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Mechanisms of allicin exposure for the sludge fermentation enhancement:Focusing on the fermentation processes and microbial metabolic traits

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Journal of Environmental Sciences 2022年第5期34卷 253-264页

作者： Feng Wang Jingyang Luo Shiyu Fang Wenxuan Huang Yunqi Zhang Le Zhang Xiaoshi Cheng wei du Fang Fang Jiashun Cao Yang Wu Key Laboratory of Integrated Regulation and Resource Development on Shallow Lakes Ministry of EducationHohai UniversityNanjing 210098China College of Environment Hohai UniversityNanjing 210098China State Key Laboratory of Pollution Control and Resource Reuse School of Environmental Science and EngineeringTongji UniversityShanghai 200092China

As a frequently used product with antimicrobial activity,consumed allicin might be dis-charged and concentrated in waste-activated sludge(WAS).However,the influence of al-licin(as an exogenous pollutant)on WAS fermentation has not been clearly revealed.This study aimed to disclose the impacts of allicin on volatile fatty acid(VFA)generation dur-ing WAS fermentation.The results showed that the appropriate presence of allicin(10 mg/g TSS)significantly enhanced the VFA yield(1894 versus 575 mg COD/L in the control)with increased acetate proportion(24.3%).Further exploration found that allicin promoted WAS solubilization,hydrolysis and acidification simultaneously.Metagenomic analysis revealed that the key genes involved in extracellular hydrolysis metabolism(i.e.,CAZymes),mem-brane transport(i.e.,gtsA and ytfT),substrate metabolism(i.e.,yhdR and pfkC)and fatty acid synthesis(i.e.,accA and accD)were all highly expressed.Allicin also induced the bacteria to produce more signalling molecules and regulate cellular functions,thereby enhancing the microbial adaptive and regulatory capacity to the unfavourable environment.Moreover,the variations in fermentative microbes and their contributions to the upregulation of func-tional genes(i.e.,ytfR,gltL,INV,iolD and pflD)for VFA generation were disclosed.Overall,the simultaneous stimulation of functional microbial abundances and metabolic activities contributed to VFA production in allicin-conditioned reactors.

关键词： Allicin Waste activated sludge(WAS) Anaerobic fermentation Metagenomic analysis Functional genes

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Free PSA performs better than total PSA in predicting prostate volume in Chinese men with PSA levels of 2.5–9.9 ng ml−1

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Asian Journal of Andrology 2023年第1期25卷 82-85页

作者： Ma-Ping Huang Ping Tang Cliff S Klein Xing-Hua wei wei du Jin-Gao Fu Tian-Hai Huang Hui Chen Ke-Ji Xie Department of Urology The First Affiliated Hospital of Jinan UniversityGuangzhou 510630China Department of Urology Guangzhou First People's HospitalSouth China University of TechnologyGuangzhou 510180China Department of Urology Guangdong Provincial Work Injury Rehabilitation HospitalGuangzhou 510440China Department of Urology Guangdong Provincial Hospital of Integrated Traditional Chinese and Western MedicineFoshan 528253China Department of Urology Jiangmen Central HospitalAffiliated Jiangmen Hospital of Sun Yat-Sen UniversityJiangmen 529099China

This study investigated whether free prostate-specific antigen(fPSA)performs better than total PSA(tPSA)in predicting prostate volume(PV)in Chinese men with different PSA levels.A total of 5463 men with PSA levels of<10 ng ml^(−1) and without prostate cancer diagnosis were included in this study.Patients were classified into four groups:PSA<2.5 ng ml^(−1),2.5–3.9 ng ml^(−1),4.0–9.9 ng ml^(−1),and 2.5–9.9 ng ml^(−1).Pearson/Spearman's correlation coefficient(r)and receiver operating characteristic(ROC)curves were used to evaluate the ability of tPSA and fPSA to predict PV.The correlation coefficient between tPSA and PV in the PSA<2.5 ng ml^(−1) cohort(r=0.422;P<0.001)was markedly higher than those of the cohorts with PSA levels of 2.5–3.9 ng ml^(−1),4.0–9.9 ng ml^(−1),and 2.5–9.9 ng ml^(−1)(r=0.114,0.167,and 0.264,respectively;all P≤0.001),while fPSA levels did not differ significantly among different PSA groups.Area under ROC curve(AUC)analyses revealed that the performance of fPSA in predicting PV≥40 ml(AUC:0.694,0.714,and 0.727)was better than that of tPSA(AUC=0.545,0.561,and 0.611)in men with PSA levels of 2.5–3.9 ng ml^(−1),4.0–9.9 ng ml^(−1),and 2.5–9.9 ng ml^(−1),respectively,but not at PSA levels of<2.5 ng ml^(−1)(AUC:0.713 vs 0.720).These findings suggest that the relationship between tPSA and PV may vary with PSA level and that fPSA is more powerful at predicting PV only in the"gray zone"(PSA levels of 2.5–9.9 ng ml^(−1)),but its performance was similar to that of tPSA at PSA levels of<2.5 ng ml^(−1).

关键词： prostate cancer prostate-specific antigen prostatic hyperplasia volume

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CircUCP2 promotes the tumor progression of non-small cell lungcancer through the miR-149/UCP2 pathway

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肿瘤学研究(英文) 2023年第6期31卷 929-936页

作者： wei du FANG YIN YATING ZHONG MINJIE LUO ZHEN WANG PENG LIN QING LIU HAN YANG Department of Pathology The First People’s Hospital of Changde CityChangde415000China State Key Laboratory of Oncology in South China Sun Yat-sen University Cancer CenterGuangzhou510000China

Non-small cell lung cancer(NSCLC)is a highly lethal cancer,and better treatments are urgently needed.Many studies have implicated circular RNAs(circRNAs)in the progression of multiple malignant tumors.Nonetheless,the functions of circRNAs in NSCLC remain unclear.To study new targets for the treatment of NSCLC,circRNA expression profiling was performed on NSCLC tissues and para-carcinoma nonmalignant tissues.RNA was isolated and used for circRNA sequencing.Biological studies were performed in vitro and in vivo to determine the functions of circRNAs in NSCLC,including their functions in cell proliferation and migration.How circRNAs function in NSCLC was explored to clarify the underlying regulatory mechanisms.We found that circUCP2 was upregulated in NSCLC tissues compared with neighboring nonmalignant tissues.circUCP2 promoted the proliferation and metastasis of NSCLC cells.circUCP2 promoted NSCLC progression by sponging miR-149 and upregulating UCP2.The circUCP2/miR-149/UCP2 axis accelerates the progression of NSCLC,and circUCP2 may therefore be a novel diagnostic biomarker for the progression of NSCLC.

关键词： CircUCP2 miR-149 UCP2 CeRNAs NSCLC

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Central venous pressure value can assist in adjusting norepinephrine dosage after the initial resuscitation of septic shock

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Chinese Medical Journal 2019年第10期132卷 1159-1165页

作者： Dong-Kai Li wei du Department of Critical Care Medicine Peking Union Medical College Hospital Peking Union Medical College Chinese Academy of Medical Sciences Beijing 100730 China

Background: New definitions for sepsis and septic shock (Sepsis-3) were published, but the strategy to adjust vasopressors a initial guidelines is still unclear. We conducted a retrospective observational study to explore dosing strategy of norepinephrine (NE). Methods: A retrospective observational study in the 15-bed mixed intensive care unit of a tertiary care university hospital. The study was performed on septic shock patients after 30 mL/kg fluid resuscitation and mean arterial pressure (MAP) levels reached >65 mmHg requiring NE. We divided patients into NE dosage increase and decrease groups, and collected hemodynamic and tissue perfusion parameters before (Tl) and after (T2) adjusting NE dosage. Results: In both NE increase and decrease groups, central venous pressure (CVP) and pressure difference between usual MAP and MAP (dMAP) at the T1 time point were associated with lactate clearance. In groups LC HM (CVP 10 mmHg, dMAP > 0 mmHg), decrease in NE dosage decreased lactate level, while in group HC LM (CVP >10 mmHg, dMAP < 0 mmHg), both increase and decrease in NE dosage led to increase lactate level. Conclusions: After patients with septic shock (Sepsis-3) resuscitated to reach the initial recovery target goals, combination of CVP and MAP refer to usual levels can help doctors make the next decision to make the correct choice of increase NE dosage or decrease NE dosage.

关键词： Septic shock Vasopressors Central venous pressure Hemodynamics

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TM_(3)(TM=V,Fe,Mo,W)single-cluster catalyst confined on porous BN for electrocatalytic nitrogen reduction

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Journal of Materials Science & Technology 2022年第13期108卷 46-53页

作者： Shuaishuai Gao Zuju Ma Chengwei Xiao Zhitao Cui wei du Xueqin Sun Qiaohong Li Rongjian Sa Chenghua Sun School of Environmental and Materials Engineering Yantai UniversityYantai 264005China School of Materials Science and Engineering Anhui University of TechnologyMaanshan 243002China State Key Laboratory of Structural Chemistry Fujian Institute of Research on the Structure of MatterChinese Academy of SciencesFuzhou 350002China Institute of Oceanography Ocean CollegeMinjiang UniversityFuzhou 350108China College of Chemical Engineering and Energy Technology Dongguan University of TechnologyDongguan 523808China Department of Chemistry and Biotechnology Faculty of ScienceEngineering&TechnologySwinburne University of TechnologyHawthornVIC 3122Australia

Confined metal clusters as sub-nanometer reactors for electrocatalytic N_(2) reduction reaction(eNRR)have received increasing attention due to the unique metal-metal interaction and higher activity than singleatom catalysts.Herein,the inspiration of the superior capacitance and unique microenvironment with regular surface cavities of the porous boron nitride(p-BN)nanosheets,we systematically studied the catalytic activity for NRR of transition-metal single-clusters in the triplet form(V_(3),Fe_(3),Mo_(3) and W_(3))confined in the surface cavities of the p-BN sheets by spin-polarized density functional theory(DFT)calculations.After a two-step screening strategy,Mo_(3)@p-BN was found to have high catalytic activity and selectivity with a rather low limiting potential(-0.34 V)for the NRR.The anchored Mo_(3) singlecluster can be stably embedded on the surface cavities of the substrate preventing the diffusion of the active Mo atoms.More importantly,the Mo atoms in the Mo_(3) single-cluster would act as“cache”to accelerate electron transfer between active metal centers and nitrogen-containing intermediates via the intimate Mo-Mo interactions.The cooperation of Mo atoms can also provide a large number of occupied and unoccupied d orbitals to make the"donation-backdonation"mechanism more effective.This work not only provides a quite promising electrocatalyst for NRR,but also brings new insights into the rational design of triple-atom NRR catalysts.

关键词： Electrocatalytic N_(2)reduction Density functional theory Single-cluster Porous boron nitride

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Photometric Redshift Estimates using Bayesian Neural Networks in the CSST Survey

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Research in Astronomy and Astrophysics 2022年第11期22卷 190-206页

作者： Xingchen Zhou Yan Gong Xian-Min Meng Xuelei Chen Zhu Chen wei du Liping Fu Zhijian Luo National Astronomical Observatories Chinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China Science Center for China Space Station Telescope National Astronomical ObservatoriesChinese Academy of SciencesBeijing 100101China Key Laboratory of Computational Astrophysics National Astronomical ObservatoriesChinese Academy of SciencesBeijing 100101China Center for High Energy Physics Peking UniversityBeijing 100871China Shanghai Key Lab for Astrophysics Shanghai Normal UniversityShanghai 200234China

Galaxy photometric redshift(photoz)is crucial in cosmological studies,such as weak gravitational lensing and galaxy angular clustering measurements.In this work,we try to extract photoz information and construct its probability distribution function(PDF)using the Bayesian neural networks from both galaxy flux and image data expected to be obtained by the China Space Station Telescope(CSST).The mock galaxy images are generated from the Hubble Space Telescope-Advanced Camera for Surveys(HST-ACS)and COSMOS catalogs,in which the CSST instrumental effects are carefully considered.In addition,the galaxy flux data are measured from galaxy images using aperture photometry.We construct a Bayesian multilayer perceptron(B-MLP)and Bayesian convolutional neural network(B-CNN)to predict photoz along with the PDFs from fluxes and images,respectively.We combine the B-MLP and B-CNN together,and construct a hybrid network and employ the transfer learning techniques to investigate the improvement of including both flux and image data.For galaxy samples with signal-to-noise ratio(SNR)>10 in g or i band,we find the accuracy and outlier fraction of photoz can achieve σ_(NMAD)=0.022 and η=2.35% for the B-MLP using flux data only,and σ_(NMAD)=0.022 and η=1.32% for the B-CNN using image data only.The Bayesian hybrid network can achieve σ_(NMAD)=0.021 and η=1.23%,and utilizing transfer learning technique can improve results to σ_(NMAD)=0.019 and η=1.17%,which can provide the most confident predictions with the lowest average uncertainty.

关键词： (cosmology:)large-scale structure of universe methods:statistical techniques:image processing

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板式无砟轨道层间黏结参数对界面损伤的影响

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华中科技大学学报（自然科学版） 2024年第2期52卷 120-126页

作者：杜威任娟娟杜俊宏屈昌衡西南交通大学高速铁路线路工程教育部重点实验室四川成都610031 西南交通大学土木工程学院四川成都610031

为探究层间黏结参数对轨道板与自密实混凝土界面连接性能的影响,建立含内聚力模型的CRTSⅢ型板式无砟轨道有限元仿真模型,分析了温度梯度作用下不同法向和切向黏结参数对层间损伤发展规律的影响.研究结果表明:降低界面刚度和增大断裂能... 详细信息

为探究层间黏结参数对轨道板与自密实混凝土界面连接性能的影响,建立含内聚力模型的CRTSⅢ型板式无砟轨道有限元仿真模型,分析了温度梯度作用下不同法向和切向黏结参数对层间损伤发展规律的影响.研究结果表明:降低界面刚度和增大断裂能分别对延缓界面损伤萌生和层间脱黏具有一定的效果,但不显著;增大内聚强度可有效控制界面损伤的发展,提高损伤萌生和层间脱黏的起始温度梯度的最大幅度分别为125%和54%;正温度梯度90℃/m作用下,改变法向黏结参数对层间脱黏率影响较小,但增大切向内聚强度和断裂能均可有效减小界面损伤区域,层间脱黏率降低值大于15%.

关键词：板式无砟轨道界面损伤黏结参数温度梯度荷载脱黏率

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复合框架、综合判断与融合表达——新文科视域下中国应用新闻学教育的转型

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新闻大学 2024年第5期 32-44,117,118页

作者：林晖杜薇上海财经大学人文学院上海200433

无论中外,从记者职业诞生到专业新闻教育发轫,融通理论和业务的应用新闻学教育和研究都奠定了新闻人才培养的基础和方向。20世纪初,中国本土新闻学理论和实务初兴。此后百年间,人才培养也从起初的杂家应用型、复合型、专门型过渡到大融... 详细信息

无论中外,从记者职业诞生到专业新闻教育发轫,融通理论和业务的应用新闻学教育和研究都奠定了新闻人才培养的基础和方向。20世纪初,中国本土新闻学理论和实务初兴。此后百年间,人才培养也从起初的杂家应用型、复合型、专门型过渡到大融合时代的“专家型”。当前尚未完全适应网络技术转型的应用新闻教育在人工智能的强烈冲击下又一次到了转折期。“新闻专业危机”背后映射的是信任危机与职业认同危机,是对新闻传播专业的质疑与叩问。“融+通”的新文科,贯通人文学科内部、跨越文理工的界限,以复合框架、综合判断、融合表达为目标,将为百年来中国应用新闻教育带来剧烈、深刻的变革。

关键词：应用新闻学教育人才培养新文科融合

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坚守农村宅基地制度改革底线:风险问题与优化思路

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四川师范大学学报（社会科学版） 2024年第3期51卷 103-111,204页

作者：黄敏杜伟四川师范大学中国乡村振兴研究院成都师范学院

坚持底线思维是应对农村宅基地制度改革风险挑战、解决复杂矛盾问题的重要方法。农村宅基地制度改革底线包括集体所有权底线、农民利益不受损底线、耕地红线和粮食安全底线。在“还权赋能”、“财产价值显化”驱动下,农村宅基地制度改... 详细信息

坚持底线思维是应对农村宅基地制度改革风险挑战、解决复杂矛盾问题的重要方法。农村宅基地制度改革底线包括集体所有权底线、农民利益不受损底线、耕地红线和粮食安全底线。在“还权赋能”、“财产价值显化”驱动下,农村宅基地制度改革面临突破底线的多重风险:一是宅基地使用权的经济价值实现路径背后隐藏集体所有权实现危机;二是竞价使用、有偿退出等试点方案弱化宅基地的社会福利保障功能,使农民利益不受损的底线面临挑战;三是宅基地过度支持非农产业用地需求对耕地红线和粮食安全形成潜在威胁。面对系列风险问题,需进一步夯实宅基地集体治理权,守住集体所有权底线;协调宅基地的多重功能价值,守住农民利益底线;明确农村宅基地制度改革监管职责边界,守住耕地红线和粮食安全底线。

关键词：农村宅基地制度改革底线思维方法风险问题

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Hierarchically mesoporous carbon spheres coated with a single atomic Fe-N-C layer for balancing activity and mass transfer in fuel cells

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Carbon Energy 2022年第1期4卷 1-11页

作者： Chengyong Shu Qiang Tan Chengwei Deng wei du Zhuofan Gan Yan Liu Chao Fan Hui Jin wei Tang Xiao-dong Yang Xiaohua Yang Yuping Wu School of Chemical Engineering and Technology Xi'an Jiaotong UniversityXi'anChina State Key Laboratory for Mechanical Behavior of Materials School of Material Science and EngineeringXi'an Jiaotong UniversityXi'anChina State Key Laboratory of Space Power-Sources Technology Shanghai Institute of Space Power SourcesShanghaiChina State Key Laboratory of Multiphase Flow in Power Engineering Xi'an Jiaotong UniversityXi'anChina College of Materials Science and Engineering Huaqiao UniversityXiamenChina Institute of Quantum and Sustainable Technology(IQST) School of Chemistry and Chemical EngineeringJiangsu UniversityZhenjiangChina State Key Laboratory of Materials-Oriented Chemical Engineering School of Energy Science and Engineering and Institute of Advanced MaterialsNanjing Tech UniversityNanjingChina

Novel cost-effective fuel cells have become more attractive due to the demands for rare and expensive platinum-group metal(PGM)catalysts for mitigating the sluggish kinetics of the oxygen reduction reaction(ORR).The high-cost PGM catalyst in fuel cells can be replaced by earth-abundant transition-metalbased catalysts,that is,an Fe-N-C catalyst,which is considered one of the most promising alternatives.However,the performance of the Fe-N-C catalyst is hindered by the low catalytic activity and poor stability,which is caused by insufficient active sites and the lack of optimization of the triple-phase interface for mass transportation.Herein,a novel Fe–N–C catalyst consisting of mono-dispersed hierarchically mesoporous carbon sphere cores and single Fe atom-dispersed functional shells are presented.The synergistic effect between highly dispersed Fe-active sites and well-organized porous structures yields the combination of high ORR activity and high mass transfer performance.The half-wave potential of the catalyst in 0.1M H_(2)SO_(4) is 0.82 V versus reversible hydrogen electrode,and the peak power density is 812 mW·cm^(−2) in H_(2)–O_(2) fuel cells.Furthermore,it shows superior methanol tolerance,which is almost immune to methanol poisoning and generates up to 162 mW·cm^(−2) power density in direct methanol fuel cells.

关键词： fuel cell hierarchically mesoporous carbon spheres oxygen reduction reaction single‐atom catalysts

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