Cysteinyl leukotriene receptor 1 is involved in N-methyl-D-aspartate-mediated neuronal injury in mice
Cysteinyl leukotriene receptor 1 is involved in N-methyl-D-aspartate-mediated neuronal injury in mice作者机构：Department of Pharmacology School of Medicine Zhejiang University Hangzhou China
出 版 物：《Acta Pharmacologica Sinica》 (中国药理学报(英文版))
年 卷 期：2006年第27卷第12期
页 面：1526-1536页
核心收录：
学科分类：1002[医学-临床医学] 100204[医学-神经病学] 10[医学]
基 金：Project supported by the National Natural Science Foundation of China(№30371637)
主 题：cysteinyl leukotriene receptor excitotoxicity N-methyl-D-aspartate leukotriene receptor antagonist pranlukast NMDA receptor antagonist ketamine
摘 要：Aim:To determine whether cysteinyl leukotriene receptor 1(CysLT1receptor)isinvolved in N-methyl-D-aspartate(NMDA)-induced excitotoxic injury in the ***:Brain injury was induced by NMDA microinjection(50-150 nmolin 0.5 μL)into the cerebral *** changes in CysLT1receptor expression24 h after NMDA injection and the effects of a CysLT1receptor antagonist,pranlukast(0.01 and 0.1 mg/kg),an NMDA receptor antagonist,ketamine(30mg/kg),and an antioxidant,edaravone(9 mg/kg)were ***:In theNMDA-injured brain,the CysLT1receptor mRNA,and protein expression wereupregulated,and the receptor was mainly localized in the neurons and not in ***,ketamine and edaravone decreased NMDA-induced injury;pranlukast(0.1 mg/kg)and ketamine inhibited the upregulated expression of ***:CysLT1receptor expression in neurons isupregulated after NMDA injection,and NMDA-induced responses are inhibitedby CysLT1receptor antagonists,indicating that the increased CysLT1receptor isinvolved in NMDA excitotoxicity.
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