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中国建筑防水 2008年第4期 17-21页

作者：陆明曹伟飚朱祖熹上海隧道工程轨道交通设计研究院上海200070

针对越江道路隧道采用超大直径盾构施工的特殊工况,以崇明越江通道长江隧道工程实际防水功效为例,阐述了该类隧道主要的防水设计内容及相关的科研内容,为今后类似工程的防水设计提供参考。

关键词：超大直径盾构隧道防水设计混凝土管片衬砌接缝连接通道弹性橡胶密封垫

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地铁盾构隧道复合腔体构件性能试验研究

城市轨道交通研究 2022年第6期25卷 31-36,42页

作者：邓世舜沈张勇柳献许文曹伟飚张磊刘旭阳南京地铁运营有限责任公司南京210008 上海市隧道工程轨道交通设计研究院上海200235 同济大学地下建筑与工程系上海200092

复合腔体是一种新型的加固盾构隧道的结构材料,它能够为隧道结构提供额外的承载力,控制结构变形。对灌浆复合腔体、空腔复合腔体和空腔钢管的抗弯、抗压性能进行研究。分析了复合腔体抗压和抗弯的破坏机理,得到其受压承载力、受弯承载... 详细信息

复合腔体是一种新型的加固盾构隧道的结构材料,它能够为隧道结构提供额外的承载力,控制结构变形。对灌浆复合腔体、空腔复合腔体和空腔钢管的抗弯、抗压性能进行研究。分析了复合腔体抗压和抗弯的破坏机理,得到其受压承载力、受弯承载力和刚度的变化规律。结果表明,外层碳纤维间绷断为复合腔体构件丧失抗压、抗弯承载能力的标志;碳纤维材料的约束作用显著提高了试件的截面抗弯刚度和承载能力,但降低了构件的延性,砂浆材料显著提高了试件的抗压承载能力;碳纤维、砂浆、钢管三者共同作用效果欠佳,模拟中需考虑三者材料间的滑移。

关键词：地铁盾构隧道复合腔体构件性能试验

盾构法施工隧道加固所用复合腔体接头构件的抗弯性能试验

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城市轨道交通研究 2022年第8期25卷 112-116页

作者：殷瑞忠曹伟飚柳献乔小雷沈张勇张磊刘旭阳南京地铁运营有限责任公司南京210008 上海市隧道工程轨道交通设计研究院上海200235 同济大学地下建筑与工程系上海200092

针对盾构法施工隧道加固所用复合腔体接头处易脱开并引起复合腔体剥离破坏的问题,设计新型复合腔体接头进行抗弯试验,研究其在不同工况下的破坏过程、极限承载力及刚度,并与复合腔体本体的抗弯性能进行对比。研究发现:新型复合腔体接头... 详细信息

针对盾构法施工隧道加固所用复合腔体接头处易脱开并引起复合腔体剥离破坏的问题,设计新型复合腔体接头进行抗弯试验,研究其在不同工况下的破坏过程、极限承载力及刚度,并与复合腔体本体的抗弯性能进行对比。研究发现:新型复合腔体接头构件进入塑性阶段的标志为复合腔体与接头盖板的侧边胶水失效;负弯矩工况下的接头构件抗弯性能较弱,复合腔体接头应避免布置于隧道的负弯矩区;复合腔体接头构件的抗弯承载力与刚度均弱于本体,接头构件宜布置于隧道结构反弯点处。经隧道整环试验验证,新型复合腔体接头处无脱开现象。

关键词：盾构法隧道加固复合腔体接头抗弯性能

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射频联合CT引导下神经阻滞治疗压缩性骨折疼痛的meta分析

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上海医药 2020年第21期41卷 40-42,46页

作者：余菲刘武张维孙勇曹为标戴甫成镇江市第一人民医院江苏镇江212002

目的:系统评价射频联合神经阻滞治疗压缩性骨折疼痛的效果。方法:在数据库中检索自2015年1月至2020年3月发表的关于射频联合神经阻滞治疗压缩性骨折疼痛的文献,选取高质量文献进行meta分析,评价该治疗对压缩性骨折疼痛、功能障碍的疗效... 详细信息

目的:系统评价射频联合神经阻滞治疗压缩性骨折疼痛的效果。方法:在数据库中检索自2015年1月至2020年3月发表的关于射频联合神经阻滞治疗压缩性骨折疼痛的文献,选取高质量文献进行meta分析,评价该治疗对压缩性骨折疼痛、功能障碍的疗效。结果:纳入5篇文献,经meta分析显示射频联合神经阻滞治疗与常规治疗相比可明显降低患者的疼痛视觉模拟评分(VAS)和Oswestry功能障碍指数(ODI)(P<0.05)。结论:射频联合CT引导下神经阻滞能减轻压缩性骨折疼痛,缓解患者的功能障碍。

关键词：射频 meta 分析神经阻滞压缩性骨折疼痛

Application of SPE-GC/MS in resolution of metabolism pattern of higher alcohols in rat plasma

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Food Science and Human Wellness 2023年

作者： Yufei Liu Xiaonian cao Zhilei Zhou Qingxi Ren Zhongwei Ji Min Gong Yuezheng Xu weibiao Zhou Shuguang Chen Jian Mao Department of Food Science and Technology National University of Singapore Luzhou Laojiao Co. Ltd. Department of General Surgery Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College (CAMS & PUMC) Shaoxing Key Laboratory of Traditional Fermentation Food and Human Health Jiangnan University (Shaoxing) Industrial Technology Research Institute Jiangsu Provincial Engineering Research Center for Bioactive Product Processing Jiangnan University National Engineering Research Center of Cereal Fermentation and Food Biomanufacturing School of Food Science and Technology Jiangnan University National Engineering Research Center for Huangjiu Zhejiang Guyuelongshan Shaoxing Wine Co. Ltd Zhejiang Shaoxing Huangjiu Industry Innovation Service Complex

Higher alcohols are key factors affecting sensory quality and post-drinking comfort of alcoholic beverages. A strategy combining solid-phase extraction and gas chromatography-mass spectrometry (SPE-GC/MS) was established to analyze the metabolism pattern of higher alcohols in rat plasma after gavage of four common alcoholic beverages including huangjiu， baijiu， wine and brandy. Seven milliliter of dichloromethane was determined as the optimal extraction condition， and eight higher alcohols were precisely quantified with detection limits of 1.82-11.65 μg/L， recoveries of 89.07%-110.89% and fine repeatability. The fastest absorption and elimination rates of plasma total higher alcohols were observed in baijiu and huangjiu group， respectively， and the highest peak concentration was found in brandy group. Additionally， the metabolic rate of plasma isoamyl alcohol in huangjiu group was faster than that in wine group at the same intragastric administration dosage. This study may provide potential insight for evaluation of alcoholic beverage quality.

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Absence of FHIT expression is associated with apoptosis inhibition in colorectal cancer

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The Chinese-German Journal of Clinical Oncology 2007年第1期6卷 44-51页

作者： Jie cao Xiaoping Chen Wanglin Li Jie Xia Hong Du weibiao Tang Hui Wang Xiwen Chen Huanqing Xiao Yuyuan Li Center of Hepatic Surgery Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan 430030 China Department of Gastrointestinal Surgery Affiliated Guangzhou First People＇s Hospital Guangzhou Medical College Guangzhou 510180 China Department of Pathology Affiliated Guangzhou First People＇s Hospital Guangzhou Medical College Guangzhou 510180 China Department of Gastroenterology Affiliated Guangzhou First People＇s Hospital Guangzhou Medical College Guang- zhou 510180 China

Objective: To investigate the expression of fragile histidine triad (FHIT) protein in normal colorectal tissue, colorectal adenoma and colorectal cancer (CRC), and to study the relationships between the expression of FHIT protein and the clinical pathology, the apoptosis-associated protein (Bcl-2, Bax, Survivin), apoptosis in colorectal cancer. Methods: Tissue microarray (TMA) and immunohistochemistry SP were used to detect the expression of FHIT gene, Bcl-2, Bax and Survivin in 16 cases of the normal colorectal tissue, 16 cases of colorectal adenoma and 80 cases of the colorectal cancer. TUNEL was used to detect the apoptosis index (AI) in 80 cases of the colorectal cancer. Results: (1) The positive rates of FHIT gene expression in normal colorectal tissue, colorectal adenoma and adenocancer were 93.75%, 68.75% and 46.25% respectively. There were no significant differences in the relationships between the FHIT gene expression and histological types, the gender as well as the age (P>0.05). There were significant relationships between FHIT gene expression and lymph node metastasis, histological grades, Duke’s system as well as the 5-year survival rate after operation. (2) The positive rates of Bax, Bcl-2 and Survivin in colorectal adenocancer were 72.50%, 51.25%, 77.50% respectively. The expression of FHIT gene was positively correlated with that of Bcl-2, Bax and Survivin. (3) The mean AI in FHIT negative tumors was significantly lower than that in FHIT positive tumors (P<0.01). Conclusion: FHIT gene may play a role in the oncogenesis and progression of colorectal cancer. The abnormal regulation of apoptosis may play an important role in the pathogenesis of colorectal cancer.

关键词：结直肠癌 FHIT 表达缺失凋亡抑制相关性

Absence of FHIT expression is associated with apoptosis inhibition in colorectal cancer

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Frontiers of Medicine 2007年第2期1卷 147-156页

作者： cao Jie CHEN Xiaoping LI Wanglin XIA Jie DU Hong TANG weibiao CHEN Shanming WANG Hui CHEN Xiwen XIAO Huanqing LI Yuyuan Department of Gastrointestinal Surgery Affiliated Guangzhou First People’s HospitalGuangzhou Medical CollegeGuangzhou 510180China Center of Hepatic Surgery Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Department of Pathology Affiliated Guangzhou First People’s HospitalGuangzhou Medical CollegeGuangzhou 510180China Department of Scientific Research and Education Affiliated Guangzhou First People’s HospitalGuangzhou Medical CollegeGuangzhou 510180China Department of Gastroenterology Affiliated Guangzhou First People’s HospitalGuangzhou Medical CollegeGuangzhou 510180China

The fragile histidine triad(FHIT)gene,a candidate tumor suppressor gene located at 3p14.2,has been shown to be involved in the carcinogenesis of many human tissues,including digestive tract ***,the expression and the role of the FHIT in the initiation and the development of the colorectal cancer(CRC)are poorly *** have shown that the FHIT gene exhibits significantly decreased expression in human CRC compared to colorectal adenoma and normal colorectal tissue by tissue microarray(TMA).The positive rate of FHIT gene expression in normal colorectal tissue,adenoma and adenocarcinoma were 93.75%,68.75%and 46.25%,*** show this decreased expression to be significantly correlated with the progression of colorectal carcinoma(P<0.05)as well as with differentiation and lymph node metastasis(P<0.05).We detected two somatic alterations in the FHIT gene in human *** presence of this mutation correlated significantly with decreased FHIT expression in the human *** our present study we tested the hypothesis that the decreased FHIT expression resulted in apoptosis inhibition associated with abnormal expression of apoptosis related *** test this hypothesis we did a series of *** the first test,we assessed apoptosis status using a standard TUNEL(terminal deoxynucleotidyl transferase-mediated dUTP nick-end-labeling)assay by comparing FHIT-positive CRC ***-negative *** the second experiment,the protein expression of the FHIT and other apoptosis related proteins(Bax,Bcl-2 and Survivin)were measured in human CRC by *** combined results demonstrate the mutation in the FHIT gene significantly reduced FHIT expression in human *** TUNEL and TMA experiments demonstrated significantly inhibited apoptosis by down-regulation of Bax and the up-regulation of Survivin and ***,these studies identify the mechanism by which an important tumor suppressor gene,FHIT is inactivated specifically in human CRC contribut

关键词： fragile histidine triad expression apoptosis colorectal cancer

新型钢管混凝土柱-钢梁节点非线性有限元分析

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工业建筑 2006年第Z1期36卷 585-590页

作者：曹玉生李志刚杨蔚彪内蒙古工业大学建筑工程学院呼和浩特010062 内蒙古赤峰市建委赤峰024000 中国建筑设计标准研究院北京100044

针对以往钢管混凝土柱梁节点受力性能及应用中的缺陷,提出梁通柱断式新型加强环节点型式。通过ANSYS有限元软件分析其受力性能、节点破坏形态、承载力以及节点各参数对其约束刚度的影响,证明其能够实现“强柱弱梁”和塑性铰形成于环与... 详细信息

针对以往钢管混凝土柱梁节点受力性能及应用中的缺陷,提出梁通柱断式新型加强环节点型式。通过ANSYS有限元软件分析其受力性能、节点破坏形态、承载力以及节点各参数对其约束刚度的影响,证明其能够实现“强柱弱梁”和塑性铰形成于环与梁交角处的抗震设计理念,具有较好的适用性。

关键词：钢管混凝土节点非线性有限元

异形截面多腔钢管混凝土巨型分叉柱轴压性能试验研究

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建筑结构学报 2016年第5期37卷 57-68页

作者：杨光曹万林董宏英杨蔚彪田士川北京工业大学建筑工程学院北京100124 黑龙江八一农垦大学工程学院黑龙江大庆163319 北京市建筑设计研究院有限公司北京100045

为研究北京"中国尊"多腔钢管混凝土巨型分叉柱不同构造措施对其受压性能的影响,进行了2个1/10缩尺的分叉柱节点区域模型试件轴心受压力学性能试验。设计了原型柱缩尺试件BAC以及在试件BAC基础上未配置纵向加劲肋及构造钢筋的试件WAC。... 详细信息

为研究北京"中国尊"多腔钢管混凝土巨型分叉柱不同构造措施对其受压性能的影响,进行了2个1/10缩尺的分叉柱节点区域模型试件轴心受压力学性能试验。设计了原型柱缩尺试件BAC以及在试件BAC基础上未配置纵向加劲肋及构造钢筋的试件WAC。分析了试件破坏特征,承载力、刚度及退化过程、延性、耗能能力等。研究表明:试件BAC满足受力要求,承载力较高、刚度退化速率缓慢、延性较好、耗能能力较强;与试件BAC相比,试件WAC构造措施简化,但其承载力变化不大,刚度退化较快、延性较差、耗能能力较弱;异形截面钢管混凝土柱后期变形发展与构件截面不规则程度有关。在忽略横隔板作用情况下,采用不同承载力计算方法并按是否考虑竖向构造措施的影响进行了承载力计算,结果表明采用不同方法计算承载力时,横隔板对承载力的贡献均较大,且因计算方法不同存在差异。

关键词：多腔钢管混凝土巨型分叉柱异形截面轴压试验轴压性能

异形截面多腔钢管混凝土巨型分叉柱偏压性能试验研究

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建筑结构学报 2018年第6期39卷 41-52页

为研究多腔钢管混凝土巨型分叉柱不同构造措施对其压弯性能的影响,以北京中国尊为原型,设计了2个1/10缩尺的分叉柱分叉节点区域模型试件,包括原型分叉柱缩尺试件BEC,以及在试件BEC基础上,将下柱顶部区域的拉结钢筋用竖向钢板替换构成的... 详细信息

为研究多腔钢管混凝土巨型分叉柱不同构造措施对其压弯性能的影响,以北京中国尊为原型,设计了2个1/10缩尺的分叉柱分叉节点区域模型试件,包括原型分叉柱缩尺试件BEC,以及在试件BEC基础上,将下柱顶部区域的拉结钢筋用竖向钢板替换构成的加强试件SEC-2。通过偏心受压试验,考察试件的破坏形态、沿试件高度的侧向位移分布、竖向荷载-侧向位移曲线及骨架曲线、平截面假定的适用性,分析不同构造措施对分叉柱偏心受压性能的影响。基于纤维模型法,编制构件非线性计算程序,钢材采用理想弹塑性本构模型,核心混凝土分别采用GB 50010—2010《混凝土结构设计规范》本构模型（GB模型）、考虑钢管约束效应的Hu本构模型及Han本构模型。计算结果表明：在钢材本构模型不变的情况下,GB模型与Hu模型计算弯矩-曲率曲线与考虑P-δ效应的弯矩-曲率曲线相差较多。Han本构模型计算曲线与考虑P-δ效应的弯矩-曲率曲线的变化趋势一致。改进Han本构模型近似考虑横隔板和多腔钢管对受压区混凝土的组合约束效应,计算曲线与考虑P-δ效应的弯矩-曲率曲线峰值接近,下降段计算弯矩值略低。

关键词：多腔钢管混凝土巨型分叉柱异形截面偏压试验本构模型纤维模型法偏压性能