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激素性股骨头坏死骨髓间充质干细胞成骨分化的研究进展

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解放军医学杂志 2020年第11期45卷 1207-1214页

作者：温家福韦标方山东第一医科大学研究生处山东泰安271000 临沂市人民医院股骨头专科山东临沂276000

激素性股骨头坏死(SONFH)是长期或大剂量应用激素类药物,导致股骨头血液供应受损,多种骨基质细胞死亡,进而导致股骨头承重区骨小梁结构改变,股骨头出现不可逆的塌陷,最终导致髋关节功能障碍的一类疾病。早期表现为髋部疼痛,腹股沟区压痛... 详细信息

激素性股骨头坏死(SONFH)是长期或大剂量应用激素类药物,导致股骨头血液供应受损,多种骨基质细胞死亡,进而导致股骨头承重区骨小梁结构改变,股骨头出现不可逆的塌陷,最终导致髋关节功能障碍的一类疾病。早期表现为髋部疼痛,腹股沟区压痛;中期因疼痛而影响活动;后期进展为髋关节间隙狭窄,髋关节活动度减少,活动受限。SONFH严重影响了患者的生活质量,因此现代医学致力于通过早期干预来缓解患者的症状,以有效治疗SONFH,减轻患者的生活压力和经济负担。骨髓间充质干细胞(BMSCs)的成骨分化特性使其在早期SONFH治疗领域成为了关注的焦点。BMSCs是一种具有多向分化潜能的干细胞,具有自我增殖和分化特性,能够分化成骨,为坏死区提供机械支撑和分泌多种生长因子以支持造血,减缓疾病进展,延长关节的使用寿命。激素的不合理使用主要通过抑制BMSCs的成骨活性,从而导致SONFH的发生。该文对近年来促进BMSCs成骨分化的研究进展进行综述,以期提高对SONFH的治疗效果。

关键词：骨髓间充质干细胞激素性股骨头坏死成骨分化

Real-world Effectiveness and Tolerability of Interferonfree Direct-acting Antiviral for 15,849 Patients with Chronic Hepatitis C:A Multinational Cohort Study

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Journal of Clinical and Translational Hepatology 2024年第7期12卷 646-658页

作者： Fanpu Ji Sally Tran Eiichi Ogawa Chung-Feng Huang Takanori Suzuki Yu Jun Wong Hidenori Toyoda Dae Won Jun Liu Li Haruki Uojima Akito Nozaki Makoto Chuma Cheng-Hao Tseng Yao-Chun Hsu Masatoshi Ishigami Takashi Honda Masanori Atsukawa Hiroaki Haga Masaru Enomoto Huy Trinh Carmen Monica Preda Phillip Vutien Charles Landis Dong Hyun Lee Tsunamasa Watanabe Hirokazu Takahashi Hiroshi Abe Akira Asai Yuichiro Eguchi Jie Li Xiaozhong Wang jia Li Junping Liu Jing Liang Carla Pui-Mei Lam Rui Huang Qing Ye Hongying Pan jiajie Zhang Dachuan Cai Qi Wang Daniel Q.Huang Grace Wong Vincent Wai-Sun Wong Junyi Li Son Do Norihiro Furusyo Makoto Nakamuta Hideyuki Nomura Eiji Kajiwara Eileen L.Yoon Sang Bong Ahn Koichi Azuma Kazufumi Dohmen Jihyun An Do Seon Song Hyun Chin Cho Akira Kawano Toshimasa Koyanagi Aritsune Ooho Takeaki Satoh Kazuhiro Takahashi Ming-Lun Yeh Pei-Chien Tsai Satoshi Yasuda Yunyu Zhao Yishan Liu Tomomi Okubo Norio Itokawa Mi Jung Jun Toru Ishikawa Koichi Takaguchi Tomonori Senoh Mingyuan Zhang Changqing Zhao Raluca Ioana Alecu Wei Xuan Tay Pooja Devan Joanne Kimiko Liu Ritsuzo Kozuka Elena Vargas-Accarino Ai-Thien Do Mayumi Maeda Wan-Long Chuang Jee-Fu Huang Chia-Yen Dai Ramsey Cheung Maria Buti Junqi Niu wen Xie Hong Ren Seng Gee Lim Chao Wu Man-Fung Yuen jia Shang Qiang Zhu Yoshiyuki Ueno Yasuhito Tanaka Jun Hayashi Ming-Lung Yu Mindie H.Nguyen Department of Infectious Diseases The Second Affiliated Hospital of Xi’an Jiaotong UniversityXi’anShaanxiChina Division of Gastroenterology and Hepatology Department of MedicineStanford University Medical CenterPalo AltoCAUSA Department of General Internal Medicine Kyushu University HospitalFukuokaJapan Hepatobiliary Division Department of Internal MedicineKaohsiung Medical University HospitalKaohsiung Hepatitis Research Center College of Medicine and Center for Liquid Biopsy and Cohort ResearchKaohsiung Medical UniversityKaohsiung Department of Gastroenterology and Metabolism Nagoya City University Graduate School of Medical SciencesNagoyaJapan Gastroenterology&Hepatology Changi General HospitalSinghealthSingapore Singhealth Duke-NUS Medicine Academic Clinical Program Singapore Department of Gastroenterology Ogaki Municipal HospitalOgakiJapan Department of Internal Medicine Hanyang UniversityCollege of MedicineSeoulKorea Hanyang Institute of Bioscience and Biotechnology Hanyang UniversitySeoulKorea Department of Hepatology The Third People's Hospital of Kunming CityKunmingYunnanChina Department of Gastroenterology Internal MedicineKitasato University School of MedicineSagamiharaJapan Gastroenterological Center Yokohama City University Medical CenterYokohamaJapan Division of Gastroenterology and Hepatology Department of Internal MedicineE-Da Cancer HospitalKaohsiung Department of Gastroenterology and Hepatology Nagoya University Graduate School of MedicineNagoyaJapan Division of Gastroenterology and Hepatology Nippon Medical SchoolTokyoJapan Department of Gastroenterology Yamagata University Faculty of MedicineYamagataJapan Department of Transfusion Medicine and Department of Hepatology Osaka Metropolitan University Graduate School of MedicineOsakaJapan San Jose Gastroenterology San JoseCAUSA Gastroenterology&Hepatology Department Clinic Fundeni InstituteBucharestRomania Division of Gastroenterology and Hepatology University of WashingtonSeattleWAUSA Department of

Background and Aims:As practice patterns and hepatitis C virus(HCV)genotypes(GT)vary geographically,a global real-world study from both East and West covering all GTs can help inform practice policy toward the 2030 HCV elimination *** study aimed to assess the effectiveness and tolerability of DAA treatment in routine clinical practice in a multinational cohort for patients infected with all HCV GTs,focusing on GT3 and ***:We analyzed the sustained virological response(SVR12)of 15,849 chronic hepatitis C patients from 39 Real-World Evidence from the Asia Liver Consortium for HCV clinical sites in Asia Pacific,North America,and Europe between 07/01/2014–07/01/***:The mean age was 62±13 years,with 49.6%*** demographic breakdown was 91.1%Asian(52.9%Japanese,25.7%Chinese/Taiwan residents,5.4%Korean,3.3%Malaysian,and 2.9%Vietnamese),6.4%White,1.3%Hispanic/Latino,and 1%Black/***,34.8%had cirrhosis,8.6%had hepatocellular carcinoma(HCC),and 24.9%were treatment-experienced(20.7%with interferon,4.3%with direct-acting antivirals).The largest group was GT1(10,246[64.6%]),followed by GT2(3,686[23.2%]),GT3(1,151[7.2%]),GT6(457[2.8%]),GT4(47[0.3%]),GT5(1[0.006%]),and untyped GTs(261[1.6%]).The overall SVR12 was 96.9%,with rates over 95%for GT1/2/3/6 but 91.5%for ***12 for GT3 was 95.1%overall,98.2%for GT3a,and 94.0%for ***12 was 98.3%overall for GT6,lower for patients with cirrhosis and treatment-experienced(TE)(93.8%)but≥97.5%for tretment-naive patients regardless of cirrhosis *** multivariable analysis,advanced age,prior treatment failure,cirrhosis,active HCC,and GT3/4 were independent predictors of lower SVR12,while being Asian was a significant predictor of achieving ***:In this diverse multinational realworld cohort of patients with various GTs,the overall cure rate was 96.9%,despite large numbers of patients with cirrhosis,HCC,TE,and GT3/***12 for GT3/6 with cirrhosis and TE was lower but st

关键词： Hepatitis C virus Liver cirrhosis Hepatocellular carcinoma Genotype DAA REAL-C

金虎杂交斑三倍体、二倍体生长、发育比较及形态性状差异分析

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海洋与湖沼 2024年第5期55卷 1302-1311页

作者：邓远苏金枝李振通黎琳琳邱弈树丁小雨段鹏飞王心怡王林娜刘阳马文辉赵侠李胜忠田永胜海水养殖生物育种与可持续产出全国重点实验室中国水产科学研究院黄海水产研究所山东青岛266071 新疆农业大学生命科学学院新疆乌鲁木齐830052 中国水产科学研究院海南创新研究院海南三亚572000 莱州明波水产有限公司山东莱州261400

为了解金虎杂交斑三倍体的生长与形态特征,利用金虎杂交斑三倍体(JH-3N)和二倍体群体(JH-2N),通过对比养殖试验分析了两种不同倍性杂交石斑鱼的生长性能,同时采用多元统计分析方法对JH-3N、JH-2N及母本棕点石斑鱼(EF)和父本蓝身大斑石斑... 详细信息

为了解金虎杂交斑三倍体的生长与形态特征,利用金虎杂交斑三倍体(JH-3N)和二倍体群体(JH-2N),通过对比养殖试验分析了两种不同倍性杂交石斑鱼的生长性能,同时采用多元统计分析方法对JH-3N、JH-2N及母本棕点石斑鱼(EF)和父本蓝身大斑石斑鱼(ET)的形态特征进行统计分析。结果显示,经90 d对比养殖后,JH-3N的终末体质量较JH-2N提高9.59%。性腺组织学观察表明,JH-3N卵巢与同期JH-2N相比发育明显滞后。经卡方检验显示,JH-3N与JH-2N、父本和母本的7个可数性状都没有显著性差异。单因素方差分析显示,4个石斑鱼群体除M_(14)(臀鳍前端基部至尾鳍长)外,其他18个比例性状差异显著(P<0.05)。聚类分析显示,JH-3N为单独一支,与其他3个群体分离。主成分分析共得到累计贡献率达63.273%的3个主成分,差异主要体现在鱼体的背腹轴方向。判别分析显示,4个石斑鱼群体的判别准确率达100%,综合判别率为100%。研究结果表明,JH-3N具有生长速度更快、性腺发育滞后的优良性状,表型性状与JH-2N相比具有显著性差异,具备在生产上推广应用的前景,研究结果为金虎杂交斑倍性育种及种群鉴定提供了丰富的生物学基础数据。

关键词：金虎杂交斑三倍体生长速度形态特征多元统计

Shoot drying and its cause in Calamus simplicifolius at Nanmeiling, Hainan, China

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Journal of Forestry Research 2011年第4期22卷 681-684页

作者： LI Rong-sheng YIN Guang-tian YANG Jin-chang ZOU wen-tao LI jian-guang ZHANG Shuai jia Rui-feng KOU Liang WANG Dong-guang Research Institute of Tropical Forestry Chinese Academy of ForestryGuangzhou 510520 Gaangdong Province P.R. China

Many stems are subject to shoot drying in the plantations of Calamus simplicifolius Wei at the Nanmeiling Base of the Forestry Bureau of Baisha County, Hainan Province. As a palm, stems of C simplicifolius stop growing and later die if the shoots are dry. Generally, shoot drying means reduced cane production and reduced profit for a rattan plantation. We aimed to quantify the incidence of shoot drying and determine its reason. We sampled eight 20 m × 20 m plots in the C simplicifolius plantations. In each plot, we counted stems and categorized them as drying shoot or normal shoot, and mother stem or sucker stem. We measured stem length and categorized them as drying shoot and normal shoot for mother stems. We cut open each shoot-drying stem to determine the cause of drying from drying part to fresh part. The frequency of mother stems （259 stem·ha^-1）, was significantly lower than sucker stems （588 stem·ha^-1）. The percentage of shoot drying was 33.8% for mother stems, not significantly higher than that for sucker stems （18,9%）. The mother shoot stems were significantly shorter if they were drying than if normal. 80% of stems with a drying shoot were hollow within the leaf sheath, whereas 10% hosted lively mature larvae （one larvae per shoot） and 10% hosted several lively young larvae. Mature larvae were identified as the Red Palm Weevil, Rhynchophorus ferrugineus Oliver. To confirm the present of the weevil, three pheromone traps for the weevil were set up in the plantations and adult weevils were trapped on the next day and identified as the Red Palm Weevil. We conclude that shoot drying of C. simplicifolius is probably caused by the Red Palm Weevil.

关键词： Calamus simpliciJolius rattan shoot drying Red Palm Wee-vil Rhynchophorus ferrugineus

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紫外激光照射引起的硅酸铅玻璃结构的变化

光谱学与光谱分析 2006年第9期26卷 1660-1663页

作者：贾宏志王文澄上海理工大学光学与电子信息工程学院上海200093 复旦大学光科学与工程系上海200433

采用紫外-可见吸收光谱和电子自旋共振谱(ESR)对硅酸铅玻璃薄膜和体材料受紫外激光照射前后的结构变化进行了研究。研究发现:266nm的紫外激光照射硅酸铅玻璃体材料时,能使其Urbach能量增大,即玻璃结构的无序性增大。电子自旋共振谱研究... 详细信息

采用紫外-可见吸收光谱和电子自旋共振谱(ESR)对硅酸铅玻璃薄膜和体材料受紫外激光照射前后的结构变化进行了研究。研究发现:266nm的紫外激光照射硅酸铅玻璃体材料时,能使其Urbach能量增大,即玻璃结构的无序性增大。电子自旋共振谱研究表明,266nm激光照射不会在硅酸铅玻璃中产生顺磁缺陷中心,也不会对硅酸铅玻璃薄膜在235nm附近的吸收峰产生影响,但用248nm紫外激光照射则观察到了235nm吸收峰的光漂白现象。

关键词：硅酸铅玻璃吸收谱电子自旋共振谱紫外激光

Post-transplant infection improves outcome of hepatocellular carcinoma patients after orthotopic liver transplantation

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World Journal of Gastroenterology 2019年第37期25卷 5630-5640页

作者： jia-Shuo Chao Sen-Lin Zhao Si-wen Ou-yang Yong-Bing Qian Ai-Qun Liu Hua-Mei Tang Lin Zhong Zhi-Hai Peng Jun-Ming Xu Hong-Cheng Sun Department of General Surgery Shanghai Organ Transplantat Medical CenterShanghai General HospitalShanghai Jiaotong UniversitySchool of MedicineShanghai 200080China Department of Colorectal Surgery Fudan UniversityShanghai Cancer CenterShanghai 200032China Division of Critical Care Department of Liver SurgeryRenji HospitalShanghai Jiaotong UniversitySchool of MedicineShanghai 200127China Department of Radiology Shanghai General HospitalShanghai Jiaotong UniversitySchool of MedicineShanghai 200080China Department of Pathology Shanghai General HospitalShanghai Jiaotong UniversitySchool of MedicineShanghai 200080China

BACKGROUND Tumor recurrence after orthotopic liver transplantation(OLT)remains a serious threat for long-term survival of the recipients with hepatocellular carcinoma(HCC),since very few factors or measures have shown impact on overcoming HCC recurrence after *** infection suppresses tumor recurrence and improves patient survival in lung cancer and malignant glioma probably via stimulating the immune ***-transplant infection(PTI),a common complication,is deemed to be harmful for the liver transplant recipients from a short-term ***,whether PTI inhibits HCC recurrence after OLT and prolongs the long-term survival of HCC patients needs to be *** To investigate the potential influence of PTI on the survival and tumor recurrence of patients with HCC after *** A total of 238 patients with HCC who underwent OLT between August 2002 and July 2016 at our center were retrospectively included and accordingly subdivided into a PTI group(53 patients)and a non-PTI group(185 patients).Univariate analyses,including the differences of overall survival(OS),recurrence-free survival(RFS),and post-recurrence survival(PRS),between the PTI and non-PTI subgroups as well as survival curve analysis were performed by the Kaplan-Meier method,and the differences were compared using the log rank *** variables with a P-value<0.1 in univariate analyses were included in the multivariate survival analysis by using a Cox proportional-hazards *** The 1-,3-,and 5-year OS and RFS rates of the whole cohort were 86.6%,69.0%,and 63.6%,and 75.7%,60.0%,and 57.3%,*** 1-,3-,and 5-year OS rates for the PTI patient group(96.0%,89.3%,and 74.0%)were significantly higher than those for the non-PTI group(84.0%,63.4%,and 60.2%)(P=0.033).The absence of PTI was an independent risk factor for dismal OS(relative risk[RR]=2.584,95%CI:1.226-5.449)and unfavorable RFS(RR=2.683,95%CI:1.335-5.390).Subgroup analyses revealed that PTI remark

关键词： Liver transplantation Liver cancer Infection Survival Tumor recurrence

Stress relaxation behavior and life prediction of gasket materials used in proton exchange membrane fuel cells

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Journal of Central South University 2019年第3期26卷 623-631页

作者： LI Guo GONG jian-ming TAN Jin-zhu ZHU Da-sheng jia wen-hua School of Mechanical Engineering Nanjing Institute of Technology School of Mechanical and Power Engineering Nanjing Tech University

Silicone rubber gaskets are employed to keep fuel gases and oxidation in their own zones. Due to the viscosity and elasticity, the assembly force could relax when the silicone rubber is compressed in a proton exchange membrane fuel cell. In this work, the stress relaxation behavior of silicone rubber samples is studied under different temperatures and simulated operating conditions. The results show that the stress relaxes exponentially with time at 25% strain level, especially at higher temperature or with higher acid concentration solution. The three-term Prony series can simulate the viscoelastic behavior well, and the Master curves are established by applying a time–temperature superposition method to estimate the life of the samples. It can save approximately 50% and 78% of the test time when an operating temperature and acid solution are chosen appropriately.

关键词： stress relaxation gasket silicone rubber life prediction fuel cell

Growth inhibition and induction of apoptosis in human oral squamous cell carcinoma Tca-8113 cell lines by Shikonin was partly through the inactivation of NF-KB pathway

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中国口腔颌面外科杂志 2008年第B5期6卷 174-175页

作者： Min Ruan Tong Ji wen Hu duan Wan Tao Chen Chen Ping Zhang Department of Oral and Maxillofacial Surgery Ninth People's Hospital College of Stomatology Shanghai Jiao Tong University State Key Laboratory of Drug Research Shanghai Institute of Materia Medica SIBS Chinese Academy of ScienceShanghai 200030 China

Purpose: To investigate the effects of Shikonin on the proliferation and apoptosis of human oral squamous cell carcinoma Tca-8113 cell line in vitro and the role of NF-kB signal tmnsduction pathway involved。Methods: Inhibitory and apoptosis-induced effect of Shikonin was determined by MTT assay, electron microscopes, the DNA ladder and Flow cytometric analysis。Expression of IK Ba, phosphatase-IK Ba, Bcl-2 and Bax proteins were detected by Westem blot, NF-K B DNA-binding activity was detected by EMSA, and activities of caspase 3, caspase 8 and caspase 9 were analyzed by ELISA。Results: Treatment of the Tca-8113 cells with a variety of concentrations of shikonin (l 0 - 40 la M) resulted in dose- and time-dependent sequences of events marked by apoptosis, as shown by loss of cell viability, chromatin condensation, intemucleosomal DNA fragmentation, and sub-Gl phase accumulation。Furthermore, apoptosis in the Tca-8113 cells was accompanied by the activation ofprotease caspase 8, 9, 3 and low expression ofbcl-2 protein。Interestingly, inactivation of the NF-K B pathway was found in shikonin-induced apoptosis in Tca-8113 cells。Conclusion: Shikonin could effectively inhibit the proliferation of Tca-8113 cell lines and induce apoptosis。Anti-tumor effects of shikonin in Tca-8113 cells act at least partly through the inactivation of NF-K B pathway and subsequent activation of protease caspase family。Pharmacologic inhibition of the NF-K B activity by shikonin might be a powerful treatment option for OSCC。

关键词：口腔鳞状细胞癌治疗方法临床分析

Analysis of sleep characteristics and clinical outcomes of 139 adult patients with infective endocarditis after surgery

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World Journal of Clinical Cases 2021年第22期9卷 6319-6328页

作者： Xiang-Ming Hu Cai-Di Lin De-Yi Huang Xiao-Ming Li Fen Lu wen-Ting Wei Zhi-Hong Yu Huo-Sheng Liao Fang Huang Xue-Zhen Huang Fu-Jun jia The Second School of Clinical Medicine Southern Medical UniversityGuangzhou 510515Guangdong ProvinceChina Department of Comprehensive Medicine Guangdong Provincial People's HospitalGuangdong Academy of Medical SciencesGuangzhou 510080Guangdong ProvinceChina Guangdong Mental Health Center Guangdong Provincial People's HospitalGuangdong Academy of Medical SciencesGuangzhou 510080Guangdong ProvinceChina

BACKGROUND Little is known about the postoperative sleep quality of infective endocarditis patients during hospitalization and after *** To investigate the sleep characteristics of infective endocarditis patients and to identify potential risk factors for disturbed sleep quality after *** The Pittsburgh Sleep Quality Index(PSQI)and the Epworth Sleepiness Scale were used to assess patient sleep *** regression was used to explore the potential risk *** The study population(n=139)had an average age of 43.40±14.56 years,and 67.6%were men(n=94).Disturbed sleep quality was observed in 86 patients(61.9%)during hospitalization and remained in 46 patients(33.1%)at 6 mo after ***,both PSQI and Epworth Sleepiness Scale scores showed significant improvements at 6 mo(P<0.001 and P=0.001,respectively).Multivariable logistic regression analysis showed that the potential risk factors were age(odds ratio=1.125,95%confidence interval:1.068-1.186)and PSQI assessed during hospitalization(odds ratio=1.759,95%confidence interval:1.436-2.155).The same analysis in patients with PSQI≥8 during hospitalization suggested that not using sleep medication(odds ratio=15.893,95%confidence interval:2.385-105.889)may be another risk *** The incidence of disturbed sleep after infective endocarditis surgery is ***,the situation improves significantly over *** and early postoperative high PSQI score are risk factors for disturbed sleep quality at 6 mo after surgery.

关键词： Infective endocarditis Sleep quality Pittsburgh sleep quality index Epworth sleepiness scale Surgery