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大型体育赛事全流程急救护理保障体系的建设及实践

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中华急危重症护理杂志 2024年第7期5卷 632-637页

作者：江新伟朱莉吴亚芬戚建江詹玥杨悦吕琳朱嫒嫒姜震赵泽洋浙江大学医学院附属邵逸夫医院国际干保中心杭州市310020 浙江大学医学院附属第一医院肝胆胰外科浙江大学医学院附属第一医院国际保健中心浙江省中医院心血管内科浙江大学医学院附属精神卫生中心/杭州市第七人民医院浙江大学医学院附属第二医院急诊科浙江省人民医院国际交流与对外联络部杭州市职业病防治院医教科浙江省中医院推拿科杭州市中医院信息科

回顾分析杭州第19届亚运会医疗急救保障中护理体系的建设经验。护理工作是大型体育赛事医疗保障体系的重要环节之一,为赛事的顺利举办奠定了坚实基础,本文系统总结医疗急救保障中全流程护理保障的要点和主要做法,重点对护理人员的选拔... 详细信息

回顾分析杭州第19届亚运会医疗急救保障中护理体系的建设经验。护理工作是大型体育赛事医疗保障体系的重要环节之一,为赛事的顺利举办奠定了坚实基础,本文系统总结医疗急救保障中全流程护理保障的要点和主要做法,重点对护理人员的选拔、培训、演练考核等大型体育赛事护理保障体系建设与实践进行剖析,为今后大型体育赛事的医疗急救保障护理工作提供借鉴和参考。

关键词：大型体育赛事医疗保障全流程急救护理

Solution-processable precursor route for fabricating ultrathin silica film for high performance and low voltage organic transistors

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Chinese Chemical Letters 2017年第11期28卷 2143-2146页

作者： Shujing Guo Zhongwu Wang zeyang Xu Shuguang Wang Kunjie wu Shufeng Chen Zongbo Zhang Caihong Xu Wenfeng Qiu Liqiang Li Inner Mongolia University of College of Chemistry and Chemical Engineering Hohhot 010021 China Advanced Nano-materials Division Key Laboratory of Nano-Devices and Applications Suzhou Institute of Nano-Tech and Nano-Bionics Chinese Academy of Sciences Suzhou 215123 China Laboratory of High-Tech Materials Institute of ChemistryChinese Academy of Sciences Beijing 100190 China

Silica is one of the most commonly used materials for dielectric layer in organic thin-film transistors due to its excellent stability, excellent electrical properties, mature preparation process, and good compatibility with organic semiconductors. However, most of conventional preparation methods for silica film are generally performed at high temperature and/or high vacuum. In this paper, we introduce a simple solution spin-coating method to fabricate silica thin film from precursor route, which possesses a low leakage current, high capacitance, and low surface roughness. The silica thin film can be produced in the condition of low temperature and atmospheric environment. To meet various demands, the thickness of film can be adjusted by means of preparation conditions such as the speed of spin-coating and the concentration of solution. The p-type and n-type organic field effect transistors fabricated by using this film as gate electrodes exhibit excellent electrical performance including low voltage and high performance. This method shows great potential for industrialization owing to its characteristic of low consumption and energy saving, time-saving and easy to operate.

关键词： Silica Spin coating Thin film Transistor

Experimental study on concrete columns hybrid reinforced by steel and FRP bars under seismic loading

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Journal of Southeast University(English Edition) 2016年第4期32卷 439-444页

作者：孙泽阳吴刚王燕华吴智深东南大学混凝土及预应力混凝土结构教育部重点实验室南京210096 东南大学城市工程科学技术研究院南京210096

In order to study the dynamic behavior of hybrid reinforced concrete columns, shaking table tests of three concrete columns with equal initial stiffness were *** longitudinal reinforcements include an ordinary steel bar,a steel-fiber reinforced polymer（FRP） composite bar（SFCB）, and hybrid reinforcement（steel bar and FRP bar, CH）. Test results show that the peak ground acceleration（PGA） responses of different columns are similar to each other. For an ordinary reinforced concrete（RC） column, the plastic strain of the steel bar develops rapidly after the PGA of the input ground motion reaches 100 cm / s^2, and the corresponding residual strain develops dramatically. For a SFCB column, even after the peak strain reaches 0. 015, the residual strain is below 5 × 10^- 4. For the hybrid column C-H,the residual strain of the FRP bar is similar to that of the SFCB column. In general, concrete columns with hybrid steel and FRP bar reinforcement can achieve smaller residual deformation, and the SFCB reinforced columns can be constructed in extreme environments, such as offshore bridges, due to good anti-corrosion performance.

关键词： concrete column shaking table test hybrid reinforcement peak ground acceleration strain distribution

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玉米PDI基因家族鉴定和表达模式分析

植物遗传资源学报 2024年第1期25卷 97-110页

作者：吴金丽汤泽洋鲁鑫周志强郭长虹李新海哈尔滨师范大学生命科学与技术学院黑龙江省分子细胞遗传与遗传育种重点实验室哈尔滨150025 中国农业科学院作物科学研究所/作物分子育种国家工程实验室北京100081

蛋白质二硫键异构酶(PDI,protein disulfide isomerase)作为硫氧还蛋白家族的一员,是一种氧化还原酶,广泛存在于动物、植物及微生物中。在植物中,蛋白质二硫键的形成和异构主要由二硫键蛋白催化完成,在参与蛋白质正确组装折叠方面至关... 详细信息

蛋白质二硫键异构酶(PDI,protein disulfide isomerase)作为硫氧还蛋白家族的一员,是一种氧化还原酶,广泛存在于动物、植物及微生物中。在植物中,蛋白质二硫键的形成和异构主要由二硫键蛋白催化完成,在参与蛋白质正确组装折叠方面至关重要。本研究以拟南芥PDI家族基因序列信息为基础,利用同源序列比对方法,从玉米中鉴定出21个PDI基因,除8号染色体外,非均匀地分布在其余玉米9条染色体上。进化树分析表明,玉米PDI基因家族分为4个进化分支11个发育组,同一发育组的基因结构和保守基序相似。顺式作用元件分析表明,PDI基因家族启动子含响应逆境胁迫、植物激素及胚乳特异表达的顺式作用元件。表达模式分析表明,PDI基因家族在胚、胚乳和籽粒中表达量较高,在授粉后10~20 d的胚乳中表达量呈下降趋势,然后表达量又呈现上升趋势。生物多样性分析发现:ZmPDIL1-1基因存在多样性。亚细胞定位结果表明ZmPDIL1-1定位在内质网。本研究结果为玉米PDI家族基因功能研究提供参考。

关键词：玉米 PDI基因家族基因表达亚细胞定位

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芪苈强心胶囊联合静脉补铁治疗慢性心力衰竭合并缺铁患者的临床疗效

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医学综述 2023年第4期29卷 821-826页

作者：孙小燕吴泽阳王蕾屈伶玉杨雷张家口市第一医院心内三科河北张家口075000 张家口市第一医院康复科河北张家口075000 张家口市第一医院血液科河北张家口075000

目的研究芪苈强心胶囊联合静脉补铁治疗慢性心力衰竭合并缺铁患者的临床疗效。方法收集2020年9月至2021年9月张家口市第一医院收治的106例慢性心力衰竭合并缺铁患者的临床资料,根据治疗方式不同分为对照组(51例)和研究组(55例)。两组均... 详细信息

目的研究芪苈强心胶囊联合静脉补铁治疗慢性心力衰竭合并缺铁患者的临床疗效。方法收集2020年9月至2021年9月张家口市第一医院收治的106例慢性心力衰竭合并缺铁患者的临床资料,根据治疗方式不同分为对照组(51例)和研究组(55例)。两组均给予常规抗心力衰竭治疗,对照组在常规治疗基础上联合静脉补铁治疗,5 ml蔗糖铁溶于100 ml 0.9%氯化钠溶液中静脉滴注;研究组在对照组的基础上口服芪苈强心胶囊,每次4粒,每日3次。两组均连续治疗3个月。比较两组的临床疗效,治疗前后血清铁指标[铁蛋白(SF)、血红蛋白(Hb)、总铁结合力(TIBC)、转铁蛋白饱和度(TS)]、6 min步行试验(6MWT)距离、左心室射血分数(LVEF)、美国纽约心脏病协会(NYHA)心功能分级、血清脑钠肽(BNP)、左心室舒张末期内径(LVEDd)水平以及不良反应发生情况。结果研究组临床总有效率高于对照组[89.09%(49/55)比68.63%(35/51)](χ^(2)=6.737,P=0.009)。治疗前后血清SF、Hb、TIBC、TS水平的主效应、组间的主效应差异有统计学意义(P0.05)。结论芪苈强心胶囊联合静脉补铁治疗慢性心力衰竭合并缺铁患者的临床效果显著,更有利于改善铁指标,提高患者运动能力、心功能,降低BNP、LVEDd水平,且安全性高。

关键词：慢性心力衰竭缺铁静脉补铁芪苈强心胶囊

芪苈强心胶囊联合静脉铁剂与联合口服铁剂治疗慢性心力衰竭合并缺铁患者的临床疗效比较

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医学综述 2023年第21期29卷 4777-4783页

作者：王蕾孙小燕杨雷吴泽阳屈伶玉张家口市第一医院心内三科河北张家口075000 张家口市第一医院血液科河北张家口075000 张家口市第一医院康复科河北张家口075000

目的比较芪苈强心胶囊联合静脉铁剂与联合口服铁剂治疗慢性心力衰竭(CHF)合并缺铁患者的临床疗效。方法选取2020年10月至2021年10月于张家口市第一医院心内科就诊的128例CHF合并缺铁患者为研究对象,按照治疗方法不同分为对照组和观察组,... 详细信息

目的比较芪苈强心胶囊联合静脉铁剂与联合口服铁剂治疗慢性心力衰竭(CHF)合并缺铁患者的临床疗效。方法选取2020年10月至2021年10月于张家口市第一医院心内科就诊的128例CHF合并缺铁患者为研究对象,按照治疗方法不同分为对照组和观察组,各64例。对照组在常规治疗基础上给予芪苈强心胶囊(每次1.2 g、每日3次)联合口服铁剂多糖铁复合物胶囊(每次0.3 g,每日1次);观察组在常规治疗基础上给予芪苈强心胶囊(方法同对照组)联合静脉铁剂治疗,将10 ml蔗糖铁注射液与200 ml 0.9%氯化钠溶液均匀混合后静脉滴注,每周2次,2次给药间隔≥2 d。两组均治疗15 d,比较两组治疗前、治疗第5天、第10天、第15天心功能指标[左心室射血分数(LVEF)、左心室舒张末期内径(LVEDD)]、心肌三项[肌红蛋白(Mb)、心肌肌钙蛋白T(cTnT)、肌酸激酶同工酶MB(CK-MB)]、6 min步行距离(6MWD)、铁蛋白、血红蛋白(Hb)、转铁蛋白饱和度(TS)、血浆脑钠肽(BNP)、炎症因子[白细胞介素-6(IL-6)、C反应蛋白(CRP)、肿瘤坏死因子-α(TNF-α)]水平,并记录治疗期间主要不良心血管事件(MACE)发生情况。结果治疗前后LVEF、LVEDD、Mb、cTnT、CK-MB、6MWD的主效应差异有统计学意义(P0.05)。结论芪苈强心胶囊联合静脉铁剂可有效改善CHF合并缺铁患者心功能,提升机体铁蛋白水平、运动耐力。

关键词：慢性心力衰竭铁缺乏芪苈强心胶囊铁剂心功能

不同补铁途径对合并缺铁性贫血的心力衰竭患者血清铁指标和Hcy及NT-proBNP水平的影响

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医学综述 2023年第10期29卷 2070-2075页

作者：屈伶玉孙小燕杨雷吴泽阳王蕾张家口市第一医院康复科河北张家口075000 张家口市第一医院心内三科河北张家口075000 张家口市第一医院血液科河北张家口075000

目的分析不同补铁途径对合并缺铁性贫血的心力衰竭患者血清铁指标和同型半胱氨酸(Hcy)及N端脑钠肽前体(NT-proBNP)水平的影响。方法选取2020年8月至2021年8月张家口市第一医院收治的95例合并缺铁性贫血的心力衰竭患者为研究对象,均给予... 详细信息

目的分析不同补铁途径对合并缺铁性贫血的心力衰竭患者血清铁指标和同型半胱氨酸(Hcy)及N端脑钠肽前体(NT-proBNP)水平的影响。方法选取2020年8月至2021年8月张家口市第一医院收治的95例合并缺铁性贫血的心力衰竭患者为研究对象,均给予常规抗心力衰竭治疗,并根据补铁途径的不同分为静脉组(50例,采用静脉滴注蔗糖铁补铁)和口服组(45例,给予多糖铁复合物胶囊补铁)。比较两组血清铁指标[铁蛋白、血红蛋白(Hb)、血清铁、转铁蛋白饱和度、总铁结合力]、左心室射血分数(LVEF)、6 min步行距离、纽约心脏病协会(NYHA)心功能分级、Hcy及NT-proBNP水平变化,及不良反应发生情况。结果血清铁蛋白、Hb、血清铁、转铁蛋白饱和度水平时点间的主效应差异有统计学意义(P0.05);血清铁蛋白、转铁蛋白饱和度和总铁结合力水平组间的主效应差异无统计学意义(P>0.05),Hb、血清铁水平组间的主效应差异有统计学意义(P0.05),Hb、血清铁水平的组间与时点间存在交互作用(P0.05),组间与时点间不存在交互作用(P>0.05);与治疗前相比,治疗后两组LVEF升高、6 min步行距离延长(P0.05)。Hcy、NT-proBNP水平时点间的主效应差异有统计学意义(P0.05),组间与时点间不存在交互作用(P>0.05);与治疗前相比,治疗后两组Hcy、NT-proBNP水平均降低(P0.05)。结论静脉补充铁剂与口服补充铁剂在改善合并缺铁性贫血的心力衰竭患者铁蛋白、转铁蛋白饱和度、LVEF、6 min步行试验、心功能分级、血清Hcy、NT-proBNP水平等方面的效果相当,安全性较好,但静脉补充铁剂在提高Hb、血清铁水平方面更具优势,而口服补铁治疗更为方便。

关键词：心力衰竭缺铁性贫血补铁途径同型半胱氨酸 N端脑钠肽前体

CXCL12 derived from CD248-expressing cancer-associated fibroblasts mediates M2-polarized macrophages to promote nonsmall cell lung cancer progression

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CXCL12 derived from CD248-expressing cancer-associated fibro...

Forecasts on CMB lensing observations with AliCPT-1

2022CCTB中国肿瘤标志物学术大会暨中国整合肿瘤学大会暨第十六届肿瘤标志物青年科学家论坛暨中国肿瘤标志物产业创新大会

作者： Jieheng wu Jiangwei wu Qiaoling Zhang zeyang Yang Rui Zhang Jian Zhang Zhu Zeng Department of Immunology Guizhou Medical University Department of Immunology The Fourth Military Medical University Department of Thoracic Surgery The Affiliated Hospital of Guizhou Medical University

Nonsmall cell lung cancer(NSCLC) is among the most prevalent malignant tumours threatening human *** the tumour microenvironment(TME),cancer-associated fibroblasts(CAFs)induce M2-polarized macrophages,which strongly regulate tumour ***,little is known about the association between CAFs and M2 ***248 is a transmembrane glycoprotein found in several cancer cells,tumour stromal cells,and ***,we isolated CAFs from tumour tissues of NSCLC patients to detect the relationship between CD248 expression and patient *** knocked down the expression of CD248 on CAFs to detect CXCL12 secretion and macrophage *** then examined the effects of CD248-expressing CAF-induced M2 macrophage polarization to promote NSCLC progression in vitro and in *** found that CD248 is expressed mainly in NSCLC-derived CAFs and that the expression of CD248 correlates with poor patient *** CXCL12 receptor(CXCR4) drastically decreased M2macrophage ***248 promotes CAFs secreting CXCL12 to mediate M2-polarized macrophages to promote NSCLC progression both in vitro and in ***,our data suggest that CD248-positive CAFs induce NSCLC progression by mediating M2-polarized macrophages.

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Science China(Physics,Mechanics & Astronomy) 2022年第10期65卷 115-129页

作者： Jinyi Liu zeyang Sun Jiakang Han Julien Carron Jacques Delabrouille Siyu Li Yang Liu Jing Jin Shamik Ghosh Bin Yue Pengjie Zhang Chang Feng Zhi-Qi Huang Hao Liu Yi-Wen wu Le Zhang Zi-Rui Zhang Wen Zhao Bin Hu Hong Li Xinmin Zhang Department of Astronomy Beijing Normal UniversityBeijing 100875China Department of Astronomy School of Physics and AstronomyShanghai Jiao Tong UniversityShanghai 200240China Shanghai Key Laboratory for Particle Physics and Cosmology Shanghai 200240China Division of Astronomy and Astrophysics Tsung-Dao Lee InstituteShanghai Jiao Tong UniversityShanghai 200240China D´epartement de Physique Th´eorique et CAP Universit´e de Gen`eveGen`eve CH-1211Switzerland CNRS-UCB International Research Laboratory Centre Pierre Bin´etruyCPB-IN2P3Berkeley IRL2007USA Key Laboratory of Particle Astrophysics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China CAS Key Laboratory for Researches in Galaxies and Cosmology Department of AstronomyUniversity of Science and Technology of ChinaChinese Academy of SciencesHefei 230026China School of Astronomy and Space Science University of Science and Technology of ChinaHefei 230026China National Astronomical Observatories Chinese Academy of SciencesBeijing 100101China School of Physics and Optoelectronics Engineering Anhui UniversityHefei 230039China School of Physics and Astronomy Sun Yat-sen UniversityZhuhai 519082China CSST Science Center for the Guangdong-Hong Kong-Macao Greater Bay Area Zhuhai 519082China Peng Cheng Laboratory Shenzhen 518000China Theoretical devision Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China University of Chinese Academy of Sciences Beijing 100049China

Ali CPT-1 is the first Chinese cosmic microwave background(CMB) experiment aiming for the high-precision measurement of CMB B-mode polarization. The telescope, currently under deployment in Tibet, will observe in two frequency bands centered at 90 and 150 GHz. We forecast the CMB lensing reconstruction, lensing-galaxy, and lensing-cosmic infrared background(CIB) cross-correlation signal-to-noise ratio(SNR) for Ali CPT-1. We consider two stages with different integrated observation times, namely “4 module*yr”(first stage) and “48 module*yr”(final stage). For lensing reconstruction, we use three different quadratic estimators, namely temperature-only, polarization-only and minimum-variance(MV) estimators, using curved sky geometry. We take into account the impacts of inhomogeneous hit counts and mean-field bias due to incomplete sky *** the first stage, our results show that the 150 GHz channel can measure the lensing signals at 15σ significance with the MV estimator. In the final stage, the measurement significance will increase to 31σ. We also combine the two frequency data in the harmonic domain to optimize the SNR. Our results show that the coadding procedure can significantly reduce the reconstruction bias in the high multiple range. Owning to the high quality of the polarization data in the final stage of Ali CPT-1, the EB estimator will dominate the lensing reconstruction in this stage. We also estimate the SNR of cross-correlations between Ali CPT-1 CMB lensing and other tracers of the large scale structure of the universe. For its cross-correlation with Dark Energy Spectroscopic Instrument(DESI) galaxies/quasars, we report the cross-correlation SNR = 10-20 for the four redshift bins at 0.05 < z < 2.1. In the first stage, the total SNR is approximately 32. In the final stage, the lensing-galaxy cross-correlation can reach SNR = 52. For lensing-CIB cross-correlation, in the first stage, the cross-correlations between Ali CPT-1 lensing and Planck CIB 353

关键词： background radiation cosmic cosmology gravitational lenses and luminous ares