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Neuroscience Bulletin 2021年第2期37卷 183-200页

作者： Kuan Tian Andi Wang Junbao Wang Wei Li wenchen Shen Yamu Li Zhiyuan Luo Ying liu Yan Zhou College of Life Sciences Renmin Hospital of Wuhan UniversityWuhan UniversityWuhan430072China Frontier Science Center for Immunology and Metabolism Medical Research InstituteSchool of MedicineWuhan UniversityWuhan430071China Institute of Basic Medical Sciences Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing100730China

Long non-coding RNAs(lncRNAs)regulate transcription to control development and homeostasis in a variety of tissues and ***,their roles in the development of the cerebral cortex have not been well ***,a bioinformatics pipeline was applied to delineate the dynamic expression and potential cis-regulating effects of mouse lncRNAs using transcriptome data from 8 embryonic time points and sub-regions of the developing cerebral *** further characterized a sense lncRNA,SenZfp536,which is transcribed downstream of and partially overlaps with the protein-coding gene *** SenZfp536 and Zfp536 were predominantly expressed in the proliferative zone of the developing ***536 was cis-regulated by SenZfp536,which facilitates looping between the promoter of Zfp536 and the genomic region that transcribes ***,knocking down or activating the expression of SenZfp536 increased or compromised the proliferation of cortical neural progenitor cells(NPCs),***,overexpressing Zfp536 in cortical NPCs reversed the enhanced proliferation of cortical NPCs caused by SenZfp536 *** study deepens our understanding of how lncRNAs regulate the propagation of cortical NPCs through cis-regulatory mechanisms.

关键词： Zfp536 Sense lncRNA Self-renewal Cortical development Neural progenitor

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论“湿邪致中风”

湖南中医药大学学报 2021年第1期41卷 111-115页

作者：孙一凡李国铭翁銮坤刘文琛赵敏招远祺广州中医药大学第二临床医学院广东广州510006 广东省中医院广东广州510120

中风病是难治性脑病,历代医家对中风病病因病机观点各异。立足于湿邪和中风病的古今文献研究,结合湿邪致病的特点和中风病的证候特点,探讨湿邪与中风病之间的关系,剖析“湿邪致中风”的源流、辨证要点及临证思路,强调湿邪为中风病的重... 详细信息

中风病是难治性脑病,历代医家对中风病病因病机观点各异。立足于湿邪和中风病的古今文献研究,结合湿邪致病的特点和中风病的证候特点,探讨湿邪与中风病之间的关系,剖析“湿邪致中风”的源流、辨证要点及临证思路,强调湿邪为中风病的重要病理因素,以期加深临床上对中风病的研究,进一步拓宽治疗思路。

关键词：中风湿邪病因病机

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三种地下水水质评价方法的对比分析

水资源与水工程学报 2011年第3期22卷 113-118页

作者：张新钰辛宝东刘文臣郭高轩陆海燕纪轶群北京市水文地质工程地质大队北京100195

介绍了单因子评价法、F值评分法和模糊综合评判法等地下水水质评价方法的基本原理,随机抽取北京市2009年丰水期水样14例,运用三种方法进行水质评价,并对评价结果进行了对比分析。分析结果表明:单因子评价法能直观反映单项组分的超标情况... 详细信息

介绍了单因子评价法、F值评分法和模糊综合评判法等地下水水质评价方法的基本原理,随机抽取北京市2009年丰水期水样14例,运用三种方法进行水质评价,并对评价结果进行了对比分析。分析结果表明:单因子评价法能直观反映单项组分的超标情况,清晰判断出主要污染指标,但不能全面的反映水质的整体状况;F值评分法根据相应的分级标准确定水质类型,在指标水质分级明显、超标指标较多或者没有超标指标的情况下可以较合理的反映水质状况,但是它极突出最大污染因素,某种情况下一定程度上高估水质污染程度。模糊综合评判法充分考虑了水质分级界线的过渡性,评价结果更精确,但是计算比较复杂。

关键词：地下水水质评价方法对比分析

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从胡希恕医学思想浅析精癃的发病基础与鉴别

中国医药科学 2015年第8期5卷 193-195页

作者：任伟明胡乔铭刘文琛谭映辉张熙袁轶峰谢明霞湖南中医药大学湖南长沙410208

精癃是老年男性常见疾病,本文从胡希恕的临证思想结合《伤寒杂病论》原文及笔者的临床体会,重点阐述了气虚无力运血和瘀血阻滞为其发病基础,并分析了柴胡桂枝干姜汤证和桂枝去芍加茯苓白术汤证的临床表现,临床中极易与精癃相混淆和忽视。

关键词：胡希恕精窿伤寒论

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三种地下水水质评价方法的应用对比分析

城市地质 2011年第1期6卷 30-36页

作者：张新钰辛宝东刘文臣王晓红郭高轩陆海燕北京市水文地质工程地质大队北京100195

本文给出了目前地下水水质评价中,常用的单项组分评价方法、F值法和模糊综合评判法基本原理。并运用这三种方法分析了北京市大兴区地下水水质,阐述各种方法的优缺点及适用条件,为地下水水质评价评价方法选用提供依据。

关键词：地下水水质评价对比分析

Long non-coding RNA LncKdm2b regulates cortical neuronal differentiation by cis-activating Kdm2b

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Protein & Cell 2020年第3期11卷 161-186页

作者： Wei Li wenchen Shen Bo Zhang Kuan Tian Yamu Li Lili Mu Zhiyuan Luo Xiaoling Zhong Xudong Wu Ying liu Yan Zhou College of Life Sciences Renmin Hospital of Wuhan UniversityMedical Research Institute at School of MedicineWuhan UniversityWuhan 430072China Department of Cell Biology Tianjin Medical UniversityQixiangtai Road 22Tianjin 300070China

The mechanisms underlying spatial and temporal control of cortical neurogenesis of the brain are largely *** non-coding RNAs(lncRNAs)have emerged as essential cell fate *** we found LncKdm2b(also known as Kancr),a lncRNA divergently transcribed from a bidirectional promoter of Kdm2b,is transiently expressed during early differentiation of cortical projection ***,Kdm2b’s transcription is positively regulated in cis by LncKdm2b,which has intrinsic-activating function and facilitates a permissive chromatin environment at the Kdm2b’s promoter by associating with *** tracing experiments and phenotypic analyses indicated LncKdm2b and Kdm2b are crucial in proper differentiation and migration of cortical projection *** observations unveiled a lncRNA-dependent machinery in regulating cortical neuronal differentiation.

关键词： long non-coding RNA neuronal differentiation cerebral cortex KDM2B divergent lncRNA

基于情绪应激下心血管疾病大鼠复合模型的构建探索益气活血方对脂联素水平的影响

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云南中医学院学报 2015年第3期38卷 1-4,9页

作者：万婷郭书文吴佳妮张璐武建功陈曦刘文臣苏兆铎北京中医药大学北京100029

目的在情绪应激下心血管疾病复合模型大鼠构建的基础上,研究情绪和心血管疾病间的关系。通过观察、对比益气活血方对复合病模型大鼠心肌组织、脑海马体内脂联素含量的影响,为基础实验研究和临床心血管疾病防治、用药提供新的理论设想和... 详细信息

目的在情绪应激下心血管疾病复合模型大鼠构建的基础上,研究情绪和心血管疾病间的关系。通过观察、对比益气活血方对复合病模型大鼠心肌组织、脑海马体内脂联素含量的影响,为基础实验研究和临床心血管疾病防治、用药提供新的理论设想和依据。方法采取腹腔注射异丙肾上腺素合并慢性不可预见性情绪刺激法构建大鼠复合模型。将实验动物分为空白组、ISO模型组(单纯心肌缺血模型)、复合模型组(心肌缺血合并情志刺激模型)、中药组、西药组5组。采用超声心动图监测和行为学实验作为模型大鼠构建成功的依据。观察、对比大鼠心脏功能,行为学指标,心肌组织和脑海马体中脂联素各组用药后的变化情况。结果实验32d后,复合模型组和ISO模型组射血分数(EF)和短轴缩短率(FS)均低于空白组,差异有统计学意义(P<0.01);复合模型组、ISO模型组心肌组织、脑海马体中的脂联素含量均低于空白组,差异有统计学意义(P<0.01或P<0.05);中药组、西药组大鼠脂联素含量均高于复合模型组,差异有统计学意义(P<0.01或P<0.05)。结论益气活血药可以改善复合模型大鼠心脏功能和行为学指标,从而使模型大鼠机体走上良性循环道路,其原因可能与其对脂联素的作用有关。

关键词：脂联素慢性应激心血管疾病益气活血药情绪刺激

Periostin mediates epithelial-mesenchymal transition through the MAPK/ERK pathway in hepatoblastoma

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Cancer Biology & Medicine 2019年第1期16卷 89-99页

作者： Lu Chen Xiangdong Tian wenchen Gong Bo Sun Guangtao Li Dongming liu Piao Guo Yuchao He Ziye Chen Yuren Xia Tianqiang Song Hua Guo Department of Tumor Cell Biology Tianjin Medical University Cancer Institute and Hospital National Clinical Research Center for Cancer Key Laboratory of Cancer Prevention and TherapyTianjin Tianjin's Clinical Research Center for Cancer

Objective: The aim of the present study was to analyze the prognostic factors in patients with hepatoblastoma(HB) in our single center and to evaluate periostin(POSTN) expression in HB and its association with clinicopathological variables. In addition, the underlying mechanism of how POSTN promotes HB progression was ***: POSTN expression was investigated in HB tumors by immunohistochemistry(IHC), immunofluorescence(IF) and Western blot(WB). The association among POSTN expression, clinicopathological features and overall survival(OS) was also evaluated. The migration and adhesion ability of HB cells were measured using chemotaxis and cell-matrix adhesion assays,respectively. Epithelial-mesenchymal transition(EMT)-associated markers and activation of the ERK pathway were detected by ***: HB patients had poor prognosis which displayed lymph node metastasis, vascular invasion, POSTN and vimentin expression. POSTN expression was also associated with lymph node metastasis. Furthermore, overexpressed POSTN promoted migration and the adhesive ability of HB cells in vitro. In addition, we demonstrated that POSTN activated the MAPK/ERK pathway, upregulated the expression of Snail and decreased the expression of OVOL2. Finally, POSTN promoted the expression of EMT-associated ***: POSTN might modulate EMT via the ERK signaling pathway, thereby promoting cellular migration and *** study also suggests that POSTN may serve as a therapeutic biomarker in HB patients.

关键词： Periostin hepatoblastoma EMT MAPK/ERK

A retrospective analysis of mature T-and NK-cell lymphomas

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Cancer Biology & Medicine 2024年第3期21卷 223-229页

作者： Junlei Jia Xiaohui Wang Zheng Song Shen Meng Yue Fei Jingwei Yu Xia liu Xue Han Lanfang Li Lihua Qiu Zhengzi Qian Shiyong Zhou wenchen Gong Bin Meng Xiubao Ren Xianhuo Wang Huilai Zhang National Key Laboratory of Druggability Evaluation and Systematic Translational Medicine and Department of LymphomaTianjin Medical University Cancer Institute&HospitalNational Clinical Research Center for CancerTianjin's Clinical Research Center for CancerKey Laboratory of Cancer Prevention and TherapyTianjinThe Sino-US Center for Lymphoma and Leukemia ResearchTianjin 300060China Department of Radiation Oncology Shandong Cancer Hospital and InstituteShandong First Medical University and Shandong Academy of Medical SciencesJinan 250117China Department of Pathology Department of Immunology/Biotherapy Tianjin Medical University Cancer Institute&HospitalNational Clinical Research Center for CancerTianjin's Clinical Research Center for CancerKey Laboratory of Cancer Prevention and TherapyTianjinTianjin 300060China

Mature T-and natural killer(NK)-cell lymphomas are heterogeneous groups of malignant lymphoid neoplasms arising from T and NK cells. The incidence of mature T-and NK-cell lymphomas is 2.1 per 100,000 people, according... 详细信息

关键词： lymphoma neoplasms killer

斜钢管混凝土柱框架-核心筒-伸臂桁架结构抗震性能研究

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建筑结构学报 2023年第6期44卷 12-23页

作者：成宇刘界鹏单文臣李江重庆大学山地城镇建设与新技术教育部重点实验室重庆400045 重庆大学土木工程学院重庆400045 深圳大学土木与交通工程学院广东深圳518060

为明确钢管混凝土(CFT)柱框架-核心筒-伸臂桁架混合结构的抗震性能,结合典型工程“青岛海天中心”,采用MARC有限元软件对该结构体系进行抗震性能分析。分别进行了多遇地震、设防地震及罕遇地震作用下的弹塑性动力时程分析。结果表明:设... 详细信息

为明确钢管混凝土(CFT)柱框架-核心筒-伸臂桁架混合结构的抗震性能,结合典型工程“青岛海天中心”,采用MARC有限元软件对该结构体系进行抗震性能分析。分别进行了多遇地震、设防地震及罕遇地震作用下的弹塑性动力时程分析。结果表明:设置斜CFT框架柱可有效控制结构顶点位移,罕遇地震作用下,最大顶点位移较直CFT框架柱结构的降低约76.6%;斜CFT柱使地震剪力由核心筒向框架转移,转移后的地震剪力更接近双重抗侧力体系的设计要求,即在多遇地震作用下框架部分至少承担结构总底部剪力的20%;同时,结构倾覆力矩的变化与剪力相反。设置斜CFT框架柱的结构可充分利用材料性能,在发挥相同抗侧力作用情况下能取得较好的经济效益。在此基础上,对结构进行基于增量动力分析(IDA)的地震倒塌易损性分析,确定了结构塑性发展路径为连梁、核心筒底部、框架柱底端、伸臂桁架。易损性分析结果表明,CFT框架柱斜置未对结构抗震倒塌安全储备产生不利影响,依然表现出优异的抗地震倒塌能力;结构变截面楼层部分的连梁和周围墙底塑性损伤最为严重,在设计中应对其进行加强。

关键词：超高层建筑框架-核心筒-伸臂桁架结构斜钢管混凝土框架柱增量动力分析抗震性能