检索结果-南通市图书馆

Th17 cells are involved in mouse chronic obstructive pulmonary disease complicated with invasive pulmonary aspergillosis

引用

Chinese Medical Journal 2021年第5期134卷 555-563页

作者： wan-ru geng Hang-Yong He Qing Zhang Zhao-Hui Tong Department of Respiratory and Critical Care Medicine Beijing Institute of Respiratory MedicineBeijing Chao-Yang HospitalCapital Medical UniversityBeijing 100020China Department of Respiratory Medicine Affiliated Hospital of Inner Mongolia University for the NationalitiesTongliaoInner Mongolia 028000China Department of Respiratory and Critical Care Medicine The Second Hospital of Jilin UniversityChangchunJilin 130041China

Background:The incidence of chronic obstructive pulmonary disease(COPD)complicated with invasive pulmonary aspergillosis(IPA)has increased in the last two *** mechanism underpinning susceptibility to and high mortality of COPD complicated with IPA is unclear,and the role of T helper cells 17(Th17 cells)in the compound disease remains ***,this study aimed to assess the function of Th17 cells in COPD combined with ***:COPD,IPA,and COPD+IPA mouse models were established in male wild type C57/BL6 *** amounts of Th17 cells and retinoic acid-related orphan receptorsγt(RORyt)were tested by flow ***,serum interleukin(IL)-17 and *** were detected by enzyme-linked immunosorbent assay(ELISA)in the control,COPD,IPA and COPD+IPA *** addition,COPD+IPA was induced in IL-17 knockout(KO)mice,for determining the role of Th17 cells in COPD+***:Compared with the COPD group,the COPD+IPA group showed higher amounts of blood RORyt([35.09±16.12]%vs.[17.92±4.91]%,P=0.02)and serum IL-17(17.96±9.59 pg/mL vs.8.05±4.44 pg/mL,P=0.02),but blood([5.18±1.09]%vs.[4.15±0.87]%,P=0.28)and lung levels of Th17 cells(1.98±0.83]%vs.[2.03±0.98]%,P=0.91),lung levels of RORyt([9.58±6.93]%vs.[9.63±5.98]%,P=0.49)and serum IL-23(51.55±27.82 pg/mL us.68.70±15.20 pg/mL,P=0.15)showed no significant *** with the IPA group,the COPD+IPA group displayed lower amounts of blood([5.18±1.09]%vs.[9.21±3.56]%,P=0.01)and lung Th17 cells([1.98±0.83]%vs.[6.29±1.11]%,P=0.01)and serum IL-23(51.55±27.82 pg/mL vs.154.90±64.60 pg/mL,P=0.01)and IL-17(17.96±9.59 pg/mL uUs.39.81±2.37 pg/mL,P=0.02),while comparable blood([35.09±16.12]%Vs.[29.86±15.42]%,P=0.25)and lung levels of RORγt(9.58±6.93]%VUS,[15.10±2.95]%,P=0.18)were found in these two ***,Aspergillus load in IL-17 KO COPD+IPA mice was almost 2 times that of COPD+IPA mice(1,851,687.69±944,480.43"vs.892,958.10±686,808.80,t=2.32,P=0.02).Conclusion:These findings indicate that Th17 cells

关键词： T helper cells 17 Chronic obstructive pulmonary disease(COPD) Invasive pulmonary aspergillosis(IPA)

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Current and Potential Roles of Ferroptosis in Bladder Cancer

引用

Current Medical Science 2024年第1期44卷 51-63页

作者： Wen-xin AN Radheshyam Gupta Kun ZHAI Ya-ru wanG wan-hai XU Yan CUI Department of Urology Harbin Medical University Cancer HospitalHarbin 150081China Department of Internal Medical Oncology Harbin Medical University Cancer HospitalHarbin 150081China

Ferroptosis,a type of regulated cell death driven by iron-dependent lipid peroxidation,is mainly initiated by extramitochondrial lipid peroxidation due to the accumulation of iron-dependent reactive oxygen *** is a prevalent and primitive form of cell *** cellular metabolic processes regulate ferroptosis,including redox homeostasis,iron regulation,mitochondrial activity,amino acid metabolism,lipid metabolism,and various disease-related signaling *** plays a pivotal role in cancer therapy,particularly in the eradication of aggressive malignancies resistant to conventional *** studies have explored the connection between ferroptosis and bladder cancer,focusing on its incidence and treatment *** biomolecules and tumor-associated signaling pathways,such as p53,heat shock protein 1,nuclear receptor coactivator 4,RAS-RAF-MEK,phosphatidylinositol 3-kinase-AKT-mammalian target of rapamycin,and the Hippo-tafazzin signaling system,exert a moderating influence on ferroptosis in bladder *** inducers,including erastin,artemisinin,conjugated polymer nanoparticles,and quinazolinyl-arylurea derivatives,hold promise for enhancing the effectiveness of conventional anticancer medications in bladder cancer *** conventional therapeutic drugs and treatment methods related to ferroptosis offers a promising approach for the treatment of bladder *** this review,we analyze the research on ferroptosis to augment the efficacy of bladder cancer treatment.

关键词： ferroptosis bladder cancer ferroptosis-associated tumor signaling pathway ferroptosis inducer

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Solar-driven photothermal catalytic CO2 conversion:a review

引用

Rare Metals 2024年第7期43卷 2913-2939页

作者： Bachirou Guene Lougou Bo-Xi geng ru-Ming Pan Wei wang Tian-Tian Yan Fang-Hua Li Hao Zhang Oraléou Sangué Djandja Yong Shuai Meisam Tabatabaei Daniel Sabi Takou School of Energy Science and Engineering Harbin Institute of Technology MIIT Key Laboratory of Critical Materials Technology for New Energy Conversion and Storage Harbin Institute of Technology State Key Laboratory of Urban Water Resource and Environment Harbin Institute of Technology School of Electrical Engineering and Automation Harbin Institute of Technology Guangdong Provincial Key Laboratory of Distributed Energy Systems Engineering Research Center of None-Food Biomass Efficient Pyrolysis and Utilization Technology of Guangdong Higher Education InstitutesDongguan University of Technology Higher Institution Centre of Excellence (HICoE) Institute of Tropical Aquaculture and Fisheries (AKUATROP)Universiti Malaysia Terengganu Department of Biomaterials Saveetha Dental CollegeSaveetha Institute of Medical and Technical Sciences école Polytechnique d'Abomey-Calavi University of Abomey-Calavi

It is highly desirable to seek green and sustainable technologies,such as employing photo thermal effects to drive energy catalysis processes to address the high energy demand and associated environmental impacts induced by the current *** photothermocatalysis process is an emerging research area with great potential in efficiently converting solar energy through various catalytic ***,achieving simultaneously high conversion efficiency,cyclability,and durability is still a daunting ***,tremendous work is still needed to enhance solar photo thermal catalytic conversion and promote its large-scale *** review developed the principles of coupling solar photon and thermal fields underlying the photothermal effect,exploration of efficient nanocatalysts,development of optofluidic reactor model,and photo thermal synergistic-driven CO2reduction *** ultimate goal was to provide an effective approach that can effectively convert solar energy into photocarriers/hot-electrons and heat,and importantly,can couple them to regulate catalysis reaction pathways toward the production of value-added fuel and chemical energy.

关键词： Photochemistry Photothermal CO 2 catalytic conversion Nanomaterial Solar fuels and chemicals

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Implications of left atrial volume index in patients with three-vessel coronary disease:A 6.6-year follow-up cohort study

引用

Chinese Medical Journal 2024年第4期137卷 441-449页

作者： ru Liu Lei Song Ce Zhang Lin Jiang Jian Tian Lianjun Xu Xinxing Feng Linyuan wan Xueyan Zhao Ou Xu Chongjian Li runlin Gao rutai Hui Wei Zhao Jinqing Yuan Department of Cardiology Fuwai HospitalChinese Academy of Medical SciencesBeijing 100037China Department of Respiratory and Pulmonary Vascular Disease Fuwai Yunnan Cardiovascular HospitalKunmingYunnan 650102China Department of Endocrinology Fuwai HospitalChinese Academy of Medical SciencesBeijing 100037China Department of Echocardiography Fuwai HospitalChinese Academy of Medical SciencesBeijing 100037China Information Center Fuwai HospitalChinese Academy of Medical SciencesBeijing 100037China

Background:Risk assessment and treatment stratification for three-vessel coronary disease(TVD)remain *** study aimed to investigate the prognostic value of left atrial volume index(LAVI)with the Synergy Between Percutaneous Coronary Intervention with Taxus and Cardiac Surgery(SYNTAX)score II,and its association with the long-term prognosis after three strategies(percutaneous coronary intervention[PCI],coronary artery bypass grafting[CABG],and medical therapy[MT])in patients with ***:This study was a post hoc analysis of a large,prospective cohort of patients with TVD in China,that aimed to determine the long-term outcomes after PCI,CABG,or optimal MT alone.A total of 8943 patients with TVD were consecutively enrolled between 2004 and 2011 at Fuwai Hospital.A total of 7818 patients with available baseline LAVI data were included in the ***,procedural,and follow-up data were *** primary endpoint was major adverse cardiac and cerebrovascular events(MACCE),which was a composite of all-cause death,myocardial infarction(MI),and *** endpoints included all-cause death,cardiac death,MI,revascularization,and ***-term outcomes were evaluated among LAVI quartile ***:During a median follow-up of 6.6 years,a higher LAVI was strongly associated with increased risk of MACCE(Q3:hazard ratio[HR]1.20,95%confidence interval[CI]1.06-1.37,P=0.005;Q4:HR 1.85,95%CI 1.64-2.09,P<0.001),all-cause death(Q3:HR 1.41,95%CI 1.17-1.69,P<0.001;Q4:HR 2.54,95%CI 2.16-3.00,P<0.001),and cardiac death(Q3:HR 1.81,95%CI 1.39-2.37,P<0.001;Q4:HR 3.47,95%CI 2.71-4.43,P<0.001).Moreover,LAVI significantly improved discrimination and reclassification of the SYNTAX score ***,there was a significant interaction between LAVI quartiles and treatment strategies for *** was associated with lower risk of MACCE than MT alone,regardless of LAVI *** patients in the fourth quartile,PCI was associated with significantly incre

关键词： Three-vessel coronary disease Left atrial volume index Coronary artery bypass grafting Percutaneous coronary intervention Myocardial ischemia Prognosis

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Residual levels and health risk assessment of trace metals in Chinese resident diet

引用

Journal of Environmental Sciences 2024年第2期136卷 451-459页

作者： Yubing Dai Shuai Sun Rong Cao Haijun Zhang Jiping Chen Ningbo geng CAS Key Laboratory of Separation Science for Analytical Chemistry Dalian Institute of Chemical PhysicsChinese Academy of SciencesDalian 116023China Shenyang Pharmaceutical University Shenyang 110016China University of Chinese Academy of Sciences Beijing 100049China

Large-scale metal contamination across the food web is an intractable problem due to increasing pollutant emissions,atmospheric transport,and dry and wet deposition of *** present study focus on several trace metals that are rarely studied but have special toxicity,including tin(Sn),antimony(Sb),gold(Au),hafnium(Hf),palladium(Pd),platinum(Pt),ruthenium(ru),tellurium(Te)and iridium(Ir).We investigated trace metals residues and distribution characteristics,and further evaluated the potential health risks from major daily food intakes in 33 cities in ***,Sb,Ir,Hf,and Au were frequently detected in food samples with the concentrations ranged from ND(not detected)to 24.78μg/kg ww(wet weight).Eggs exhibited the highest residual level of all detected metals(13.70±14.70μg/kg ww in sum),while the lowest concentrations were observed in vegetables(0.53±0.17μg/kg ww in sum).Sn accounting for more than 50%of the total trace metals concentration in both terrestrial and aquatic animal origin *** terrestrial plant origin foods,Sn and Ir were the most abundant *** and Au were the most abundant elements in egg *** addition,Sb and Ir showed a clear trophic dilution effect in terrestrial environments,while in aquatic ecosystems,Sn,Hf,and Au exhibited obvious trophic amplification *** calculated average estimated daily intake(EDI)via food consumption in five regions of China was 0.09μg/(kg·day),implying the health risk of aforementioned elements was acceptable.

关键词： Trace metals Accumulation characteristics Dietary exposure Estimated daily intake(EDI)

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Laparoscopic left hemihepatectomy guided by indocyanine green fluorescence: A cranial-dorsal approach

引用

World Journal of Gastrointestinal Surgery 2024年第2期16卷 409-418页

作者： Xing-ru wang Xiao-Ju Li Dan-Dan wan Qian Zhang Tian-Xi Liu Zong-Wen Shen Hong-Xing Tong Yan Li Jian-Wei Li Institute of Hepatobiliary Surgery First Affiliated HospitalArmy Medical UniversityChongqing 400038China Department of Hepatobiliary Surgery Qujing Central Hospital of Yunnan Regional Medical CenterQujing 655000Yunnan ProvinceChina School of Clinical Medicine Qujing Medical CollegeQujing 655000Yunnan ProvinceChina

BACKGROUND Advancements in laparoscopic technology and a deeper understanding of intra-hepatic anatomy have led to the establishment of more precise laparoscopic hepatectomy(LH)*** indocyanine green(ICG)fluorescence navi-gation technique has emerged as the most effective method for identifying hepatic regions,potentially overcoming the limitations of *** laparoscopic left hemihepatectomy(LLH)is a standardized procedure,there is a need for innova-tive strategies to enhance its *** anatomical markers,surgical skills,and ICG staining *** Thirty-seven patients who underwent ICG fluorescence-guided LLH at Qujing Second People's Hospital between January 2019 and February 2022 were retrospectively *** cranial-dorsal approach was performed which involves dissecting the left hepatic vein cephalad,isolating the Arantius ligament,exposing the middle hepatic vein,and dissecting the parenchyma from the dorsal to the foot in order to complete the anatomical *** surgical methods,as well as intra-and post-surgical data,were recorded and *** hospital’s Medical Ethics Committee approved this study(Ethical review:2022-019-01).RESULTS Intraoperative blood loss during LLH was 335.68±99.869 mL and the rates of transfusion and conversion to laparotomy were 13.5%and 0%,*** overall incidence of complications throughout the follow-up(median of 18 months;range 1-36 months)was 21.6%.No mortality or severe complications(level IV)were *** LLH has the potential to become a novel,standardized approach that can effectively,safely,and simply expose the middle hepatic vein and meet the requirements of precision surgery.

关键词： Laparoscopic left hemihepatectomy Indocyanine green Cranial-dorsal approach Laparoscopic hepatectomy Arantius ligament Glissonean pedicle

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Effect of endometrial thickness on the risk of ectopic pregnancy for frozen embryo transfer

引用

Reproductive and Developmental Medicine 2024年第2期8卷 75-81页

作者： Li-Juan Huang Qu Zheng Xue-Jiao wang Zhao-Hui Zhong Li-Juan Fu Xing-Yu Lv Li-Hong geng Xiao-Jun Tang Yu-Bin Ding Qi wan Department of Obstetrics and Gynecology Women and Children’s Hospital of Chongqing Medical UniversityChongqing 401147China School of Public Health Joint International Research Laboratory of Reproduction and Development of the Ministry of Education of ChinaChongqing 400016China The Reproductive Center Chengdu Xinan Gynecology HospitalChengdu 610011China School of Public Health Research Center for Medical and Social DevelopmentChongqing Medical UniversityChongqing 400016China Department of Pharmacology Academician WorkstationChangsha Medical UniversityChangsha 410119China Department of Obstetrics and Gynecology West China Second HospitalSichuan UniversityChengdu 610041China

Objective:Few studies have explored the suitability of endometrial thickness(EMT)as a predictor of ectopic pregnancy(EP)in frozen embryo transfer(FET)*** study aimed to investigate the association between EMT and EP and explore the cutoff value of EMT to predict ***:This retrospective cohort study included women aged 20-45 years undergoing FET between March 2015 and September *** primary outcomes and measured variables were EP and EMT,*** threshold effect of EMT on EP was calculated based on a constructed smooth curve *** patients were divided into two groups based on the threshold for comparison.A subgroup analysis was conducted to examine whether the relationship between EMT and EP remained consistent across the different ***,a generalized linear model was used to analyze the interactions between the treatment factors and EMT in ***:In total,27,549 FET cycles were included,with 27,086 intrauterine and 463 ectopic *** risk of EP in the EMT≤8.7 mm group was 3.36 times higher than that in the EMT>8.7 mm group(odds ratio[OR]:3.36,95%confidence interval[CI]:2.57-4.05).Subgroup analysis further indicated that a thin EMT was a risk factor for EP,independent of other *** also noted that diminished ovarian reserve,tubal factor infertility,transfer of two embryos,or transfer of cleavage-stage embryos may further enhance the risk of EP in patients with thin ***:Thin endometrium was associated with an increased risk of *** with EMT less than 8.7 mm need close medical observation and management after embryo *** addition,diminished ovarian reserve,tubal factor infertility,transfer of two embryos,or transfer of cleavage-stage embryos may significantly enhance the effect of a thin endometrium on the risk of EP.

关键词： Endometrial thickness Thin endometrium Ectopic pregnancy FET cycle Risk factors

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

“场域—惯习—资本”理论视野中教师课程自主权的困境与出路

引用

教学与管理 2024年第21期 22-26页

作者：潘婉茹江苏理工学院教育学院江苏常州213001

教师的课程自主权主要体现在课程政策制定的参与和监督、课程文件的理解与执行、课程内容的实施与评价等方面。“场域—惯习—资本”理论视野中教师课程自主权存在三重困境:教师在课程政策制定场域中的位置处于“被代表”的参与状态;教... 详细信息

教师的课程自主权主要体现在课程政策制定的参与和监督、课程文件的理解与执行、课程内容的实施与评价等方面。“场域—惯习—资本”理论视野中教师课程自主权存在三重困境:教师在课程政策制定场域中的位置处于“被代表”的参与状态;教师的课程话语权形成“被领导”的惯习;教师的课程实施与评价能力匮乏。教师充分发挥课程自主权的主要路径有三:构建民主—自由—开放的课程改革场域;学校课程场域与教师课程领导惯习良性互动;淬炼文化资本,提升教师的课程实施与评价能力。

关键词：教师课程自主权布迪厄理论

来源：

维普期刊数据库

同方期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

A compact multi-pixel superconducting nanowire single-photon detector array supporting gigabit space-to-ground communications

引用

Light(Science & Applications) 2024年第2期13卷 254-266页

作者： Hao Hao Qing-Yuan Zhao Yang-Hui Huang Jie Deng Fan Yang Sai-Ying ru Zhen Liu Chao wan Hao Liu Zhi-Jian Li Hua-Bing wang Xue-Cou Tu La-Bao Zhang Xiao-Qing Jia Xing-Long Wu Jian Chen Lin Kang Pei-Heng Wu Research Institute of Superconductor Electronics(RISE) School of Electronic Science and EngineeringNanjing UniversityNanjingJiangsu 210023China Purple Mountain Laboratories NanjingJiangsu 211111China Hefei National Laboratory HefeiAnhui 230088China National Laboratory of Solid State Microstructures and Department of Physics Nanjing UniversityNanjing 210023China

Classical and quantum space-to-ground communications necessitate highly sensitive receivers capable of extracting information from modulated photons to extend the communication distance from near-earth orbits to deep space *** achieve gigabit data rates while mitigating strong background noise photons and beam drift in a highly attenuated free-space channel,a comprehensive design of a multi-functional detector is *** this study,we present an innovative compact multi-pixel superconducting nanowire single-photon detector array that integrates near-unity detection efficiency(91.6%),high photon counting rate(1.61 Gcps),large dynamic range for resolving different photon numbers(1-24),and four-quadrant position sensing function all within one ***,we have constructed a communication testbed to validate the advantages offered by such an *** 8-PPM(pulse position modulation)format communication experiments,we have achieved an impressive maximum data rate of 1.5 Gbps,demonstrating sensitivities surpassing previous benchmarks at respective *** incorporating photon number information into error correction codes,the receiver can tolerate maximum background noise levels equivalent to 0.8 photons/slot at a data rate of 120 Mbps—showcasing a great potential for daylight operation ***,preliminary beam tracking tests were conducted through open-loop scanning techniques,which revealed clear quantitative dependence indicating sensitivity variations based on beam *** on the device characterizations and communication results,we anticipate that this device architecture,along with its corresponding signal processing and coding techniques,will be applicable in future space-to-ground communication tasks.

关键词： photon supporting correction

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Multi-layer network embedding on scc-based network with motif

引用

Digital Communications and Networks 2024年第3期10卷 546-556页

作者： Lu Sun Xiaona Li Mingyue Zhang Liangtian wan Yun Lin Xianpeng wang Gang Xu Department of Communication Engineering Institute of Information Science TechnologyDalian Maritime UniversityDalian116026China Key Laboratory of Big Data Intelligent Computing Chongqing University of Posts and TelecommunicationsChongqing400065China Key Laboratory for Ubiquitous Network and Service Software of Liaoning Province DUT School of Software Technology&DUT-RU International School of Information Science and EngineeringDalian University of TechnologyDalian 116620China College of Information and Communication Engineering Harbin Engineering UniversityHarbin 150001China School of Information and Communication Engineering Hainan UniversityHaikou 570228China State Key Laboratory of Millimeter Waves School of Information Science and EngineeringSoutheast UniversityNanjing 210096China

Interconnection of all things challenges the traditional communication methods,and Semantic Communication and Computing(SCC)will become new *** is a challenging task to accurately detect,extract,and represent semantic information in the research of SCC-based *** previous research,researchers usually use convolution to extract the feature information of a graph and perform the corresponding task of node ***,the content of semantic information is quite *** graph convolutional neural networks provide an effective solution for node classification tasks,due to their limitations in representing multiple relational patterns and not recognizing and analyzing higher-order local structures,the extracted feature information is subject to varying degrees of ***,this paper extends from a single-layer topology network to a multi-layer heterogeneous topology *** Bidirectional Encoder Representations from Transformers(BERT)training word vector is introduced to extract the semantic features in the network,and the existing graph neural network is improved by combining the higher-order local feature module of the network model representation network.A multi-layer network embedding algorithm on SCC-based networks with motifs is proposed to complete the task of end-to-end node *** verify the effectiveness of the algorithm on a real multi-layer heterogeneous network.

关键词： Semantic communication and computing Multi-layer network Graph neural network Motif

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：