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Encapsulation mechanism of metal-organic frameworks and bovine serum albumin

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Encapsulation mechanism of metal-organic frameworks and bovi...

中国化学会第七届全国热分析动力学与热动力学学术会议

作者： Yi Ke wen-wen ren Ai-Min Bai Yan-Jun Hu Hubei Key Laboratory of Pollutant Analysis ＆ Reuse Technology Department of ChemistryHubei Normal University

Metal-organic frameworks（MOFs） are a class of coordination polymers,consisting of metal ions or clusters linked together by chemically mutable organic *** to its high porosity,high specific surface area and strong thermal stability,low toxicity and biocompatibility,it has attracted much *** studies have shown that MOF can be combined with biomacromolecules to produce new biocomposities via a biomimetic mineralization *** mineralization with MOF,typically zeolitic imidazolate framework-8（ZIF-8）,is an emerging strategy to protect sensitive biological substances against denaturing environmental stressors like heat and proteolytic *** serum albumin（BSA）,a globulin in bovine serum,has a wide range of application in biochemical *** this study,molecular docking method has been used to seek the encapsulation of BSA and *** can provide valuable reference for the study of MOF encapsulation of other drugs.

关键词： metal-organic frameworks bovine serum albumin molecular docking

Interaction of nitrogen-doped graphene quantum dots with HSA and its Hg2+ responsiveness recognition

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Interaction of nitrogen-doped graphene quantum dots with HSA...

中国化学会第七届全国热分析动力学与热动力学学术会议

作者： Yong-Chang Liu Li-Hui Wu wen-wen ren Yan-Jun Hu Hubei Key Laboratory of Pollutant Analysis & Reuse Technology Department of ChemistryHubei Normal University

Nitrogen-doped graphene quantum dots(GQDs) exhibit low toxicity,superior solubility,chemical inertness,stable fluorescence and other properties,which make them show good prospects in optoelectronic devices,detectors,and biological *** serum albumin(HSA) is the most abundant protein in human plasma and can bind to many endogenous and exogenous compounds.A new GQDs was prepared by simple hydrothermal synthesis using citric acid as carbon source and glycine as nitrogen *** mechanism of interaction between GQDs and HSA and its responsiveness to Hg in HSA environment were studied by various spectroscopy methods and electrochemical *** gel electrophoresis method,the interaction between GQDs and HSA is visualized,which visually demonstrates the responsiveness of GQDs to Hg in the presence of *** study is expected to provide a meaningful reference for the research methods of quantum dots and biological macromolecules.

关键词： Nitrogen-doped spectroscopic methods gel electrophoresis imaging ion recognition human serum albumin

A cross-sectional study on predictors of patients'tinnitus severity

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World Journal of Otorhinolaryngology-Head and Neck Surgery 2024年第3期10卷 173-179页

作者： Teng-Fei Li Xu-Dong Cha Tian-Yu Wang Cai-Quan Liang Feng Zhen Li Sheng-Lei Wang Hu Peng wen-wen ren Yue Deng Huan-Hai Liu Department of Otorhinolaryngology Changzheng HospitalNaval Medical University(Second Military Medical University)ShanghaiChina

Objective:To identify factors that influence the severity of tinnitus via a hierarchical multiple linear regression ***:The study was a retrospective cross-sectional *** study included 331 patients experiencing tinnitus as their primary concern,who visited Shanghai Changzheng Hospital of the Navy Medical University between 2019 and *** on general health status and disease characteristics were collected from all *** their consent,participants underwent audiological evaluatons and completed questionnaires to analyze the characteristics of their tinnitus and the factors influencing its ***:The correlation analysis showed a positive relationship between tinnitus frequency,tinnitus loudness,SAS scores,and PSQI scores with THI scores(P<0.05)among nine examined variables(gender,handedness,employment status,age,BMI,tinnitus frequency,tinnitus loudness,SAS scores,and PSQI scores).The variables that were extracted from the multiple regression were;for the constant;β=-51.797,t=-4.484,P<0.001,variable is significant;for the tinnitus loudness;β=0.161,t=2.604,P<0.05,variable is significant;for the tinnitus frequency;β=0.000,t=1.269,P=0.206,variable is not significant;for the SAS scores;β=1.310,t=7.685,P<0.001,variable is significant;for the PSQI scores;β=1.680,t=5.433,P<0.001,variable is ***,the most accurate model for predicting severity in tinnitus patients is a linear combination of the constant,tinnitus loudness,SAS scores,and PSQI scores,Y(Tinnitus severity)=β0+β1(Tinnitus loudness)+β2(SAS scores)+β3(PSQI scores).β0,β1,β2,andβ3 are-51.797,0.161,1.310 and 1.680,***:Tinnitus severity is positively associated with loudness,anxiety levels,and sleep *** effectively manage tinnitus in patients,it is essential to promptly identify and address these accompanying factors and related symptoms.

关键词： hierarchical multiple linear regression tinnitus

Down-regulation of 67LR reduce the migratory activity of Human Glioma Cell

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中国神经科学学会第四次会员代表大会暨第七届全国学术会议

作者： wen-wen ren,Yan-Hong DUAN,Yan-Rong QIAN,Yong-Hua JI,Fu-Xue CHEN~* Laboratory of Neural Molecular Biology,School of Life Sciences,Shanghai University,Shanghai,China

＜正＞Glioma is the most common brain tumor in central nervous *** therapies are not effective to cure this *** evidence indicates that the 67 kDa elastin-laminin receptor（67LR） subunit is a high-affinity non-integrin laminin-binding protein that is over-expressed on the tumor cell surface in a variety of cancers and plays an important role in several physiological as well as pathological processes,including cell differentiation,growth,migration and cancer *** this study,we testified whether 67LR was constitutively over-expressed in high-grade astrocytomas, and then investigated the role of a low level of 67LR expression in glioma cells by constructing an interfering RNA expression *** results showed that the 67LR was constitutively overexpressed in high-grade astrocytomas and glioma cells reduced their migratory activity after interference of the 67LR expression by *** hypothesized a low level of 67LR expression could reduced migtratoty activity of glioma cell,which further proved that 67LR played an important role in tumor invasion by mediating essential tumor cell functions leading to *** study provides a new alternative to gene therapy for glioma treatment.

关键词： Glioma 67LR RNAi migratory

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本质与价值:数字时代广告本体的再认识

武汉大学学报（哲学社会科学版） 2025年第1期78卷 125-132页

作者：姚曦任文姣武汉大学新闻与传播学院湖北武汉430072 武汉大学媒体发展研究中心

用传播的方式促进从生产到消费转换的行为皆为存在意义上的广告,广告的本体是本质与价值的统一。本体的坚守要建立开放的认识观,在不变的广告本质中解释变化着的广告形态,而非用未触及本体的不确定认识窄化新的广告事实。彰显广告价值... 详细信息

用传播的方式促进从生产到消费转换的行为皆为存在意义上的广告,广告的本体是本质与价值的统一。本体的坚守要建立开放的认识观,在不变的广告本质中解释变化着的广告形态,而非用未触及本体的不确定认识窄化新的广告事实。彰显广告价值需深耕数字广告实践,用创意提升广告的社会吸引力,建构多主体参与的沟通网络。彰显广告价值还需要在理论层面,以本体观为支点,立足于本土广告实践,重新组织数字广告研究范畴,使用大数据技术与混合研究法探究新问题,为广告学知识体系的建构提供框架与方向。

关键词：广告广告本质广告价值广告本体

维普期刊数据库博看期刊

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微波接力机远程分布式监测系统

四川大学学报（工程科学版） 2002年第4期34卷 89-91页

作者：陈波康戈文任文伟四川大学制造科学与工程学院四川成都610065

微波接力机远程分布式无线监测系统由监测站工控机采集各接力机状态和机房状态 ,数据由工控机串口送入无线传输设备传输。服务器端采用智能多串口卡实现数据通讯 ,具有数据处理、状态显示、数据库管理及报警等多种功能。实际应用表明 ,... 详细信息

微波接力机远程分布式无线监测系统由监测站工控机采集各接力机状态和机房状态 ,数据由工控机串口送入无线传输设备传输。服务器端采用智能多串口卡实现数据通讯 ,具有数据处理、状态显示、数据库管理及报警等多种功能。实际应用表明 ,该系统具有性价比高、受地理条件限制少、易于扩展、易于维护和操作、实时数据采集、实时声音动画报警、数据远距离无线传输等特点 ,适用于在高山丛林、沼泽。

关键词：远程分布式监测系统无线数据传输微波接力机电力微波通信网

The direction of synaptic plasticity mediated by C-fibers in spinal dorsal horn is decided by Src-family kinases in microglia

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The direction of synaptic plasticity mediated by C-fibers in...

中国神经科学学会第四次会员代表大会暨第八届全国学术会议

作者： Yi ZHONG,Li-Jun ZHOU,wen-Jie ren,wen-Jun XIN,Yong-Yong LI,Tong ZHANG,Xian-Guo LIU~* Pain Research Center and Department of Physiology,Zhongshan School of Medicine,Sun Yat-sen University,Guangzhou 510080,China

＜正＞Previous studies have shown that Src-family kinases（SFKs） are selectively activated in spinal microglia following peripheral nerve injury,which play a key role in the development of neuropathic *** investigate the underlying mechanism,in the present study the role of SFKs in synaptic plasticity mediated by afferent C-fibers in spinal dorsal horn was evaluated in adult *** data revealed that pretreatment with either microglia inhibitor（minocycline, 200μM） or SFKs inhibitors（PP2,100μM and SU6656,200μM） reversed the effect of high frequency stimulation（HFS）, that is,HFS,which induces long-term potentiation（LTP） normally,induced long-term depression（LTD） after inhibition of either microglia or *** blotting analysis showed that the level of phosphorylated SFKs（p-SFKs） in ipsilateral spinal dorsal horn was transiently increased after LTP induced by HFS,starting at 15 min and returning to control level at 60 min after *** immunofluorescence staining demonstrated that p-SFKs were highly restricted to microglia. Furthermore,we found that the inhibitory effects of minocycline or SU6656 on spinal LTP were reversed by spinal application of rat recombinant TNF-α（500 pg/mL） and that HFS failed to induce LTP of C-fiber evoked field potentials in TNFRl’" *** results suggest that activated microglia may control the direction of plastic changes at C-fiber synapses in spinal dorsal horn via release of TNF-α.

关键词： synaptic plasticity long-term potentiation long-term depression microglia

microRNA-222通过Akt信号通路调控人外周血内皮祖细胞迁移

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中国急救医学 2018年第3期38卷 208-212,I0003页

作者：许文峰王翠平张浩蔡华忠施良孙文文任国庆江苏大学附属医院急诊科江苏镇江212001 江苏大学附属医院心内科江苏镇江212001 江苏大学附属医院核医学科江苏镇江212001

目的探讨microRNA-222（miR-222）通过调控Akt信号通路对内皮祖细胞（EPCs）迁移功能的影响及对靶向调控转录因子ETS-1（ETS proto-oncogene 1, transcription factor）的影响。方法从正常成人外周静脉血分离、体外培养后鉴定EPCs。... 详细信息

目的探讨microRNA-222（miR-222）通过调控Akt信号通路对内皮祖细胞（EPCs）迁移功能的影响及对靶向调控转录因子ETS-1（ETS proto-oncogene 1, transcription factor）的影响。方法从正常成人外周静脉血分离、体外培养后鉴定EPCs。分别向人内皮祖细胞（hEPCs）转染人工合成的miR-222的模拟物（mimic）、抑制物（inhibitor）和相应的阴性对照（NC）。用荧光定量PCR法测miR-222及ETS-1 mRNA的表达。应用Western blot测量每组的ETS-1、p-Akt和Akt的蛋白表达。各组EPCs用Transwell检测其迁移。结果 miR-222可以靶向影响ETS-1的mRNA和蛋白表达。与对照组比较，上调miR-222表达可致ETS-1的mRNA和蛋白表达降低，同时抑制EPCs的迁移能力（均P＜0.05）。相反，下调miR-222表达可致ETS-1的mRNA和蛋白表达升高，同时增强EPCs的迁移能力（均P＜0.05）。Western blot检测显示，上调miR-222表达抑制p-Akt的蛋白水平；下调miR-222表达增强p-Akt的蛋白水平（均P＜0.05）。结论 miR-222可通过调控Akt信号通路和靶向转录因子ETS-1影响EPCs的迁移功能。

关键词：内皮祖细胞(EPCs) microRNA-222 转录因子(miR-222) Akt信号通路

Tailoring Light–Matter Interactions in Overcoupled Resonator for Biomolecule Recognition and Detection

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Nano-Micro Letters 2025年第1期17卷 262-280页

作者： Dongxiao Li Hong Zhou Zhihao ren Cheng Xu Chengkuo Lee Department of Electrical and Computer Engineering National University of SingaporeSingapore 117583Singapore Center for Intelligent Sensors and MEMS(CISM) National University of SingaporeSingapore 117608Singapore

Plasmonic nanoantennas provide unique opportunities for precise control of light–matter coupling in surface-enhanced infrared absorption(SEIRA)spectroscopy,but most of the resonant systems realized so far suffer from the obstacles of low sensitivity,narrow bandwidth,and asymmetric Fano resonance ***,we demonstrated an overcoupled resonator with a high plasmon-molecule coupling coefficient(μ)(OC-Hμresonator)by precisely controlling the radiation loss channel,the resonator-oscillator coupling channel,and the frequency detuning *** observed a strong dependence of the sensing performance on the coupling state,and demonstrated that OC-Hμresonator has excellent sensing properties of ultra-sensitive(7.25%nm^(−1)),ultra-broadband(3–10μm),and immune asymmetric Fano *** characteristics represent a breakthrough in SEIRA technology and lay the foundation for specific recognition of biomolecules,trace detection,and protein secondary structure analysis using a single array(array size is 100×100μm^(2)).In addition,with the assistance of machine learning,mixture classification,concentration prediction and spectral reconstruction were achieved with the highest accuracy of 100%.Finally,we demonstrated the potential of OC-Hμresonator for SARS-CoV-2 *** findings will promote the wider application of SEIRA technology,while providing new ideas for other enhanced spectroscopy technologies,quantum photonics and studying light–matter interactions.

关键词： Plasmonic nanoantennas Light-matter interaction Surface-enhanced infrared absorption Overcoupled Biosensing