Shenqi Fuzheng injection alleviates chemotherapy-induced cachexia by restoring glucocorticoid signaling in hypothalamus

作     者：Entezar Berik Zijia Zhang Wei Li Yawen Liu Sihan Chen Wenyong Wu Zhaojun Wang Xinqin Kong Wenqiang Pei Huiqing Dong Huali Long Min Lei Jennifer Yiyang Wang Liangfeng Liu Jinjun Hou Jing Feng Zhaoxia Li Wanying Wu De-an Guo Entezar Berik;Zijia Zhang;Wei Li;Yawen Liu;Sihan Chen;Wenyong Wu;Zhaojun Wang;Xinqin Kong;Wenqiang Pei;Huiqing Dong;Huali Long;Min Lei;Jennifer Yiyang Wang;Liangfeng Liu;Jinjun Hou;Jing Feng;Zhaoxia Li;Wanying Wu;De-an Guo

作者机构：Beijing Key Lab of TCM Collateral Disease Theory ResearchSchool of Traditional Chinese MedicineCapital Medical UniversityBeijing100069China National Engineering Research Center of TCM Standardization TechnologyShanghai Institute of Materia MedicaChinese Academy of SciencesShanghai201203China University of Chinese Academy of SciencesBeijing100049China School of Chinese Materia MedicaNanjing University of Chinese MedicineNanjing210029China Limin Pharmaceutical FactoryLivzon Group LimitedShaoguanGuangdong512028China Guangdong Corporate Key Laboratory of High-End Liquid Medicine R&DIndustrilizationShaoguanGuangdong512028China Center for Neurological and Psychiatric Research and Drug DiscoveryShanghai Institute of Materia MedicaChinese Academy of ScienceShanghai201203China 

出 版 物：《Journal of Pharmaceutical Analysis》 (药物分析学报（英文版）)

年 卷 期：2024年第14卷第3期

页      面：431-434页

核心收录：

学科分类：1008[医学-中药学(可授医学、理学学位)] 1006[医学-中西医结合] 081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070302[理学-分析化学] 0703[理学-化学] 100602[医学-中西医结合临床] 10[医学] 

基　　金：the National Key Research and Development Program of China(Grant No.:2022YFC3501700) the Key-Area Research and Development Program of Guangdong Province,China(Grant No.:2020B1111110001) the Youth Program of the National Natural Science Foundation of China(Grant No.:82003939) 

主　　题：injection drugs glucocorticoid chemotherapy 

摘      要：Chemotherapy-induced cachexia(CIC)is a debilitating condition characterized by weight loss,muscle atrophy,and anorexia[1].While peripheral mechanisms of cachexia have been extensively studied,the involvement of the central nervous system(CNS)in CIC is often *** drugs cause stress responses and inflammation,which may impact the hypothalamus and disrupt systemic energy and neuroendocrine *** hypothalamic roles in regulating these processes can provide insights into CIC s mechanisms and aid in developing novel therapies.