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Mucosal immune responses and protective efficacy in yellow catfish after immersion vaccination with bivalent inactivated Aeromonas veronii and Edwardsiella ictaluri vaccine

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Water Biology and Security 2022年第2期1卷 38-48页

作者： wei guang kong Da Cheng Qin Qing Jiang Mu Zhao Ran Dong Yang Zhi Luo Tao Shan Ai Zhen Xu State Key Laboratory of Freshwater Ecology and Biotechnology Institute of HydrobiologyChinese Academy of SciencesWuhanHubei430072China Department of Aquatic Animal Medicine College of FisheriesHuazhong Agricultural UniversityWuhanHubei430070China Wuhan Chopper Fishery Bio-Tech Co. LtdWuhan Academy of Agricultural ScienceWuhan430207China

Mucosal vaccination,which has the potential to induce both mucosal and systemic immune responses,is considered the most suitable method of preventing infectious diseases in farmed *** veronii and Edwardsiella ictaluri are two pathogenic bacteria found in yellow catfish and often infect the fish through mucosal *** of a bivalent inactivated vaccine by injection has been shown to induce a strong systemic immune response against both bacterial ***,mucosal immune responses and protective efficiency induced by this inactivated vaccine administrated via immersion are yet to be *** developed a bivalent vaccine containing formalin-inactivated *** and *** and evaluated the immune response in yellow catfish after immersion vaccination using body fluids biochemistry indices,agglutinating antibody titers,and the expression level of immune-related genes in the skin,gills,spleen,and head *** activities of innate immune-related enzymes and specific agglutination antibody titers in body fluids,as well as the expression of innate and adaptive immune-related genes in both the mucosal and systemic tissues of vaccinated fish,were significantly higher than that in control ***,we assessed the protective efficacy by a challenge model of virulent strains of *** and *** relative survival percent of vaccinated fish was 80%and 87%after challenging fish with *** and ***,respectively,which was higher than unvaccinated control fish(43%and 57%).These results confirm that the bivalent inactivated vaccine administered via immersion induces a strong mucosal immune response and confers good protection against both *** and *** results also reinforce the notion that immersion vaccination could stimulate both mucosal and systemic immunity contributing to protection against pathogens.

关键词： Mucosal immune response Bivalent inactivated vaccine Immersion vaccination Aeromonas veronii Edwardsiella ictaluri Yellow catfish

Triterpenoid Saponins from Roots of Gypsophila pacifica

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Chinese Herbal Medicines 2010年第2期2卷 145-147页

作者： NIE wei,LUO Jian-guang,kong Ling-yi Department of Natural Medicinal Chemistry,China Pharmaceutical University,Nanjing 210009,China Department of Natural Medicinal Chemistry China Pharmaceutical UniversityNanjing 210009China

Objective To study the chemical constituents from the roots of Gypsophila *** The chemical constituents were isolated by various column chromatographic methods and their structures were identified by spectral data together with physicochemical *** Five compounds were isolated and identified as 3-O-β-D-galactopyranosyl-(1→2)-[β-D-xylopyranosyl-(1→3)]-β-D-glucuronopyranosyl gypsogenin 28-O-β-D-xylopyranosyl-(1→4)-α-L-rhamnopyranosyl-(1→2)-β-D-fucopyranoside(1),3-O-β-D-galactopyranosyl-(1→2)-[β-D-xylopyranosyl-(1→3)]-β-D-glucuronopyranosyl quillaic acid 28-O-β-D-xylopyranosyl-(1→4)-α-L-rhamnopyranosyl-(1→2)-β-D-fucopyranoside(2),3-O-β-D-galactopyranosyl-(1→2)-[β-D-xylopyranosyl-(1→3)]-β-D-glucuronopyranosyl gypsogenin 28-O-β-D-glucopyranosyl-(1→3)-[β-D-xylopyranosyl-(1→4)]-α-L-rhamnopyranosyl-(1→2)-β-D-fucopyranoside(3),3-O-β-D-galactopyranosyl-(1→2)-[β-D-xylopyranosyl-(1→3)]-β-D-glucuronopyranosyl quillaic acid 28-O-β-D-glucopyranosyl-(1→3)-[β-D-xylopyranosyl-(1→4)]-α-L-rhamnopyranosyl-(1→2)-β-D-fucopyranoside(4),3-O-β-D-galactopyranosyl-(1→2)-[β-D-xylopyranosyl-(1→3)]-β-D-glucuronopyranosyl quillaic acid 28-O-α-L-arabino-pyranosyl-(1→4)-α-L-arabinopyranosyl-(1→3)-β-D-xylopyranosyl-(1→4)-α-L-rhamnopyranosyl-(1→2)-β-D-fucopyranoside(5).Conclusion The five compounds are isolated from this plant for the first time.

关键词： Caryophyllaceae Gypsophila pacifica triterpenoid saponins

A low redox potential and long life organic anode material for sodium-ion batteries

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Journal of Energy Chemistry 2025年第1期100卷 557-564页

作者： Zhi Li Yang wei Kang Zhou Xin Huang Xing Zhou Jie Xu Taoyi kong Junwei Lucas Bao Xiaoli Dong Yonggang Wang Department of Chemistry and Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials Institute of New Energy Collaborative Innovation Center of Chemistry for Energy Materials (iChEM) Fudan University Department of Chemistry Boston College School of Materials Science and Engineering Anhui University of Technology

Sodium-ion batteries （SIBs） with organic electrodes are an emerging research direction due to the sustainability of organic materials based on elements like C,H,O,and sodium ***,organic electrode materials for SIBs are mainly used as cathodes because of their relatively high redox potentials（>1 V）.Organic electrodes with low redox potential that can be used as anode are ***,a novel organic anode material （tetrasodium 1,4,5,8-naphthalenetetracarboxylate,Na4TDC） has been developed with low redox potential （<0.7 V） and excellent cyclic *** three-sodium storage mechanism was demonstrated with various in-situ/ex-situ spectroscopy and theoretical calculations,showing a high capacity of 208 mAh/g and an average decay rate of merely 0.022%per ***,the Na4TDC-hard carbon composite can further acquire improved capacity and cycling stability for 1200 cycles even with a high mass loading of up to 20 mg *** pairing with a thick Na3V2（PO4）3cathode (20.6 mg cm-2),the as-fabricated full cell exhibited high operating voltage （2.8 V）,excellent rate performance and cycling stability with a high capacity retention of 88.7% after 200 cycles,well highlighting the Na4TDC anode material for SIBs.

关键词： Organic anode material Low redox potential Composite anode Sodium-ion batteries

NMR Analysis to Identify Biuret Groups in Common Polyureas

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Chinese Journal of Polymer Science 2018年第10期36卷 1150-1156页

作者： wei-guang Qiu Fei-Long Zhang Xu-Bao Jiang Xiang-Zheng kong College of Chemistry and Chemical Engineering University of Jinan

Polyureas （PU） are well known as a class of high impact engineering materials, and widely used also in emerging advanced applications. As a general observation, most of them are only soluble in a very limited number of highly protonic solvents, which makes their chemical structure analysis a great challenge. Besides the presence of abundant hydrogen bonding, the poor solubility of PU in common organic solvents is often ascribed to the formation of biuret crosslinking in their molecular chains. To clarify the presence of biuret groups in PU has been of great interest. To this end, two samples, based on hexamethylene diisocyanate （HDI） and toluene diisocyanate （TDI） respectively, were synthesized by precipitation polymerization of each of these diisocyanates in water-acetone at 30℃. Their chemical structures were analyzed by high resolution magic angle spinning （HR-MAS） NMR, and through comparison of their NMR spectra with those of specially prepared biuret-containing polyurea oligomers, it was concluded that biuret group was absent in all the PU prepared at 30 ℃. In addition, this NMR analysis was also applied to a PU obtained by copolymerization of TDI with ethylene diamine （EDA） and water at 65 ℃ in EDA aqueous solution. It was confirmed that biuret unit was also absent in this PU and that EDA was more active than water towards TDI. The presence of EDA was crucial to the formation of uniform PU microspheres. This study provides therefore a reliable method for the analysis of PU chemical structure.

关键词： Diisocyanate Polyurea Chemical structure Biuret NMR spectroscopy

Cold tolerance and cold hardening strategy of the Japanese pine sawyer Monochamus alternatus （Coleoptera： Cerambycidae）

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Insect Science 2008年第4期15卷 307-316页

作者： Jing Tian Shu-guang Hao wei-Na kong Rui-Yan Ma Le Kang Department of Entomology Shanxi Agncultural University Taigu Shanxi Province State Key Laboratory of Integrated Management of Pest Insects and Rodents Institute of Zoology Chinese Academy of Sciences Beijing China

The Japanese pine sawyer, Monochamus alternatus, is an important pine forest pest and vector transmitting the pine wilt nematode that causes pine wilt disease. Low temperatures in autumn, winter and spring often differentially affect mortality of M. alternatus larvae. In this paper, we mainly compared the differences of mortality and cold hardening of larvae from different seasons, based on supercooling point （SCP） and cumulative probability of individuals freezing （CPIF）. The cold hardening of the larvae from autumn, winter and spring seasons were largely different. Correlations between mortality and CPIF of autumn and spring larvae were highest on day 1/4, and gradually decreased with prolonged exposure duration. This beetle＇s death mainly resulted from freezing in short exposure duration. However, the correlation between mortality and CPIF of winter larvae increased gradually with the prolonged exposure duration. Death did not mainly result from freezing in long exposure duration. Autumn larvae are more susceptible and adaptable than winter and spring larvae. Winter larvae have a slight freeze-tolerance trend. Our research showed that M. alternatus came into complex cold-hardening strategies under natural selection. Freeze avoidance is the primary strategy; with prolonged exposure duration to above SCP or 〈 0℃, chill tolerance is more important; this is followed by freeze tolerance during harsh winters.

关键词： cold acclimatization cold adaptation cold hardiness cold hardening strategy,Monochamus alternatus mortality supercooling point

A Steroidal Glycoside from Cynanchum versicolor Bunge

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Chinese Chemical Letters 2006年第7期17卷 919-921页

作者： Zhao guang ZHENG Run Hui LIU Ling Yi kong wei Dong ZHANG Department of Phytochemistry Second Military Medical University Shanghai 200433 Departmentof Natural Medicinal Chemistry China Pharmaceutical University Nanjing 210038 School of Pharmacy Shanghai Jiaotong University Shanghai 200030

A new C21 steroidal glycoside, named cynanversicoside F （1）, was isolated from the root of Cynanchum versicolor Bunge. Its structure was established as glaucogenin-A 3-O-β-D- digitoxopyranosyl-（1→4）-β-D-cymarop... 详细信息

关键词： Cynanchum versicolor C21 steroidal glycoside cynanversicoside F.

Synthesis and Structure-Activity Relationships of Ring-Opened Bengamide Analogues against Methicillin-Resistant Staphylococcus aureus

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Chinese Journal of Chemistry 2021年第3期39卷 671-676页

作者： Chen-Xi Yu Bing-Yan wei Xue-Qing kong Cai-guang Yang Fa-Jun Nan State Key Laboratory of Drug Research the National Center for Drug ScreeningShanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China University of Chinese Academy of Sciences No.19A Yuquan RoadBeijing 100049China School of Pharmaceutical Science and Technology Hangzhou Institute for Advanced StudyUCASHangzhouZhejiang 310024China Yantai Key Laboratory of Nanomedicine&Advanced Preparations Yantai Institute of Materia MedicaYantaiShandong 264000China

Main observation and conclusion Methicillin-resistant Staphylococcus aureus(MRSA)has become a major threat on public health because of the increase of clinically isolated strains that exhibit resistance to many ***,development of new antibiotics for the treatment of MRSA in-fection is a sustained *** have previously identified a ring-opened bengamide analogue L472-2 that displays moderate ac-tivity against the growth of *** our previous work,we started from L472-2 and identified a class of analogues containing al-kynyl groups which have the potential to activate SaCIpP activity but moderate antibacterial ***,we focused on the anti-bacterial activity of L472-2,and a novel series of ring-opened bengamide analogues were synthesized and their activities were evalu-ated against *** conducting a compact analysis of the structure-activity relationships(SAR)of these analogues,we found that an adamantane ethanol ester bengamide 2j showed excellent antibacterial activity towards six *** strains,including MRSA,while it does not activate ***,these bengamide analogues represent a new class of candidates that suppress MRSA via-bility..

关键词： Bengamides Staphylococcus aureus Antibiotics Structure-activity relationships Pharmacokinetic

The Energy State and Phase Transition of Cu Clusters in bcc-Fe Studied by a Molecular Dynamics Simulation

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Chinese Physics Letters 2012年第9期29卷 125-128页

作者： GAO Ning wei kong-Fang ZHANG Shi-Xu WANG Zhi-guang Laboratory of Advanced Nuclear Materials Institute of Modern PhysicsChinese Academy of SciencesLanzhou 730000 School of Nuclear Science and Technology Lanzhou UniversityLanzhou 730000

The total energy of bcc Fe containing Cu clusters with different sizes and number densities are calculated using the molecular dynamics(MD)*** results indicate that the Cu atoms prefer to form Cu clusters instead of being uniformly distributed in the bcc Fe *** binding energy of substitutional Cu to Cu clusters is also found to increase with the number of Cu *** a large-sized Cu precipitate,the change of the local stress state is found to relate to the phase transition from bcc to fcc Cu based on MD and common neighbor analysis.

关键词： Transition sized sizes

Influence of electronic structure on Compton scattering through comparing Cu-Ni alloys with Cu-Ni powder mixtures

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Acta Metallurgica Sinica(English Letters) 2012年第1期25卷 55-64页

作者： guang LUO Xianquan HU guangyu XIAO Chunyang kong College of Physics and Electronic Engineering Chongqing Normal UniversityChongqing 400047China

The application fields of Compton scattering have been further broadened through the studies of theories and experiments as well as the electronic structure of the scatters. The relationship between the contents of binary alloys （also binary powder mixtures） and the number of Compton scattered photons has been thoroughly examined. The linear expression of the relationship has been obtained approximately according to the Compton scattering theory. And the relationship has been validated well through the Compton scattering experiments with the scatters of Cu-Ni binary alloys or Cu- Ni binary powder mixtures. Furthermore, it is found that the slope of Cu-Ni powder mixture series is steeper than that of Cu-Ni alloy series, and through the pseudopotential plane wave theory of DFT the microscopic principles of Compton scattering of Cu-Ni alloy and Cu-Ni powder mixture series have been discussed and compared with each other. The results show that the electronic structure is the main reason for the difference of the linear slopes, and the line slope of Cu-Ni powder mixtures series is steeper than that of Cu-Ni alloy series.

关键词： Compton scattering Microscopic principle Cu-Ni Line slope