CircUCP2 promotes the tumor progression of non-small cell lungcancer through the miR-149/UCP2 pathway
作者机构：Department of PathologyThe First People’s Hospital of Changde CityChangde415000China State Key Laboratory of Oncology in South ChinaSun Yat-sen University Cancer CenterGuangzhou510000China
出 版 物：《Oncology Research》 (肿瘤学研究（英文）)
年 卷 期：2023年第31卷第6期
页 面：929-936页
核心收录：
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
基 金：supported by grants from the Science and Technology Program of Guangzhou(202102080084,Han Yang) the Key Project of Scientific Research Plan of Hunan Provincial Health Commission(C202301047982,Wei Du) the Wings Scientific and Technological Foundation of The First People’s Hospital of Changde City(2022ZZ05,Wei Du) the Traditional Chinese Medicine Bureau of Guangdong Province(20161062,Qing Liu)
主 题：CircUCP2 miR-149 UCP2 CeRNAs NSCLC
摘 要：Non-small cell lung cancer(NSCLC)is a highly lethal cancer,and better treatments are urgently *** studies have implicated circular RNAs(circRNAs)in the progression of multiple malignant ***,the functions of circRNAs in NSCLC remain *** study new targets for the treatment of NSCLC,circRNA expression profiling was performed on NSCLC tissues and para-carcinoma nonmalignant *** was isolated and used for circRNA *** studies were performed in vitro and in vivo to determine the functions of circRNAs in NSCLC,including their functions in cell proliferation and *** circRNAs function in NSCLC was explored to clarify the underlying regulatory *** found that circUCP2 was upregulated in NSCLC tissues compared with neighboring nonmalignant ***2 promoted the proliferation and metastasis of NSCLC ***2 promoted NSCLC progression by sponging miR-149 and upregulating *** circUCP2/miR-149/UCP2 axis accelerates the progression of NSCLC,and circUCP2 may therefore be a novel diagnostic biomarker for the progression of NSCLC.
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