A micelle-based stage-by-stage impelled system for efficient doxorubicin delivery

作     者：Sunfan Li Fangzhou Li Dong Wan Zuqin Chen Jie Pan Xing-Jie Liang 

作者机构：School of Chemical Engineering and TechnologyTiangong UniversityTianjin300387PR China CAS Key Laboratory for Biomedical Effects of Nanomaterials and NanosafetyCAS Center for Excellence in NanoscienceNational Center for Nanoscience and Technology of ChinaNo.11First North RoadZhongguancunBeijing100190PR China University of Chinese Academy of SciencesBeijing100049PR China Medical School of Chinese PLANo.28 Fuxing RoadBeijing100853PR China Department of RadiologyThe First Medical CentreChinese PLA General HospitalBeijingPR China Department of RadiologyChinese PAP Guangxi Corps HospitalNanningGuangxiPR China 

出 版 物：《Bioactive Materials》 (生物活性材料（英文）)

年 卷 期：2023年第25卷第7期

页      面：783-795页

核心收录：

学科分类：0831[工学-生物医学工程（可授工学、理学、医学学位）] 1002[医学-临床医学] 0805[工学-材料科学与工程（可授工学、理学学位）] 100214[医学-肿瘤学] 10[医学] 

基　　金：This work was supported by the National Key Research and Development Program of China(grant Nos.2021YFA1201000 and 2018YFE0117800) the National Natural Science Foundation of China(NSFC)key project(grant No.32030060) the NSFC International Collaboration Key Project(grant No.51861135103) the National Natural Science Foundation of China(grant No.22078246,22178270 and 82102204) The authors also appreciate the support by“the Beijing-Tianjin-Hebei Basic Research Cooperation Project”(19JCZDJC64100) the China Postdoctoral Science Foundation funded project(grant No.2020M680478). 

主　　题：Doxorubicin Delivery Peptide Missiles Chemotherapy 

摘      要：Chemotherapy remains the mainstay of cancer treatment,benefiting millions of patients each year,but the side effects of chemotherapy drugs severely limit their clinical use.Doxorubicin(DOX)can cause various side effects such as heart damage and treatment-related tumors.The effective use of active and passive targeting will improve the clinical application of DOX.Here,TPGS3350 and bioactive peptides were utilized to construct a micelle-based stage-by-stage impelled efficient system(missiles)for DOX delivery(DOX missiles).By taking advantage of the EPR effect,DOX missiles are efficiently enriched at the tumor site.After being cleaved by matrix metalloproteinase2(MMP2),the peptide(VRGD)targets tumor cells to facilitate uptake of the missiles by the tumor cells via receptor-mediated endocytosis.The intracellular activated caspase-3-catalyzed explosion of DOX missiles further enables efficient tumor killing.This study provides an efficient approach for DOX delivery and toxicity reduction.