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Physical Simulation of New Desulphurization Technology Using Pulsed and Rotary Stirring-Injection

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Journal of Iron and Steel Research International 2008年第1期15卷 15-18页

作者： WU wei HU yan-bin liu liu DING Yong-liang Metallurgical Technology Research Department Central Iron and Steel Research Institute Beijing 100081 China

The contrast experiment of different stirring modes,which includes a new type of stirring-injection with the method of pulse and rotation,and the initial one-way stirring method,is done through physical simulation in the *** stirring methods of pulse and rotation are of two *** is pulsed and rotary stirrer with positive and opposite *** other is pulsed and rotary stirrer with *** results show that the stirring mode of pulse and rotation has better effects than the one-way stirring *** specific effects are that the mixing time of the melting bath is apparently shortened,the number of grains involved in the liquid surface is increased,and the residence time of air bubble in water is doubled.

关键词： hot metal desulphurization injection physical simulation pulse rotation

In(OTf)_3 catalyzed allylation reaction of imines with tetraallyltin

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Chinese Chemical Letters 2009年第1期20卷 40-43页

作者： Xiao Ning wei Ling yan liu Bing Wang wei Xing Chang Jing Li The State Key Laboratory Elemento-Organic Chemistry Institute of Elemento-Organic Chemistry Nankai University Tanjin 300071 China

In the presence of catalytic amount of In（OTf）3 （10 mol%）, a series of aldimines reacted with tetraallyltin in a 2：1 molar ratio to afford the corresponding homoallylic amines in good yields. The good atom efficiency was achieved under mild reaction conditions and a new protocol （allyl）4Sn/In（OTf）3 for simple imines was developed.

关键词： Catalytic allylation Aldimine Tetraallyltin In(OTf)3

Characteristics of Surface Plasmon Resonance Imaging lnterferometer

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稀有金属材料与工程 2006年第A3期35卷 595-599页

作者： wei Xing Deng yan liu Fangfang Yu Xinglong Dept. of Precision Instruments Tsinghua University Beijing 100084 China

In recent life science research,identifying and characterizing entire biomolecular interaction networks is prerequisite to understanding cellular processes on a molecular and biophysical level.A surface plasmon resonance (SPR) imaging interferometer based on spatial phase modulation detection is presented to meet this *** this method,the SPR sensing chip surface is illuminated with collimated parallel light beam,and a Wollaston prism is introduced into the reflected light path to produce the interference of polarized light reflected from SPR sensing *** of biomolecular interactions can be obtained by extracting the phase change from the SPR interference *** our interferometer,we made experiments on a series concentration of NaCl solutions to investigate its detection range,linearity,sensitivity and *** results indicate that the SPR imaging interferometer is mainly sufficient for biomolecular interaction detection.

关键词： surface plasmon resonance(SPR) detection range linearity sensitivity resolution

Role of the brain-gut axis in gastrointestinal cancer

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World Journal of Clinical Cases 2019年第13期7卷 1554-1570页

作者： yang-Zi Di Bo-Sheng Han Jun-Mao Di wei-yan liu Qiang Tang Department of General Surgery Shiyan Taihe HospitalHubei University of MedicineShiyan 442000Hubei ProvinceChina Department of Gastrointestinal Surgery Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 443000Hubei ProvinceChina

Several studies have largely focused on the significant role of the nervous and immune systems in the process of tumorigenesis, including tumor growth, proliferation, apoptosis, and metastasis. The brain-gut-axis is a new paradigm in neuroscience, which describes the biochemical signaling between the gastrointestinal (GI) tract and the central nervous system. This axis may play a critical role in the tumorigenesis and development of GI cancers. Mechanistically, the bidirectional signal transmission of the brain-gut-axis is complex and remains to be elucidated. In this article, we review the current findings concerning the relationship between the brain-gut axis and GI cancer cells, focusing on the significant role of the brain-gut axis in the processes of tumor proliferation, invasion, apoptosis, autophagy, and metastasis. It appears that the brain might modulate GI cancer by two pathways: the anatomical nerve pathway and the neuroendocrine route. The simulation and inactivation of the central nervous, sympathetic, and parasympathetic nervous systems, or changes in the innervation of the GI tract might contribute to a higher incidence of GI cancers. In addition, neurotransmitters and neurotrophic factors can produce stimulatory or inhibitory effects in the progression of GI cancers. Insights into these mechanisms may lead to the discovery of potential prognostic and therapeutic targets.

关键词： Brain-gut axis Gastrointestinal cancer Neurotransmitters Neuropeptides

Microstructure analysis of deep rock in Meilinmiao Mine

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Journal of Coal Science & Engineering(China) 2013年第4期19卷 468-473页

作者： Ren-Liang SHAN Li-wei SONG yan liu Wen-Feng ZHAO Hui-Xian CHEN School of Mechanics and Civil Engineering China University of Mining and Technology (Beijing) Beijing 100083 China

SEM tests were conducted on four kinds of typical deep rocks in Meilinmiao Mine, and the micro properties were analyzed. The particles of gritstone are unbroken and particle diameter ranges from 80 lam to 400 pro, and the void between particles is wide. The macroscopic failure of gritstone is caused by breakage of the dung distributed between particles, and po- tassium feldspars contained in gritstone are not leached. The failure of medium sandstone is caused by micro cracks distributed in sandstone particles, and potassium feldspars are leached seriously, so the pores penetrate each other and there is close hy- draulic connection in medium sandstone. The particles of fine sandstone are broken, and the particle diameters range from 60 pm to 300 pm, which determines the pores have good connectivity between particles. The dolomites contained in fine sand- stone are corroded, and the micro fracture form belongs to inter-granular fracture. There are no particles and blocks in micro- structure of sandy mudstone, but there are diverse micro cracks. The failure of mudstone arises from the extension of micro cracks, and the microstructure is different from the other three kinds of sandstones obviously.

关键词： SEM test deep rock microstructure leaching crack

Proinflammatory effects and molecular mechanisms of interleukin-17 in intestinal epithelial cell line HT-29

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World Journal of Gastroenterology 2014年第47期20卷 17924-17931页

作者： Yi-Lin Wang Meng Fang Xiao-Ming Wang wei-yan liu Yun-Jiang Zheng Xu-Bo Wu Ran Tao Center for Organ Transplantation and Department of Surgery Ruijin HospitalShanghai Jiaotong University School of Medicine Department of General Surgery Minhang HospitalFudan University Department of Anesthesia The 88th Hospital of PLA Department of Hepatobiliary Surgery Yijishan HospitalWannan Medical College Department of Emergency Xin Hua HospitalShanghai Jiaotong University School of Medicine

AIM:To evaluate the proinflammatory effects and molecular mechanisms of interleukin(IL)-17 in intestinal epithelial cell line ***:HT-29 cells were cultured with IL-17,tumor necrosis factor(TNF)-α,or the combination of both IL-17 and TNF-α.Real-time PCR and Western blot were used to measure the gene expression levels of neutrophil chemokines CXCL1,CXCL2,CXCL5,CXCL6,IL-8and TH-17 cell chemokine CCL20,the phosphorylation levels of p38 and TNF-α,and the expression level of IL-8,after using the p38 inhibitor in HT-29 *** stable Act1 knockdown HT-29 cell line was established to further test the phosphorylation changes of p38,after using IL-17 and TNF-α.RESULTS:After HT-29 cells were cultured with IL-17and TNF-α,the expression levels of neutrophil chemokines(CXCL1,CXCL2,CXCL5,CXCL6,IL-8)and Th17chemokine(CCL20)significantly improved(24.96±2.53,28.47±2.87,38.08±2.72,33.47±2.41,31.7±2.38,44.37±2.73,respectively),and the differences were all statistically significant(P<0.01).Western blot results showed that IL-17 obviously enhanced the phosphorylation level of p38,which was induced by TNF-α.Compared with the control group,the expression level of IL-8 significantly declined(9.47±1.36 vs 3.06±0.67,P<0.01)when TH-29 cells were cultured with IL-17and TNF-α.p38 inhibition assay showed that the p38pathway played an essential role in the inflammatory response induced by IL-17.p38 phosphorylation levels could not be changed after using IL-17 and TNF-αin the stable Act1 knockdown HT-29 cell ***:IL-17 significantly promoted the gene expression levels of TNF-α-induced neutrophil chemokines and Th17 cell *** is obvious that IL-17and TNF-αhave synergistic effects on p38.

关键词： IL-17 HT-29 TNF-α Inflammatory bowel disease

Alterations to biological soil crusts with alpine meadow retrogressive succession affect seeds germination of three plant species

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Journal of Mountain Science 2016年第11期13卷 1995-2005页

作者： LI Yi-kang OUyanG Jing-zheng LIN Li XU Xing-liang ZHANG Fa-wei DU yan-gong liu Shu-li CAO Guang-min HAN Fa Key Laboratory of Adaptation and Evolution of Plateau Biota Northwest Institute of Plateau BiologyChinese Academy of SciencesXining 810001China University of Chinese Academy of Sciences Beijing 100049China Institute of Geographic Sciences&Natural Resources Research the Chinese Academy of SciencesBeijing 100101China Liancheng National Nature Reserve of Gansu Province Yongdeng Country 730000China

Biological soil crusts(BSCs) are the important components of alpine meadow *** extent and morphology of BSCs vary greatly with alpine meadow retrogressive succession due to grazing *** is significant interest in impacts of crust composition on plant seed germination,especial l y in(semi-) arid ***,little is known about the influences of BSCs,and their associations with alpine meadow succession,on germination of typical alpine meadow vascular plant *** a full factorial common-gardenexperiment,we studied effects of:(1) crust type,(2) seed position,and(3) surface texture on seed *** chose three typical alpine meadow plant species(*** pratensis,Tibetia himalaica and Potentillen nivea),which belonged to different functional groups(graminoids,legumes,and forbs) and play important roles in all alpine meadow succession *** type and seed position influenced seed germination,and the inhibitory effects of BSCs depended on the crust type and seed species *** major factors influencing seed germination were BSC type,seed position,soil texture,and the interactions between BSC type and seed position; species and seed position; species andsurface texture; and species,crust type,and surface *** crust significantly inhibited germination of all *** position also had a significant effect on seed germination(p yanobacteria and lichen *** germination rates of *** on the soil surface were significantly correlated with plant occurrence frequency within the alpine meadow *** poor correlation for the other two species is possibly that they are *** results clearly demonstrated that BSCs can be biological filters during seed germination,depending on the BSC succession *** their influences on seed germination,BSCs can strongly

关键词： Crust type Seed position Microenvironment Germination Tibetan Plateau Vascular plants

Role of Recursive Partitioning Analysis and Graded Prognostic Assessment on Identifying Non-Small Cell Lung Cancer Patients with Brain Metastases Who May Benefit from Postradiation Systemic Therapy

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Chinese Medical Journal 2018年第10期131卷 1206-1213页

作者： Shuai liu Peng Chen yan-wei liu Xue-Nan GU Xiao-Guang Qiu Bo Li Department of Radiation Oncology BeijLng Tiantan Hospital Capital Medical University Beijing 100050 China Department of Thoracic Oncology Tianjin Medical University Cancer Institute and Hospital Tianjin 300060 China

Background：The role ofpostradiation systemic therapy in non-small cell lung cancer （NSCLC） patients with brain metastasis （BM） was ***,we explored the role of Radiation Therapy Oncology Group recursive partitioning analysis （RTOG-RPA） and graded prognostic assessment （GPA） in identifying population who may benefit from postradiation systemic ***：The clinical data of NSCLC patients with documented BM from August 2007 to April 2015 of two hospitals were studied *** regression was used for multivariate *** of patients with or without postradiation systemic therapy was compared in subgroups stratified according to RTOG-RPA or ***：Of 216 included patients,67.1% received stereotactic radiosurgery （SRS）,24.1% received whole-brain radiation therapy （WBRT）,and 8.8% received *** radiotherapy,systemic therapy was administered in 58.3% of *** analysis found that postradiation systemic therapy （yes ***）（hazard ratio [HR] =0.36 l,95% confidence interval [CI] =0.202-0.648,P =0.001）,radiation technique （SRS ***）（HR =0.462,95% CI =0.238-0.849,P =0.022）,extracranial metastasis （yes ***）（HR =3.970,95% CI =1.757-8.970,P =0.001）,and Kamofsky performance status （〈70 vs.≥70）（HR =5.338,95% CI =2.829-10.072,P 〈 0.001） were independent factors for *** analysis found that subsequent tyrosine kinase inhibitor （TKI） therapy could significantly reduce the risk of mortality of patients in RTOG-RPA Class IⅡ （HR =0.411,95% CI =0.183-）.923,P =0.031） or with a GPA score of 1.5-2.5 （HR =0.420,95% CI =0.182-0.968,P =0.042）.However,none of the subgroups stratified according to RTOG-RPA or GPA benefited from the additional conventional ***：RTOG-RPA and GPA may be useful to identify beneficial populations in NSCLC patients with BM ifTKIs were chosen as postradiation systemic therapy.

关键词： Chemotherapy Non-Small Cell Lung Cancer Recursive Partitioning Analysis Stereotactic Radiosurgery Tyrosine Kinase Inhibitors Whole-Brain Radiation Therapy

An Infrasellar Craniopharyngioma Involving the Sphenoid Sinus and Clivus

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Chinese Medical Journal 2015年第6期128卷 844-845页

作者： Zhong Zhang Ming-yang Li yan-wei liu Yong-ZhiWang Department of Neurosurgery Beijing Tiantan Hospital Capital Medical University Beijing 100050 China China National Clinical Research Center for Neurological Diseases Beijing 100050 China Beijing Neurosurgical Institute Beijing 100050 China

Craniopharyngiomas are rare, benign, epithelial neoplasms that account for about 5% of all intracranial neoplasms. Craniopharyngiomas are mainly confined to the intrasellar and suprasellar regions, with the suprasellar location being the most common. Exclusively infrasellar craniopharyngiomas with no sellar involvement are extremely rare. We reported an infrasellar craniopharyngioma involving the sphenoid sinus and clivus in a 16-year-old girl, and discussed the clinical features and management of this tumor.

关键词： Endoscopic Endonasal Approach lnfrasellar Craniopharyngioma