research 2023年第1期35卷 19-43页

作者： Aiping Huang wenhu zhou Xiangya School of Pharmaceutical Sciences Central South UniversityChangsha 410013China Changsha Medical University Academician WorkstationChangsha 410219China

Immunotherapy has efficiently revolutionized the treatment of human neoplastic ***,the overall responsive rate of current immunotherapy is still unsatisfactory,benefiting only a small proportion of ***,significant attention has been paid to the modulation of tumor microenvironment(TME)for the enhancement of ***,recent studies have shown that cyclic GMP-AMP synthasestimulator of interferon gene(cGAS-STING)was initially found as an innate immune sensor to recognize cytoplasmic DNA(such as bacterial,viral,micronuclei,and mitochondrial).It is a promising signaling pathway to activate antitumor immune responses via type I interferon ***,Mn^(2+)was found to be a critical molecule to sensitize the activation of the cGAS-STING pathway for better *** activation led to the development of Mn^(2+)-based strategies for tumor immunotherapy via the activation of the cGAS-STING *** this critical review,we aimed to summarize the recent progress of this field,focusing on the following three ***,we briefly introduced the signaling pathway of cGAS-STING activation,and its regulation effect on the antitumor immunity cycle has been *** with this,several agonists of the cGAS-STING pathway were introduced with their potential as immunotherapeutic ***,the basic biological functions of Mn^(2+)have been illustrated,focusing on its critical roles in the cGAS-STING pathway ***,we systematically reviewed the Mn^(2+)-based strategies for tumor immunotherapy,which can be classified by the methods based on Mn^(2+)alone or Mn^(2+)combined with other therapeutic *** finally speculated the future perspectives of the field and provided rational suggestions to develop better Mn^(2+)-based therapeutics.

关键词： Tumor immunity metal ions combinatorial therapy targeting nanoparticles

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Harnessing bacteria for tumor therapy:Current advances and challenges

引用

Chinese Chemical Letters 2024年第2期35卷 97-106页

作者： Lina Guo Jinsong Ding wenhu zhou Xiangya School of Pharmaceutical Sciences Central South UniversityChangsha 410013China Changsha Medical University Academician WorkstationChangsha 410219China Key Laboratory of Biological Nanotechnology of National Health Commission Changsha 410008China

After a century of standstill,bacteria-based tumor therapy has resurged recently benefiting from the revolution of tumor immunotherapy,which provides unique solutions to tackle the obstacles of traditional tumor *** and facultative anaerobes with active tropism can selectively colonize at tumor sites and suppress tumor growth via different mechanisms,serving as attractive tools for tumor treatment either as a monotherapy or combining with other therapies for synergistic anti-tumor *** this critical review,we introduce the recent advances of bacteria-based tumor therapy from the following ***,the general properties of bacteria are reviewed emphasizing on their structural components related to tumor immunotherapy,and the main bacteria that have been used in tumor therapy are ***,the benefits of bacteria for tumor therapy are illustrated,such as tumor targetability,deep penetration,and facile genetic engineering for attenuation,enhanced efficacy,as well as ***,anti-tumor mechanisms of bacteria are summarized,which refer to intrinsic tumoricidal activities,immune activation,bacteria metabolism,and their capability to regulate gut microbiota ***,bacteria could act as carriers to deliver various types of therapeutics to achieve combination therapy with improved *** addition,several challenges for anti-tumor applications of bacteria are discussed regarding the delivery,efficacy and safety issues,and potential solutions are also ***,the possible improvements and perspectives are discussed in the end,which provide a guideline for the design of advanced bacteria-based tumor therapeutics in the future.

关键词： Bacteria Tumor targeting Immunotherapy Combination therapy Genetic engineering Surface decoration

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Converting bacteria into autologous tumor vaccine via surface biomineralization of calcium carbonate for enhanced immunotherapy

引用

Acta Pharmaceutica Sinica B 2023年第12期13卷 5074-5090页

作者： Lina Guo Jinsong Ding wenhu zhou Xiangya School of Pharmaceutical Sciences Central South UniversityChangsha 410013China Key Laboratory of Biological Nanotechnology of National Health Commission Xiangya HospitalChangsha 410008China

Autologous cancer vaccine that stimulates tumor-specific immune responses for personalized immunotherapy holds great potential for tumor ***,its efficacy is still suboptimal due to the immunosuppressive tumor microenvironment(ITM).Here,we report a new type of bacteria-based autologous cancer vaccine by employing calcium carbonate(CaCO_(3))biomineralized Salmonella(Sal)as an in-situ cancer vaccine producer and systematical ITM ***_(3) can be facilely coated on the Sal surface with calcium ionophore A23187 co-loading,and such biomineralization did not affect the bioactivities of the *** intratumoral accumulation,the CaCO_(3) shell was decomposed at an acidic microenvironment to atenuate tumor acidity,accompanied by the release of Sal and Ca^(2+)/***,Sal served as a cancer vaccine producer by inducing cancer cells'immunogenic cell death(ICD)and promoting the gap junction formation between tumor cells and dendritic cells(DCs)to promote antigen ***^(2+),on the other hand,was intermalized into various types of immune cells with the aid of A23187 and synergized with Sal to systematically regulate the immune system,including DCs maturation,macrophages polarization,and T cells *** a result,such bio-vaccine achieved remarkable effcacy against both primary and metastatic tumors by eliciting potent anti-tumor immunity with full *** work demonstrated the potential of bioengineered bacteria as bio-active vaccines for enhanced tumor immunotherapy.

关键词： Bacteria-mediated cancer therapy Tumor microenvironment Calcium carbonate Mineralization Metalloimmunology Autologous tumor vaccine Immunotherapy Tumor metastasis

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Macrophage-targeted nanomedicine for chronic diseases immunotherapy

引用

Chinese Chemical Letters 2022年第2期33卷 597-612页

作者： Yuejia Song Yaqian Huang Fang zhou Jinsong Ding wenhu zhou Xiangya School of Pharmaceutical Sciences Central South UniversityChangsha 410013China Academician Workstation Changsha Medical UniversityChangsha 410219China Department of Pharmacy Southern University of Science and Technology HospitalShenzhen 518055China

Macrophage is the key innate immune effector in first-line defense against the pathogens, and can be polarized into different phenotypes to regulate a variety of immunological functions. However, the plasticity of macrophage is extraordinarily recruited, activated, and polarized under pathological conditions,playing paramount roles in occurrence, development, and prognosis of various chronic diseases, such as rheumatoid arthritis(RA), atherosclerosis(AS), and cancer. To this end, macrophage has become an important therapeutic target for etiological treatment of these diseases. Meanwhile, with the development of nanotechnology, various nano-drug delivery systems have been explored to target macrophages for disease modulation, displaying unique advantages to address both pharmaceutic and biopharmaceutic limitations of various drugs. This review aims to summarize the recent progress of macrophage-targeted nanomedicine for chronic diseases immunotherapy. First, the origin, polarization and biological functions of macrophages have been introduced, in which macrophages can differentiate into different phenotypes in response to physiological stimuli to play various immunological roles. Then, the macrophage disorder has been reviewed in related with various chronic diseases, and several representative diseases, including AS, RA, obesity, and cancer, have been discussed in detail to elucidate the pathological contributions of macrophages for disease progress. Next, strategies to regulate macrophages for diseases immunotherapy, such as macrophages depletion, macrophage reprograming, inhibition of macrophage recruitment,are summarized, and particular attention has been paid on bio-functional nanomaterials to engineer macrophages via different mechanisms. Further, methods for macrophage-targeting delivery nanosystems are discussed based on both passive and active targeting approaches. Finally, the perspective is speculated for potential clinical translation, and there still has

关键词： Nanoparticles Delivery Macrophages Polarization Immunotherapy

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Recent progress of vaccines administration via microneedles for cancer immunotherapy

引用

Chinese Chemical Letters 2024年第3期35卷 96-103页

作者： Yuanzheng Chen Jiaojiao Zhu Jinsong Ding wenhu zhou Xiangya School of Pharmaceutical Sciences Central South UniversityChangsha 410013China Key Laboratory of Biological Nanotechnology of National Health Commission Changsha 410008China

Therapeutic cancer vaccines have undergone a resurgence in the past *** of the high level of immune cell accumulation and abundant capillary lymphatic system in the dermis,percutaneous vaccination is considered to be an ideal treatment *** convenient administration,the recent development of microneedles(MNs)provides a safe,painless,and low-cost transdermal delivery strategy,which could bypass the first-pass metabolism of vaccines for enhanced stability and ***,the therapeutic effect of MNs-based cancer vaccines is not optimal,which is limited by the complex set of host,tumor,and environmental factors,as well as the limited vaccine loading ***,further improvements are still required to push their clinical *** this critical review,we deliberate on how to improve the therapeutic effect of MNs-based vaccines for cancer immunotherapy,summarize the recent advances in MNs-based cancer vaccination,and provide an overview of various design strategies and mechanisms for active or passive targeting delivery,aiming to develop safer,more effective,and more stable MNs-based cancer ***,we briefly describe the potential of vaccine platforms in combination with other therapies,suggest the need to design vaccines according to specific circumstances,and discuss the biosafety of repeated administration for enhancing clinical efficacy.

关键词： Transdermal delivery Microneedles Cancer vaccine Immunotherapy Nanoparticle Lymph node

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

A PET probe targeting polyamine transport system for precise tumor diagnosis and therapy

引用

Asian Journal of Pharmaceutical Sciences 2024年第3期19卷 146-159页

作者： Ming zhou Xiaoqin Yin Bei Chen Shuo Hu wenhu zhou Department of Nuclear Medicine Xiangya HospitalCentral South UniversityChangsha 410008China Xiangya School of Pharmaceutical Sciences Central South UniversityChangsha 410013China Key Laboratory of Biological Nanotechnology of National Health Commission Changsha 410008China National Clinical Research Center for Geriatric Disorders(Xiangya) Changsha 410008China

Polyamine metabolism dysregulation is a hallmark of many cancers,offering a promising avenue for early tumor *** study presents the development of a nuclear probe derived from spermidine(SPM)for dual-purpose tumor PET imaging and internal radiation *** probe,radiolabeled with either[68Ga]Ga for diagnostic applications or[177Lu]Lu for therapeutic use,was synthesized with exceptional purity,stability,and specific *** testing involving 12 different tumor cell lines revealed remarkable specificity towards B16 melanoma cells,showcasing outstanding tumor localization and target-to-non-target *** investigations employing polyamines,non-labeled precursor,and polyamine transport system(PTS)inhibitor,consistently affirmed the probe?s targetability through recognition of the ***,while previous reports indicated PTS upregulation in various tumor types for targeted therapy,this study observed no positive signals,highlighting a concentration-dependent discrepancy between targeting for therapy and ***,when labeled with[177Lu],the probe demonstrated its therapeutic potential by effectively controlling tumor growth and extending mouse *** into biodistribution,excretion,and biosafety in healthy humans laid a robust foundation for clinical *** study introduces a versatile SPM-based nuclear probe with applications in precise tumor theranostics,offering promising prospects for clinical implementation.

关键词： PET imaging Polyamine metabolism Spermine Radiopharmaceutical Melanoma

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Macrophages-regulating nanomedicines for sepsis therapy

引用

Chinese Chemical Letters 2023年第3期34卷 100-112页

作者： Jiali Deng Rui Wang Shu Huang Jinsong Ding wenhu zhou Xiangya School of Pharmaceutical Sciences Central South UniversityChangsha 410013China Department of Orthopedics Hunan Provincial People’s HospitalThe First-Affiliated Hospital of Hunan Normal UniversityChangsha 410005China

Sepsis is the leading cause of death in intensive care unit(ICU), which is caused by deregulated immune responses to pathogens infection. Clinically, sepsis treatment is limited to antibiotics and supportive care, while there still lacks of specific molecular therapy. As a type of immune dysfunction disease,macrophages have been recognized as the key immune cells precipitating in the whole process of sepsis,which is activated into M1-like to trigger various inflammatory responses at early stage whereas polarized into M2-like to cause immunosuppression in later stage. Therefore, great attention has been paid on the design of nanomedicines to regulate the functions of macrophages for etiological treatment of sepsis, by virtue of the unique advantages of nano-drug delivery systems, such as enhanced drug bioavailability, targetability, reduced side-effects. This critical review aims to summarize the recent progress of macrophages-regulating nanoparticles for sepsis therapy. First, the essential roles of macrophages in the development and progression of sepsis have been introduced, including the positive roles of macrophages to combat infections and dysfunction of macrophages to cause body damages. We then focus our main attention to discuss the nanomedicines with different therapeutic mechanisms corresponding to each stage of sepsis, such as infection blockage, inflammation inhibition, immune functions recovery, as well as multifunctional nanomedicines. Finally, a few limitations of current nanomedicines are highlighted,and future perspective are speculated for potential clinical translation, which might pave the way for the development of macrophages-centered nanomedicines for more effective sepsis therapy.

关键词： Nanomedicine Sepsis Macrophages Infections Inflammation Immunity

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Copper carbonate nanoparticles as an effective biomineralized carrier to load macromolecular drugs for multimodal therapy

引用

Chinese Chemical Letters 2023年第9期34卷 204-209页

作者： Liping Dong Jinsong Ding Lemei Zhu Yujun Liu Xiang Gao wenhu zhou Changsha Medical University Academician WorkstationChangsha 410219China Xiangya School of Pharmaceutical Sciences Central South UniversityChangsha 410013China State Key Laboratory of Toxicology and Medical Countermeasures Institute of Pharmacology and ToxicologyBeijing 100850China Key Laboratory of Biological Nanotechnology of National Health Commission Changsha 410000China

Macromolecular drugs have attracted great interest as biotherapy to cure previously untreatable *** clinical translation,biomacromolecules encounter several common druggability difficulties,such as in vivo instability and poor penetration to cross physiologic barriers,thus requiring sophisticated systems for drug *** by the natural biomineralization via interaction between inorganic ions and biomacromolecules,herein we rationally screened biocompatible transition metals to biomineralize with carbonate for macromolecules *** the metal ions,Cu^(2+)was found to be the best candidate,and its superiority over the widely studied Ca^(2+)minerals was also *** on this finding,copper carbonate nanoparticles were prepared via a simple mixing process to co-load glucose oxidase(GOx)and a HIF-αDNAzyme(DZ),achieving ultra-high loading capacity of 61%.Upon encapsulation into nanoparticles,enzymatic activity of both drugs was passivated to avoid potential side-effects during circulation,while the drugs could be rapidly released within 1 h in response to acidic p H to fully recover their *** nanoparticles could accumulate into tumor via intravenous injection,facilitate the cell membrane penetration,and release the payloads of GOx,DZ and Cu^(2+)inside cells to exert a series of anti-tumor *** caused tumor starvation by catalytic glucose consumption,and the concomitantly generated H_(2)O_(2)byproduct boosted the Cu^(2+)-mediated chemodynamic therapy(CDT).Meanwhile,the DZ silenced HIF-αexpression to sensitize both starvation therapy and *** a result,a synergistic tumor growth inhibition was *** work provides a simple method to prepare biomineralized nanoparticles,and offers a general approach for macromolecular drugs delivery via Cu^(2+)-based biomineralization.

关键词： Metal ions Biomineralization Drug delivery Nanomedicine Tumor therapy

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

A smart MnO_(2)-doped graphene oxide nanosheet for enhanced chemo-photodynamic combinatorial therapy via simultaneous oxygenation and glutathione depletion

引用

Acta Pharmaceutica Sinica B 2021年第3期11卷 823-834页

作者： Peng Liu Xin Xie Miao Liu Shuo Hu Jinsong Ding wenhu zhou Xiangya School of Pharmaceutical Sciences Central South UniversityChangsha 410013China School of Pharmaceutical Sciences Gannan Medical UniversityGanzhou 341000China Department of Nuclear Medicine Xiangya HospitalCentral South UniversityChangsha 410008China Key Laboratory of Biological Nanotechnology of National Health Commission Changsha 410008China

The combination of chemotherapy and photodynamic therapy provides a promising approach for enhanced tumor eradication by overcoming the limitations of each individual therapeutic ***,tumor is pathologically featured with extreme hypoxia together with the adaptable overexpression of anti-oxidants,such as glutathione(GSH),which greatly restricts the therapeutic ***,a combinatorial strategy was designed to simultaneously relieve tumor hypoxia by self-oxygenation and reduce intracellular GSH level to sensitize chemo-photodynamic *** our system,a novel multifunctional nanosystem based on MnO_(2)-doped graphene oxide(GO)was developed to co-load cisplatin(Cis Pt)and a photosensitizer(Ce6).With Mn O_(2)doping,the nanosystem was equipped with intelligent functionalities:(1)catalyzes the decomposition of H_(2)O_(2)into oxygen to relieve the tumor hypoxia;(2)depletes GSH level in tumor cells,and(3)concomitantly generates Mn^(2+)to proceed Fenton-like reaction,all of which contribute to the enhanced anti-tumor ***,the surface hyaluronic acid(HA)modification could facilitate the targeted delivery of the nanosystem into tumor cells,thereby resulting in amplified cellular toxicity,as well as tumor growth inhibition in nude mice *** work sheds a new light on the development of intelligent nanosystems for synergistic combination therapy via regulating tumor microenvironment.

关键词： Cisplatin Nanoparticles Photosensitizer Tumor microenvironment Oxygenation GSH depletion Nanozyme Targeting

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Photothermal Nano-Vaccine Promoting Antigen Presentation and Dendritic Cells Infiltration for Enhanced Immunotherapy of Melanoma via Transdermal Microneedles Delivery

引用

Research 2023年第2期2022卷 139-157页

作者： Jiaojiao Zhu Ruimin Chang Benliang Wei Yao Fu Xiang Chen Hong Liu wenhu zhou Xiangya School of Pharmaceutical Sciences Central South UniversityChangshaHunan 410013China Department of Dermatology Hunan Engineering Research Center of Skin Health and DiseaseHunan Key Laboratory of Skin Cancer and PsoriasisXiangya HospitalCentral South UniversityChangsha410008 HunanChina National Engineering Research Center of Personalized Diagnostic and Therapeutic Technology Xiangya Hospital.Central South UniversityChangsha410008 HunanChina Department of Thoracic Surgery Xiangya HospitalCentral South UniversityChangshaHunan 410008China

Immunotherapy has demonstrated the potential to cure melanoma,while the current response rate is still unsatisfactory in *** evidence indicates the correlation between the eficacy and pre-existing T-cell in tumors,whe... 详细信息

关键词： melanoma Antigen Vaccine

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：