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Synthesis and structure characterization of a novel series of N-alkylphthalimidylaminocarbonylmethoxylcalix[4]arenes

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Chinese Chemical Letters 2007年第12期18卷 1493-1495页

作者： Zhi Qiang Shi Ya Qing Feng Bing zhao wen Xiang wang School of Chemical Engineer and Technology Tianjin University Tianjin 300072 China

A novel series of N-alkylphthalimidylaminocarbonylmethoxylcalix[4]arenes with the reaction between 4-（N-bromoacetyla- mino）-phthalimide derivatives and calix[4]arene has been synthesized and structurally characteriz... 详细信息

关键词： Calixarene 4-(N-Bromoacetylamino)-phthalimide Fluorescent

Physical aging in Zr_(46.75)Ti_(8.25)Cu_(7.5)Ni_(10)Be_(27.5) typical bulk metallic glass manifested as enthalpy relaxation

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Science China(Physics,Mechanics & Astronomy) 2008年第4期51卷 356-364页

作者： wen Ping,zhao ZuoFeng & wang WeiHua Institute of Physics,Chinese Academy of Sciences,Beijing 100080,China 1. Institute of Physics Chinese Academy of Sciences Beijing 100080 China

Enthalpy recovery is not only an important characteristic of physical aging of glass,but also a good tool to investigate the physical aging. Using differential scanning calorimeter (DSC),the enthalpy recovery of Zr46.75Ti8.25Cu7.5Ni10Be27.5 bulk metallic glass (BMG) was studied. The typical characteristics of enthalpy recovery of glass including the sub-Tg peak and ‘overshot’ were found in BMG. The evolution of the sub-Tg peak and ‘overshot’ were described by the free volume theory and Hodge’s model,respectively. It was found that the former failed to describe the enthalpy recovery in the BMG,while the latter could give a qualitative explanation. In com-bination with the dynamics in the BMG,the origin of the enthalpy recovery in the BMG was discussed. The results show that BMGs are an ideal material to investi-gate the physical aging. The further understanding of physical aging of BMGs is useful to clarify the nature of glass and improve the application and device of new types of BMGs.

关键词： bulk metallic glass enthalpy recovery physical aging

Neuroprotective mechanisms of rutin for spinal cord injury through anti-oxidation and anti-inflammation and inhibition of p38 mitogen activated protein kinase pathway

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Neural Regeneration Research 2018年第1期13卷 128-134页

作者： Hong-liang Song Xiang Zhang wen-zhao wang Rong-han Liu Kai zhao Ming-yuan Liu Wei-ming Gong Bin Ning Department of Spinal Surgery Jinan Central Hospital Affiliated to Shandong University Hospital Pharmacy Jinan Central Hospital Affiliated to Shandong University Department of Gynecology and Obstetrics Jinan Maternity and Child Care Hospital

Rutin has anti-inflammatory, antioxidant, anti-viral, anti-tumor and immune regulatory effects. However, the neuroprotective effects of rutin in spinal cord injury are unknown. The p38 mitogen activated protein kinase （p38 MAPK） pathway is the most important member of the MAPK family that controls inflammation. We assumed that the mechanism of rutin in the repair of spinal cord injury is associated with the inhibition of p38 MAPK pathway. Allen’s method was used to establish a rat model of spinal cord injury. The rat model was intraperitoneally injected with rutin （30 mg/kg） for 3 days. After treatment with rutin, Basso, Beattie and Bresnahan locomotor function scores increased. Water content, tumor necrosis factor alpha, interleukin 1 beta, and interleukin 6 levels, p38 MAPK protein expression and caspase-3 and -9 activities in T8–9 spinal cord decreased. Oxidative stress related markers superoxide dismutase and glutathione peroxidase levels increased in peripheral blood. Rutin exerts neuroprotective effect through anti-oxidation, anti-inflammation, anti-apoptosis and inhibition of p38 MAPK pathway.

关键词： nerve regeneration spinal cord injury rutin oxidative stress antioxidant anti-inflammation p38 mitogen activated protein kinase pathway anti-apoptosis caspase-3 caspase-9 neural regeneration

Phosphatases of regenerating liver： a novel target in human solid tumors

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Chinese Medical Journal 2008年第15期121卷 1469-1474页

作者： zhao wen-bo wang Xin Department of Hematology Provincial Hospital Shandong University Jinan Shandong 250021 China

Protein tyrosine phosphorylation is a major posttranslational modification used by cells to regulate signal transduction and essentially participate in every aspect of cellular physiologic and pathogenic processes. The protein tyrosine phosphatase （PTP） super family of enzymes coordinately function with protein tyrosine kinases in signaling pathways that underlie a broad spectrum of fundamental physiological processes. Abnormal regulation of tyrosine phosphorylation or deregulation of phosphorylation is known to result in neoplastic or non-neoplastic diseases. Having evolved into separate families that are structurally and mechanistically distinct, PTPs have been implicated in a variety of diseases and efforts have been made to seek therapeutic clues from them. The phosphatases of regenerating liver （PRL） PRL-1, PRL-2, PRL-3 （also known as PTP4A1, PTP4A2, and PTP4A3, respectively） constitute a subfamily of the protein tyrosine phosphatases that have been suggested to play a key role in oncogenic and metastatic phenotypes.5 Here we review what is known about this novel class of small, prenylated phosphatases and its value in diagnosis and therapy of solid tumors.

关键词： phosphatases of regenerating liver tumor invasion metastasis angiogenesis

Raman spectroscopy and quantum chemical calculation on YCl_(3)-KCl molten salt system

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Rare Metals 2023年第11期42卷 3886-3896页

作者： Can Xu Xian-Wei Hu Jiang-Yu Yu Peng-Wei Li Ai-Min Liu Shao-Hua Luo Zhong-Ning Shi zhao-wen wang Key Laboratory Ecological Metallurgy of Multimetallic Mineral‘Ministry of Education’ School of MetallurgyNortheastern UniversityShenyang110819China State Key Laboratory of Rolling and Automation Northeastern UniversityShenyang110819China School of Materials Science and Engineering Northeastern UniversityShenyang110819China Department of Chemistry and Bioscience Aalborg University9220AalborgDenmark

The knowledge on the ionic structure of YCl_(3)-KCl molten system is of guiding significance for the practical production of yttrium metals and yttrium alloys via molten salt electrolysis using this system as *** this paper,the theoretical Raman spectra of the ionic groups which may exist in YCl_(3)-KCl molten system are simulated by quantum chemical calculation using Gaussian09 and Gauss View 5.0 programs based on density functional theory(DFT).Then the ionic structures of 20 mol%-60 mol%YCl_(3)-KCl molten salt systems are studied by comparing the Raman shift values of the bands in the theoretical Raman spectra of different ionic groups with the experimental spectra of this ***_(6)^(3-),Y_(2)Cl_(7)^(-),Y_(2)Cl_(8)^(2-)and Y_(2)Cl_(9)^(3-)are thought to exist in the molten *** the increase of temperature,the relative content of YCl_(6)^(3-)ionic groups increases while those of Y_(2)Cl_(7)^(-),Y_(2)Cl_(8)^(2-)and Y_(2)Cl_(9)^(3-)ionic groups ***,the"lifetime"of all ionic groups decreases within the temperature range of 692-730℃.Meanwhile,the relative contents of Y_(2)Cl_(7)^(-),Y_(2)Cl_(8)^(2-)and Y_(2)Cl_(9)^(3-)increase with the increase of YCl_(3)content,while that of YCl_(6)^(3-)*** wave function analysis of the four ionic groups(YCl_(6)^(3-),Y_(2)Cl_(7)^(-),Y_(2)Cl_(8)^(2-),and Y_(2)Cl_(9)^(3-))is carried out by Multiwfn *** net charge in each group,the direction of electron migration during the formation of each group,the sites where electrophilic and nucleophilic reactions are most likely to occur in each ionic group,and the order of bond breaking during chemical reactions for the four groups are obtained.

关键词： YCl_(3)-KCl molten salt Ionic structure Raman spectroscopy Quantum chemical calculation Wave function analysis

A light-through-side cell and co-used furnace designed for micro-Raman spectra study on volatile melts

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Chinese Chemical Letters 2012年第11期23卷 1291-1294页

作者： Xian Wei Hu Huan Li Bing Liang Gao Jing Jing Liu Zhong Ning Shi Jiang Yu Yu zhao wen wang School of Materials and Metallurgy Northeastern UniversityShenyang 110004China

A new type of sample cell specially designed for micro-Raman spectra study on volatile melts is described. The cell is made of quartz. The lower section of the cell is circular ring-shaped and the one-end-closed hole in the cell is used for locating the heating body. The tube attached to the cell lid for placing the thermal couple is inserted into the sample, which ensures that the temperature measurement accuracy is good. The cell can be sealed for reducing the effect of the composition change caused by the in_homogeneous volatilization. During the Raman spectra scanning, the laser beam is transmitted into the cell through the side but not the top. Meanwhile, a furnace has been designed to match the cell. The heating body is closely coupled with the sample cell, and there is a hole on the side wall of the furnace for the entrance of the microlens. The assembly has performed well in the tested Raman spectrum measurement of molten NaNO3 at 602 ℃.

关键词： Light-through-side cell Raman spectroscopy Volatile melts Comer microlens Cell-around-heating body furnace

Role of circular RNA expression in the pathological progression after spinal cord injury

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Neural Regeneration Research 2021年第10期16卷 2048-2055页

作者： wen-zhao wang Jun Li Lei Liu Zheng-Dong Zhang Ming-Xin Li Qin Li Hui-Xu Ma Hai Yang Xiao-Ling Hou Department of Orthopedics National Clinical Research Center for GeriatricsWest China HospitalSichuan University/West China School of NursingSichuan UniversityChengduSichuan ProvinceChina

Differential expression of non-coding RNA after traumatic spinal cord injury(TSCI)is closely related to the pathophysiological *** purposes of this study were to systematically profile and characterize expression of circular RNA(circRNA)in the lesion epicenter of spinal tissues after TSCI,and predict the structure and potential function of the regulatory circRNA/miRNA ***-eight C57BL/6 mice were randomly and equally assigned to two groups:one subjected to TSCI at T8–10 with an Allen’s drop impactor,and a second subjected to laminectomy without *** cord samples were stained with hematoxylin and eosin,sequenced,and ***-Seq,Gene Ontology analysis,Kyoto Encyclopedia of Genes and Genomes analysis,and network analyses(Targetscan and miRanda)were used to predict and annotate the circRNA/miRNA/mRNA *** reporter,quantitative reverse transcription polymerase chain reaction,and western blot assays were used to profile expression and regulation patterns of the network in mouse models of ***-eosin staining revealed severe damage to the blood-spinal cord barrier after *** expressed circRNA and miRNA profiles were obtained after TSCI;differentially expressed circRNAs,which were abundant in the cytoplasm,were involved in positive regulation of transcription and protein ***-135b-5p was the most significantly downregulated miRNA after TSCI;circRNAAbca1 and KLF4 were predicted to be its target circRNA and mRNA,***,the circAbca1/miR-135b-5P/KLF4 regulatory axis was predicted and constructed,and its targeted binding was *** inhibiting circAbca1,GAP43 expression was *** expression of circRNAs might play an important role after ***1 plays a neuroinhibitory role by targeted binding of the miR-135b-5P/KLF4 *** identified circRNA/miRNA/mRNA network could provide the basis for understanding pathophysiological mechanisms underlying

关键词： bioinformatics circRNA/miRNA/mRNA network circular RNA gene KLF4 miR-135b-5p spinal cord injury trauma

Indicators of prognosis after liver transplantation in Chinese hepatocellular carcinoma patients

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World Journal of Gastroenterology 2009年第33期15卷 4170-4176页

作者： Jin Li Lu-Nan Yan Jan Yang Zhe-Yu Chen Bo Li Yong Zeng Tian-Fu wen Ji-Chun zhao wen-Tao wang Jia-Yin Yang Ming-Qing Xu Yu-Kui Ma Division of Liver Transplantation West-China Hospital West China Medical School of Sichuan University Chengdu 610041 Sichuan Province China

AIM： To identify prognostic factors of patients with hepatocellular carcinoma （HCC）, who were treated by orthotopic liver transplantation （OLT）. METHODS： From January 2000 to October 2006, 165 patients with HCC underwent OLT. Various clinicopathological risk factors for actuarial and recurrencefree survival were identified using the Kaplan-Meier method with the log-rank test. The Cox proportional hazards model was used to identify independently predictive factors for actuarial and recurrence-free survival, which were used to propose new selection criteria. We compared the outcome of the subgroup patients meeting different criteria. Survival analysis was performed using the Kaplan-Meier method with the log-rank test. RESULTS： The median follow-up was 13.0 mo （2.8-69.5 too）. Overall, 1-, 2-, 3- and 5-year actuarial survival was 73.3%, 45.6%, 35.4% and 32.1%, respectively. One-, 2-, 3- and 5-year overall recurrencefree survival was 67.0%, 44.3%, 34.5% and 34.5%, respectively. In univariate analysis, number of tumors, total tumor size, lobar distribution, differentiation, macrovascular invasion, microvascular invasion, capsulation of the tumor, and lymph node metastasis were found to be associated significantly with actuarial and tumor-free survival. By means of using the multivariate Cox proportional hazards model, total tumor size and macrovascular invasion were found to be independent predictors of actuarial and tumor-free survival. When the selection criteria were expanded into the proposed criteria, there was no significant difference in 1-, 2-, 3- and 5-year actuarial and tumor-free survival of the 49 patients who met the proposed criteria （97.6%, 82.8%, 82.8% and 82.8%, and 90.7%, 82.8%, 68.8% and 68.8%, respectively） compared with that of patients who met the Milan or University of California, San Francisco （UCSF） criteria. CONCLUSION： Macrovascular invasion and total tumor diameter are the strongest prognostic factors. The proposed criteria do not adversely aff

关键词： Hepatocellular carcinoma Prognosis Liver transplantation Outcome assessment Survival

Preparation，Characterization and Catalytic Activity of Anionic Clay Pillared by GaW＿9Zn＿3

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Chemical Research in Chinese Universities 1995年第4期11卷 354-356页

作者： ZHAHG Ji-yu ZHANG Shu-yun YU Xin-wu HU Chang-wen Liang zhao-jun and wang En-bo (Department of Chemistry,Northeast Normal University,Changchun,130024) NE NORMAL UNIV DEPT CHEMCHANGCHUN 130024PEOPLES R CHINA

Ｐｒｅｐａｒａｔｉｏｎ，ＣｈａｒａｃｔｅｒｉｚａｔｉｏｎａｎｄＣａｔａｌｙｔｉｃＡｃｔｉｖｉｔｙｏｆＡｎｉｏｎｉｃＣｌａｙＰｉｌｌａｒｅｄｂｙＧａＷ＿９Ｚｎ＿３ＺＨＡＨＧＪｉ－ｙｕ；ＺＨＡＮＧＳｈｕ－ｙｕｎ；ＹＵＸｉ... 详细信息

Ｐｒｅｐａｒａｔｉｏｎ，ＣｈａｒａｃｔｅｒｉｚａｔｉｏｎａｎｄＣａｔａｌｙｔｉｃＡｃｔｉｖｉｔｙｏｆＡｎｉｏｎｉｃＣｌａｙＰｉｌｌａｒｅｄｂｙＧａＷ＿９Ｚｎ＿３ＺＨＡＨＧＪｉ－ｙｕ；ＺＨＡＮＧＳｈｕ－ｙｕｎ；ＹＵＸｉｎ－ｗｕ；ＨＵＣｈａｎｇ－ｗｅｎＬ...

关键词： Anionic caly Heteropoiyanion Trisubstituted with transition metal Esterification activity