Effects of trimetazidine on atrial structural remodeling and platelet activation in dogs with atrial fibrillation

作     者：HAN Wei LI Wei-min ZHOU Hong-yan HUO Hong WEI Na DONG Guo CAO Yong ZHOU Guo YANG Shu-sen 

作者机构：Department of Cardiology First Clinical College of Harbin Medical University Harbin Heilongjiang 150001 China 

出 版 物：《Chinese Medical Journal》 (中华医学杂志（英文版）)

年 卷 期：2009年第122卷第18期

页      面：2180-2183页

核心收录：

学科分类：1002[医学-临床医学] 100210[医学-外科学(含：普外、骨外、泌尿外、胸心外、神外、整形、烧伤、野战外)] 10[医学] 

基　　金：This study was funded by Harbin Science and Technique Department (No. 2005AA9CS116-1) and Heilongjiang Science and Technique Department (No. QC05C30) 

主　　题：atrialfibrillation structural remodeling thrombosis trimetazidine 

摘      要：Atrial fibrillation （AF） is one of the most common .arrhythmias in clinical practice. AF results in electrophysiological alterations which involve increased atrial effective refractory period and atrial effective refractory period dispersion, reduced rate adaptation of atrial effective refractory period, and slowed atrial conduction. These variances promote their own maintenance-AF begets AF.1 Previous study suggested that Ca^2＋ overload and metabolic derangement contributed to electrophysiological remodeling in AF. However, we did not demonstrate a persistent disturbance in energy metabolism during AF in our previous study,