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A modified fixation technique for the treatment of buried penis in children

Asian Journal of Andrology 2023年第1期25卷 78-81页

作者： Xu Cui Bing-Jing Gao Liu Chen wen-hua huang Chao-Ming Zhou Department of Pediatric Surgery Fujian Maternity and Child Health HospitalCollege of Clinical Medicine for Obstetrics&Gynecology and PediatricsFujian Medical UniversityFuzhou 350001China Central Sterile Supply Department Fujian Provincial Hospital South BranchFuzhou 350001China

For many years,surgical treatment of buried penis in children has been researched by several scholars,and numerous methods exist.This study aimed to explore the clinical effect of a modified fixation technique in treating buried penis in children.Clinical data of 94 patients with buried penis who were treated using the modified penile fixation technique from March 2017 to February 2019 in Fujian Maternity and Child Health Hospital(Fuzhou,China)were retrospectively collected,compared,and analyzed.Clinical data of 107 patients with buried penis who were treated using traditional penile fixation technique from February 2014 to February 2017 were chosen for comparison.The results showed that at 6 months and 12 months after surgery,the penile lengths in the modified penile fixation group were longer than those in the traditional penile fixation group(both P<0.05).The incidence of postoperative skin contracture and penile retraction in the modified penile fixation group was less than that in the traditional penile fixation group(P=0.034 and P=0.012,respectively).When the two groups were compared in terms of parents'satisfaction scores,the scores for penile size,penile morphology,and voiding status in the modified penile fixation group were higher than those in the traditional penile fixation group at 2-week,6-month,and 12-month follow-ups after surgery(all P<0.05).We concluded that the modified penile fixation technique could effectively reduce the incidence of skin contracture and penile retraction and improve the penile length and satisfaction of patients'parents.

关键词： buried penis modified fixation technique penile retraction

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The effect of scrotal versus inguinal orchiopexy on the testicular function of children with clinically palpable,inguinal undescended testis:a randomized controlled trial

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Asian Journal of Andrology 2023年第6期25卷 745-749页

作者： wen-hua huang Long-Yao Xu Shu-Shen Chen Zhi-Qiang Chen Xu Cui Chao-Ming Zhou Department of Pediatric Surgery Fujian Maternity and Child Health HospitalCollege of Clinical Medicine for Obstetrics&Gynecology and PediatricsFujian Medical UniversityFuzhou 350005China Department of Urinary Surgery Fujian Children’s HospitalCollege of Clinical Medicine for Obstetrics&Gynecology and PediatricsFujian Medical UniversityFuzhou 350001China

To compare the impact of the scrotal vs inguinal orchidopexy approach on the testicular function of infants with cryptorchidism,a randomized controlled trial was conducted involving boys who were 6–12 months old at surgery and were diagnosed with clinically palpable,inguinal undescended testis.Between June 2021 and December 2021,these boys at Fujian Maternity and Child Health Hospital(Fuzhou,China)and Fujian Children’s Hospital(Fuzhou,China)were enrolled.Block randomization with a 1:1 allocation ratio was employed.The primary outcome was testicular function assessed by testicular volume,serum testosterone,anti-Müllerian hormone(AMH),and inhibin B(InhB)levels.Secondary outcomes included operative time,amount of intraoperative bleeding,and postoperative complications.Among 577 screened patients,100(17.3%)were considered eligible and enrolled in the study.Of the 100 children who completed the 1-year follow-up,50 underwent scrotal orchidopexy and 50 underwent inguinal orchidopexy.The testicular volume,serum testosterone,AMH,and InhB levels in both groups increased markedly after surgery(all P0.05).No differences between the scrotal and inguinal groups were noted regarding the operative time(P=0.987)and amount of intraoperative bleeding(P=0.746).The overall complication rate(2.0%)of the scrotal group was slightly lower than that of the inguinal group(8.0%),although this difference was not statistically significant(P>0.05).Both scrotal and inguinal orchiopexy exerted protective effects on testicular function in children with cryptorchidism,with similar operative status and postoperative complications.Scrotal orchiopexy is an effective alternative to inguinal orchiopexy in children with cryptorchidism.

关键词： cryptorchidism orchiopexy scrotum testicular function

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Transcriptome sequencing and experiments reveal the effect of formyl peptide receptor 2 on liver homeostasis

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World Journal of Gastroenterology 2023年第24期29卷 3793-3806页

作者： Hui Liu Ze-Yu Sun hua Jiang Xu-Dong Li Yong-Qiang Jiang Peng Liu wen-hua huang Qing-Yu Lv Xiang-Lilan Zhang Rong-Kuan Li Department of Gastroenterology Second Hospital of Dalian Medical UniversityDalian 116000Liaoning ProvinceChina State Key Laboratory of Pathogen and Biosecurity Institute of Microbiology and EpidemiologyAcademy of Military Medical SciencesBeijing 100071China Microbiology Teaching and Research Office Anhui Medical UniversityHefei 230032Anhui ProvinceChina Department of Infectious Diseases Second Hospital of Dalian Medical UniversityDalian 116000Liaoning ProvinceChina

BACKGROUND Formyl peptide receptor 2(Fpr2)is an important receptor in host resistance to bacterial infections.In previous studies,we found that the liver of Fpr2-/-mice is the most severely damaged target organ in bloodstream infections,although the reason for this is unclear.AIM To investigate the role of Fpr2 in liver homeostasis and host resistance to bacterial infections.METHODS Transcriptome sequencing was performed on the livers of Fpr2-/-and wild-type(WT)mice.Differentially expressed genes(DEGs)were identified in the Fpr2-/-and WT mice,and the biological functions of DEGs were analyzed by Gene Ontology(GO)and Kyoto Encyclopedia of Genes and Genomes(KEGG)enrichment analysis.Quantitative real time-polymerase chain reaction(qRT-PCR)and western blot(WB)analyses were used to further validate the expression levels of differential genes.Cell counting kit-8 assay was employed to investigate cell survival.The cell cycle detection kit was used to measure the distribution of cell cycles.The Luminex assay was used to analyze cytokine levels in the liver.The serum biochemical indices and the number of neutrophils in the liver were measured,and hepatic histopathological analysis was performed.RESULTS Compared with the WT group,445 DEGs,including 325 upregulated genes and 120 downregulated genes,were identified in the liver of Fpr2-/-mice.The enrichment analysis using GO and KEGG showed that these DEGs were mainly related to cell cycle.The qRT-PCR analysis confirmed that several key genes(CycA,CycB1,Cdc20,Cdc25c,and Cdk1)involved in the cell cycle had significant changes.The WB analysis confirmed a decrease in the expression of CDK1 protein.WRW4(an antagonist of Fpr2)could inhibit the proliferation of HepG2 cells in a concentration dependent manner,with an increase in the number of cells in the G0/G1 phase,and a decrease in the number of cells in the S phase.Serum alanine aminotransferase levels increased in Fpr2-/-mice.The Luminex assay measurements showed that interleukin(IL)-10 and chemokine(C-X-C motif)ligand(CXCL)-1

关键词： Cell cycle Cell proliferation Cdk1 Differentially expressed genes Formyl peptide receptor 2 RNA-sequencing

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Feasibility of Subtraction Coronary Computed Tomographic Angiography and Influencing Factor Analysis: a Retrospective Study

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Current Medical Science 2021年第4期41卷 821-826页

作者： Chao huang Wei-jia WAN Yu-huan YAO Li-ming XIA wen-hua huang Department of Radiology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China

Objective To investigate the feasibility of subtraction coronary computed tomographic(CT)angiography(SubCCTA)to decline calcium artifacts and improve diagnostic accuracy in the presence of coronary calcification and analyze the factors that influence SubCCTA.Methods A total of 294 patients suspected of having coronary artery diseases underwent coronary computed tomographic angiography(CCTA)and SubCCTA.Coronary stenoses were blindly evaluated by two experienced radiologists,which were compared with invasive coronary angiography(ICA).Multiple statistical indexes were adopted to analyze the value of SubCCTA for the diagnosis of calcium stenoses.Results The diagnosable rate of SubCCTA was 67.2%(n=197),and the non-diagnosable rate was 32.8%(n=97).Using SubCCTA,the false positive rate decreased from 56.5%to 17.4%,and the corresponding diagnostic accuracy was increased from 83.6%to 92.9%.Univariate logistic regression analysis showed that height(OR=1.029,95%CI=1.001–1.058),weight(OR=1.025,95%CI=1.004–1.046),left ventricular size(OR=1.018,95%CI=1.007–1.030),cardiothoracic ratio(OR=39.917,95%CI=1.244–1281.098),the average heart rate(OR=0.866,95%CI=0.836–0.896)and heart rate range(OR=0.882,95%CI=0.853–0.912)might be the factors influencing SubCCTA.Conclusion This study suggested that SubCCTA could help improve diagnostic accuracy in the presence of calcium plaques.Moreover,several factors were discovered for the first time to possibly influence SubCCTA,which will be helpful in improving the subtracted image quality.

关键词： coronary computed tomographic angiography calcification artifacts coronary subtraction diagnosis accuracy influencing factors

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Re:Commentary on“A modified fixation technique for the cure of buried penis in children”

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Asian Journal of Andrology 2023年第1期25卷 146-146页

作者： Xu Cui Bing-Jing Gao Liu Chen wen-hua huang Chao-Ming Zhou Department of Pediatric Surgery Fujian Maternity and Child Health HospitalAffiliated Hospital of Fujian Medical UniversityFuzhou 350001China Central Sterile Supply Department Fujian Provincial Hospital South BranchFuzhou 350001China

In this article,we respond to the comments by Gereta et al.1 on our modified fixation method for congenital buried penis of children.Buried penis is not only associated with the shape and exposed length of the penis,but it is much more important that it may lead to serious psychological problems of children,for example self-confidence,self-esteem,and gender awareness.

关键词： buried congenital

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Repair of peripheral nerve defects with chemically extracted acellular nerve allografts loaded with neurotrophic factors-transfected bone marrow mesenchymal stem cells

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Neural Regeneration Research 2015年第9期10卷 1498-1506页

作者： Yan-ru Zhang Ka Ka Ge-chen Zhang Hui Zhang Yan Shang Guo-qiang Zhao wen-hua huang Medical College Henan Polytechnic University Institute of Clinical Anatomy Southern Medical University Department of Orthopedics First Affiliated Hospital of Zhengzhou University Department of Laboratory Medicine Children’s Hospital of Zhengzhou School of Basic Medical Sciences Zhengzhou University

Chemically extracted acellular nerve allografts loaded with brain-derived neurotrophic fac- tor-transfected or ciliary neurotrophic factor-transfected bone marrow mesenchymal stem cells have been shown to repair sciatic nerve injury better than chemically extracted acellular nerve allografts alone, or chemically extracted acellular nerve allografts loaded with bone marrow mesenchymal stem cells. We hypothesized that these allografts compounded with both brain-derived neurotrophic factor- and ciliary neurotrophic factor-transfected bone marrow mesenchymal stem cells may demonstrate even better effects in the repair of peripheral nerve injury. We cultured bone marrow mesenchymal stem cells expressing brain-derived neuro- trophic factor and/or ciliary neurotrophic factor and used them to treat sciatic nerve injury in rats. We observed an increase in sciatic functional index, triceps wet weight recovery rate, myelin thickness, number of myelinated nerve fibers, amplitude of motor-evoked potentials and nerve conduction velocity, and a shortened latency of motor-evoked potentials when al- lografts loaded with both neurotrophic factors were used, compared with allografts loaded with just one factor. Thus, the combination of both brain-derived neurotrophic factor and cili- ary neurotrophic factor-transfected bone marrow mesenchymal stem cells can greatly improve nerve injury.

关键词： nerve regeneration peripheral nerve injury brain-derived neurotrophic factor ciliaryneurotrophic factor chemically extracted acellular nerve allografis bone marrow mesenchymal stemcells peripheral nerve neural regeneration

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Testicular descent and fixation through a scrotal stria incision for the treatment of palpable cryptorchidism in children aged<3 years:10-year experience with 1034 cases

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Asian Journal of Andrology 2020年第6期22卷 649-652页

作者： Liu Chen wen-hua huang Yun-Jin Wang Qi-Liang Zhang Chao-Ming Zhou Xu Cui Jian-Qin Zhang Department of Pediatric Surgery Fujian Maternity and Child Health HospitalAffiliated Hospital of Fujian Medical UniversityFuzhou 350001China

This study was performed to summarize our clinical experience with testicular descent and fixation through a scrotal stria incision for the treatment of palpable cryptorchidism in children.This study included 1034 children with palpable cryptorchidism from March 2009 to March 2019.A scrotal stria incision was used to perform testicular descent and fixation.Overall,1020 children successfully underwent surgical testicular descent and fixation through a scrotal stria incision,and 14 patients underwent conversion to inguinal incision surgery.All patients were discharged 1-2 days after the operation.During hospitalization and follow-up,55 patients developed complicationsy including 10 patients with testicular retraction,7 with poor healing of the incision,and 38 with a scrotal hematoma.No patients developed testicular atrophy,an in direct ingui nal hernia,or a hydrocoele.Testicular descent and fixation through a scrotal stria incision for the treatment of palpable cryptorchidism in children is safe and feasible in well-selected cases.This method has the advantages of no scarring and a good cosmetic effect.

关键词： children cosmetic effect palpable cryptorchidism scrotal stria incision testicular descending fixation

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Integrative molecular characterization of Chinese prostate cancer specimens

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Asian Journal of Andrology 2020年第2期22卷 162-168页

作者： Shi-Dong Lv Hong-Yi Wang Xin-Pei Yu Qi-Liang Zhai Yao-Bin Wu Qiang Wei wen-hua huang National Key Discipline of Human Anatomy School of Basic Medical SciencesSouthern Medical UniversityGuangzhou 510515China Guangdong Engineering Research Center for Translation of Medical 3D Printing Application Guangzhou 510515China Department of Urology Nanfang HospitalSouthern Medical UniversityGuangzhou 510515China Department of Oncology Affiliated Cancer Hospital and Institute of Guangzhou Medical UniversityGuangzhou 510095China

Prostate cancer(PCa)exhibits epidemiological and molecular heterogeneity.Despite extensive studies of its phenotypic and genetic properties in Western populations,its molecular basis is not clear in Chinese patients.To determine critical molecular characteristics and explore correlations between genomic markers and clinical parameters in Chinese populations,we applied an integrative genetic/transcriptomic assay that combines targeted next-generation sequencing and quantitative real-time PCR(qRT-PCR)on samples from 46 Chinese patients with PCa.Lysine(K)-specific methyltransferase 2D(KMT2D),zinc finger homeobox 3(ZFHX3),A-kinase anchoring protein 9(AKAP9),and GLI family zinc finger 1(GLI1)were frequently mutated in our cohort.Moreover,a clinicopathological analysis showed that RB transcriptional corepressor 1(RB1)deletion was common in patients with a high risk of disease progression.Remarkably,four genomic events,MYC proto-oncogene(MYC)amplification,RB1 deletion,APC regulator of WNT signaling pathway(APC)mutation or deletion,and cyclin-dependent kinase 12(CDK12)mutation,were correlated with poor disease-free survival.In addition,a close link between KMT2D expression and the androgen receptor(AR)signaling pathway was observed both in our cohort and in The Cancer Genome Atlas Prostate Adenocarcinoma(TCGA-PRAD)data.In summary,our results demonstrate the feasibility and benefits of integrative molecular characterization of PCa samples in disease pathology research and personalized medicine.

关键词： androgen receptor molecular subtyping next generation sequencing prostate cancer quantitative real-time-polymerase chain reaction

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基于近红外光谱法的党参醇沉上清液中多种成分的同时定量（英文）

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2017年第5期18卷 383-392页

作者： Yu LUO wen-long LI wen-hua huang Xue-hua LIU Yan-gang SONG Hai-bin QU Pharmaceutical informatics Institute Zhejiang UniversityHangzhou 310058China Livzon(Group)Limin Pharmaceutical Factory Shaoguan 512028China

目的:建立党参醇沉上清液中多指标的快速近红外光谱分析法,帮助实现党参醇沉中间体的实时放行检测。创新点:采用近红外光谱技术建立党参醇沉过程中间体的质控方法,实现醇沉上清液中4种关键质量属性的同时定量。方法:将近红外光谱技术与... 详细信息

目的:建立党参醇沉上清液中多指标的快速近红外光谱分析法,帮助实现党参醇沉中间体的实时放行检测。创新点:采用近红外光谱技术建立党参醇沉过程中间体的质控方法,实现醇沉上清液中4种关键质量属性的同时定量。方法:将近红外光谱技术与多变量数据处理相结合,在建模样本制备中,通过实验设计的方法引入过程参数的波动(表1和表2),先浓缩后稀释的方法进一步扩大样品浓度范围,以模型预测能力为指标选择了最优的预处理方法、建模波段和回归算法,得到4个指标的最佳回归模型。结论:实现了党参醇沉上清液中4类指标的近红外光谱快速分析法,所建党参炔苷、总黄酮、色素和固含量模型的预测均方根误差(RMSEP)值分别为1.22μg/ml、10.50μg/ml、1.43μg/ml和0.433%。

关键词：近红外光谱法党参醇沉实时放行检测多成分定量

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Goniodilactone and gomoheptenolactone,two novel cytotoxic styryllactones from the leaves of Goniothalamus cheliensis

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Chinese Chemical Letters 2012年第5期23卷 583-586页

作者： Jiu Xiang Zhu Dong Lei Yu wen hua huang Lan Sun Yang Lv Qi Tai Zheng Kuo Hsiung Lee Jing Guang Yu Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine Ministry of EducationInstitute of Medicinal Plant DevelopmentChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100193China Division of Medicinal Chemistry and Natural Products School of PharmacyUniversity of North CarolinaUSA Institute of Materia Medica Chinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100050China

Two novel styryllactones,goniodilactone（1） and gonioheptenolactone（2）,were isolated from the leaves of Goniothalamus cheliensis Hu.Their structures were determined on the basis of spectroscopic data as well as X-ray crystallography analysis. Compounds 1 and 2 exhibited significant cytotoxicities in a panel of human cancer cells,including DU-145,PC-3,MCF-7,A-549, KB and KBvin,with GI_（50）S in the range of 1.29-4.56μg/mL.

关键词： Goniothalamus cheliensis Goniodilactone Gonioheptenolactone Cytotoxic activity Styryllactones

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