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Endoscopic extraction of a submucosal esophageal foreign body piercing into the thoracic aorta:A case report

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World Journal of Clinical Cases 2022年第8期10卷 2484-2490页

作者： Zhi-cao Chen Gui-Quan Chen Xiao-Chun Chen Chang-Ye Zheng wei-dong cao Gang-Hao Deng Department of Gastroenterology Affiliated Dongguan HospitalSouthern Medical UniversityDongguan 523000Guangdong ProvinceChina Department of Radiology Affiliated Dongguan HospitalSouthern Medical UniversityDongguan 523000Guangdong ProvinceChina Department of Cardiovascular Surgery Affiliated Dongguan HospitalSouthern Medical UniversityDongguan 523000Guangdong ProvinceChina

BACKGROUND Aorto-esophageal injury is a rare but life-threatening complication of esophageal foreign bodies,which typically requires open *** best way to treat patients with this condition remains *** date,few reports have described an aortic wall directly penetrated by a sharp foreign ***,we present a rare case of a fishbone completely embedded in the esophageal muscularis propria and directly piercing the aorta,which was successfully treated by endoscopy and thoracic endovascular aortic repair(TEVAR).CASE SUMMARY We report the case of a 71-year-old man with a 1-d history of retrosternal pain after eating *** abnormal findings were observed by the emergency *** tomography showed a fishbone that had completely pierced through the esophageal mucosa and into the *** patient refused to undergo surgery for personal reasons and was *** days after the onset of illness,he was readmitted to our *** examination showed a nodule with a smooth surface in the middle of the *** ultrasonography confirmed a fishbone under the *** performing TEVAR,we incised the esophageal mucosa under an endoscope and successfully removed the *** patient has remained in good condition for 1 *** Incising the esophageal wall under endoscope and extracting a foreign body after TEVAR may be a feasible option for cases such as ours.

关键词： Endoscopy Esophageal foreign body Esophageal perforation Aortic penetration Case report

Upregulation of MiR-126 Delays the Senescence of Human Glomerular Mesangial Cells Induced by High Glucose via Telomere-p53-p21-Rb Signaling Pathway

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Current Medical Science 2018年第5期38卷 758-764页

作者： dong-wei cao Chun-ming JIANG Cheng WAN Miao ZHANC Qing-yan ZHANG Min ZHAO Bo YANG Da-long ZHU Xiao HAN Department of Nephrology Nanjing Drum Tower HospitalClinical College of Nanjing Medical UniversityNanjing 210008China Department of Nephrology Nanjing Drum Tower Hospitalthe Affiliated Hospital of Nanjing University Medical SchoolNanjing 210008China Department of Dermatology Longhua HospitalShanghai University of Traditional Chinese MedicineShanghai 200032China Department of Endocrinology Nanjing Drum Tower HospitalClinical College of Nanjing Medical UniversityNanjing 210008China Basic Medical School Naniing Medical UniversityNanjing 210000China

Diabetic kidney disease (DKD)is a microvascular complication of type 2 *** study of DKD mechanisms is the most important target for the prevention of *** senescence is one of the important pathogeneses for DKD,but the mechanism of renal and cellular senescence is *** expression of circulating miR-126 is associated with the development of DKD and may be a promising blood-based biomarker for *** study is to probe the effect and mechanism of miR-126 on the aging of human glomerular mesangial cells (HGMCs)induced by high *** were cultured with Roswell Park Memorial Institute (RPMI-1640)in *** effect of high glucose on morphology of HGMCs was observed 72h after *** cell cycle was examined by flow *** telomere length was measured by Southern *** expression levels of p53,p21 and Rb proteins in p53-p21-Rb signaling pathway and p-statl,p-stat3 in JAK/STAT signaling pathway were detected by Western blotting *** expression of miR-126 was examined by ***-126 mimics was transfected into *** effects of miR-126 mimics transfection on cell morphology,cell cycle,telomere length,p53,p21,Rb,p-stat1 and p-stat3 were observed. The results showed that high glucose not only arrested the cell cycle in G1phase but also shortened the telomere *** glucose led to high expression of p53,p21,Rb,p-statl and p-stat3 and premature senescence of HGMCs by activating the telomere-p53-p21-Rb and JAK/STAT signaling ***,the miR-126 was decreased in HGMCs induced by high *** was suggested that the transfection of miR-126 mimics could inhibit the telomere-p53-p21-Rb and JAK/STAT signaling pathway activity in vitro and delay the senescence of *** results may serve as a new strategy for the treatment of DKD.

关键词： diabetic kidney disease miR-126 human glomerular mesangial cells senescence telomere-p53-p21-Rb signaling pathway

Effects of trimetazidine on atrial structural remodeling and platelet activation in dogs with atrial fibrillation

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Chinese Medical Journal 2009年第18期122卷 2180-2183页

作者： HAN wei LI wei-min ZHOU Hong-yan HUO Hong wei Na dong Guo cao Yong ZHOU Guo YANG Shu-sen Department of Cardiology First Clinical College of Harbin Medical University Harbin Heilongjiang 150001 China

Atrial fibrillation （AF） is one of the most common .arrhythmias in clinical practice. AF results in electrophysiological alterations which involve increased atrial effective refractory period and atrial effective refractory period dispersion, reduced rate adaptation of atrial effective refractory period, and slowed atrial conduction. These variances promote their own maintenance-AF begets AF.1 Previous study suggested that Ca^2＋ overload and metabolic derangement contributed to electrophysiological remodeling in AF. However, we did not demonstrate a persistent disturbance in energy metabolism during AF in our previous study,

关键词： atrialfibrillation structural remodeling thrombosis trimetazidine

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旋转调制式惯导系统隔离载体运动算法

中国惯性技术学报 2017年第4期25卷 432-435页

作者：孙伟强曹东戚嘉兴刘伟张灵妍天津航海仪器研究所中国人民解放军72433部队自动化工作站

旋转调制式惯导系统中,转位运动受载体运动的影响,误差调制效果受影响。针对这一问题,提出基于载体姿态角解耦的隔离载体运动算法。首先建立载体运动姿态角与旋转机构之间的数学关系,然后设计了隔离载体运动的力矩信号施加量的实时解耦... 详细信息

旋转调制式惯导系统中,转位运动受载体运动的影响,误差调制效果受影响。针对这一问题,提出基于载体姿态角解耦的隔离载体运动算法。首先建立载体运动姿态角与旋转机构之间的数学关系,然后设计了隔离载体运动的力矩信号施加量的实时解耦算法,最终推导了隔离载体运动力矩信号的公式,完成了载体运动隔离算法的设计。数字仿真结果表明,通过该算法,可以降低载体运动对误差调制规律的影响。跑车试验结果表明,通过隔离载体运动算法的应用,转向对系统定位误差影响由不隔离载体运动时约0.5 nm降低到了基本为0 nm。

关键词：旋转调制捷联惯性导航系统隔离载体运动姿态角解耦算法

Gut microbiota-astrocyte axis: new insights into age-related cognitive decline

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Neural Regeneration Research 2025年第4期20卷 990-1008页

作者： Lan Zhang Jingge wei Xilei Liu Dai Li Xiaoqi Pang Fanglian Chen Hailong cao Ping Lei Haihe Laboratory of Cell Ecosystem Department of GeriatricsTianjin Medical University General HospitalTianjinChina Tianjin Geriatrics Institute Tianjin Medical University General HospitalTianjinChina Department of Gastroenterology and Hepatology Tianjin Medical University General HospitalNational Key Clinical SpecialtyTianjin Institute of Digestive DiseasesTianjin Key Laboratory of Digestive DiseasesTianjinChina Department of Urology Tianjin Medical University General HospitalTianjinChina Tianjin Neurological Institution Tianjin Medical University General HospitalTianjinChina

With the rapidly aging human population,age-related cognitive decline and dementia are becoming increasingly prevalent *** is considered the main risk factor for cognitive decline and acts through alterations in the composition of the gut microbiota,microbial metabolites,and the functions of *** microbiota–gut–brain axis has been the focus of multiple studies and is closely associated with cognitive *** article provides a comprehensive review of the specific changes that occur in the composition of the gut microbiota and microbial metabolites in older individuals and discusses how the aging of astrocytes and reactive astrocytosis are closely related to age-related cognitive decline and neurodegenerative *** article also summarizes the gut microbiota components that affect astrocyte function,mainly through the vagus nerve,immune responses,circadian rhythms,and microbial ***,this article summarizes the mechanism by which the gut microbiota–astrocyte axis plays a role in Alzheimer’s and Parkinson’s *** findings have revealed the critical role of the microbiota–astrocyte axis in age-related cognitive decline,aiding in a deeper understanding of potential gut microbiome-based adjuvant therapy strategies for this condition.

关键词： age aging Alzheimer’s disease astrocytes cognitive decline dementia gut microbiota gut–brain axis microbial metabolites neuroinflammation Parkinson’s disease

Enhancement of motor functional recovery in thoracic spinal cord injury: voluntary wheel running versus forced treadmill exercise

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Neural Regeneration Research 2025年第3期20卷 836-844页

作者： Do-Hun Lee Dan cao Younghye Moon Chen Chen Nai-Kui Liu Xiao-Ming Xu wei Wu Spinal Cord and Brain Injury Research Group Stark Neurosciences Research InstituteIndiana University School of MedicineIndianapolisINUSA Department of Neurological Surgery Indiana University School of MedicineIndianapolisINUSA Department of Neuroscience Baylor College of MedicineHoustonTXUSA

Spinal cord injury necessitates effective rehabilitation strategies, with exercise therapies showing promise in promoting recovery. This study investigated the impact of rehabilitation exercise on functional recovery and morphological changes following thoracic contusive spinal cord injury. After a 7-day recovery period after spinal cord injury, mice were assigned to either a trained group(10 weeks of voluntary running wheel or forced treadmill exercise) or an untrained group. Bi-weekly assessments revealed that the exercise-trained group, particularly the voluntary wheel exercise subgroup, displayed significantly improved locomotor recovery, more plasticity of dopaminergic and serotonin modulation compared with the untrained group. Additionally, exercise interventions led to gait pattern restoration and enhanced transcranial magnetic motor-evoked potentials. Despite consistent injury areas across groups, exercise training promoted terminal innervation of descending axons. In summary, voluntary wheel exercise shows promise for enhancing outcomes after thoracic contusive spinal cord injury, emphasizing the role of exercise modality in promoting recovery and morphological changes in spinal cord injuries. Our findings will influence future strategies for rehabilitation exercises, restoring functional movement after spinal cord injury.

关键词： behavioral assessment motor function neural plasticity running wheel exercise spinal cord injury treadmill exercise voluntary exercise

Experimental Observing Damage Evolution in Cement Pastes Exposed to External Sulfate Attack by in situ X-ray Computed Tomography

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Journal of Wuhan University of Technology(Materials Science) 2025年第1期40卷 164-170页

作者： WU Min cao Kailei XIAO weirong YU Zetai cao Jierong DING Qingjun LI Jinhui China Railway Construction Corporation Harbour and Channel Engineering Bureau Group Co. LTDZhuhai 519000China Con-struction Headquarters of Zhoushan Liuheng Bridge Phase II Project Zhoushan 316000China China Railway Construction Bridge En-gineering Bureau Group Co. LTDTianjin 300000China State Key Laboratory of Silicate Material for Architecture(Wuhan University of Technology) Wuhan 430070China College of Materials Science and Engineering Wuhan Textile UniversityWuhan 430200China

The paper presents experimental investigation results of crack pattern change in cement pastes caused by external sulfate attack(ESA).To visualize the formation and development of cracks in cement pastes under ESA,an X-ray computed tomography(X-ray CT)was used,i e,the tomography system of Zeiss Xradia 510 *** results indicate that X-CT can monitor the development process and distribution characteristics of the internal cracks of cement pastes under ESA with attack *** addition,the C3A content in the cement significantly affects the damage mode of cement paste specimens during sulfate *** damage of ordinary Portland cement(OPC)pastes subjected to sulfate attack with high C3A content are severe,while the damage of sulfate resistant Portland cement(SRPC)pastes is much smaller than that of OPC ***,a quadratic function describes the correlation between the crack volume fraction and development depth for two cement pastes immermed in sulfate solution.

关键词： concrete external sulfate attack damage evolution situ X-ray computed tomography

A two edges sword:O6-methylguanine-DNA methyltransferase promoter methylation status associates with contrasting roles of YKL-40 in glioblastoma

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A two edges sword:O6-methylguanine-DNA methyltransferase pro...

Asymmetric interfacial engineering regulated charge distribution on Ru/Ni-N-C sites for efficient hydrogen evolution reaction in alkaline and seawater electrolytes

第十三届中国医师协会神经外科医师年会

作者： wei Zhang wei-jun Chen Xiang Zhang Jian-nan Lv En-ming Kang Hiro Wakimoto wei-dong cao wei-ping Liu Xiao-fan Jiang Xiao-sheng He Luo-an Fu Bing Li Xi-tuan Ji Guang Chen Qing-dong Guo Da-kuan Gao wei Lin Hai-ning Zhen Xing-gang Mao Huan Bian Takashi Tamiya Hua Han Department of Neurosurgery Xijing HospitalThe Fourth Military Medical University Department of Medical Genetics and Developmental Biology The Fourth Military Medical University Department of Neurosurgery Massachusetts General HospitalHarvard Medical SchoolBoston Department of Biochemistry and Molecular Biology The Fourth Military Medical University Department of Neurological Surgery Faculty of MedicineKagawa University

Inter-and intra-tumoral heterogeneity is a hallmark of glioblastoma(GBM)that facilitates recurrence and treatment *** only gene expression profiles or mutations but also epigenetic states dictate GBM biology.O-methylguanine-DNA methyltransferase(MGMT)promoter methylation is a significant prognostic marker for GBM patients’ survival,however,underlying mechanisms by which MGMT epigenetics impacts patient outcomes are not fully ***,using in vitro cultures and in vivo orthotopic models of IDH1/2-wild-type GBM stem-like cells(GSCs)we show that MGMT promoter methylation status,but not molecular subtypes of GBM,is tightly associated with contrasting roles of ***-40 promotes the RAS-MEK-ERK signaling pathway and stemness,chemoresistance and tumorigenicity in MGMT-unmethylated *** contrast,YKL-40 suppresses the RAS-MEK-ERK signaling pathway and the stem-like properties in MGMT-methylated *** study demonstrates previously underappreciated epigenetic status association with distinct functions of cancer-relevant genes,and supports the need of epigenome characterization into tumor stratification and targeted therapeutic development.

关键词： MGMT Methylation YKL-40 ERK Gliobalstoma

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Science China Chemistry 2025年

作者： Rui Yu Xi cao Chengyang Zhu Qingqing Chen Ziyi Yan Binbin Jiang Junjie Mao Xianwen wei Key Laboratory of Electrochemical Clean Energy of Anhui Higher Education Institutes College of Chemistry and Materials ScienceAnhui Normal University Anhui Provincial Key Laboratory of Advanced Catalysis and Energy Materials School of Chemistry and Chemical Engineering Anqing Normal University School of Chemistry and Chemical Engineering Anhui University of Technology

Developing highly efficient and cost-effective electrocatalysts for hydrogen evolution reaction（HER） is grandly challenging in alkaline and alkaline seawater electrolytes. Herein, the asymmetric interfacial active sites with Ru nanoparticles and Ni single atoms in Ru/Ni-N-C were designed through a solvothermal-pyrolysis process. Constructing highly asymmetric interfacial active sites with a strong electron delocalization effect significantly improves HER kinetics. As expected, Ru/Ni-N-C requires low overpotentials with around 20 mV at 10 mA cm-2and robust durability over 48 h in alkaline and alkaline seawater *** at 200 mA cm-2, the overpotentials are close to 100 mV in both above electrolytes for Ru/Ni-N-C. Density function theory calculation results suggest that the asymmetric interface between Ru nanoparticle and Ni-N-C could accelerate the dissociation of water molecules and modulate the hydrogen species, consequently improving the HER performances. This work opens a unique approach for constructing advanced materials for energy conversion.

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