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红细胞分布宽度对急性脑梗死患者预后的临床意义

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中国现代医学杂志 2019年第11期29卷 94-98页

作者：潘晓帆秦琳周其达郭强董万利苏州大学附属第一医院神经内科江苏苏州215006 东南大学附属中大医院无锡分院神经内科江苏无锡214105 苏州大学附属第一医院重症医学科江苏苏州215006

目的通过美国国立卫生研究院卒中量表(NIHSS)和日常生活活动(ADL)评估,比较分析基质金属蛋白酶-9(MMP-9)、同型半胱氨酸(Hcy)水平及出血转化(HT)、多器官功能障碍综合征(MODS)发生率,探讨红细胞分布宽度(RDW)对急性脑梗死(ACI)患者预后... 详细信息

目的通过美国国立卫生研究院卒中量表(NIHSS)和日常生活活动(ADL)评估,比较分析基质金属蛋白酶-9(MMP-9)、同型半胱氨酸(Hcy)水平及出血转化(HT)、多器官功能障碍综合征(MODS)发生率,探讨红细胞分布宽度(RDW)对急性脑梗死(ACI)患者预后水平以及并发症发生的影响。方法回顾性分析2015年2月-2018年3月初次就诊于东南大学附属中大医院无锡分院ACI患者267例,根据RDW区分为较高组78例(RDW>15%),较低组189例(RDW≤15%),同时设立对照组,即健康人群30例。检测血清中MMP-9、Hcy及高敏C反应蛋白(hs-CRP)水平,同时评估出院时患者NIHSS、ADL评分,再统计患者当中HT以及MODS的发生率,将RDW不同水平与上述事件进行对比分析。结果相比健康人群,ACI患者血清中RDW、Hcy、MMP-9及hs-CRP水平较高(P <0.05);将RDW不同水平组进行比较,发现RDW水平较高组的MMP-9、Hcy及hs-CRP水平均较高(P<0.05),与此同时,HT发生率也高于RDW水平较低组(P <0.05);出院时将两组患者NIHSS和ADL进行评估,发现RDW水平较低组患者预后更好(P <0.05)。结论 ACI患者血清RDW水平较高;ACI患者中,RDW水平越高,MMP-9、Hcy及hsCRP水平也越高,同时HT的发生率也越高,预后更差。

关键词：急性脑梗死/脑梗塞多器官功能障碍综合征红细胞分布宽度出血转化预后

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矩阵与线性变换几何意义的教学探索

高师理科学刊 2018年第7期38卷 61-64页

作者：吴明月李万东汪波曹富军内蒙古科技大学理学院内蒙古包头014010

通过几何图形对矩阵与线性代数中的一些抽象概念进行了详细的描述和几何解释,几何图形能够以其生动直观的表达与阐释给学生留下深刻的印象.从而可以帮助学生建立对线性代数具体形象的理解,使其从根本上理解矩阵的概念及其几何意义.旨在... 详细信息

通过几何图形对矩阵与线性代数中的一些抽象概念进行了详细的描述和几何解释,几何图形能够以其生动直观的表达与阐释给学生留下深刻的印象.从而可以帮助学生建立对线性代数具体形象的理解,使其从根本上理解矩阵的概念及其几何意义.旨在激发学生的兴趣,提高教学效果,帮助学生能够应用所学知识解决实际问题.

关键词：矩阵线性代数特征值与特征向量几何意义

A micelle-based stage-by-stage impelled system for efficient doxorubicin delivery

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Bioactive Materials 2023年第7期25卷 783-795页

作者： Sunfan li Fangzhou li dong wan Zuqin Chen Jie Pan Xing-Jie liang School of Chemical Engineering and Technology Tiangong UniversityTianjin300387PR China CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety CAS Center for Excellence in NanoscienceNational Center for Nanoscience and Technology of ChinaNo.11First North RoadZhongguancunBeijing100190PR China University of Chinese Academy of Sciences Beijing100049PR China Medical School of Chinese PLA No.28 Fuxing RoadBeijing100853PR China Department of Radiology The First Medical CentreChinese PLA General HospitalBeijingPR China Department of Radiology Chinese PAP Guangxi Corps HospitalNanningGuangxiPR China

Chemotherapy remains the mainstay of cancer treatment,benefiting millions of patients each year,but the side effects of chemotherapy drugs severely limit their clinical ***(DOX)can cause various side effects such as heart damage and treatment-related *** effective use of active and passive targeting will improve the clinical application of ***,TPGS3350 and bioactive peptides were utilized to construct a micelle-based stage-by-stage impelled efficient system(missiles)for DOX delivery(DOX missiles).By taking advantage of the EPR effect,DOX missiles are efficiently enriched at the tumor *** being cleaved by matrix metalloproteinase2(MMP2),the peptide(VRGD)targets tumor cells to facilitate uptake of the missiles by the tumor cells via receptor-mediated *** intracellular activated caspase-3-catalyzed explosion of DOX missiles further enables efficient tumor *** study provides an efficient approach for DOX delivery and toxicity reduction.

关键词： Doxorubicin Delivery Peptide Missiles Chemotherapy

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羊草不同组织实时定量PCR内参基因的筛选

草业科学 2017年第7期34卷 1434-1441页

作者：胡宁宁郭慧琴李西良孔令琪武自念张继泽常春万东莉臧辉任卫波中国农业科学院草原研究所内蒙古呼和浩特010010 中国农业科学院研究生院北京100081 内蒙古农业大学生命科学学院内蒙古呼和浩特010018

为筛选羊草(Leymus chinensis)不同组织实时定量PCR(qRT-PCR)试验体系中的最佳内参基因,以羊草叶、茎、根、穗为研究材料,利用qRT-PCR技术分析TUA、TUB、18SrRNA、EF-1α、APRT、CYP、Actin和CBP20共8个常用候选管家基因的表达情况,并使... 详细信息

为筛选羊草(Leymus chinensis)不同组织实时定量PCR(qRT-PCR)试验体系中的最佳内参基因,以羊草叶、茎、根、穗为研究材料,利用qRT-PCR技术分析TUA、TUB、18SrRNA、EF-1α、APRT、CYP、Actin和CBP20共8个常用候选管家基因的表达情况,并使用geNorm和NormFinder软件进行综合评价,以期筛选出羊草不同组织中最稳定的内参基因。结果表明,8个候选内参基因在羊草不同组织表达稳定性不同,其中,叶片中稳定性较高的内参基因是Actin;茎中稳定性较高的内参基因是EF-1a;根中稳定性较高的内参基因是APRT和18SrRNA;穗中稳定性较高的内参基因是TUB。本研究结果将为开展羊草功能基因的表达分析提供重要参考。

关键词：羊草 qRT—PCR 内参基因组织

Effect and mechanism of siderite on reverse flotation of hematite

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International Journal of Minerals,Metallurgy and Materials 2016年第4期23卷 373-379页

作者： wan-zhong Yin dong li Xi-mei Luo Jin Yao Qian-yu Sun College of Resources and Civil Engineering Northeastern University College of Zijin Mining Fuzhou University Faculty of Land Resource Engineering Kunming University of Science and Technology

The effects of siderite on reverse flotation of hematite were investigated using micro flotation, adsorption tests, and Fourier transform infrared spectroscopy. The flotation results show that interactions between siderite and quartz are the main reasons that siderite significantly influences the floatability. The interactions are attributed to dissolved siderite species and fine siderite particles. The interaction due to the dissolved species is, however, dominant. Derjaguin-Landau-Verwey-Overbeek（DLVO） theoretical calculations reveal that adhesion on quartz increases when the siderite particle size decreases and that fine particles partly influence quartz floatability. Chemical solution calculations indicate that the dissolved species of siderite might convert the surface of active quartz to CaCO_3 precipitates that can be depressed by starch. The theoretical calculations are in good agreement with the results of adsorption tests and FTIR spectroscopy and explain the reasons why siderite significantly influences reverse flotation of hematite.

关键词： hematite siderite reverse flotation solution chemistry

Experimental investigation of early assessment of corpora cavernosa fibrosis with two-dimensional shear wave elastography

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Asian Journal of Andrology 2022年第2期24卷 207-212页

作者： li Yu wan-Ting Rao Jing-dong Tang Jin-Fang Xing Department of Special Inspection Shanghai Shibei Hospital of Jing’an DistrictShanghai 200435China Department of Medical Ultrasound Fudan University Pudong Medical CenterShanghai 201399China Shanghai Key Laboratory of Vascular Lesions Regulation and Remodeling Fudan University Pudong Medical CenterShanghai 201399China

This study explored the usefulness of two-dimensional shear wave elastography(2D-SWE)in the early assessment of corpora cavernosa fibrosis(CCF).New Zealand male rabbits were randomly assigned to an experimental group or a control *** human transforming growth factor beta 1(TGF-β1)was injected into the dorsal penis tissue of rabbits in the experimental *** ultrasound and 2D-SWE examinations were performed before and 20 days after *** histological analysis was performed by hematoxylin–eosin staining,sirius red staining,and *** of 2D-SWE examination results was performed using shear wave elastography quantitative measurement(SWQ).Histological analysis outcomes were the proportion of smooth muscle cells(SMCs),collagen fibers(CFs),collagen type I(Col I),and collagen type III(Col III),as well as the SMCs/CFs ratio,measured by sirius red *** histological analysis outcomes were the positive area proportion(PAP)of TGF-β1(PAPT),fibronectin(PAPF),and Col III(PAPC),measured by *** recombinant human TGF-β1 injection,SWQ was higher in the experimental group than that in the control group(P<0.001);however,there were no differences in conventional ultrasound *** were significant differences in histological outcomes between the two groups(all P<0.05).These results indicated that 2D-SWE was superior for identifying early histological changes in CCF.

关键词： collagen type I collagen type III elastography penis smooth muscle cells

Contribution of aboveground litter to soil respiration in Populus davidiana Dode plantations at different stand ages

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Journal of Mountain Science 2016年第6期13卷 1000-1012页

作者： ZHAO Xin li Fa-dong ZHANG wan-jun AI Zhi-pin Key Laboratory of Ecosystem Network Observation and Modeling Institute of Geographic Sciences and Natural Resources Research Chinese Academy of Sciences Beijing 100101 China University of Chinese Academy of Sciences Beijing 100049 China Key Laboratory of Agricultural Water Resources Hebei key Laboratory of Agricultural Water-saving Center for Agricultural Resources Research Institute of Genetics and Developmental Biology Chinese Academy of Sciences Shijiazhuang 050021 China

Soil respiration from decomposing aboveground litter is a major component of the terrestrial carbon cycle. However, variations in the contribution of aboveground litter to the total soil respiration for stands of varying ages are poorly understood. To assess soil respiration induced by aboveground litter, treatments of litter and no litter were applied to 5-, l0-, and 20-year-old stands of Populus davidiana Dode in the sandstorm source area of Beijing-Tianjin, equations were applied to China. Optimal nonlinear model the combined effects of soil temperature and soil water content on soil respiration. Results showed that the monthly average contribution of aboveground litter to total soil respiration were 18.46% ± 4.63%, 16.64% ± 9.31%, and 22.37% ± 8.17% for 5-, 10-, and ao-year-old stands, respectively. The relatively high contribution in 5- and 20-year-old stands could be attributed to easily decomposition products and high accumulated litter, resoectivelv. Also. it fluctuated monthly for all stand ages due to substrate availability caused by phenology and environmental factors. litter removal significantly decreased soil respiration and soil water content for all stand ages （P 〈 0.05） but not soil temperature （P 〉 0.05）. Variations of soil respiration could be explained by soil temperature at 5-cm depth using an exponential equation and by soil water content at lo-cm depth using a quadratic equation, whereas soil respiration was better modeled using the combined parameters of soil temperature and soil water content than with either soil temperature or soil water content alone. Temperature sensitivity （Q10） increased with stand age in both the litter and the no litter treatments. Considering the effects of aboveground litter, this study provides insights for predicting future soil carbon fluxes and for accurately assessing soil carbon budgets.

关键词： Aboveground litter Nonlinear equation Populus davidiana Dode Soil respiration Temperature sensitivity

一株沙棘果酵母菌株的分子鉴定及发酵特性研究

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酿酒科技 2009年第4期 51-53页

作者：段开红田瑞华万永青万东莉赵宏军内蒙古农业大学内蒙古呼和浩特010018

从天然沙棘果上成功分离到一株耐酸能力强、发酵力较高、凝聚性适中的酵母菌,命名为FB1#-2006。通过对酵母菌26S rDNAD1/D2区域序列比对和分析鉴定,菌株FB1#-2006属于Hanseniaspora uvarum种。该菌株可以直接利用沙棘果为原料,发酵生产... 详细信息

从天然沙棘果上成功分离到一株耐酸能力强、发酵力较高、凝聚性适中的酵母菌,命名为FB1#-2006。通过对酵母菌26S rDNAD1/D2区域序列比对和分析鉴定,菌株FB1#-2006属于Hanseniaspora uvarum种。该菌株可以直接利用沙棘果为原料,发酵生产特色沙棘果酒。

关键词：微生物酵母菌沙棘果发酵力鉴定果酒

Interaction of major facilitator superfamily domain containing 2A with the blood-brain barrier

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Neural Regeneration Research 2025年第8期20卷 2133-2152页

作者： Yilun Ma Taiwei dong Fei Luan Juanjuan Yang Feng Miao Peifeng Wei College of Pharmacy and First Clinical Medical College Shaanxi University of Chinese MedicineXianyangShaanxi ProvinceChina National Drug Clinical Trial Agency The Second Affiliated Hospital of Shaanxi University of Chinese Medicine/Xixian New District Central HospitalXi′anShaanxi ProvinceChina

The functional and structural integrity of the blood-brain barrier is crucial in maintaining homeostasis in the brain microenvironment;however,the molecular mechanisms underlying the formation and function of the blood-brain barrier remain poorly *** major facilitator superfamily domain containing 2A has been identified as a key regulator of blood-brain barrier *** plays a critical role in promoting and maintaining the formation and functional stability of the blood-brain barrier,in addition to the transport of lipids,such as docosahexaenoic acid,across the blood-brain ***,an increasing number of studies have suggested that major facilitator superfamily domain containing 2A is involved in the molecular mechanisms of blood-brain barrier dysfunction in a variety of neurological diseases;however,little is known regarding the mechanisms by which major facilitator superfamily domain containing 2A affects the blood-brain *** paper provides a comprehensive and systematic review of the close relationship between major facilitator superfamily domain containing 2A proteins and the blood-brain barrier,including their basic structures and functions,cross-linking between major facilitator superfamily domain containing 2A and the blood-brain barrier,and the in-depth studies on lipid transport and the regulation of blood-brain barrier *** comprehensive systematic review contributes to an in-depth understanding of the important role of major facilitator superfamily domain containing 2A proteins in maintaining the structure and function of the blood-brain barrier and the research progress to *** will not only help to elucidate the pathogenesis of neurological diseases,improve the accuracy of laboratory diagnosis,and optimize clinical treatment strategies,but it may also play an important role in prognostic *** addition,the effects of major facilitator superfamily domain containing 2A on blood-brain barrier lea

关键词： blood-brain barrier(BBB) caveolin-1 central nervous system docosahexaenoic acid endothelial cells lysophosphatidylcholine major facilitator superfamily domain containing 2A(MFSD2A) transcytosis