Macrophages-regulating nanomedicines for sepsis therapy

作     者：Jiali Deng Rui Wang Shu Huang Jinsong Ding Wenhu Zhou Jiali Deng;Rui Wang;Shu Huang;Jinsong Ding;Wenhu Zhou

作者机构：Xiangya School of Pharmaceutical SciencesCentral South UniversityChangsha 410013China Department of OrthopedicsHunan Provincial People’s HospitalThe First-Affiliated Hospital of Hunan Normal UniversityChangsha 410005China 

出 版 物：《Chinese Chemical Letters》 (中国化学快报（英文版）)

年 卷 期：2023年第34卷第3期

页      面：100-112页

核心收录：

学科分类：1007[医学-药学(可授医学、理学学位)] 1004[医学-公共卫生与预防医学(可授医学、理学学位)] 07[理学] 070205[理学-凝聚态物理] 100401[医学-流行病与卫生统计学] 0703[理学-化学] 10[医学] 0702[理学-物理学] 

基　　金：supported by National Natural Science Foundation of China(Nos.U1903125,82073799) Natural Science Foundation of Hunan Province in China(Nos.2021JJ20084,2021JJ70016) the Science and Technology Innovation Program of Hunan Province(No.2021RC3020)。 

主　　题：Nanomedicine Sepsis Macrophages Infections Inflammation Immunity 

摘      要：Sepsis is the leading cause of death in intensive care unit(ICU), which is caused by deregulated immune responses to pathogens infection. Clinically, sepsis treatment is limited to antibiotics and supportive care, while there still lacks of specific molecular therapy. As a type of immune dysfunction disease,macrophages have been recognized as the key immune cells precipitating in the whole process of sepsis,which is activated into M1-like to trigger various inflammatory responses at early stage whereas polarized into M2-like to cause immunosuppression in later stage. Therefore, great attention has been paid on the design of nanomedicines to regulate the functions of macrophages for etiological treatment of sepsis, by virtue of the unique advantages of nano-drug delivery systems, such as enhanced drug bioavailability, targetability, reduced side-effects. This critical review aims to summarize the recent progress of macrophages-regulating nanoparticles for sepsis therapy. First, the essential roles of macrophages in the development and progression of sepsis have been introduced, including the positive roles of macrophages to combat infections and dysfunction of macrophages to cause body damages. We then focus our main attention to discuss the nanomedicines with different therapeutic mechanisms corresponding to each stage of sepsis, such as infection blockage, inflammation inhibition, immune functions recovery, as well as multifunctional nanomedicines. Finally, a few limitations of current nanomedicines are highlighted,and future perspective are speculated for potential clinical translation, which might pave the way for the development of macrophages-centered nanomedicines for more effective sepsis therapy.