Free PSA performs better than total PSA in predicting prostate volume in Chinese men with PSA levels of 2.5–9.9 ng ml−1

作     者：Ma-Ping Huang Ping Tang Cliff S Klein Xing-Hua Wei Wei Du Jin-Gao Fu Tian-Hai Huang Hui Chen Ke-Ji Xie 

作者机构：Department of UrologyThe First Affiliated Hospital of Jinan UniversityGuangzhou 510630China Department of UrologyGuangzhou First People's HospitalSouth China University of TechnologyGuangzhou 510180China Department of UrologyGuangdong Provincial Work Injury Rehabilitation HospitalGuangzhou 510440China Department of UrologyGuangdong Provincial Hospital of Integrated Traditional Chinese and Western MedicineFoshan 528253China Department of UrologyJiangmen Central HospitalAffiliated Jiangmen Hospital of Sun Yat-Sen UniversityJiangmen 529099China 

出 版 物：《Asian Journal of Andrology》 (亚洲男性学杂志（英文版）)

年 卷 期：2023年第25卷第1期

页      面：82-85页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：supported by grants from Guangzhou Municipal Science and Technology,China (grant No.201804010453 to PT,and grant No.201904010256 to CSK) Medical Scientific Research Foundation of Guangdong Province,China (grant No.A2018503 to MPH) Scientific and Technological Projects,Guangdong Province (grant No.2015A020210005 to SLM) 

主　　题：prostate cancer prostate-specific antigen prostatic hyperplasia volume 

摘      要：This study investigated whether free prostate-specific antigen(fPSA)performs better than total PSA(tPSA)in predicting prostate volume(PV)in Chinese men with different PSA levels.A total of 5463 men with PSA levels of10 ng ml^(−1) and without prostate cancer diagnosis were included in this *** were classified into four groups:PSA2.5 ng ml^(−1),2.5–3.9 ng ml^(−1),4.0–9.9 ng ml^(−1),and 2.5–9.9 ng ml^(−1).Pearson/Spearman s correlation coefficient(r)and receiver operating characteristic(ROC)curves were used to evaluate the ability of tPSA and fPSA to predict *** correlation coefficient between tPSA and PV in the PSA2.5 ng ml^(−1) cohort(r=0.422;P0.001)was markedly higher than those of the cohorts with PSA levels of 2.5–3.9 ng ml^(−1),4.0–9.9 ng ml^(−1),and 2.5–9.9 ng ml^(−1)(r=0.114,0.167,and 0.264,respectively;all P≤0.001),while fPSA levels did not differ significantly among different PSA *** under ROC curve(AUC)analyses revealed that the performance of fPSA in predicting PV≥40 ml(AUC:0.694,0.714,and 0.727)was better than that of tPSA(AUC=0.545,0.561,and 0.611)in men with PSA levels of 2.5–3.9 ng ml^(−1),4.0–9.9 ng ml^(−1),and 2.5–9.9 ng ml^(−1),respectively,but not at PSA levels of2.5 ng ml^(−1)(AUC:0.713 vs 0.720).These findings suggest that the relationship between tPSA and PV may vary with PSA level and that fPSA is more powerful at predicting PV only in thegray zone(PSA levels of 2.5–9.9 ng ml^(−1)),but its performance was similar to that of tPSA at PSA levels of2.5 ng ml^(−1).