The utility of two-dimensional shear wave elastography and texture analysis for monitoring liver fibrosis in rat model

作     者：Li-Hong Gu Guang-Xiang Gu Ping Wan Feng-Hua Li Qiang Xia Li-Hong Gu;Guang-Xiang Gu;Ping Wan;Feng-Hua Li;Qiang Xia

作者机构：Department of Liver SurgeryRenji HospitalSchool of MedicineShanghai Jiaotong UniversityShanghai 200127China Department of UltrasoundRenji HospitalSchool of MedicineShanghai Jiaotong UniversityShanghai 200127China 

出 版 物：《Hepatobiliary & Pancreatic Diseases International》 (国际肝胆胰疾病杂志（英文版）)

年 卷 期：2021年第20卷第1期

页      面：46-52页

核心收录：

学科分类：0831[工学-生物医学工程（可授工学、理学、医学学位）] 100207[医学-影像医学与核医学] 1002[医学-临床医学] 08[工学] 1010[医学-医学技术（可授医学、理学学位）] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：the National Natural Science Foundation of China(81900594) Clinical Research Plan of Shanghai Hospital Development Center(Grant 16CR3109B) Shanghai Youth Sci&Tech Talent Jump starting Program(18YF1412700) 

主　　题：Shear wave elastography Ultrasound Texture analysis Fibrosis Rat 

摘      要：Background:Liver fibrosis is a common pathological change caused by a variety of *** diagnosis and timely treatment can reverse or delay disease progression and improve the *** study aimed to assess the potential utility of two-dimensional shear wave elastography and texture analysis in dynamic monitoring of the progression of liver fibrosis in rat ***:Twenty rats were divided into control group(n=4)and experimental groups(n=4 per group)with carbon tetrachloride administration for 2,3,4,and 6 *** liver stiffness measurement was performed by two-dimensional shear wave elastography,while the optimal texture analysis subsets to distinguish fibrosis stage were generated by *** results of elastography and texture analysis were validated through comparing with ***:Liver stiffness measurement was 6.09±0.31 kPa in the control group and 7.10±0.41 kPa,7.80±0.93 kPa,8.64±0.93 kPa,9.91±1.13 kPa in the carbon tetrachloride induced groups for 2,3,4,6 weeks,respectively(P0.05).By texture analysis,histogram and co-occurrence matrix had the most frequency texture parameters in staging liver *** operating characteristic curve of liver elasticity showed that the sensitivity and specificity were 95.0%and 92.5%to discriminate liver fibrosis and non-fibrosis,*** texture analysis,five optimal parameters were selected to classify liver fibrosis and ***:Two-dimensional shear wave elastography showed potential applications for noninvasive monitoring of the progression of hepatic fibrosis,even in mild *** analysis can further extract and quantify the texture features in ultrasonic image,which was a supplementary to further visual information and acquired high diagnostic accuracy for severe fibrosis.