Post-transplant infection improves outcome of hepatocellular carcinoma patients after orthotopic liver transplantation

作     者：Jia-Shuo Chao Sen-Lin Zhao Si-Wen Ou-yang Yong-Bing Qian Ai-Qun Liu Hua-Mei Tang Lin Zhong Zhi-Hai Peng Jun-Ming Xu Hong-Cheng Sun 

作者机构：Department of General SurgeryShanghai Organ Transplantat Medical CenterShanghai General HospitalShanghai Jiaotong UniversitySchool of MedicineShanghai 200080China Department of Colorectal SurgeryFudan UniversityShanghai Cancer CenterShanghai 200032China Division of Critical CareDepartment of Liver SurgeryRenji HospitalShanghai Jiaotong UniversitySchool of MedicineShanghai 200127China Department of RadiologyShanghai General HospitalShanghai Jiaotong UniversitySchool of MedicineShanghai 200080China Department of PathologyShanghai General HospitalShanghai Jiaotong UniversitySchool of MedicineShanghai 200080China 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2019年第25卷第37期

页      面：5630-5640页

核心收录：

学科分类：10[医学] 

基　　金：Supported by the National Natural Science Foundation of China No.81672846 and No.81670595 

主　　题：Liver transplantation Liver cancer Infection Survival Tumor recurrence 

摘      要：BACKGROUND Tumor recurrence after orthotopic liver transplantation(OLT)remains a serious threat for long-term survival of the recipients with hepatocellular carcinoma(HCC),since very few factors or measures have shown impact on overcoming HCC recurrence after *** infection suppresses tumor recurrence and improves patient survival in lung cancer and malignant glioma probably via stimulating the immune ***-transplant infection(PTI),a common complication,is deemed to be harmful for the liver transplant recipients from a short-term ***,whether PTI inhibits HCC recurrence after OLT and prolongs the long-term survival of HCC patients needs to be *** To investigate the potential influence of PTI on the survival and tumor recurrence of patients with HCC after *** A total of 238 patients with HCC who underwent OLT between August 2002 and July 2016 at our center were retrospectively included and accordingly subdivided into a PTI group(53 patients)and a non-PTI group(185 patients).Univariate analyses,including the differences of overall survival(OS),recurrence-free survival(RFS),and post-recurrence survival(PRS),between the PTI and non-PTI subgroups as well as survival curve analysis were performed by the Kaplan-Meier method,and the differences were compared using the log rank *** variables with a P-value0.1 in univariate analyses were included in the multivariate survival analysis by using a Cox proportional-hazards *** The 1-,3-,and 5-year OS and RFS rates of the whole cohort were 86.6%,69.0%,and 63.6%,and 75.7%,60.0%,and 57.3%,*** 1-,3-,and 5-year OS rates for the PTI patient group(96.0%,89.3%,and 74.0%)were significantly higher than those for the non-PTI group(84.0%,63.4%,and 60.2%)(P=0.033).The absence of PTI was an independent risk factor for dismal OS(relative risk[RR]=2.584,95%CI:1.226-5.449)and unfavorable RFS(RR=2.683,95%CI:1.335-5.390).Subgroup analyses revealed that PTI remark