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Approaches to establish Q-markers for the quality standards of traditional Chinese medicines

Acta Pharmaceutica Sinica B 2017年第4期7卷 439-446页

作者： Wenzhi Yang Yibei Zhang wanying wu Luqi Huang Dean Guo Changxiao Liu National Engineering Laboratory for Standardization of Traditional Chinese Medicine Shanghai Institute of Materia Medica Research Center for Chinese Medicinal Resources China Academy of Chinese Medical Sciences Research Center for New Drug Evaluation Tianjin Institute of Pharmaceutical Research

Traditional Chinese medicine(TCM) has played a pivotal role in maintaining the health of Chinese people and is now gaining increasing acceptance around the global scope. However, TCM is confronting more and more concerns with respect to its quality. The intrinsic "multicomponent and multitarget" feature of TCM necessitates the establishment of a unique quality and bioactivity evaluation system, which is different from that of the Western medicine. However, TCM is investigated essentially as"herbal medicine" or "natural product", and the pharmacopoeia quality monographs are actually chemicalmarkers-based, which can ensure the consistency only in the assigned chemical markers, but, to some extent, have deviated from the basic TCM theory. A concept of "quality marker"(Q-marker), following the "property-effect-component" theory, is proposed. The establishment of Q-marker integrates multidisciplinary technologies like natural products chemistry, analytical chemistry, bionics, chemometrics,pharmacology, systems biology, and pharmacodynamics, etc. Q-marker-based fingerprint and multicomponent determination conduce to the construction of more scientific quality control system of *** review delineates the background, definition, and properties of Q-marker, and the associated technologies applied for its establishment. Strategies and approaches for establishing Q-marker-based TCM quality control system are presented and highlighted with a few TCM examples.

关键词： Traditional Chinese medicine Q-marker Quality control Property-effect-component

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Novel C-17 spirost protostane-type triterpenoids from Alisma plantago-aquatica with antiinflammatory activity in Caco-2 cells

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Acta Pharmaceutica Sinica B 2019年第4期9卷 809-818页

作者： Qinghao Jin Jianqing Zhang Jinjun Hou Min Lei Chen Liu Xia Wang Yong Huang Shuai Yao Bang Yeon Hwang wanying wu Dean Guo Shanghai Institute of Materia Medica Chinese Academy of SciencesShanghai 201203China School of Pharmacy Shenyang Pharmaceutical UniversityShenyang 110016China University of Chinese Academy of Sciences Beijing 100049China College of Pharmacy Chungbuk National UniversityCheongju 2816South Korea

Twenty-one protostane-type triterpenoids with diverse structures, including nine new compounds(1 e9), were isolated from the of Alisma plantago-aquatica Linn. Structurally, alisolides A-F(1 e6), composed of an oxole group coupled to a five-membered ring, represent unusual C-17 spirost protostane-type triterpenoids. Alisolide H(8) is a novel triterpenoid with an unreported endoperoxide bridge. Alisolide I(9) represents the first example of 23,24-acetal triterpenoid. Their structures were elucidated based on spectroscopic analysis, wherein the absolute configurations of 4-6, 8 were further confirmed by the Mo2(OAc)4-induced ECD method. Furthermore, all isolates were evaluated for their inhibitory effects on LPS-induced NO production in Caco-2 cells, and all the compounds showed remarkable inhibitory activities, with IC50 values in the range of 0.76 e38.20 mmol/L.

关键词： Alisma plantago-aquatica Linn. Protostane-type triterpenoids Caco-2 cells LPS-induced NO production

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Targeted trace ingredients coupled with chemometric analysis for consistency evaluation of Panax notoginseng saponins injectable formulations

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Chinese Journal of Natural Medicines 2023年第8期21卷 631-640页

作者： ZHANG Jingxian ZHANG Zijia WANG Zhaojun ZHANG Tengqian ZHOU Yang CHEN Ming HUANG Zhanwen HE Qingqing LONG Huali HOU Jinjun wu wanying GUO Dean National Engineering Research Center of TCM Standardization Technology Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China NMPA Key Laboratory for Quality Control of Traditional Chinese Medicine Shanghai Institute for Food and Drug ControlShanghai 201203China Guangxi Key Laboratory of Comprehensive Utilization Technology of Pseudo-Ginseng Guangxi Zhongheng Innovative Pharmaceutical Research Co.Ltd.Guangxi 530032China School of Pharmacy University of Chinese Academy of SciencesBeijing 100049China

Evaluating the consistency of herb injectable formulations could improve their product quality and clinical safety,particularly concerning the composition and content levels of trace *** notoginseng Saponins Injection(PNSI),widely used in China for treating acute cardiovascular diseases,contains low-abundance(10%-25%)and trace saponins in addition to its five main constituents(notoginsenoside R1,ginsenoside Rg1,ginsenoside Re,ginsenoside Rb1,and ginsenoside Rd).This study aimed to establish a robust analytical method and assess the variability in trace saponin levels within PNSI from different vendors and formulation *** achieve this,a liquid chromatography-triple quadrupole mass spectrometry(LC-MS/MS)method employing multiple ions monitoring(MIM)was developed.A“post-column valve switching”strategy was implemented to eliminate highly abundant peaks(NR_(1),Rg_(1),and Re)at 26 min.A total of 51 saponins in PNSI were quantified or relatively quantified using 18 saponin standards,with digoxin as the internal *** study evaluated 119 batches of PNSI from seven vendors,revealing significant variability in trace saponin levels among different vendors and formulation *** findings highlight the importance of consistent content in low-abundance and trace saponins to ensure product control and clinical *** of these ingredients is crucial for maintaining the quality and effectiveness of PNSI in treating acute cardiovascular diseases.

关键词： Consistency evaluation Panax notoginseng saponins PCA analysis Xueshuantong Xuesaitong

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Current status and future development of aortic stent fenestration-assisted techniques

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Chinese Medical Journal 2024年第6期137卷 752-754页

作者： Gezheng Chen Xiaoyu Qi wanying wu Dongsheng Fu Li Qin Chao Yang Department of Vascular Surgery Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei 430022China Department of Vascular Surgery Nanjing Drum Tower HospitalAffiliate Hospital of Nanjing University Medical SchoolNanjingJiangsu 210008China

To the Editor:In 1996,Parodi et al^([1])introduced the technique of fenestrated endovascular aneurysm repair(f-EVAR)for treatment of pararenal abdominal aortic *** use physician modified stent grafts(PMSGs)for fenestration,which allows for stent grafts to gain sufficient proximal sealing zones and maintain the blood perfusion of visceral arteries.^([2])Stent grafts used in the f-EVAR technique developed from PMSGs to Company Modified Devices(CMDs)and off-the-shelf devices.^([3])To improve the precision of PMSGs and shorten the time of stent graft modification,various techniques that assist in the process of fenestration have been researched and developed,including 3-dimensional(3D)printing technique,the Mixed Reality(MR)technique,and the 3D parametric surface planar topological guide *** article describes the current status and future development of these techniques.

关键词： aortic perfusion arteries

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Shenqi Fuzheng injection alleviates chemotherapy-induced cachexia by restoring glucocorticoid signaling in hypothalamus

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Journal of Pharmaceutical Analysis 2024年第3期14卷 431-434页

作者： Entezar Berik Zijia Zhang Wei Li Yawen Liu Sihan Chen Wenyong wu Zhaojun Wang Xinqin Kong Wenqiang Pei Huiqing Dong Huali Long Min Lei Jennifer Yiyang Wang Liangfeng Liu Jinjun Hou Jing Feng Zhaoxia Li wanying wu De-an Guo Beijing Key Lab of TCM Collateral Disease Theory Research School of Traditional Chinese MedicineCapital Medical UniversityBeijing100069China National Engineering Research Center of TCM Standardization Technology Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghai201203China University of Chinese Academy of Sciences Beijing100049China School of Chinese Materia Medica Nanjing University of Chinese MedicineNanjing210029China Limin Pharmaceutical Factory Livzon Group LimitedShaoguanGuangdong512028China Guangdong Corporate Key Laboratory of High-End Liquid Medicine R&D IndustrilizationShaoguanGuangdong512028China Center for Neurological and Psychiatric Research and Drug Discovery Shanghai Institute of Materia MedicaChinese Academy of ScienceShanghai201203China

Chemotherapy-induced cachexia(CIC)is a debilitating condition characterized by weight loss,muscle atrophy,and anorexia[1].While peripheral mechanisms of cachexia have been extensively studied,the involvement of the central nervous system(CNS)in CIC is often *** drugs cause stress responses and inflammation,which may impact the hypothalamus and disrupt systemic energy and neuroendocrine *** hypothalamic roles in regulating these processes can provide insights into CIC's mechanisms and aid in developing novel therapies.

关键词： injection drugs glucocorticoid chemotherapy

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中药国际质量标准体系构建的几点思考

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世界科学技术-中医药现代化 2014年第3期16卷 496-501页

作者：吴婉莹果德安中药标准化技术国家工程实验室/中国科学院上海药物研究所上海201203

中药标准进入《美国药典》与《欧洲药典》是实现"中药标准主导国际标准制订"目标的前提与基础。通过对中、美、欧3个国家与地区的药典以及质量标准制订的关键问题进行比较分析,对如何完成中药国际质量标准的构建提出了建议。同时,为目... 详细信息

中药标准进入《美国药典》与《欧洲药典》是实现"中药标准主导国际标准制订"目标的前提与基础。通过对中、美、欧3个国家与地区的药典以及质量标准制订的关键问题进行比较分析,对如何完成中药国际质量标准的构建提出了建议。同时,为目前国际大环境重压下的中药国际化进程如何艰难破局提供借鉴与参考。

关键词：中药复杂体系国际质量标准中国药典美国药典欧洲药典

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乳腺癌病人内分泌治疗症状评估工具的研究进展

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护理研究 2020年第19期34卷 3443-3448页

作者：李晴晴吴婉英浙江中医药大学护理学院浙江310022 浙江省肿瘤医院

对国内外开发的乳腺癌病人内分泌治疗症状评估工具进行综述,指出目前制订的评估工具缺乏特异性、全面性及准确性。建议在已有量表的基础上,研制我国本土化的乳腺癌病人内分泌治疗症状评估工具,全面评估该群体症状表现及对生活的困扰程度... 详细信息

对国内外开发的乳腺癌病人内分泌治疗症状评估工具进行综述,指出目前制订的评估工具缺乏特异性、全面性及准确性。建议在已有量表的基础上,研制我国本土化的乳腺癌病人内分泌治疗症状评估工具,全面评估该群体症状表现及对生活的困扰程度,为后续相关症状领域的研究及针对性干预措施的实施提供参考和依据。

关键词：乳腺癌内分泌治疗症状评估工具进展综述

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文旅融合下平顶山非物质文化遗产发展路径探析———以马街书会为例

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管理工程师 2023年第6期28卷 54-58页

作者：吴婉莹河南城建学院艺术设计学院河南平顶山467036

平顶山文化资源丰富,非物质文化遗产种类繁多,彰显了中原历史文化的博大精深。其中马街书会作为平顶山市首批入选国家级非物质文化遗产的代表性项目,对其进行文化旅游开发是实现乡村振兴的关键。本文以宝丰县马街书会为例,剖析马街书会... 详细信息

平顶山文化资源丰富,非物质文化遗产种类繁多,彰显了中原历史文化的博大精深。其中马街书会作为平顶山市首批入选国家级非物质文化遗产的代表性项目,对其进行文化旅游开发是实现乡村振兴的关键。本文以宝丰县马街书会为例,剖析马街书会的发展现状及所面临的问题,梳理其文化的资源价值,挖掘可开发元素。通过多方位探索马街书会的发展路径,传承与创新传统曲艺文化,以期对平顶山其他非物质文化遗产的保护开发利用提供借鉴。

关键词：非物质文化遗产乡村旅游马街书会

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子宫腺肌病的临床诊疗研究进展

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实用妇科内分泌电子杂志 2023年第6期10卷 36-39页

作者：吴晚英梧州市红十字会医院妇科广西梧州543002

子宫腺肌病是临床常见妇科疾病,子宫腺肌症也称为子宫腺肌病,以往称为“内在性内异症”,是指子宫内膜腺体及间质侵入子宫肌层,并保持周期性增生、剥脱、出血等功能性改变,引起相应症状。主要表现为继发渐进性加重痛经、月经量增多以及... 详细信息

子宫腺肌病是临床常见妇科疾病,子宫腺肌症也称为子宫腺肌病,以往称为“内在性内异症”,是指子宫内膜腺体及间质侵入子宫肌层,并保持周期性增生、剥脱、出血等功能性改变,引起相应症状。主要表现为继发渐进性加重痛经、月经量增多以及子宫增大等,对患者的生活质量造成了不同程度的影响。子宫腺肌病发病机制尚不明确,治疗以药物、手术治疗为主。本文就子宫腺肌病的概念、发病机制、诊断及治疗现状进行综述,旨在临床治疗提供参考。

关键词：子宫腺肌病诊断治疗研究进展

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乳腺癌患者化疗相关认知障碍的研究进展

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护理与康复 2024年第10期23卷 93-96页

作者：刘卉吴婉英浙江省肿瘤医院浙江杭州310022

综述化疗相关认知障碍概念及理论模型、测评工具、乳腺癌患者化疗相关认知障碍纵向研究现状,为我国医护人员开展此类研究提供参考。

关键词：乳腺癌化疗认知障碍综述

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