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Ki-67 Change in Anthracyline-containing Neoadjuvant Chemotherapy Response in Breast Cancer

Current Medical Science 2024年第1期44卷 156-167页

作者： Zi-guo yanG Le-hao REN Feng wang Pi-lin wang wen-yan wang Shu-ye LIN Department of General Surgery Beijing Tiantan HospitalCapital Medical UniversityBeijing 100070China Department of Critical Care Medicine Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Cancer Research Center Beijing Chest HospitalCapital Medical University/Beijing Tuberculosis and Thoracic Tumor Research InstituteBeijing 101149China

Objective Anthracycline-containing regimens are irreplaceable in neoadjuvant chemotherapy(NAC)for breast cancer(BC)at ***,30% of early breast cancer(EBC)patients are resistant to anthracycline-containing chemotherapy,leading to poor prognosis and higher ***-67 is associated with the prognosis and response to therapy,and it changes after *** A total of 105 BC patients who received anthracycline-containing NAC were ***,the optimal model of Ki-67 was selected,and its predictive efficacy was ***(IHC)was used to determine the estrogen receptor(ER),progesterone receptor(PR),and human epidermal growth factor receptor 2(HER-2)status and Ki-67 *** in situ hybridization(FISH)was used to verify the HER-2 when the IHC score was 2+.Results The post-NAC Ki67 level after treatment with anthracycline drugs was lower than pre-NAC Ki-67(19.6%±23.3%vs.45.6%±23.1%,P<0.001).Furthermore,patients with the Ki-67 decrease had a border line higher pathological complete response(pCR)rate(17.2%vs.0.0%,P=0.068),and a higher overall response rate(ORR)(73.6%vs.27.8%,P<0.001),when compared to patients without the Ki-67 *** ΔKi-67 and ΔKi-67%were valuable markers for the prediction of both the pCR rate and *** area under the curve(AUC)for ΔKi-67 on pCR and ORR was 0.809(0.698-0.921)and 0.755(0.655-0.855),respectively,while the AUC for ΔKi-67% on pCR and ORR was 0.857(0.742-0.972)and 0.720(0.618-0.822),*** logistic regression model 1 revealed thatΔKi-67 was an independent predictor for both pCR[odds ratio(OR)=61.030,95% confidence interval(CI)=4.709-790.965;P=0.002]and ORR(OR=10.001,95%CI:3.044-32.858;P<0.001).Multivariate logistic regression model 2 revealed thatΔKi-67%was also an independent predictor for both pCR(OR=408.922,95%CI=8.908-18771.224;P=0.002)and ORR(OR=5.419,95%CI=1.842-15.943;P=0.002).Conclusions The present study results suggest thatΔKi67 andΔKi67%are candidate predictor

关键词： breast cancer change in Ki-67 neoadjuvant chemotherapy anthracycline,response

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Ranks of the Common Solution to Six Quaternion Matrix Equations

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Acta Mathematicae Applicatae Sinica 2011年第3期27卷 443-462页

作者： Qing-wen wang yan Zhou Qin Zhang Department of Mathematics Shanghai University 99 Shangda Road Shanghai 200444 China

A new expression is established for the common solution to six classical linear quaternion matrix equations A 1 X = C 1 , X B 1 = C 3 , A 2 X = C 2 , X B 2 = C 4 , A 3 X B 3 = C 5 , A 4 X B 4 = C 6 which was investigated recently by wang, Chang and Ning （Q. wang, H. Chang, Q. Ning, The common solution to six quaternion matrix equations with applications, Appl. Math. Comput. 195： 721-732 （2008））. Formulas are derived for the maximal and minimal ranks of the common solution to this system. Moreover, corresponding results on some special cases are presented. As an application, a necessary and sufficient condition is presented for the invariance of the rank of the general solution to this system. Some known results can be regarded as the special cases of the results in this paper.

关键词： system of matrix equations quaternion matrix minimal rank maximal rank linear matrixexpression generalized inverse

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Toughening mechanism of lined Al_2O_3-ZrO_2 multiphaseceramics in SHS composite pipes

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Journal of University of Science and Technology Beijing 2006年第2期13卷 178-182页

作者： Guibo Yu wen yan Shuhai wang Baoxin Su Baolai Tan Mechanical Engineering College of Shijiazhuang Shijiazhuang 050003 China

Hypoeutectic and hypereutectic Al2O3-ZrO2 multiphase ceramics-lined composite pipes were produced by using the gravitational separation self-propagate high-temperature synthesis （SHS） process. The microstructure of the ceramics was observed by means of SEM and EPMA. The fracture toughness of the multiphase ceramics was tested by using the Vickers indentation method. The fracture toughness of hypoeutectic Al2O3-ZrO2 multiphase ceramics is 15.96 MPa·m^1/2 and that of hypoeutectic Al2O3-ZrO2 multiphase ceramics is 15.23 MPa·m^1/2. The toughening mechanisms were systematically investigated by means of SEM and XRD. The results show that the bridging toughening mechanism, stress induced ZrO2 transformation toughening mechanism, and microcrack toughening mechanism are the predominant toughening mechanism.

关键词： SHS multiphase ceramics eutectic structure toughening mechanism

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Increased interleukin-26 expression in proliferative diabetic retinopathy

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International Journal of Ophthalmology(English edition) 2019年第11期12卷 1688-1692页

作者： Peng wang wen-yan wang Xue-Dong Zhang Department of Ophthalmology the First Affiliated Hospital of Chongqing Medical University Chongqing Key Laboratory of Ophthalmology Chongqing Eye Institute

AIM: To detect the possible role of interleukin(IL)-26 in diabetic retinopathy(DR) ***: Subjects were divided into diabetes without retinopathy(DWR) group(n=20), non-proliferative diabetic retinopathy(NPDR) group(n=20), proliferative diabetic retinopathy(PDR) group(n=20) and normal control group(n=20). The protein expression of IL-26 in the serum and vitreous fluid were measured by enzyme-linked immunosorbent assay(ELISA). The m RNA change of IL-26 in peripheral blood mononuclear cells(PBMCs) was assessed by real-time polymerase chain ***: The serum expression of IL-26 in PDR group was significantly elevated compared with the normal control group, DWR group and NPDR group. The vitreous fluid concentration of IL-26 in PDR patients(without antiVEGF therapy) was also higher compared to normal controls. However, no obvious significance was found concerning the expression of IL-26 in vitreous fluid between PDR after anti-VEGF therapy and normal controls. In PDR group, the m RNA level of IL-26 significantly increased compared with the normal controls and DWR patients in the ***: Protein and m RNA expression of IL-26 are increased in serum, vitreous fluid and PBMCs in PDR patients, suggesting that IL-26 may be associated with the pathogenesis of PDR.

关键词： interleukin-26 serum vitreous fluid peripheral blood mononuclear cells proliferative diabetic retinopathy

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Postoperative Elevations of Neutrophil-to-lymphocyte and Platelet-to- lymphocyte Ratios Predict Postoperative Pulmonary Complications in Non-small Cell Lung Cancer Patients: A Retrospective Cohort Study

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Current Medical Science 2020年第2期40卷 339-347页

作者： yan wang Xu HUt Meng-chan SU yan wen wang Guo-wei CHEI Deparment of Thoracic Surgery West China HospitalSichuan UniversityChengdu 610041China West China School of Medicine Sichuan UniversityChengdu 610041China

The neutrophil-to-lymphocyte ratio(NLR)and the platelet-to-lymphocyte ratio(PLR)are found to increase in patients who develop postoperative complications(PCs).The aim of the present study was to explore the association of the perioperative changes of NLR(ANLR)and PLR(OPLR)with PCs in non-small cell lung cancer(NSCLC).Clinical data of 509 patients,who were diagnosed with NSCLC and underwent thoracoscopic radical resection between January 1,2014 and July 31,2016 at the Department of Thoracic Surgery,West China Hospital,were *** were divided into PC and non-PC groups,and clinical characteristics including ANLR and APLR were compared between *** optimal cut-off values of ONLR and APLR were determined by receiver operating characteristics(ROC)curves and patients were assigned to high ANLR/APLR and low ONLR/OPLR groups in terms of the cut-off *** characteristics and the incidence of different PCs were compared between the dichotomized *** and multivariate logistic regression analyses were performed to identify the independent risk factors for *** results showed that the ANLR and APLR in the PC group were significantly higher than those in the non-PC group(P6.6 or 0PLR>49 were more likely to experience postoperative pulmonary complications(PPCs)(P6.6(OR:2.453,95%CI:1.2244.914,P-0.011)and APLR>49(OR:2.231,95%CI:1.182-4.212,P-0.013)were predictive of *** conclusion,the ONLR and APLR may act as novel predictors for PPCs in NSCLC patients undergoing thoracoscopic radical lung resection,and patients with ONLR>6.6 or APLR>49 should be treated more actively to prevent or reduce PPCs.

关键词： neutrophil-to-lymphocyte ratio platelet-to-lymphocyte ratio non-small cell lung cancer postoperative pulmonary complication

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Application of DC component to select fault branch in arc suppression coil grounding system

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Journal of Coal Science & Engineering(China) 2013年第3期19卷 396-401页

作者： Zhi-Jie wang yan-wen wang School of Mechanical Electrical and Information Engineering China University of Mining and Technology (Beijing) Beijing 100083 China

When single phase earth fault occurs in the arc suppression coil grounding system, the amplitude of the transient capacitance current is high and decays fast, but the attenuation of the transient inductance current is much slower. This paper analyses the DC component of fault branch, and has found it is much bigger than that of the normal branches in transient state. All the simulation results obtained from three compensation types, different fault time and different wave cycles show that the DC component of fault branch is much higher than that of those normal branches. These results verify the effectiveness of taking the DC component as the method of fault line selection in the arc suppression coil grounding system.

关键词： DC component arc suppression coil fault line selection transient state

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Charge transporting materials for perovskite solar cells

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Rare Metals 2021年第10期40卷 2690-2711页

作者： Ting Ji Ying-Kui wang Lin Feng Guo-Hui Li wen-yan wang Zhan-Feng Li Yu-Ying Hao yan-Xia Cui College of Physics and Optoelectronics Taiyuan University of TechnologyTaiyuan 030024China Key Laboratory of Advanced Transducers and Intelligent Control System Ministry of Education and Shanxi ProvinceTaiyuan University of TechnologyTaiyuan 030024China

Perovskite solar cells(PSCs) have made great progress since 2009 and become the focus of current research. As an important part of PSCs, charge transporting materials play an important role in the performance of the devices. In this review, we introduce the evolution of electron and hole transporting materials in PSCs in recent years and summarize some typical charge transporting materials and their applications in PSCs. For electron transporting materials, metal oxides(TiO_(2), SnO_(2) and ZnO) and organic materials(fullerenes, non-fullerenes and their derivatives)are the most widely used materials in PSCs. For hole transporting materials, small molecule spiro-OMeTAD(2,2’,7,7’-Tetrakis[N,N-di(4-methoxyphenyl)amino]-9,9’-spirobifluorene), polymer PEDOT:PSS(poly(3,4-ethylenedioxythiophene): polystyrene sulfonate), PTAA(poly-[bi(4-phenyl)](2,4,3-trimethylphenyla-mine)), P3 HT(poly(3-hexythiophene)) and inorganic materials(NiOx, CuSCN, CuO) are adopted in PSCs. Finally, different types of charge transporting materials are summarized and their future development is prospected.

关键词： Perovskite Solar cells Electron transporting materials Hole transporting materials

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Regulation of a vacuolar proton-pumping P-ATPase MdPH5 by MdMYB73 and its role in malate accumulation and vacuolar acidification

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aBIOTECH 2023年第4期4卷 303-314页

作者： Xiao-Yu Huang Ying Xiang Yu-wen Zhao Chu-Kun wang Jia-Hui wang wen-yan wang Xiao-Long Liu Quan Sun Da-Gang Hu National Research Center for Apple Engineering and Technology Shandong Collaborative Innovation Center of Fruit and Vegetable Quality and Efficient ProductionCollege of Horticulture Science and EngineeringShandong Agricultural UniversityTai’an 271018ShandongChina

As the main organic acid in fruits,malate is produced in the cytoplasm and is then transported into the *** accumulates by vacuolar proton pumps,transporters,and channels,affecting the taste and flavor of *** the three types of proton pumps(V-ATPases,V-PPases,and P-ATPases),the P-ATPases play an important role in the transport of malate into *** this study,the transcriptome data,collected at different stages after blooming and during storage,were analyzed and the results demonstrated that the expression of MdPH5,a vacuolar proton-pumping P-ATPase,was associated with both pre-and post-harvest malate ***,MdPH5 is localized at the tonoplast and regulates malate accumulation and vacuolar *** addition,MdMYB73,an upstream MYB transcription factor of MdPH5,directly binds to its promoter,thereby transcriptionally activating its expression and enhancing its *** this way,MdMYB73 can also affect malate accumulation and vacuolar ***,this study clarifies how MdMYB73 and MdPH5 act to regulate vacuolar malate transport systems,thereby affecting malate accumulation and vacuolar pH.

关键词： Apple Malate accumulation P-ATPase MdPH5 MdMYB73

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Accumulation and distribution of arsenic and cadmium by tea plants

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2008年第3期9卷 265-270页

作者： Yuan-zhi SHI Jian-yun RUAN Li-feng MA wen-yan HAN Fang wang Tea Research Institute Chinese Academy of Agricultural Sciences Hangzhou 310008 China

It is important to research the rules about accumulation and distribution of arsenic and cadmium by tea plants,which will give us some scientific ideas about how to control the contents of arsenic and cadmium in *** this study,by field investigation and pot trial,we found that mobility of arsenic and cadmium in tea plants was *** arsenic and cadmium absorbed were fixed in feeding roots and only small amount was transported to the above-ground *** of arsenic and cadmium,based on their concentrations of unit dry matter,in tea plants grown on un-contaminated soil was in the order:feeding roots>stems≈main roots>old leaves>young *** tea plants were grown on polluted soils simulated by adding salts of these two metals,feeding roots possibly acted as a buffer and defense,and arsenic and cadmium were transported less to the aboveground *** concentration of cadmium in soil significantly and negatively correlated with chlorophyll content,photosynthetic rate,transpiration rate and biomass production of tea plants.

关键词： Tea plant Arsenic (As) Cadmium (Cd) Absorption Accumulation

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TiN/γ-Fe interface orientation relationship and formation mechanism of TiN precipitates in Mn18Cr2 steel

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China Foundry 2021年第3期18卷 180-184页

作者： Zheng-hui wang Jing-pei Xie Qian Li wen-yan wang Ai-qin wang Pei Liu School of Materials Science and Engineering Zhengzhou UniversityZhengzhou 450001China School of Materials Science and Engineering Henan University of Science and TechnologyLuoyang 471023China National Center of International Research for Micro-nano Molding Technology Zhengzhou UniversityZhengzhou 450001China Provincial and Ministerial Co-construction of Collaborative Innovation Center for Non-ferrous Metal New Materials and Advanced Processing Technology Henan University of Science and TechnologyLuoyang 471023China

A Mn18Cr2 steel containing TiN precipitates was fabricated by vacuum induction *** morphology of TiN precipitates and the interface orientation relationship between TiN and γ-Fe were characterized by means of SEM,TEM and SAED,and the formation mechanism of TiN precipitates in Mn18Cr2 steel was *** show that the TiN precipitates are more likely to exhibit a cubic-shaped morphology and form both within the grain and at the grain boundary of γ-*** interface orientation relationship between TiN and γ-Fe is determined as follows:(100)_(TiN)//■_(γ-Fe),■_(TiN)//■_(γ-Fe).Because of the smallest interfacialmisfit,the secondary close-packed lane {100} of TiN preferentially combines with the close-packed plane {111} of γ-Fe during the precipitation in order to minimize the interface *** nucleation,the TiN precipitates exhibit cubic appearance due to the fact that the TiN has a FCC structure with rock salt type *** study provides reference for the material design of the austenitic high-manganese steels with excellent yield strength.

关键词： Mn18Cr2 steel TiN precipitates interface orientation relationship interface misfit

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