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DeepGCN based on variable multi‐graph and multimodal data for ASD diagnosis

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CAAI Transactions on Intelligence Technology 2024年第4期9卷 879-893页

作者： Shuaiqi Liu siqi wang Chaolei Sun Bing Li Shuihua wang Fei Li College of Electronic and Information Engineering Hebei UniversityBaodingChina Machine Vision Technology Innovation Center of Hebei Province BaodingChina The State Key Laboratory of Multimodal Artificial Intelligence Systems Institute of AutomationChinese Academy of SciencesBeijingChina School of Computer Science and Technology Henan Polytechnic UniversityJiaozuoChina

Diagnosing individuals with autism spectrum disorder(ASD)accurately faces great chal-lenges in clinical practice,primarily due to the data's high heterogeneity and limited sample *** tackle this issue,the authors constructed a deep graph convolutional network(GCN)based on variable multi‐graph and multimodal data(VMM‐DGCN)for ASD ***,the functional connectivity matrix was constructed to extract primary ***,the authors constructed a variable multi‐graph construction strategy to capture the multi‐scale feature representations of each subject by utilising convolutional filters with varying kernel ***,the authors brought the non‐imaging in-formation into the feature representation at each scale and constructed multiple population graphs based on multimodal data by fully considering the correlation between *** extracting the deeper features of population graphs using the deep GCN(DeepGCN),the authors fused the node features of multiple subgraphs to perform node classification tasks for typical control and ASD *** proposed algorithm was evaluated on the Autism Brain Imaging Data Exchange I(ABIDE I)dataset,achieving an accuracy of 91.62%and an area under the curve value of 95.74%.These results demon-strated its outstanding performance compared to other ASD diagnostic algorithms.

关键词： machine learning medical image processing medical signal processing

Non-destructive Testing and Intelligent Evaluation of Road Structural Conditions using GPR and FWD

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Journal of Traffic and Transportation Engineering(English Edition) 2024年

作者： Zhen Liu siqi wang Xingyu Gu Qiao Dong National Demonstration Center for Experimental Road and Traffic Engineering Education (Southeast University) Department of Roadway Engineering， School of Transportation， Southeast University

Aiming at the assessment of road structural conditions， a method of combining ground penetrating radar (GPR) and falling weight deflectometer (FWD) for assessing the pavement structural integrity and strength was proposed in this study. First， 3D GPR was performed to detect the thickness and internal distress of pavement structural layers using the canny edge detection and you only look once version eight (YOLOv8) detection algorithms. Results showed that the error of thickness extraction was approximately 3%， and the distress detection achieved a mean average precision (mAP) of 0.859 and an inference time of 11.43 ms with a GTX 1070 GPU. Then， the extracted thickness was used for the modulus (E) inversion of pavement structure layers based on FWD test data and regression analysis. Finally， the distress ratio inside pavement structures (DRIPS) was proposed as a structural integrity index. The relationship between E and DRIPS was revealed and showed a good correlation. The greater the DRIPS value， the worse the pavement structural integrity and strength. It provides a reference for the evaluation of road structural conditions. This strategy proved to be reliable for nondestructive testing and evaluation of road structures， which could improve the comprehensiveness and effectiveness for evaluating road structural conditions.

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LncRNAs are involved in regulating ageing and age-related disease through the adenosine monophosphate-activated protein kinase signalling pathway

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Genes & Diseases 2024年第5期11卷 183-197页

作者： Jiamei Li Feng Xiao siqi wang Xiaolan Fan Zhi He Taiming Yan Jia Zhang Mingyao Yang Deying Yang College of Animal Science and Technology Sichuan Agricultural UniversityChengduSichuan 611130China Farm Animal Genetic Resources Exploration and Innovation Key Laboratory of Sichuan Province Sichuan Agricultural UniversityChengduSichuan 611130China Chengdu Women’s and Children’s Central Hospital School of MedicineUniversity of Electronic Science and Technology of ChinaChengduSichuan 610017China

A long noncoding RNA(lncRNA)is longer than 200 *** regulates various biological processes mainly by interacting with DNA,RNA,or protein in multiple kinds of biological *** monophosphate-activated protein kinase(AMPK)is activated during nutrient starvation,especially glucose starvation and oxygen deficiency(hypoxia),and exposure to toxins that inhibit mitochondrial respiratory chain complex *** is an energy switch in organisms that controls cell growth and multiple cellular processes,including lipid and glucose metabolism,thereby maintaining intracellular energy homeostasis by activating catabolism and inhibiting *** AMPK signalling pathway consists of AMPK and its upstream and downstream *** upstream targets include proteins such as the transforming growth factor b-activated kinase 1(TAK1),liver kinase B1(LKB1),and calcium/calmodulindependent protein kinase b(CaMKKb),and its downstream targets include proteins such as the mechanistic/mammalian target of rapamycin(mTOR)complex 1(mTORC1),hepatocyte nuclear factor 4a(HNF4a),and silencing information regulatory 1(SIRT1).In general,proteins function relatively independently and *** this article,a review of the currently known lncRNAs involved in the AMPK signalling pathway is presented and insights into the regulatory mechanisms involved in human ageing and age-related diseases are provided.

关键词： Age-related diseases Ageing AMPK signalling pathway Long noncoding RNA microRNA

Gynecology Under Probe

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The World of Chinese 2024年第3期 46-52页

作者： Ana Chen wang siqi 不详

Chinese women are speaking up about pain and shame on the gynecologist’s table In December, 23-year-old Wu Jiayi emerged,shaking, from the hospital. Though her gynecological appointment had only lasted 15 minutes, Wu, who agreed to be interviewed under a pseudonym, had spent almost an hour in the hospital bathroom, bleeding into the toilet after an invasive exam.

关键词： shaking interview let

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Spice It Up

The World of Chinese 2024年第3期 110-115页

作者： Tan Yunfei wang siqi 不详

Known for its spicy, stir-fried dishes, Hunan cuisine has enjoyed a surge in popularity in recent years. But not everyone is happy about *** 9 p.m. on April 1, half an hour before her train arrived in Beijing, food blogger “Zhengqi Kong” opened a food delivery app and ordered several dishes from Hunan restaurant Xiaoxiangge so that they would be waiting for her at her accommodation. Despite the late, spicy, and oily dinner going against everything she knows about maintaining a healthy diet, eating Hunan food when traveling in and out of Beijing, as well as frequenting the capital’s Hunan restaurants, has become something of a ritual for the 28-year-old over the last several years.

关键词： restaurant something everyone

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Grinding for Gold

The World of Chinese 2024年第3期 54-59页

作者： Roman Kierst Yang Tingting wang siqi 不详

In the sometimes murky world of China’s game boosters, the promise of easy money masks harsh realities. In a small, cluttered apartment in Shanghai, 23-year-old Lin Li is finally getting ready for bed after a long session fighting monsters as a mysterious bluehaired archer in Genshin Impact. Lin spends most of his days completing missions for rewards on the popular Chinese role-playing game—not for enjoyment, but to make ends meet.

关键词： fighting money spend

Inetetamab combined with pyrotinib and oral vinorelbine for patients with human epidermal growth factor receptor 2 positive advanced breast cancer:A single-arm phase 2 clinical trial

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Cancer Pathogenesis and Therapy 2024年第1期2卷 31-37页

作者： Nan Jin Yi Xu siqi wang Chunxiao Sun Xueqi Yan Fan Yang Yan Liang Weiwei Chen Xiang Huang Department of Oncology The First Affiliated Hospital of Nanjing Medical UniversityNanjingJiangsu 210029China Department of Pathology The First Affiliated Hospital of Nanjing Medical UniversityNanjingJiangsu 210029China Radiology Department The First Affiliated Hospital of Nanjing Medical UniversityNanjingJiangsu 210029China Department of Oncology Affiliated Jinling HospitalMedical School of Nanjing UniversityNanjingJiangsu 210000China

Background Human epidermal growth factor receptor 2(HER2)-targeted agents have significantly improved the outcomes of patients with HER2-positive breast cancer;however,a large proportion of patients still develop resistance to *** this study,we investigated the efficacy and safety of inetetamab,another anti-HER2 antibody,combined with pyrotinib and oral vinorelbine in patients with HER2-positive advanced breast cancer so as to provide new ideas for the *** In this prospective,single-arm,phase 2 trial,patients with HER2-positive advanced breast cancer with disease progression after trastuzumab were *** received a combination of inetetamab(loading dose of 8 mg/kg and subsequent doses of 6 mg/kg intravenously once every 3 weeks),pyrotinib(400 mg orally once daily),and vinorelbine(60 mg/m^(2)orally once weekly)until disease progression or intolerable *** primary endpoint was progression-free survival(PFS).The secondary endpoints included objective response rate(ORR),overall survival(OS),disease control rate(DCR),and *** Between February 13,2022 and December 25,2022,30 patients were screened and enrolled in this *** median age of the patients at enrollment was 54 years,12 patients(40.0%)had hormone-receptor-positive disease and 23 patients(76.7%)had visceral *** median PFS was 8.63 months(95%confidence interval[CI]4.15-13.12 months).The median OS was not *** ORR was 53.3%(16/30)and the DCR was 96.7%(29/30).The most common Grade III/IV adverse events were leukopenia(n=5,16.7%),neutropenia(n=4,13.3%),and diarrhea(n=3,10%).No treatment-related serious adverse events or deaths *** The combination regimen of inetetamab,pyrotinib,and oral vinorelbine showed encouraging efficacy and favorable safety in patients with HER2-positive advanced breast cancer and could be considered as an alternative treatment option for the patients.

关键词： Human epidermal growth factor receptor 2 Breast cancer Inetetamab Pyrotinib Vinorelbine

Exploration of Teaching Development Strategies for Double-Qualified Teachers in University- Affiliated Hospitals Based on Role Conflict Theory

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Journal of Contemporary Educational Research 2024年第6期8卷 121-127页

作者： Yuanyuan Jia Yu Cai siqi wang Ying Yang Ge Wu Faculty Development and Teaching Evaluation Office The First Affiliated Hospital of Xi’an Medical UniversityXi’an 710000Shaanxi ProvinceChina Xi’an Medical University Xi’an 710000Shaanxi ProvinceChina

This study draws on the classic theories and research achievements of university teacher development,and from the perspective of role conflict in social psychology,proposes policy recommendations for the development of clinical teachers in medical colleges,including following different stages of teacher development and designing teaching development strategies at different levels;designing the content and form of teaching development activities to meet the temporal and spatial needs of clinical teachers;and building an academic community for clinical teachers to promote the creation of teaching development behaviors.

关键词： University-affiliated hospitals Double-qualified teachers Role conflict theory Teaching development strategies

Theoretical Analysis and Practical Reflection on the Role Conflict of Double-Qualified Teachers in University-Affiliated Hospitals

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Journal of Contemporary Educational Research 2024年第5期8卷 27-36页

Taking role conflict as the starting point,this article examines and reflects on the development of clinical *** the process of the occurrence,development,and resolution of role conflicts among clinical teachers,there are many hidden issues related to the development of clinical *** development of clinical teacher teaching and role conflict management contain similar educational philosophies and practical *** study draws on classic theories and research achievements in the development of university teachers and conducts theoretical analysis and practical reflection on the development of clinical teachers in medical colleges from the perspective of role conflict in social *** recommendations are proposed,including strengthening the construction of teaching systems at the hospital organizational environment level,enhancing the role identity and teacher beliefs of clinical teachers,promoting their teaching development and academic learning,and ensuring their normal teaching investment;promoting leadership support at the level of interpersonal interaction and leveraging the role of colleague support in alleviating role conflicts;enhancing individual teacher beliefs,teacher role learning,and role skills.

关键词： University-affiliated hospitals Double-qualified teachers Role conflict