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Novel insights into D-Pinitol based therapies:a link between tau hyperphosphorylation and insulin resistance

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Neural Regeneration Research 2024年第2期19卷 289-295页

作者： Dina Medina-Vera Antonio Jesús López-Gambero Juan Antonio Navarro Carlos Sanjuan Elena Baixeras Juan decara Fernando Rodríguez de Fonseca Instituto de Investigación Biomédica de Málaga y Plataforma en Nanomedicina-IBIMA Plataforma BIONAND UGC Salud MentalMálagaSpain Facultad de Ciencias Universidad de MálagaMálagaSpain CIBER Enfermedades Cardiovasculares(CIBERCV) Hospital Universitario Virgen de la VictoriaUGC del CorazónMálagaSpain University of Bordeaux INSERMNeurocentre MagendieBordeauxFrance Euronutra S.L.Calle Johannes Kepler MálagaSpain departamento de Bioquímica y Biología Molecular Facultad de MedicinaUniversidad de MálagaMálagaSpain

Alzheimer’s disease is a neurodegenerative disorder characterized by the amyloid accumulation in the brains of patients with Alzheimer’s *** pathogenesis of Alzheimer’s disease is mainly mediated by the phosphorylation and aggregation of tau *** the multiple causes of tau hyperphosphorylation,brain insulin resistance has generated much attention,and inositols as insulin sensitizers,are currently considered candidates for drug *** present narrative review revises the interactions between these three elements:Alzheimer’s disease-tau-inositols,which can eventually identify targets for new disease modifiers capable of bringing hope to the millions of people affected by this devastating disease.

关键词： Alzheimer’s disease cyclin-dependent kinase 5 diabetes D-Pinitol inositols insulin resistance kinases phosphorylation PI3K/Akt tau

Analyzing the Effects of Milling and Sintering Parameters on Crystalline Phase Evolution and Mechanical Properties of Al_(86)Ni_(8)Y_(6) and Al_(86)Ni_(6)Y_(4.5)Co_(2)la_(1.5) Amorphous Ribbons

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Acta Metallurgica Sinica(English Letters) 2022年第6期35卷 1043-1054页

作者： Ashutosh Sahu ram Sajeevan Maurya lavish Kumar Singh Tapas laha department of Mechanical Engineering School of Engineering and TechnologySharda UniversityGreater Noida 201310India department of Metallurgy Engineering and Materials Science Indian Institute of Technology IndoreIndore 453552India department of Metallurgical and Materials Engineering Indian Institute of Technology KharagpurKharagpur 721302India

In the present study,Al_(86)Ni_(8)Y_(6) and Al_(86)Ni_(6)Y_(4.5)Co_(2)la_(1.5) bulk amorphous nanocomposites were synthesized by spark plasma sintering of milled melt spun ribbon *** as-cast ribbons were of near amorphous nature with minute amount of FCC Al embedded in the amorphous *** of the ribbons resulted in partial devitrifi cation due to mechanical *** milled ribbon particles were sintered in the temperature and pressure range of 300-500℃ and 500-700 MPa,*** was observed that nominal amount of amorphous phase was retained at 500℃ and 500 *** increase in sintering pressure and decrease in sintering temperature,the amount of crystalline phase evolution decreased,and maximum amount of amorphous phase was retained at 300℃ and 700 *** microstructure consisting of amorphous phase embedded with hard intermetallic phases led to increase in the nanohardness of Al_(86)Ni_(8)Y_(6) and Al_(86)Ni_(6)Y_(4.5)Co_(2)la_(1.5) as-cast ribbons from 3.26±0.59 GPa and 3.81±0.58 GPa to 6.06±0.70 GPa and 6.14±0.82 GPa,respectively,for the corresponding consolidated amorphous *** of the three and five component system bulk samples was 4.19±0.13GPa and 3.6±0.13 GPa,respectively.

关键词： Amorphous alloy Milled ribbon Spark plasma Sintering Nanohardness Internetallic compound

Two upper bounds for the Erdos-Hooley delta-function

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Science China Mathematics 2023年第12期66卷 2683-2692页

作者： Regis de la Breteche Gerald Tenenbaum Institut de Mathematiques Universite Paris CiteSorbonne UniversiteCNRSParis F-75013France Institut Elie Cartan Universite de LorraineVandoeuvre-les-NancyBP 70239France

For integer n≥1 and real u,let Δ(n,u):=|{d:d] n,e^(u)deltafunction is then defined by Δ(n):=Max_(u∈R)Δ(n,u).We improve the current upper bounds for the average and normal orders of ... 详细信息

关键词： concentration of divisors average order normal order Waring’s problem

Thinking outside the black box:are the brain endothelial cells the new main target in Alzheimer's disease?

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Neural Regeneration Research 2023年第12期18卷 2592-2598页

作者： Enrique Estudillo Adolfo López-Ornelas Alejandro Rodríguez-Oviedo Neptali Gutiérrez de la cruz Marco Antonio Vargas-Hernández Adriana Jiménez laboratorio de Reprogramación Celular Instituto Nacional de Neurología y Neurocirugía Manuel Velasco SuárezMexico CityMexico División de Investigación Hospital Juárez de MéxicoMexico CityMexico Hospital Nacional Homeopático Hospitales Federales de ReferenciaMexico CityMexico Facultad de Ciencias Universidad Nacional Autónoma de MéxicoMexico CityMexico laboratorio de Morfología Escuela Militar de Graduados de SanidadSecretaría de la Defensa NacionalBatalla de CelayaLomas de SoteloMiguel HidalgoMexico CityMexico Escuela Militar de Graduados de Sanidad Secretaría de la Defensa NacionalBatalla de CelayaLomas de SoteloMiguel HidalgoMexico CityMexico

The blood-brain barrier is the interface through which the brain interacts with the milieu and consists mainly of a sophisticated network of brain endothelial cells that forms blood vessels and selectively moves molecules inside and outside the brain through multiple mechanisms of *** brain endothelial cell function is crucial for brain homeostasis,their role in neurodegenerative diseases has historically not been considered with the same importance as other brain cells such as microglia,astroglia,neurons,or even molecules such as amyloid beta,Tau,or ***'s disease is the most common neurodegenerative disease,and brain endothelial cell dysfunction has been reported by several ***,its impairment has barely been considered as a potential therapeutic *** we review the most recent advances in the relationship between Alzheimer's disease and brain endothelial cells commitment and analyze the possible mechanisms through which their alterations contribute to this neurodegenerative disease,highlighting their inflammatory phenotype and the possibility of an impaired secretory pattern of brain endothelial cells that could contribute to the progression of this ***,we discuss why shall brain endothelial cells be appreciated as a therapeutic target instead of solely an obstacle for delivering treatments to the injured brain in Alzheimer's disease.

关键词： dementia endothelial cells neurodegeneration neuroinflammation neuronal death paracellular transport transcellular transport

deregulation of interferon-gamma receptor 1 expression and its implications for lung adenocarcinoma progression

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World Journal of Clinical Oncology 2024年第2期15卷 195-207页

作者： Angeles C Tecalco-cruz Karen H Medina-Abreu Enrique Oropeza-Martínez Jesus Zepeda-Cervantes AleidaVázquez-Macías Marina Macías-Silva Posgrado en Ciencias Genómicas Universidad Autónoma de la Ciudad de MéxicoCDMX 03100Mexico Facultad de Medicina Veterinaria y Zootecnia Universidad Nacional Autónoma de MéxicoCDMX 04510Mexico Colegio de Ciencias y Humanidades Universidad Autónoma de la Ciudad de MéxicoCDMX 03100Mexico Instituo de Fisiología Celular Universidad Nacional Autónoma de MéxicoCDMX 04510Mexico

Interferon-gamma(IFN-γ)plays a dual role in cancer;it is both a pro-and an antitumorigenic cytokine,depending on the type of *** deregulation of the IFN-γcanonic pathway is associated with several disorders,including vulner-ability to viral infections,inflammation,and cancer *** particular,the interplay between lung adenocarcinoma(LUAD)and viral infections appears to exist in association with the deregulation of IFN-γ*** this mini-review,we investigated the status of the IFN-γsignaling pathway and the expression level of its components in ***,a reduction in IFNGR1 expression seems to be associated with LUAD progression,affecting defenses against viruses such as severe acute respiratory syndrome coronavirus *** addition,alterations in the expression of IFNGR1 may inhibit the antiproliferative action of IFN-γsignaling in LUAD.

关键词： Interferon-gamma IFNGR1 JAK1 Antiviral Anti-tumor Lung adenocarcinoma

A compact multi-pixel superconducting nanowire single-photon detector array supporting gigabit space-to-ground communications

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Light(Science & Applications) 2024年第2期13卷 254-266页

作者： Hao Hao Qing-Yuan Zhao Yang-Hui Huang Jie deng Fan Yang Sai-Ying Ru Zhen Liu Chao Wan Hao Liu Zhi-Jian Li Hua-Bing Wang Xue-Cou Tu la-Bao Zhang Xiao-Qing Jia Xing-Long Wu Jian Chen Lin Kang Pei-Heng Wu Research Institute of Superconductor Electronics(RISE) School of Electronic Science and EngineeringNanjing UniversityNanjingJiangsu 210023China Purple Mountain laboratories NanjingJiangsu 211111China Hefei National laboratory HefeiAnhui 230088China National laboratory of Solid State Microstructures and department of Physics Nanjing UniversityNanjing 210023China

Classical and quantum space-to-ground communications necessitate highly sensitive receivers capable of extracting information from modulated photons to extend the communication distance from near-earth orbits to deep space *** achieve gigabit data rates while mitigating strong background noise photons and beam drift in a highly attenuated free-space channel,a comprehensive design of a multi-functional detector is *** this study,we present an innovative compact multi-pixel superconducting nanowire single-photon detector array that integrates near-unity detection efficiency(91.6%),high photon counting rate(1.61 Gcps),large dynamic range for resolving different photon numbers(1-24),and four-quadrant position sensing function all within one ***,we have constructed a communication testbed to validate the advantages offered by such an *** 8-PPM(pulse position modulation)format communication experiments,we have achieved an impressive maximum data rate of 1.5 Gbps,demonstrating sensitivities surpassing previous benchmarks at respective *** incorporating photon number information into error correction codes,the receiver can tolerate maximum background noise levels equivalent to 0.8 photons/slot at a data rate of 120 Mbps—showcasing a great potential for daylight operation ***,preliminary beam tracking tests were conducted through open-loop scanning techniques,which revealed clear quantitative dependence indicating sensitivity variations based on beam *** on the device characterizations and communication results,we anticipate that this device architecture,along with its corresponding signal processing and coding techniques,will be applicable in future space-to-ground communication tasks.

关键词： photon supporting correction

Importance of Quercus *** diversity and biomass of vascular epiphytes in a managed pine-oak forest in Southern Mexico

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Forest Ecosystems 2022年第3期9卷 366-377页

作者： Nayely Martínez-Meléndez Neptalí ramírez-Marcial José G. García-Franco Manuel Jesús Cach-Pérez Pablo Martínez-Zurimendi departamento de Conservacion de la Biodiversidad El Colegio de la Frontera Sur(ECOSUR)San Cristobal de Las Casas29290ChiapasMexico Red de Ecología Functional Instituto de EcologíaA.C.Xalapa91073VeracruzMexico departamento de Agricultura Sociedad y AmbienteEl Colegio de la Frontera Sur(ECOSUR)Villahermosa86280TabascoMexico

Background:Forestry management modifies the diversity,structure,and functioning of intervened *** extraction reduces tree density and basal area,leading to changes in the communities of vascular *** objective of this study was to evaluate the diversity and biomass of vascular epiphytes in Quercus trees remaining in two pine-oak forest stands that have been subjected to two stages of the Silvicultural development Method(release cutting,and thinning)in comparison with an unharvested old-secondary forest in southern *** each treatment,richness of epiphytes present on 60 oak trees was recorded and their dry biomass *** calculated the true diversity(Hill numbers)and beta diversity using the Jaccard coefficient of similarity,and generated rank abundance curves per taxonomic epiphyte group(bromeliads,orchids,ferns and others).For each treatment,the relationships between overall diversity and epiphyte biomass to the host trees basal area were analyzed using log linear ***:We recorded a total of 67 species of epiphytes species belonging to 10 families hosted by five species of *** greatest species richness(^(0)D)was recorded in the old-secondary *** common(^(1)D)and dominant(^(2)D)species were recorded in the release cutting than in the other *** diversity and biomass were both slightly related to host tree basal *** of epiphytes was similar(60%)among treatments,although orchids,bromeliads,and other families were more diverse in the old-secondary *** bromeliad species were shared across all treatments,although orchids presented the most exclusive species in the unharvested *** bromeliad Tillandsia seleriana provided the greatest contribution to biomass in all treatments,followed by the orchid Camaridium *** linear models indicated that epiphyte diversity was significantly related to treatment,and epiphyte biomass to basal area of host ***:Alt

关键词： Bromeliads Chiapas Ferns Orchids Richness Sierra Madre Silvicultural development method(SDM)