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Cavity optomechanics with cold atomic gas

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Frontiers of physics 2011年第3期6卷 237-250页

作者： Ke-ye zhang Lu ZHOU Guang-jiong DONG wei-ping zhang State Key Laboratory of Precision Spectroscopy Department of Physics East China Normal University Shanghai 200062 China

We present a tutorial review on the topics related to current development in cavity optomechanics, with special emphasis on cavity optomechanical effects with ultracold gases, Bose-Einstein condensates, and spinor Bos-Einstein condensates. Topics including the quantum model and nonlinearity of the cavity optomechanics, the principles of optomechanical cooling, radiation-pressure-induced nonlinear states, the chaotic dynamics in a condensate-mirror-hybrid optomechanical setup, and the spin-mixing dynamics controlled by optical cavities are covered.

关键词： cavity optomechanics Bose-Einstein condensate spinor Bose-Einstein condensate,optical bistability

Complications of proximal hypospadias repair with transverse preputial island flap urethroplasty: a 15-year experience with long-term follow-up

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Asian Journal of Andrology 2019年第3期21卷 300-303页

作者： Chao-Xu Wang wei-ping zhang Hong-Cheng Song Department of Urology Beijing Children's Hospital Affiliated to Capital Medical University Beijing 100045 China

There is still debate regarding the optimal surgical approach for proximal hypospadias. This retrospective study aims to evaluate the long-term outcomes using transverse preputial island flap urethroplasty. A total of 320 patients were included, with a mean follow-up of 40.2 months (range: 1–156 months). Complications were encountered in 125 patients (39.1%), including fistulas in 53 (16.6%), urethral strictures in 31 (9.7%), and diverticula in 41 (12.8%). The mean timing of presentation with a complication was 15.8 months (median: 1.7, range: 1–145), of which 79.2% were early complications and 20.8% were late complications. In all, 20.8% of the patients with complications presented after ≥1 year, and 12.8% presented after ≥5 years. Univariate analysis revealed that age at the time of surgery, flap length, and location of the urethral meatus were not correlated with complications. A stricture was present in 31.7%(13/41) of those with diverticula (P < 0.001), while late urethral diverticula were accompanied by urethral strictures in 11.1%(1/9) of cases (P = 0.213). These results indicate that transverse preputial island flap urethroplasty still has a high incidence of complications, even when performed by highly experienced physicians. Most complications of hypospadias are diagnosed within 1 year postoperatively, while fistulas and urinary strictures generally occur within 2 months and diverticula tend to be present by 1 year.

关键词： diverticulum fistula follow-up hypospadias late complications urethral stricture

Comparison of outcomes in three surgical techniques for proximal hypospadias:staged transverse preputial island flap urethroplasty versus single-stage repairs

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Asian Journal of Andrology 2023年第5期25卷 616-620页

作者： Yu-Si Wang Hong-Chengg Song Pei Liu Yi-wei Fang wei-ping zhang Department of Urology Beijing Children's Hospital Affiliated to Capital Medical UniversityNational Center for Children's HealthBeijing 100045China

To evaluate and compare the outcomes and complications of three different surgical techniques for treating primary proximal hypospadias with ventral curvature(VC)≥30°,we retrospectively reviewed the medical records of patients who underwent primary repair of proximal hypospadias with vC≥30°after degloving at Beijing Children's Hospital Affiliated to Capital Medical University(Beijing,China)from January 2019 to January 2021.A total of 152 patients were divided into three groups:transverse preputial island flap(TPIF)combined with Duplay,modified Koyanagi,and staged TPIF,which were performed on 55,16,and 81 patients,respectively.A total of 39(25.7%)patients had *** rates were similar for the TPIF combined with the Duplay group(40.0%)and modified Koyanagi group(50.0%)but lower for the staged TPIF group(11.1%;P<0.01).The incidence of urethrocutaneous fistulas was significantly higher in TPIF combined with Duplay group(21.8%)compared to staged TPIF group(4.9%;P=0.01).In univariate analysis,the length of the urethral defect was the single factor that could predict complications;the cutoff was 4.55 *** patients in the long urethral defect group than in the short one had complications(34.1%vs 15.7%,P=O.O1).These results indicate that staged TPIF produced a better outcome,whereas more patients in the TPIF combined with Duplay group presented with two or more complications.

关键词： complications proximal hypospadias ventral curvature

Study on the Set-up and Set-down Induced by Breaking Waves Over A Reef

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China Ocean Engineering 2020年第6期34卷 853-862页

作者： LIU Qing-jun WANG Deng-ting wei zhang-ping XU Hua SUN Tian-ting Nanjing Hydraulic Research Institute Nanjing 210029China College of Harbour Coastal and Offshore Engineering Hohai UniversityNanjing 210098China Key Laboratory of Port Waterway&Sedimentation Engineering of MOTNanjing 210029China Department of Physics and Physical Oceanography University of North Carolina WilmingtonWilmingtonNC 28403USA

This paper proposes an equation to calculate breaking wave induced wave set-up and set-down along reef flat. The mathematical equation was derived based on the theory of radiation stress and the conservation of wave energy. The equation is primarily determined by several physical variables including the breaking wave index, the stable wave index, the attenuation coefficient of wave energy flux, and the flow velocity in the re-stabilization zone. A series of laboratory experiments were carried out to calibrate the theoretical equations. Specifically, the breaking wave index,the stable wave index, and the velocity over the reef flat were measured in the laboratory. The attenuation coefficient of wave energy flux in our theoretical equation was determined by calibration by comparing with the laboratory measured wave height. Furthermore, it has been put forward that the velocity based on cnoidal wave theory could be used to determine the velocity over the reef flat if there is no velocity measurement available. Overall, the proposed equation can provide satisfactory prediction of wave set-up and set-down along the reef flat.

关键词： wave set-up and set-down streamwise variation breaking waves reef flat reef terrain

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Acid-base cooperativity of heterogeneous catalyst containing acidic framework and sterically hindered base for aldol condensation

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Chinese Chemical Letters 2009年第9期20卷 1051-1054页

作者： Hua Li Shu Tao Xu Xiao Bing Lu wei ping zhang State Key Laboratory of Fine Chemicals Dalian University of Technology Dalian 116012 China State Key Laboratory of Catalysis Dalian Institute of Chemical Physics Chinese Academy of Sciences Dalian 116023 China

A bifunctional heterogeneous catalyst containing two mutually incompatible acidic and basic sites, which exhibits cooperative catalytic behavior in the aldol condensation of acetone and various aldehydes, was synthesized by postgrafting of 1,5,7- triazabicyclo[4.4.0] dec-5-ene （TBD, a sterically hindered organic base） onto AI-MCM-41 molecular sieve. 2009 Xiao Bing Lu. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.

关键词： Bifunctional catalyst Acid-base cooperative catalysis Mesoporous material Aldol reaction

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Genotype-phenotype correlations,surgical selections,and postoperative complications of 5α-reductase 2 deficiency in 69 children with hypospadias

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Asian Journal of Andrology 2023年第6期25卷 731-736页

作者： Xu Wen Li-Jun Fan wei-ping zhang Xin Ni Chun-Xiu Gong Department of Urology Beijing Children’s HospitalCapital Medical UniversityNational Center for Children’s HealthBeijing 100045China Department of Endocrinology GeneticsMetabolismBeijing Children’s HospitalCapital Medical UniversityNational Center for Children’s HealthBeijing 100045China Beijing Key Laboratory for Genetics of Birth Defects MetabolismBeijing Children’s HospitalCapital Medical UniversityNational Center for Children’s HealthBeijing 100045China Department of Otolaryngology Head and Neck Surgery Beijing Children’s HospitalCapital Medical UniversityNational Center for Children’s HealthBeijing 100045China

5α-reductase 2 deficiency prevents testosterone from being converted to dihydrotestosterone,which causes abnormal urogenital sinus *** aim of this study was to analyze the relationship between genotype–phenotype,surgical selections,and postoperative complications of 5α-reductase 2-deficient patients with *** retrospectively evaluated the medical records of patients who were diagnosed with 5α-reductase 2 deficiency after genetic testing in the Department of Endocrinology and underwent initial hypospadias surgery in the Department of Urology in Beijing Children’s Hospital,Capital Medical University(Beijing,China),from April 2007 to December 2021.A total of 69 patients were included in this study;the mean age at surgery was 34.1 months,and the average follow-up time was 54.1 *** children were treated with preoperative hormone stimulation(PHS)to promote penile *** average penis length and glans width were increased by 1.46 cm and 0.62 cm,*** most frequent mutations were p.R227Q(39.1%,54/138),p.Q6^(*)(15.2%,21/138),p.G203S(12.3%,17/138),and p.R246Q(11.6%,16/138).In 64 patients who were followed up,43 had a one-stage operation and 21 had a staged operation,and there were significant differences in external masculinization score(EMS)(P=0.008)and the average number of operation required to cure(P<0.001)between one-stage and staged *** had a positive effect(P<0.001)on penile *** p.R227Q mutation was associated with higher EMS and less severe ***-stage surgery can be selected if conditions *** growth and development of children are acceptable in the long term,but penis growth remains *** complications of hypospadias should be considered during puberty.

关键词： 5α-reductase 2 deficiency disorders of sex development hypospadias

Management of Wilms tumor with intravenous thrombus in children:a single center experience

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World Journal of Pediatrics 2019年第5期15卷 476-482页

作者： Shuai Xu Ning Sun wei-ping zhang Hong-Cheng Song Cheng-Ru Huang Department of Urology Surgery Beijing Children's Hospital Affiliated to Capital Medical UniversityNational Center for Children's Health56 South Lishi RoadXicheng DistrictBeijing 100045China

Background Wilms tumor tends to grow into vena cava,even invade atrium,which increased operating difficulty and frequency of surgical *** Forty-two patients of Wilms tumor with intravenous thrombus were retrospective *** diagnosis and therapy were discussed according to the medical records and interrelated *** Forty-two children with thrombus were diagnosed by computed tomography and 41 cases by ultrasound simultaneously.36 children had received preoperative *** resection was performed in all *** bypass was used for the removal of the intra-atrial thrombus in 5 *** were no surgical complications *** patients received chemotherapy and radiotherapy according to clinical staging by National Wilms'Tumor Study(NWTS)-4 or NWTS-5.34 patients were successfully followed up,32 patients survive at present,including one who has been followed up more than 20 years since *** Standardized sequential treatment,including preoperative chemotherapy and radiotherapy,nephrectomy combining resection of thrombus,postoperative adjuvant therapy,is the mainstay of treatment of Wilms tumor with intravenous thrombus.

关键词： Experience Intravenous thrombus Management Wilms tumor

Synergistic effect of oxymatrine and angiogenesis inhibitor NM-3 on modulating apoptosis in human gastric cancer cells

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World Journal of Gastroenterology 2007年第12期13卷 1788-1793页

作者： Ming-Quan Song Jin-Shui Zhu Jin-Lian Chen Long Wang wei Da Li Zhu wei-ping zhang Department of Gastroenterology The Sixth Affiliated Hospital of Shanghai Jiaotong University Shanghai 200233 China

AIM: To investigate the synergistic effect of oxymatrine(OM) and angiogenesis inhibitor NM-3 on modulatingapoptosis in human gastric cancer cell lines SGC-7901,MKN-45, MKN-74. METHODS: Human gastric cancer lines SGC-7901,MKN-45, MKN-74 were treated with OM in the absenceand presence of NM-3. The inhibitory rates weredetected by MTT assay. Synergistic effect of OM andNM-3 on the growth of survivin, bcl-2, bax and p53 inSGC-7901 cells were examined by semiquantitative RT-PCR and Western blotting, and their growth inhibitoryeffects were also observed on SGC-7901 tumor xenograftin nude ***: OM combined with NM-3 exhibited asynergistic inhibitory effect on the growth of SGC-7901,MKN-45 and MKN-74 cells in a time-dependent ***-four hours after treatment with OM, NM-3 aloneand their combination, mRNA expression of survivin andbcl-2 in SGC-7901 cells decreased, p53 mRNA expressionincreased. OM (4 g/L) combined with NM-3 significantlyincreased the expression of p53 mRNA and decreasedthe expression of survivin and bcl-2 compared witheither agent alone (193% ± 34% vs 129% ± 12%;44% ± 18% vs 92% ± 18%; 36 ± 17% vs 93% ± 23%,P < 0.05). Western blotting showed that the synergisticeffect of OM and NM-3 on protein translation of survivin,bcl-2 and p 53 was in accordance with their ***, OM/NM-3 combination obviously exhibitedantitumor growth effect in xenografted human gastriccancer cells SGC-7901 compared with either agent ***: OM combined with NM-3 has synergisticinhibitory effects on human gastric cancer cells in vitro and can suppress the growth of xenografted human gastric cancer cells SGC-7901 in vivo.

关键词： NM-3 compound Oxymatrine Gastric cancer Apoptosis

Cysteinyl leukotriene receptor 1 is involved in N-methyl-D-aspartate-mediated neuronal injury in mice

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Acta Pharmacologica Sinica 2006年第12期27卷 1526-1536页

作者： Qian DING Er-qing wei~2 Yan-jun zhang wei-ping zhang Zhong CHEN Department of Pharmacology,School of Medicine,Zhejiang University,Hangzhou 310058,China Department of Pharmacology School of Medicine Zhejiang University Hangzhou China

Aim:To determine whether cysteinyl leukotriene receptor 1(CysLT1receptor)isinvolved in N-methyl-D-aspartate(NMDA)-induced excitotoxic injury in the ***:Brain injury was induced by NMDA microinjection(50-150 nmolin 0.5 μL)into the cerebral *** changes in CysLT1receptor expression24 h after NMDA injection and the effects of a CysLT1receptor antagonist,pranlukast(0.01 and 0.1 mg/kg),an NMDA receptor antagonist,ketamine(30mg/kg),and an antioxidant,edaravone(9 mg/kg)were ***:In theNMDA-injured brain,the CysLT1receptor mRNA,and protein expression wereupregulated,and the receptor was mainly localized in the neurons and not in ***,ketamine and edaravone decreased NMDA-induced injury;pranlukast(0.1 mg/kg)and ketamine inhibited the upregulated expression of ***:CysLT1receptor expression in neurons isupregulated after NMDA injection,and NMDA-induced responses are inhibitedby CysLT1receptor antagonists,indicating that the increased CysLT1receptor isinvolved in NMDA excitotoxicity.

关键词： cysteinyl leukotriene receptor excitotoxicity N-methyl-D-aspartate leukotriene receptor antagonist pranlukast NMDA receptor antagonist ketamine