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LINC01268 promotes epithelial-mesenchymal transition,invasion and metastasis of gastric cancer via the PI3K/Akt signaling pathway and targeting MARCKS

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World Journal of Gastrointestinal Oncology 2023年第8期15卷 1366-1383页

作者： Ling-Han Tang Peng-Cheng Ye Lin Yao Ya-Jun Luo wang Tan wan-ping xiang Zi-Lin Liu Ling Tan Jiang-Wei Xiao Department of Gastrointestinal Surgery Clinical Medical College and the First Affiliated Hospital of Chengdu Medical CollegeChengdu 610000Sichuan ProvinceChina Department of Gastrointestinal Surgery The Affiliated Hospital of North Sichuan Medical CollegeNanchong 637000Sichuan ProvinceChina Department of Gastrointestinal Surgery Sichuan Cancer HospitalChengdu 610000Sichuan ProvinceChina Department of Gastrointestinal Surgery Yaan People’s HospitalYaan 625000Sichuan ProvinceChina Department of Thoracic Surgery The Affiliated Hospital of North Sichuan Medical CollegeNanchong 637000Sichuan ProvinceChina Department of Surgery People’s Hospital Affiliated to Chongqing Three Gorges Medical CollegeChongqing 404041China

BACKGROUND Long non-coding RNAs(lncRNAs)with differential expression characteristics have been found to be closely related to the tumorigenesis and development of gastric cancer(GC),but their specific mechanisms and roles still need to be further *** To investigate the expression of LINC01268 in GC and its mechanism of affecting GC *** Real-time quantitative polymerase chain reaction was used to detect the expression of LINC01268 in GC tissues,cell lines and *** Kaplan-Meier method was used to evaluate the value of LINC01268 in the prognostication of GC *** receiver operating characteristic curve was constructed to evaluate the value of LINC01268 in the diagnosis of *** migration and invasion assays and wound healing assays were used to confirm the effect of LINC01268 on the invasion and migration of GC *** regulatory relationship between LINC01268 and myristoylated alanine rich protein kinase C substrate(MARCKS),the PI3K/Akt signaling pathway,and the epithelial-mesenchymal transition(EMT)process in GC was demonstrated by western blot *** The expression of LINC01268 was increased in GC tissues and cell *** expression level of LINC01268 was significantly correlated with lymph node metastasis,TNM stage,and tumor differentiation in patients with ***-expression of LINC01268 indicated a poor prognosis for patients with GC,and it had a certain auxiliary diagnostic value for *** vitro functional experiments proved that the abnormal expression of LINC01268 further activated the PI3K/Akt signaling pathway and promoted EMT by targeting and regulating MARCKS and ultimately promoted the invasion and metastasis of *** This study elucidates that LINC01268 in GC may be an oncogene that further activates the PI3K/Akt signaling pathway and EMT by targeting and regulating MARCKS,and ultimately promotes the invasion and metastasis of ***01268 may be a potential effective target for the trea

关键词： Gastric cancer Long non-coding RNA LINC01268 Myristoylated alanine rich protein kinase C substrate Invasion Metastasis

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Decreased expression of the long non-coding RNA HOXD-AS2 promotes gastric cancer progression by targeting HOXD8 and activating PI3K/Akt signaling pathway

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World Journal of Gastrointestinal Oncology 2020年第11期12卷 1237-1254页

作者： Lin Yao Peng-Cheng Ye wang Tan Ya-Jun Luo wan-ping xiang Zi-Lin Liu Zhi-Ming Fu Fei Lu Ling-Han Tang Jiang-Wei Xiao Department of Gastrointestinal Surgery Clinical Medical College and The First Affiliated Hospital of Chengdu Medical CollegeChengdu 610000Sichuan ProvinceChina The Hepatobiliary Research Institute North Sichuan Medical CollegeNanchong 637000Sichuan ProvinceChina Department of Gastrointestinal Surgery The Affiliated Hospital of North Sichuan Medical CollegeThe Hepatobiliary Research InstituteNorth Sichuan Medical CollegeNanchong 637000Sichuan ProvinceChina Department of Gastrointestinal Surgery Yaan People’s HospitalYaan 625000Sichuan ProvinceChina Department of Gastrointestinal Surgery The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400010China Department of Thoracic Surgery Nanchong Central HospitalNanchong 637000Sichuan ProvinceChina

BACKGROUND Long non-coding RNAs(lncRNAs) have been shown to be associated with many tumors. However, the specific mechanism of lncRNAs in the occurrence and development of gastric cancer(GC) has not been fully *** To explore the expression level and molecular mechanism of HOXD-AS2 in GC tissues and cells, and analyze its significance in the prognosis of *** Real-time quantitative PCR was used to detect the expression of HOXD-AS2 in 79 pairs of GC tissues and five cell lines. The pc HOXD-AS2 plasmid vector was constructed and transfected into SGC-7901 and SNU-1 GC cells. Matrigel Transwell and wound healing assays were used to confirm the effect of HOXDAS2 on invasion and migration of GC cells. Cell counting kit-8 assay and flow cytometry were used to verify the effect of HOXD-AS2 on the proliferation, cell cycle, and apoptosis of GC cells. The relevant regulatory mechanism between HOXD-AS2 and HOXD8 and PI3K/Akt signaling pathway was verified by Western blot *** The low expression of lncRNA HOXD-AS2 was associated with lymph node metastasis and tumor-node-metastasis stage in GC. In vitro functional experiments demonstrated that overexpression of HOXD-AS2 inhibited GC cell progression. Mechanistic studies revealed that HOXD-AS2 regulated the expression of its nearby gene HOXD8 and inhibited the activity of the PI3K/Akt signaling *** These results indicate that downregulation of HOXD-AS2 significantly promotes the progression of GC cells by regulating HOXD8 expression and activating the PI3K/Akt signaling pathway. HOXD-AS2 may be a novel diagnostic biomarker and effective therapeutic target for GC.

关键词： Long non-coding RNA Gastric cancer HOXD-AS2 HOXD8 PI3K/Akt Progression

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On the Initial Layer and the Limit Behavior for Chemotaxis System with the Effect of Fluid in Fourier Space

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Acta Mathematicae Applicatae Sinica 2024年第4期40卷 1015-1024页

作者： Jian-xiang wan Hai-ping ZHONG Department of Mathematics Jiangxi University of Finance and EconomicsNanchang 330032China School of Mathematics and Computer Yuzhang Normal UniversityNanchang 330103China

The paper deals with a Cauchy problem for the chemotaxis system with the effect of fluid■where d≥*** is known that for each∈>0 and all sufficiently small initial data(u_(0),n_(0),c_(0))belongs to certain Fourier space,the problem possesses a unique global solution(u^(∈),n^(∈),c^(∈))in Fourier *** present work asserts that these solutions stabilize to(u^(∞),n^(∞),c^(∞))as∈^(-1)→***,we show that c^(∈)(t)has the initial layer as∈^(-1)→*** one expects its limit behavior maybe give a new viewlook to understand the system.

关键词： chemotaxis system initial layer limit behavior Fourier space

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Exact Solution for Jaynes-Cummings Model with Bosonic Field Nonlinearity and Strong Boson-Fermion Coupling

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Communications in Theoretical Physics 2006年第1期45卷 143-146页

作者： YANG Jin YU wan-Lun xiang An-ping Department of Optics and Electronics Chengdu University of Information Technology~ Chengdu 610225 China

We use Lewis Riesenfeld invariant approach to treat the modified Jaynes-Cummings models involving any forms of nonlinearty of the bosonic field when strong boson-fermion couplings are nilpotent Grassmann valued. The general state functions, time evolution operator and the time-evolution expressions for both the bosonic number and the fermionic number are presented.

关键词： nonlinear Jaynes-Cummings model invariant method exact solution

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早期玻璃体切除治疗白内障术后感染性眼内炎

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临床医学 2013年第6期33卷 51-53页

作者：万平祥李伟张丽丽朱炎华湖北省石首市人民医院眼科石首434400 长江大学附属第一医院眼科

目的探讨早期玻璃体切除手术治疗白内障术后眼内炎的临床疗效。方法分析石首市人民医院2006年1月至2012年12月白内障手术后感染性眼内炎行玻璃体切除手术者12例的临床资料,将发病后3 d内行玻璃体手术的患者与3 d后手术患者进行比较。结... 详细信息

目的探讨早期玻璃体切除手术治疗白内障术后眼内炎的临床疗效。方法分析石首市人民医院2006年1月至2012年12月白内障手术后感染性眼内炎行玻璃体切除手术者12例的临床资料,将发病后3 d内行玻璃体手术的患者与3 d后手术患者进行比较。结果所有发病后3 d内行玻璃体切除者术后视力均好于术后第2天视力,无一例患者需玻璃体腔填充硅油,3 d后行玻璃体手术者均需玻璃体填充硅油,术后最佳矫正视力均低于术后第2天视力。结论白内障术后眼内眼一旦确诊,在玻璃体腔注药无效时应马上行玻璃体切除手术,可以最大限度保留患者的视力。

关键词：感染性眼内炎玻璃体切除术

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BIFURCATION AND SPATIOTEMPORAL PATTERNS IN A HOMOGENEOUS DIFFUSION-COMPETITION SYSTEM WITH DELAYS

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International Journal of Biomathematics 2012年第6期5卷 19-41页

作者： JIA-FANG ZHANG wan-TONG LI xiang-ping YAN School of Mathematics and Information Sciences Henan University Kaifeng Henan 575001 P. R. China School of Mathematics and StatisticsLanzhou University Lanzhou Gansu 730000 P. R. China Department of MathematicsLanzhou Jiaotong University Lanzhou Gansu 730070 P. R. China

A competitive LotkaVolterra reactiondiffusion system with two delays subject to Neumann boundary conditions is considered. It is well known that the positive con stant steady state of the system is globally asymptotically stable if the interspecies competition is weaker than the intraspecies one and is unstable if the interspecies com petition dominates over the intraspecies one. If the latter holds, then we show that Hopf bifurcation can occur as the parameters （delays） in the system cross some critical val ues. In particular, we prove that these Hopf bifurcations are all spatially homogeneous if the diffusive rates are suitably large, which has the same properties as Hopf bifur cation of the corresponding delayed system without diffusion. However, if the diffusive rates are suitably small, then the system generates the spatially nonhomogeneous Hopf bifurcation. Furthermore, we derive conditions for determining the direction of spatially nonhomogeneous Hopf bifurcations and the stability of bifurcating periodic solutions. These results indicate that the diffusion plays an important role for deriving the complex spatiotemporal dynamics.

关键词： LotKa-Volterra competition system time delay spatial diffusion Hopf bifur-cation periodic solution.

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四川转变农业发展方式中农业研发创新驱动研究

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农业科技管理 2017年第2期36卷 3-6页

作者：唐江云李晓杜兴端万志玲向平四川省农业科学院农业信息与农村经济研究所成都610066

科技创新是驱动农业发展的主要动力,依靠科技进步转变农业生产方式,驱动研发创新、内生增长成为现代化农业发展的新趋势。文章阐述了四川农业科技研发现状,分析了制约四川农业研发创新驱动的因素,提出驱动发展新型研发机构、驱动发展"... 详细信息

科技创新是驱动农业发展的主要动力,依靠科技进步转变农业生产方式,驱动研发创新、内生增长成为现代化农业发展的新趋势。文章阐述了四川农业科技研发现状,分析了制约四川农业研发创新驱动的因素,提出驱动发展新型研发机构、驱动发展"拓展与参与"的管理体制、以市场需求驱动农业研发等提升科技研发创新驱动能力的措施,以期为四川农业深入实施创新驱动战略、推进农业科技创新工程建设奠定理论基础。

关键词：四川农业研发创新驱动制约因素措施

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The utility of two-dimensional shear wave elastography and texture analysis for monitoring liver fibrosis in rat model

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Hepatobiliary & Pancreatic Diseases International 2021年第1期20卷 46-52页

作者： Li-Hong Gu Guang-xiang Gu ping wan Feng-Hua Li Qiang Xia Department of Liver Surgery Renji HospitalSchool of MedicineShanghai Jiaotong UniversityShanghai 200127China Department of Ultrasound Renji HospitalSchool of MedicineShanghai Jiaotong UniversityShanghai 200127China

Background:Liver fibrosis is a common pathological change caused by a variety of *** diagnosis and timely treatment can reverse or delay disease progression and improve the *** study aimed to assess the potential utility of two-dimensional shear wave elastography and texture analysis in dynamic monitoring of the progression of liver fibrosis in rat ***:Twenty rats were divided into control group(n=4)and experimental groups(n=4 per group)with carbon tetrachloride administration for 2,3,4,and 6 *** liver stiffness measurement was performed by two-dimensional shear wave elastography,while the optimal texture analysis subsets to distinguish fibrosis stage were generated by *** results of elastography and texture analysis were validated through comparing with ***:Liver stiffness measurement was 6.09±0.31 kPa in the control group and 7.10±0.41 kPa,7.80±0.93 kPa,8.64±0.93 kPa,9.91±1.13 kPa in the carbon tetrachloride induced groups for 2,3,4,6 weeks,respectively(P<0.05).By texture analysis,histogram and co-occurrence matrix had the most frequency texture parameters in staging liver *** operating characteristic curve of liver elasticity showed that the sensitivity and specificity were 95.0%and 92.5%to discriminate liver fibrosis and non-fibrosis,*** texture analysis,five optimal parameters were selected to classify liver fibrosis and ***:Two-dimensional shear wave elastography showed potential applications for noninvasive monitoring of the progression of hepatic fibrosis,even in mild *** analysis can further extract and quantify the texture features in ultrasonic image,which was a supplementary to further visual information and acquired high diagnostic accuracy for severe fibrosis.

关键词： Shear wave elastography Ultrasound Texture analysis Fibrosis Rat

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Efficient Slew-Rate Enhanced Operational Transconductance Amplifier

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Journal of Electronic Science and Technology 2015年第1期13卷 14-19页

作者： Xiao-Peng wan Fei-xiang Zhang Shao-Wei Zhen Ya-Juan He ping Luo School of Microelectronics and Solid-State Electronics University of Electronic Science and Technology of China

Today, along with the prevalent use of portable equipment, wireless, and other battery powered systems, the demand for amplifiers with a high gain-bandwidth product（GBW）, slew rate（SR）, and at the same time very low static power dissipation is growing. In this work, an operational transconductance amplifier（OTA） with an enhanced SR is proposed. By inserting a sensing resistor in the input port of the current mirror in the OTA, the voltage drop across the resistor is converted into an output current containing a term in proportion to the square of the voltage, and then the SR of the proposed OTA is significantly enhanced and the current dissipation can be reduced. The proposed OTA is designed and simulated with a 0.5μm complementary metal oxide semiconductor（CMOS） process. The simulation results show that the SR is 4.54V/μs, increased by 8.25 times than that of the conventional design, while the current dissipation is only 87.3%.

关键词： Efficient gain-bandwidth product operational transconductance amplifier slew rate

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Key Technology of Embedded System Implementation for Software-based CNC System

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Chinese Journal of Mechanical Engineering 2010年第2期23卷 217-224页

作者： wan Jiafu LI Di ZHANG ping College of Computer Science and Engineering South China University of Technology Guangzhou 510006 China School of Mechanical and Automotive Engineering South China University of Technology Guangzhou 510640 China Department of Computer Guangdong College of Mechanical and Electrical Technology Guangzhou 510515 China

The software-based computer numerical control（CNC） system includes three types of tasks： periodic real-time tasks, aperiodic real-time tasks, and non-real-time tasks. The tasks are characterized by concurrency, hybridization, and correlation, which make system implementation difficult. The conventional scheduling algorithm can not meet the demands of system implementation in the software-based CNC system completely. The uncertainty factors when running real-time tasks affect control performance by degrading manufacturing accuracy as a result of system resource and processor use restrictions. To address the technical difficulty of embedded system implementation, a novel fuzzy feedback scheduling algorithm based on output jitter of key real-time tasks for a software-based CNC system is proposed. Time characteristics, such as sampling jitter, input-output jitter, and non-schedulability are discussed, followed by quantification through simulations of the impact of time characteristics on manufacturing accuracy. On the basis of this research, the scheduler architecture is designed, and then the algorithm table is calculated. When the system resource changes, the key periodic real-time tasks meet their deadlines by means of dynamically adjusting the task period. The simulated results show that the machining precision rises by an order of magnitude for the proposed scheduler in resource-constrained software-based CNC systems. Moreover, unlike conventional feedback scheduling methods, the algorithm in this paper does not rely on the availability of task execution times and is easy to implement while incurring only a small overhead.

关键词： software-based CNC system embedded system implementation output jitter fuzzy feedback scheduling manufacturing accuracy

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