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Anti-inflammatory and Anti-oxidative Effects of the Ethanol Extract of Cryptocarya densiflora Blume in Lipopolysaccharide-Stimulated RAW264,7 Mouse Macrophages

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Journal of Pharmacy and Pharmacology 2014年第1期2卷 26-37页

作者： Ji-Won Park Ok-Kyoung Kwon Doo-Young Kim Jung-Hee Kim In Sik Shin Sei-Ryang Oh Sang-Woo lee Jae-Hong Kim Hang Jin wan yi lee Kyung-Seop Ahn Natural Medicine Research Center Korea Research Institute of Bioscience and Biotechnology 30 Yeongudanji-ro Ochang-eupCheongwon-gun Chungbuk 363-883 Republic of Korea College of Life Sciences and Biotechnology University of Korea Anam-dong 5-ga Seongbuk-gu Seoul 136-701 Republic ofKorea Department of Toxicology College of Pharmacy University of Chungnam National Yuseong-gu Daejeon 305-764 Republic ofKorea International Biological Material Research Center Research Institute of Bioscience and Biotechnology Yuseong-gu Daejeon305-806 Republic of Korea Yunnan Academy of Agricultural Sciences Medicinal Plants Research Institute Beijing 2238 China

CD （Cryptocarya densiflora） Blume has traditionally been used as an herbal medicine. In this study, the effects of CDEE （CD ethanol extract） on inflammation were investigated in LPS （lipopolysaccharide）-stimulated mouse RAW264.7 macrophages. We investigated the effects of CDEE on the production of NO, PGE2 interleukin （IL）-6, IL-1β, and tumor necrosis factor （TNF）-α in LPS-stimulated RAW264.7 cells. We measured the mRNA or protein expression of the pro-inflammatory mediators induced by CDEE in LPS-stimulated RAW264.7 cells. We explored the expression of Nrf-2, heme oxygenase （HO）-I and NADPH-quinone oxidoreductase （NQO）-I to elucidate the antioxidative mechanisms. CDEE significantly inhibited the production of NO, PGE2, IL-6, IL-1β and TNF-α in LPS-stimulated RAW264.7 cells. CDEE suppressed the mRNA or protein expression of iNOS, COX-2, and the MAPKs with a reduction in the translocation of NF-κB in LPS-stimulated RAW264.7 cells. In addition, CDEE significantly increased the expression of HO-I and NQO-1 with an increase in the translocation of Nrf-2 into the nucleus. These results indicate that CDEE inhibits the LPS-induced inflammatory and oxidative responses via suppression of NF-κB activation and the enhancement of Nrf2 activation. We suggest that CDEE may be therapeutic for treating inflammatory diseases.

关键词： Cryptocarya densiflora inflammation MAPK NF-κB Nrf-2.

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Aligned Ion Conduction Pathway of Polyrotaxane‑Based Electrolyte with Dispersed Hydrophobic Chains for Solid‑State Lithium–Oxygen Batteries

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Nano-Micro Letters 2025年第2期17卷 169-186页

作者： Bitgaram Kim Myeong‑Chang Sung Gwang‑Hee lee Byoungjoon Hwang Sojung Seo Ji‑Hun Seo Dong‑wan Kim Department of Materials Science and Engineering Korea University145 Anam‑RoSeongbuk‑GuSeoul 02841Republic of Korea School of Civil Environmental and Architectural EngineeringKorea University145 Anam‑RoSeongbuk‑GuSeoul 02841Republic of Korea Materials Science and Chemical Engineering Center Institute for Advanced Engineering(IAE)Yongin 17180Republic of Korea

A critical challenge hindering the practical application of lithium–oxygen batteries(LOBs)is the inevitable problems associated with liquid electrolytes,such as evaporation and safety *** study addresses these problems by proposing a modified polyrotaxane(mPR)-based solid polymer electrolyte(SPE)design that simultaneously mitigates solvent-related problems and improves ***-SPE exhibits high ion conductivity(2.8×10^(−3)S cm^(−1)at 25℃)through aligned ion conduction pathways and provides electrode protection ability through hydrophobic chain *** this mPR-SPE into solid-state LOBs resulted in stable potentials over 300 *** situ Raman spectroscopy reveals the presence of an LiO_(2)intermediate alongside Li_(2)O_(2)during oxygen *** situ X-ray diffraction confirm the ability of the SPE to hinder the permeation of oxygen and moisture,as demonstrated by the air permeability *** present study suggests that maintaining a low residual solvent while achieving high ionic conductivity is crucial for restricting the sub-reactions of solid-state LOBs.

关键词： Solid polymer electrolyte Lithium-oxygen batteries Polyrotaxane ion conductivity Hydrophobic chain

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Infiltration by monocytes of the central nervous system and its role in multiple sclerosis: reflections on therapeutic strategies

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Neural Regeneration Research 2025年第3期20卷 779-793页

作者： Guangyong Zhang Qing Yao Chubing Long Pengcheng yi Jiali Song Luojia Wu Wei wan Xiuqin Rao Yue Lin Gen Wei Jun ying Fuzhou Hua Department of Anesthesiology the Second Affiliated Hospital of Nanchang UniversityNanchangJiangxi ProvinceChina Key Laboratory of Anesthesiology of Jiangxi Province NanchangJiangxi ProvinceChina

Mononuclear macrophage infiltration in the central nervous system is a prominent feature of neuroinflammation. Recent studies on the pathogenesis and progression of multiple sclerosis have highlighted the multiple roles of mononuclear macrophages in the neuroinflammatory process. Monocytes play a significant role in neuroinflammation, and managing neuroinflammation by manipulating peripheral monocytes stands out as an effective strategy for the treatment of multiple sclerosis, leading to improved patient outcomes. This review outlines the steps involved in the entry of myeloid monocytes into the central nervous system that are targets for effective intervention: the activation of bone marrow hematopoiesis, migration of monocytes in the blood, and penetration of the blood–brain barrier by monocytes. Finally, we summarize the different monocyte subpopulations and their effects on the central nervous system based on phenotypic differences. As activated microglia resemble monocyte-derived macrophages, it is important to accurately identify the role of monocyte-derived macrophages in disease. Depending on the roles played by monocyte-derived macrophages at different stages of the disease, several of these processes can be interrupted to limit neuroinflammation and improve patient prognosis. Here, we discuss possible strategies to target monocytes in neurological diseases, focusing on three key aspects of monocyte infiltration into the central nervous system, to provide new ideas for the treatment of neurodegenerative diseases.

关键词： blood–brain barrier macrophages monocytes multiple sclerosis neuroinflammation review therapy

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Maintaining moderate levels of hypochlorous acid promotes neural stem cell proliferation and differentiation in the recovery phase of stroke

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Neural Regeneration Research 2025年第3期20卷 845-857页

作者： Lin-Yan Huang yi-De Zhang Jie Chen Hai-Di Fan wan wang Bin wang Ju-Yun Ma Peng-Peng Li Hai-Wei Pu Xin-yian Guo Jian-Gang Shen Su-Hua Qi School of Medical Technology Xuzhou Key Laboratory of Laboratory DiagnosticsXuzhou Medical UniversityXuzhouJiangsu ProvinceChina School of Pharmacy Xuzhou Medical UniversityXuzhouJiangsu ProvinceChina Department of Laboratory Medicine Branch Hospital of Huai’an First People’s HospitalHuai’anJiangsu ProvinceChina Department of Laboratory Medicine the Affiliated Hospital of Xuzhou Medical UniversityXuzhouJiangsu ProvinceChina School of Chinese Medicine The University of Hong KongHong Kong Special Administrative RegionChina

It has been shown clinically that continuous removal of ischemia/reperfusion-induced reactive oxygen species is not conducive to the recovery of late ***,previous studies have shown that excessive increases in hypochlorous acid after stroke can cause severe damage to brain *** previous studies have found that a small amount of hypochlorous acid still exists in the later stage of stroke,but its specific role and mechanism are currently *** simulate stroke in vivo,a middle cerebral artery occlusion rat model was established,with an oxygen-glucose deprivation/reoxygenation model established in vitro to mimic *** found that in the early stage(within 24 hours)of ischemic stroke,neutrophils produced a large amount of hypochlorous acid,while in the recovery phase(10 days after stroke),microglia were activated and produced a small amount of hypochlorous ***,in acute stroke in rats,hypochlorous acid production was prevented using a hypochlorous acid scavenger,taurine,or myeloperoxidase inhibitor,4-aminobenzoic acid *** results showed that high levels of hypochlorous acid(200μM)induced neuronal apoptosis after oxygen/glucose deprivation/***,in the recovery phase of the middle cerebral artery occlusion model,a moderate level of hypochlorous acid promoted the proliferation and differentiation of neural stem cells into neurons and *** suggests that hypochlorous acid plays different roles at different phases of cerebral ischemia/reperfusion *** levels of hypochlorous acid(5 and 100μM)promoted nuclear translocation ofβ-*** transfection of single-site mutation plasmids,we found that hypochlorous acid induced chlorination of theβ-catenin tyrosine 30 residue,which promoted nuclear ***,our study indicates that maintaining low levels of hypochlorous acid plays a key role in the recovery of neurological function.

关键词： cell differentiation cerebral ischemia/reperfusion injury chlorination hypochlorous acid microglia neural stem cell neurogenesis nuclear translocation stroke β-catenin

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Intensive use of an intertidal mudflat by foraging adult American horseshoe crabs Limulus polyphemus in the Great Bay estuary, New Hampshire

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Current Zoology 2010年第5期56卷 611-617页

作者： wan-Jean lee Department of Biological Sciences University of New Hampshire

Although concerns about harvesting levels of the American Horseshoe Crab, Limulus polyphemus have prompted increased research into its ecology, current understanding of the species＇ foraging ecology is mostly limited to mid-Atlantic populations. This study elucidates the spatial and temporal pattern of Limulus foraging on an intertidal mudflat of a northern New Eng- land estuary. A novel survey method was used to monitor Limulus foraging activity without disturbing the sediment. A fixed 50 mx2 m transect was monitored with monthly surveys of the number of Limulus feeding pits from June to October 2009, May and June 2010. Snorkelling surveys were also carried out to observe individual behavior and examine the spatial scale of activity of individual animals. Results showed frequent and intensive use of the mudflat by foraging Limulus. Limulus were actively foraging within the survey area during all months surveyed. Foraging patterns exhibited a seasonal pattern with activity levels peaking in August 2009 and increased significantly towards the end of the study in June 2010. It was also shown that Limulus intertidal foraging persisted and peaked after the spring breeding season. Observations of foraging Limulus revealed that individual predators dig multiple pits within a single high tide, with little disturbance to the sediment in between. In addition to altering the perception of Limulus as a subtidal predator outside of the breeding season, findings from this study suggests a segregation of spawning and feeding habitats, thus underscoring the need to consider a wider range of critical habitats in the management of Limulus populations

关键词： Foraging Epibenthic predator Intertidal Estuary Disturbance

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Machine learning-based direct solver for one-to-many problems on temporal shaping of relativistic electron beams

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Frontiers of physics 2022年第6期17卷 15-24页

作者： Jinyu wan yi Jiao Key Laboratory of Particle Acceleration Physics and Technology Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China University of Chinese Academy of Sciences Beijing 100049China China Spallation Neutron Source Dongguan 523803China

To control the temporal profile of a relativistic electron beam to meet requirements of various advanced scientific applications like free-electronlaser and plasma wakefield acceleration,a widely-used technique is to manipulate the dispersion terms which turns out to be one-to-many *** to their intrinsic one-to-many property,current popular stochastic optimization approaches on temporal shaping may face the problems of long computing time or sometimes suggesting only one *** we propose a real-time solver for one-to-many problems of temporal shaping,with the aid of a semi-supervised machine learning method,the conditional generative adversarial network(CGAN).We demonstrate that the CGAN solver can learn the one-to-many dynamics and is able to accurately and quickly predict the required dispersion terms for different custom temporal *** machine learning-based solver is expected to have the potential for wide applications to one-to-many problems in other scientific fields.

关键词： beam shaping one-to-many problem machine learning

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Highly parallel implementation of sub-pixel interpolation for AVS HDTV decoder

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2008年第12期9卷 1638-1643页

作者： wan-yi LI Lu YU Institute of Information and Communication Engineering Zhejiang University Hangzhou 310027 China

In this paper, we propose an effective VLS1 architecture of sub-pixel interpolation for motion compensation in the AVS HDTV decoder. To utilize the similar arithmetical operations of 15 luma sub-pixel positions, three types of interpolation filters are proposed. A simplified multiplier is presented due to the limited range of input in the chroma interpolation process. To improve the processing throughput, a parallel and pipelined computing architecture is adopted. The simulation results show that the proposed hardware implementation can satisfy the real-time constraint for the AVS HDTV （1 920× 1 088） 30 fps decoder by operating at 108 MHz with 38.18k logic gates. Meanwhile, it costs only 216 cycles to accomplish one macroblock, which means the B frame sub-pixel interpolation can be realized by using only one set of the proposed architecture under real-time constraints.

关键词： VLSI architecture Interpolation AVS HDTV

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Molecular Dynamics Study of Tension Process of Ni-Based Superalloy

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Acta Metallurgica Sinica(English Letters) 2020年第5期33卷 741-750页

作者： Hui Li wan Du yi Liu Materials Genome Institute Shanghai UniversityShanghai 200444China

To understand the atomistic mechanisms of tension failure of Ni-based superalloy,in this study,the classical molecular dynamics(MD)simulations were used to study the uniaxial tension processes of both the Ni/Ni3 Al interface systems and the pure Ni and Ni3 Al *** examine the effects of interatomic potentials,we adopted embedded atom method(EAM)and reactive force field(ReaxFF)in the MD *** results of EAM simulations showed that the amorphous structures and voids formed near the interface,facilitating further crack propagation within Ni *** EAM potentials also predicted that dislocations were generated and annihilated alternatively,leading to the oscillation of yielding stress during the tension *** ReaxFF simulations predicted more amorphous formation and larger tensile *** atomistic understanding of the defect initiation and propagation during tension process may help to develop the strengthening strategy for controlling the defect evolution under loading.

关键词： Ni-based superalloy Molecular dynamics Embedded atom method(EAM) Reactive force field(ReaxFF) Uniaxial tension

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Preparation of a cationic azobenzene dye-montmorillonite intercalation compound and its photochemical behavior

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Journal of University of Science and Technology Beijing 2006年第3期13卷 281-286页

作者： Tao wan yi Yuan Wenqiong He College of Materials and Chemistry ＆ Chemical Engineering Chengdu University of Technology Chengdu 610059 China

Montmorillonite/cationic azobenzene dye （GTL） intercalation compounds were prepared by the conventional ion exchange method. As compared with that of pure GTL, the thermal stability of the intercalated GTL was greatly enhanced, and the absorption band corresponding to azobenzene group in intercalated GTL shifted towards a longer wavelength by 55 nm, which could be ascribed to the strong conjugation of GTL supramolecular order structure （J cluster） confined in a nanoscale space of montmorillonite interlayer gallery. The microstructures of the resulting intercalation compounds could be successfully controlled by varying the amount of dye loaded as evidenced by the basal spacing of the intercalation compounds. The intercalated azo dye in the montmorillonite interlayer space exhibited reversible trans-to-cis photoisomerization and thermal cis-to-trans reaction. FTIR proved the successful intercalation of GTL into the silicate layer.

关键词： Na-montmorillonite azobenzene intercalation photoisomerization

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NUMERICAL SIMULATION OF FISH SWIMMING WITH RIGID PECTORAL FINS

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Journal of Hydrodynamics 2012年第2期24卷 263-272页

作者： XU yi-gang wan De-cheng State Key Laboratory of Ocean Engineering School of Naval ArchitectureOcean and Civil EngineeringShanghai Jiao Tong UniversityShanghai 200240China

The numerical simulation of the self-propelled motion of a fish with a pair of rigid pectoral fins is presented.A Navier-Stokes equation solver incorporating with the multi-block and overset grid method is developed to deal with the multi-body and moving body *** lift-based swimming mode is selected for the fin *** the lift-based swimming mode,the fin can generate great thrust and at the same time have no generation of lift *** can be found when a pair of rigid pectoral fins generates the hydrodynamic moment,it may also generate a lateral force opposite to the centripetal direction,which has adverse effect on the turn motion of the ***,the periodic vortex structure generation and shedding,and their effects on the generation of hydrodynamic force are also demonstrated in this article.

关键词： pectoral fins lift-based swimming mode self-propelled motion overset grid method

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