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The cGAS-STING-interferon regulatory factor 7 pathway regulates neuroinflammation in Parkinson's disease

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Neural Regeneration Research 2025年第8期20卷 2361-2372页

作者： Shengyang Zhou Ting li wei Zhang Jian Wu Hui Hong wei Quan Xinyu Qiao Chun Cui Chenmeng Qiao weijiang Zhao Yanqin Shen Laboratory of Neurodegenerative and Neuroinjury Diseases Wuxi Medicine SchoolJiangnan UniversityWuxiJiangsu ProvinceChina

Interferon regulatory factor 7 plays a crucial role in the innate immune ***,whether interferon regulatory factor 7-mediated signaling contributes to Parkinson's disease remains *** we report that interferon regulatory factor 7 is markedly up-regulated in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced mouse model of Parkinson's disease and co-localizes with microglial *** the selective cyclic guanosine monophosphate adenosine monophosphate synthase inhibitor RU.521 and the stimulator of interferon genes inhibitor H151 effectively suppressed interferon regulatory factor 7 activation in BV2 microglia exposed to 1-methyl-4-phenylpyridinium and inhibited transformation of mouse BV2 microglia into the neurotoxic M1 *** addition,si RNA-mediated knockdown of interferon regulatory factor 7 expression in BV2 microglia reduced the expression of inducible nitric oxide synthase,tumor necrosis factorα,CD16,CD32,and CD86 and increased the expression of the anti-inflammatory markers ARG1 and *** together,our findings indicate that the cyclic guanosine monophosphate adenosine monophosphate synthase-stimulator of interferon genes-interferon regulatory factor 7 pathway plays a crucial role in the pathogenesis of Parkinson's disease.

关键词： cyclic guanosine monophosphate adenosine monophosphate synthase H151 interferon regulatory factor 7 M1 phenotype neurodegenerative disease neuroinflammation Parkinson’s disease RU521 STING type I interferon

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膝关节后交叉韧带损伤的临床流行病学分析

中国骨伤 2015年第7期28卷 638-642页

作者：陈刚付维力唐新李棋李箭四川大学华西医院骨科四川成都610041

目的：研究膝关节后交叉韧带损伤的临床特点及其分布规律。方法：回顾性分析2006年1月至2013年6月确诊的326例膝关节后交叉韧带损伤患者临床资料,将病例按损伤类型分组,对性别、侧别、年龄、受伤原因、受伤至就诊时间、合并损伤等因素... 详细信息

目的：研究膝关节后交叉韧带损伤的临床特点及其分布规律。方法：回顾性分析2006年1月至2013年6月确诊的326例膝关节后交叉韧带损伤患者临床资料,将病例按损伤类型分组,对性别、侧别、年龄、受伤原因、受伤至就诊时间、合并损伤等因素进行分析,同时比较不同类型后交叉韧带损伤的个体化因素及合并损伤情况。结果：后交叉韧带损伤患者男性占73%,30~50岁是发病高峰（59%）,患者多于伤后1个月内就诊（62.6%）;受伤原因以交通伤为主（59%）;合并损伤中前交叉韧带损伤最多（46.9%）,其次为内侧副韧带（29.8%）和后外侧角（26.1%）;后交叉韧带实质部损伤较止点撕脱骨折多,发生合并损伤的概率也较后者高（P〈0.05）,受伤原因差异也具有统计学意义（P〈0.05）;单纯止点撕脱骨折与单纯实质部损伤在发生率和就诊时间方面差异具有统计学意义（P〈0.05）。结论：后交叉韧带损伤以实质部损伤为主,合并损伤率较高,以ACL损伤最常见;止点撕脱骨折以胫骨侧为主,多由低能量暴力导致,合并损伤较少;实质部损伤多由高能量暴力所致,多有合并损伤;单纯止点撕脱骨折发病率较单纯实质部损伤高。

关键词：后交叉韧带流行病学创伤和损伤膝关节

PI3K/AKT signaling and neuroprotection in ischemic stroke:molecular mechanisms and therapeutic perspectives

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Neural Regeneration Research 2025年第10期20卷 2758-2775页

作者： Tianlong liu Xiaolin li Xiaowei Zhou wei Chen Aidong Wen Minna liu Yi Ding Department of Pharmacy Xijing HospitalFourth Military Medical UniversityXi’anShaanxi ProvinceChina Department of Pharmacy The 940 Hospital of Joint Logistics Support Forces of Chinese PLALanzhouGansu ProvinceChina Department of Pharmacy The 944 Hospital of Joint Logistics Support Forces of Chinese PLAJiuquanGansu ProvinceChina Department of Nephrology The 940 Hospital of Joint Logistics Support Forces of Chinese PLALanzhouGansu ProvinceChina

It has been reported that the PI3K/AKT signaling pathway plays a key role in the pathogenesis of ischemic *** a result,the development of drugs targeting the PI3K/AKT signaling pathway has attracted increasing attention from *** article reviews the pathological mechanisms and advancements in research related to the signaling pathways in ischemic stroke,with a focus on the PI3K/AKT signaling *** key findings include the following:(1)The complex pathological mechanisms of ischemic stroke can be categorized into five major types:excitatory amino acid toxicity,Ca^(2+)overload,inflammatory response,oxidative stress,and apoptosis.(2)The PI3K/AKT-mediated signaling pathway is closely associated with the occurrence and progression of ischemic stroke,which primarily involves the NF-κB,NRF2,BCL-2,mTOR,and endothelial NOS signaling pathways.(3)Natural products,including flavonoids,quinones,alkaloids,phenylpropanoids,phenols,terpenoids,and iridoids,show great potential as candidate substances for the development of innovative anti-stroke medications.(4)Recently,novel therapeutic techniques,such as electroacupuncture and mesenchymal stem cell therapy,have demonstrated the potential to improve stroke outcomes by activating the PI3K/AKT signaling pathway,providing new possibilities for the treatment and rehabilitation of patients with ischemic *** investigations should focus on the direct regulatory mechanisms of drugs targeting the PI3K/AKT signaling pathway and their clinical translation to develop innovative treatment strategies for ischemic stroke.

关键词： apoptosis autophagy inflammation ischemic stroke neuroprotection oxidative stress pathogenesis phosphatidylinositol 3-kinase protein kinase B therapeutics

中心管三点同步起爆方式对杀伤战斗部毁伤威力的影响

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火工品 2018年第2期 1-4页

作者：付伟栗保华曹玉武西安近代化学研究所陕西西安710065

对杀伤战斗部在中心管三点同步起爆方式下的毁伤威力进行数值仿真研究及验证试验。结果表明:相同装药结构战斗部条件下,相对于两端点同步起爆方式,采用中心管三点同步起爆方式的破片初速峰值降低10.1%,破片初速最小值提高8.1%,爆轰能量... 详细信息

对杀伤战斗部在中心管三点同步起爆方式下的毁伤威力进行数值仿真研究及验证试验。结果表明:相同装药结构战斗部条件下,相对于两端点同步起爆方式,采用中心管三点同步起爆方式的破片初速峰值降低10.1%,破片初速最小值提高8.1%,爆轰能量沿轴向得到匀化分布;且破片的飞散角提高32.0%,打击范围增大。静爆试验结果验证了其对毁伤威力的影响。

关键词：三点同步起爆破片战斗部数值仿真

Amperometric Glucose Sensor Based on Batch CuO-Modified Screen-Printed Silver-Carbon Electrodes

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Journal of Wuhan University of Technology(Materials Science) 2025年第1期40卷 35-41页

作者： XIA Haiyan HUANG Yin YANG Hua WANG Xintian SHI Jianping liU lixia fu Yacheng QUAN Changyun li Suyuan Cofoe Medical Technology Company limited Changsha 410000China Institute of New Energy Hexi UniversityZhangye 734000China Chemistry and Chemical Engineering Central South UniversityChangsha 410000China

CuO nanoparticles were successfully synthesized via a two-jet electrospun method,and then screen-printed on silver-carbon electrodes,forming CuO-modified Ag-C(CuO/Ag-C)disposable strip *** natural environment condition for glucose detection,the obtained CuO/Ag-C electrodes show a high sensitivity of 540 nA·mM^(-1)·cm^(-2),and a low limit of detection(0.68 mM)in a wide linear response range of 0.68 mM and 3 mM(signal/noise=3),*** addition,the CuO/Ag-C electrodes also exhibit excellent anti-interference,air stability and *** a result,the fabrication of CuO nanoparticles via an electrospun process and the technique of screen-printed electrodes are of great significance for glucose detection.

关键词： electrochemical sensor CuO nanoparticles glucose detection screen-printing technique

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我国儿童、青少年诚信观发展现状研究

教育科学 2011年第2期27卷 1-7页

作者：李德显傅维利刘磊王丹辽宁师范大学田家炳教育书院暨教育学院辽宁大连116029 河北外国语职业学院河北秦皇岛006311

诚信观是个体关于"诚信"的含义、价值及其判断标准的系统性认识。我国儿童、青少年基本上能够对诚信的含义有准确的把握,其诚信观在对己、对他两个范畴上存在显著的差异性;在诚实观上,男女学生的对己诚实观存在显著的性别差异,女生高于... 详细信息

诚信观是个体关于"诚信"的含义、价值及其判断标准的系统性认识。我国儿童、青少年基本上能够对诚信的含义有准确的把握,其诚信观在对己、对他两个范畴上存在显著的差异性;在诚实观上,男女学生的对己诚实观存在显著的性别差异,女生高于男生,在对他诚实维度上不存在显著的性别差异。在守信观上,不存在显著的性别差异;在诚信对象的选择上,具有依亲情的亲疏程度选择个人诚信对象的倾向性。

关键词：儿童青少年诚实守信诚信观发展特征

构建开放式课程体系提升学生综合职业能力——以绍兴市中等专业学校为例

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职业教育研究 2015年第1期 79-82页

作者：傅卫莉绍兴市中等专业学校浙江绍兴312000

以具备"专、知、能、善、健、雅"全人素质标准的技术技能型人才培养为出发点,以提升学生综合职业能力为目标,紧贴经济社会发展需求,依托产业、企业、职业实际需要,构建以"必修课程+选修课程+活动课程"为主体,以"专业能力+方法能力+社会... 详细信息

以具备"专、知、能、善、健、雅"全人素质标准的技术技能型人才培养为出发点,以提升学生综合职业能力为目标,紧贴经济社会发展需求,依托产业、企业、职业实际需要,构建以"必修课程+选修课程+活动课程"为主体,以"专业能力+方法能力+社会能力"三项能力培养为主线,以职业技能鉴定和岗位要求为准则的开放式课程体系,促进人才培养质量的提高,为地方经济发展服务。

关键词：综合职业能力开放式课程体系

利用油藏规模序列法预测大庆西部最终可探明储量

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价值工程 2012年第21期31卷 108-110页

作者：付卫丽大庆油田第九采油厂地质大队大庆163853

大庆西部油气勘探已经历50多年,油气勘探程度高。应用油藏规模序列法对该区资源量进行了评价,结果表明:大庆长垣以西油气聚集区仍有477个22×104t级地质储量以上的待发现油藏,剩余资源总量达43965.3×108t。待发现油藏的规模不仅局限于... 详细信息

大庆西部油气勘探已经历50多年,油气勘探程度高。应用油藏规模序列法对该区资源量进行了评价,结果表明:大庆长垣以西油气聚集区仍有477个22×104t级地质储量以上的待发现油藏,剩余资源总量达43965.3×108t。待发现油藏的规模不仅局限于百万吨以下的小规模油藏,200万吨级以上的油藏还有43个,地质储量20545.2×104t。应用油藏规模序列法所计算的大庆长垣以西油气聚集区剩余资源量及其规模分布能够为该地区今后的勘探工作及开发规划工作提供指导。

关键词：油藏规模序列长垣以西资源评价剩余资源潜力

Genistein inhibits carotid sinus baroreceptor activity in anesthetized male rats

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Acta Pharmacologica Sinica 2005年第7期26卷 840-844页

作者： Hui-juan MA Yi-xian liU fu-wei WANG li-xuan WANG Rui-rong HE Yu-ming WU~2 Department of Physiology,Institute of Basic Medicine,Hebei Medical University,Shijiazhuang 050017,China Department of Physiology Institute of Basic Medicine Hebei Medical University Shijiazhuang 050017 China

Aim:To study the effect of genistein(GST)on carotid baroreceptor activity(CBA).Methods:The functional curve of carotid baroreceptor(FCCB)was con-structed and the functional parameters of carotid baroreceptor were measured byrecording sinus nerve afferent discharge in anesthetized male rats with perfusedisolated carotid ***:GST at 50,100,and 200 μmol/L inhibited theCBA,which shifted FCCB to the fight and downward,with a marked decrease inpeak slope and peak integral value of carotid sinus nerve discharge in a concen-tration-dependent *** with 100 μmol/L N~G-nitro-L-arginine me-thyl ester,an inhibitor of nitric oxide synthase,did not affect the effect of GST *** with 500 nmol/L Bay K8644,an agonist of calcium channels,could completely abolish the effect of GST on CBA.A potent inhibitor of tyrosinephosphatase,sodium orthovanadate(1 mmol/L),could attenuate the inhibitoryeffect of ***:GST inhibits CBA,and the effect may be mediated byprotein tyrosine kinase inhibition and a decrease in Ca2+influx through the stretch-activated channels.

关键词： genistein carotid sinus baroreflex proteintyrosine kinase Bay K8644 L-NAME