Mn-based cGAS-STING activation for tumor therapy

作     者：Aiping Huang Wenhu Zhou Aiping Huang;Wenhu Zhou

作者机构：Xiangya School of Pharmaceutical SciencesCentral South UniversityChangsha 410013China Changsha Medical UniversityAcademician WorkstationChangsha 410219China 

出 版 物：《Chinese Journal of Cancer Research》 (中国癌症研究（英文版）)

年 卷 期：2023年第35卷第1期

页      面：19-43页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：National Natural Science Foundation of China(No.U1903125,82073799) Natural Science Foundation of Hunan province in China(No.2021JJ20084) the Science and Technology Innovation Program of Hunan Province(No.2021RC3020) 

主　　题：Tumor immunity metal ions combinatorial therapy targeting nanoparticles 

摘      要：Immunotherapy has efficiently revolutionized the treatment of human neoplastic ***,the overall responsive rate of current immunotherapy is still unsatisfactory,benefiting only a small proportion of ***,significant attention has been paid to the modulation of tumor microenvironment(TME)for the enhancement of ***,recent studies have shown that cyclic GMP-AMP synthasestimulator of interferon gene(cGAS-STING)was initially found as an innate immune sensor to recognize cytoplasmic DNA(such as bacterial,viral,micronuclei,and mitochondrial).It is a promising signaling pathway to activate antitumor immune responses via type I interferon ***,Mn^(2+)was found to be a critical molecule to sensitize the activation of the cGAS-STING pathway for better *** activation led to the development of Mn^(2+)-based strategies for tumor immunotherapy via the activation of the cGAS-STING *** this critical review,we aimed to summarize the recent progress of this field,focusing on the following three ***,we briefly introduced the signaling pathway of cGAS-STING activation,and its regulation effect on the antitumor immunity cycle has been *** with this,several agonists of the cGAS-STING pathway were introduced with their potential as immunotherapeutic ***,the basic biological functions of Mn^(2+)have been illustrated,focusing on its critical roles in the cGAS-STING pathway ***,we systematically reviewed the Mn^(2+)-based strategies for tumor immunotherapy,which can be classified by the methods based on Mn^(2+)alone or Mn^(2+)combined with other therapeutic *** finally speculated the future perspectives of the field and provided rational suggestions to develop better Mn^(2+)-based therapeutics.