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Age exerts a continuous effect in the outcomes of Asian breast cancer patients treated with breast-conserving therapy

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Cancer Communications 2018年第1期38卷 410-420页

作者： Fuh Yong Wong Wei Ying Tham wen long nei Cindy Lim Hui Miao Division of Radiation Oncology National Cancer Centre Singapore11 Hospital DriveSingapore 169610Singapore Saw Swee Hock School of Public Health National University of SingaporeSingaporeSingapore

Background:Asians are diagnosed with breast cancer at a younger age than Caucasians *** studied the effect of age on locoregional recurrence and the survival of Asian breast cancer patients treated with breast-conserving ***:Medical records of 2492 patients treated with breast-conserving therapy between 1989 and 2012 were *** Kaplan-Meier method was used to estimate locoregional recurrence,breast cancer-free survival,and breast cancer-specific survival *** rates were then compared using log-rank *** and age were modeled by Cox proportional *** polynomials were then used to test for non-linear relationships between age and ***:Patients≤40 years old were more likely to have locoregional recurrence than were older patients(Hazard ratio[HR]=2.32,P<0.001).Locoregional recurrence rates decreased year-on-year by 4%for patients with luminal-type breast cancers,compared with 8%for those with triple-negative ***,breast cancer-free survival rates increased year-on-year by 4%versus 8%for luminal-type and triple-negative cancers,*** cancer-spe-cific survival rates increased with age by 5%*** breast cancer-free survival and breast cancer-specific survival rates in patients with luminal cancers exhibited a non-linear(“L-shaped”)relationship-where decreasing age at presentation was associated with escalating risks of relapse and *** influence of age on overall survival was confounded by competing non-cancer deaths in older women,resulting in a“U-shaped”***:Young Asian breast cancer patients have a continuous year-on-year increase in rates of disease relapse and cancer deaths compared with older patients with no apparent threshold.

关键词： Breast cancer Breast-conserving therapy Locoregional recurrence Breast cancer-specific survival Breast cancer-free survival Younger age

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年龄对接受保乳治疗的亚洲乳腺癌患者结局的影响呈现连续性

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癌症 2018年第6期37卷 229-239页

作者： Fuh Yong Wong Wei Ying Tham wen long nei Cindy Lim Hui Miao Division of Radiation Oncology National Cancer Centre Singapore Saw Swee Hock School of Public Health National University of Singapore

背景与目的亚洲人被诊断为乳腺癌的年龄比高加索人年轻。我们研究了年龄对接受保乳治疗的亚洲乳腺癌患者的局部区域复发及生存期的影响。方法分析了1989年至2012年接受保乳治疗的2492例乳腺癌患者的病历。采用Kaplan-Meier法分析了局部... 详细信息

背景与目的亚洲人被诊断为乳腺癌的年龄比高加索人年轻。我们研究了年龄对接受保乳治疗的亚洲乳腺癌患者的局部区域复发及生存期的影响。方法分析了1989年至2012年接受保乳治疗的2492例乳腺癌患者的病历。采用Kaplan-Meier法分析了局部区域复发率、无乳腺癌生存期和乳腺癌特异生存期,log-rank检验进行差异比较。采用Cox比例风险回归模型分析了结局与年龄的关系。分段多项式函数法用于评估年龄与结局之间的非线性关系。结果年龄≤40岁的患者出现局部区域复发的可能性更大(风险比[hazard ratio,HR]=2.32,P<0.001)。管腔型乳腺癌局部区域复发率降低4%,同比三阴性乳腺癌降低8%。与之相似,管腔型和三阴性乳腺癌患者的无乳腺癌生存率分别增加4%和8%。乳腺癌特异生存率随年龄同比增加5%。管腔型乳腺癌患者的无乳腺癌生存率和乳腺癌特异生存率都呈非线性("L型")关系:递减的发病年龄与逐步增加的复发和死亡风险相关。在年老女性中年龄对总生存的影响受到非癌症死亡的混杂,导致"U-型"关系。结论与年老患者相比,年轻亚洲乳腺癌患者的疾病复发率和癌症死亡率呈持续逐年递增趋势,但无明显年龄阈值。

关键词：乳腺癌保乳治疗局部区域复发乳腺癌特异生存期无乳腺癌生存期较年轻

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Targeting TrkB–PSD-95 coupling to mitigate neurological disorders

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Neural Regeneration Research 2025年第3期20卷 715-724页

作者： Xin Yang Yu-wen Alvin Huang John Marshall Department of Molecular Biology Cell Biology and BiochemistryBrown UniversityProvidenceRIUSA Department of Neurology Warren Alpert Medical School of Brown UniversityProvidenceRIUSA Center for Translational Neuroscience Robert J.and Nancy D.Carney Institute for Brain Science and Brown Institute for Translational ScienceBrown UniversityProvidenceRIUSA

Tropomyosin receptor kinase B(TrkB)signaling plays a pivotal role in dendritic growth and dendritic spine formation to promote learning and *** activity-dependent release of brain-derived neurotrophic factor at synapses binds to pre-or postsynaptic TrkB resulting in the strengthening of synapses,reflected by long-term ***,the association of postsynaptic density protein-95 with TrkB enhances phospholipase Cγ-Ca^(2+)/calmodulin-dependent protein kinaseⅡand phosphatidylinositol 3-kinase-mechanistic target of rapamycin signaling required for long-term *** this review,we discuss TrkB-postsynaptic density protein-95 coupling as a promising strategy to magnify brain-derived neurotrophic factor signaling towards the development of novel therapeutics for specific neurological disorders.A reduction of TrkB signaling has been observed in neurodegenerative disorders,such as Alzheimer's disease and Huntington's disease,and enhancement of postsynaptic density protein-95 association with TrkB signaling could mitigate the observed deficiency of neuronal connectivity in schizophrenia and *** with brain-derived neurotrophic factor is problematic,due to poor pharmacokinetics,low brain penetration,and side effects resulting from activation of the p75 neurotrophin receptor or the truncated TrkB.T1 *** TrkB agonists and antibodies that activate TrkB are being intensively investigated,they cannot distinguish the multiple human TrkB splicing isoforms or cell type-specific *** TrkB–postsynaptic density protein-95 coupling provides an alternative approach to specifically boost TrkB signaling at localized synaptic sites versus global stimulation that risks many adverse side effects.

关键词： Angelman syndrome autism brain-derived neurotrophic factor depression neurodegenerative disorder neurodevelopmental disorder postsynaptic density protein-95 synaptic plasticity TrkB

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Mountain pass solutions to a generalized Frenkel-Kontorova model

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Science China Mathematics 2022年第6期65卷 1293-1318页

作者： wen-long Li School of Mathematics Sun Yat-Sen UniversityGuangzhou 510275China

We study a generalized Frenkel-Kontorova model and obtain periodic and heteroclinic mountain pass *** heteroclinic mountain pass solution in the second laminations is new to the generalized Frenkel-Kontorova *** proof follows that of Bolotin and Rabinowitz(2005)for an Allen-Cahn equation,which is different from the heat flow method of finding the critical point of the Frenkel-Kontorova model in the *** proofs depend on suitable choices of functionals and working *** also study the multiplicity of these mountain pass solutions.

关键词： mountain pass solution periodic solution heteroclinic solution Frenkel-Kontorova model

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The Security of Using Large Language Models:A Survey With Emphasis on ChatGPT

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IEEE/CAA Journal of Automatica Sinica 2025年第1期 1-26页

作者： Wei Zhou Xiaogang Zhu Qing-long Han Lin Li Xiao Chen Sheng wen Yang Xiang the School of Science Computing and Engineering Technologies Swinburne University of Technology IEEE the School of Computer and Mathematical Sciences the University of Adelaide Adelaide the Faculty of Science and Engineering Southern Cross University the School of Information and Physical Sciences the University of Newcastle

ChatGPT is a powerful artificial intelligence(AI)language model that has demonstrated significant improvements in various natural language processing(NLP) tasks. However, like any technology, it presents potential security risks that need to be carefully evaluated and addressed. In this survey, we provide an overview of the current state of research on security of using ChatGPT, with aspects of bias, disinformation, ethics, misuse,attacks and privacy. We review and discuss the literature on these topics and highlight open research questions and future *** this survey, we aim to contribute to the academic discourse on AI security, enriching the understanding of potential risks and mitigations. We anticipate that this survey will be valuable for various stakeholders involved in AI development and usage, including AI researchers, developers, policy makers, and end-users.

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Synthesis and Properties of a Novel 3D Europium Coordination Polymer with Helical Chain and （3,6）-Connected rtl Net

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Chinese Journal of Chemistry 2016年第12期34卷 1304-1308页

作者： Zhifeng Liu Bowen Lai Huiliang wen Julianne Robbins nei Huang State Key Laboratory of Food Science and Technology Nanchang University Nanchang Jiangxi 330047 China Chemicals' Analysis Department Nanchang Institute for Food and Drug Control Nanchang Jiangxi 330038 China School of Chemistry and Biochemistry Georgia Institute of Technology Atlanta Georgia 30332 United States Jiangxi Sinograin Quality Supervision Center Nanchang Jiangxi 330000 China

The first coordination polymer of 2,2＇-（（4-carboxymethyl-1,3-phenylene）bis（oxy）） diacetic acid （H3L） with eu- ropium（[II） ion, [Eu（L）（H2O）]＇3H2O （1）, has been hydrothermally synthesized and structurally characterized. Complex 1 exhibits a 3D coordination polymer with helical chain and rtl topology of the point symbol （4·6^2）2（4^2·6^10·8^3） based on [Eu2（COO）4] as secondary building unit （SBU）. Furthermore, the luminescent and magnetic properties of complex 1 are studied.

关键词： europium coordination polymer helix topological structure luminescence magnetism

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Modal Parameters Identification of A Real Offshore Platform From the Response Excited by Natural Ice Loading

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China Ocean Engineering 2020年第4期34卷 558-570页

作者： YANG wen-long WANG Shu-qing ESI North America Farmington HillsMI 48334USA Shandong Provincial Key Lab of Ocean Engineering Ocean University of ChinaQingdao 266100China

This paper investigates the possibility of utilizing response from natural ice loading for modal parameter identification of real offshore *** test platform is the JZ20-2 MUQ jacket platform located in the Liaodong Bay,China.A field experiment is carried out in winter season,as the platform is excited by floating *** feasibility is demonstrated by the acceleration response of two different *** the SSI-data method,the modal frequencies and damping ratios of four structural modes can be successfully identified from both *** estimated information from both segments is almost identical,which demonstrates that the modal identification is ***,by taking the Jacket platform as a benchmark,the numerical performance of five popular time-domain EMA methods is systematically compared from different *** comparisons are categorized as:(1)stochastic methods versus deterministic methods;(2)high-order methods versus low-order methods;(3)data-driven versus covariance-driven stochastic subspace identification methods.

关键词： modal identification experimental modal analysis offshore platform ambient excitation natural ice loading comparative study

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Black hole evaporation and its remnants with the generalized uncertainty principle including a linear term

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Communications in Theoretical Physics 2024年第2期76卷 125-136页

作者： Bo Yu Zheng-wen long College of Physics Guizhou UniversityGuiyang550025China

In recent years,researchers have investigated the evaporation of Schwarzschild black holes using various forms of the generalized uncertainty principle(GUP),metric quantum correction,and noncommutative geometry,***,there are differences between the GUP correction and the other two methods in terms of describing the later stages of black hole ***,some studies argue that the GUP with a negative parameter cannot effectively correct black hole evaporation,while others contend that the positivity or negativity of the GUP parameters should not affect the correction *** the above into consideration,we reconsider black hole evaporation with the generalized uncertainty principle including a linear term(LGUP),and examine the case of negative *** results indicate that the evaporation behavior of both Schwarzschild black holes and Reissner–Nordstr?m black holes,under LGUP correction,is consistent with the results of metric quantum correction and non-commutative ***,the negative parameter LGUP can also effectively correct for black hole evaporation.

关键词： black hole evaporation generalized uncertainty principle negative parameter

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Dynamic Power Saving via Least-Square Self-Tuning Regulator in the Virtualized Computing Systems

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Journal of Systems Science & Complexity 2015年第1期28卷 60-79页

作者： wen Chengjian long Xiang MU Yifen School of Computer Science and Engineering Beihang University Key Laboratory of Systems and Control Institute of Systems ScienceAcademy of Mathematics and Systems ScienceChinese Academy of Sciences

In recent years,power saving problem has become more and more important in many fields and attracted a lot of research *** this paper,the authors consider the power saving problem in the virtualized computing *** there are multiple objectives in the system as well as many factors influencing the objectives,the problem is complex and *** authors will formulate the problem as an optimization problem of power consumption with a prior requirement on performance,which is taken as the response time in the *** solve the problem,the authors design the adaptive controller based on least-square self-tuning regulator to dynamically regulate the computing resource so as to track a given reasonable reference performance and then minimize the power consumption using the tracking result supplied by the controller at each *** is implemented based on the data collected from real machines and the time delay of turning on/off the machine is included in the *** results show that this method based on adaptive control theory can save power consumption greatly with satisfying the performance requirement at the same time,thus it is suitable and effective to solve the problem.

关键词： Adaptive control green computing least square self-tuning regulator (LS-STR) performance constraint power saving.

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Enabling Highly Efficient k-Means Computations on the SW26010 Many-Core Processor of Sunway TaihuLight

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Journal of Computer Science & Technology 2019年第1期34卷 77-93页

作者： Min Li Chao Yang Qiao Sun wen-Jing Ma wen-long Cao Yu-long Ao Institute of Software Chinese Academy of SciencesBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China School of Mathematical Sciences Peking UniversityBeijing 100871China Center for Data Science Peking UniversityBeijing 100871China peng Cheng Laboratory Shenzhen 518052China

With the advent of the big data era,the amounts of sampling data and the dimensions of data features are rapidly *** is highly desired to enable fast and efficient clustering of unlabeled samples based on feature similarities. As a fundamental primitive for data clustering,the k-means operation is receiving increasingly more attentions *** achieve high performance k-means computations on modern multi-core/many-core systems,we propose a matrix-based fused framework that can achieve high performance by conducting computations on a distance matrix and at the same time can improve the memory reuse through the fusion of the distance-matrix computation and the nearest centroids *** implement and optimize the parallel k-means algorithm on the SW26010 many-core processor,which is the major horsepower of Sunway *** particular,we design a task mapping strategy for load-balanced task distribution,a data sharing scheme to reduce the memory footprint and a register blocking strategy to increase the data *** techniques such as instruction reordering and double buffering are further applied to improve the sustained *** on block-size tuning and performance modeling are also *** show by experiments on both randomly generated and real-world datasets that our parallel implementation of k-means on SW26010 can sustain a double-precision performance of over 348.1 Gflops,which is 46.9% of the peak performance and 84%of the theoretical performance upper bound on a single core group,and can achieve a nearly ideal scalability to the whole SW26010 processor of four core *** comparisons with the previous state-of-the-art on both CPU and GPU are also provided to show the superiority of our optimized k-means kernel.

关键词： parallel k-means performance optimization SW26010 processor Sunway TaihuLight

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