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Advances in pharmacological effects of tanshinone ⅡA on pain

中国药理学与毒理学杂志 2023年第7期37卷 524-525页

作者： cheng wenjing CHEN Xi ZHANG Danshen JING Yongshuai College of Chemistry and Pharmaceutical Engineering Hebei University of Science and Technology

Pain is one of the most serious problems plaguing human health today. Drug therapy is one of the main ways to treat pain in clinic. The analgesic drugs commonly used in clinical treatment of pain are often accompanied by many side effects, the analgesic effect is still not ideal. Salvia miltiorrhiza is a traditional medicinal material with the same origin as food and medicine. It has the functions of promoting blood circulation and removing blood stasis, relieving pain through menstrual circulation, and contains many effective ingredients such as tanshinone and salvianolic acid. Tanshinone is a kind of rosin diterpenoid compound, which mainly consists of o-quinone type and p-quinone type parent nucleus, and tanshinone Ⅱ A is the representative compound. The pharmacological mechanism of tanshinone Ⅱ A in labor pain mainly includes:(1) Regulate inflammatory *** cytokines played an important role in the occurrence and progression of pain. It was found that the analgesic effect of tanshinone ⅡA was related to the antiinflammatory effect. Tanshinone Ⅱ A showed anti-injurious activity in various pain models, such as bone cancer pain and sciatic nerve ligation, and related studies found that tanshinone Ⅱ A could inhibit the expression of inflammatory factors TNF-α, IL-1β and IL-6 in the spinal cord of model rats. In the spinal nerve ligation model,tanshinone ⅡA also promoted the release of anti-inflammatory cytokine IL-10 in the spinal cord of rats.(2) Regulate signal pathways related to regulating spinal cord oxidation and apoptosis. Apoptosis and oxidation played an important role in the process of pain. When nerve injury was caused by stimulation, oxidative stress and apoptosis of nerve cells were involved in the mechanism of hyperalgesia. Tanshinone Ⅱ A sodium sulfonate could relieve pain by regulating apoptosis-related pathways. In neuralgia model, tanshinone ⅡA could reduce the apoptosis of spinal cord neurons by inhibiting oxidative stress response

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伊马替尼靶向治疗后胃肠间质瘤伴横纹肌肉瘤分化1例及文献复习

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临床与病理杂志 2024年第3期44卷 488-493页

作者：袁亦姝冯智超谭娟程文静刘杨中南大学湘雅三医院病理科长沙410013 中南大学湘雅三医院放射科长沙410013

胃肠间质瘤(gastrointestinal stromal tumor,GIST)是消化道最常见的间叶源性肿瘤。随着伊马替尼的应用,晚期GIST的疗效得到了显著改善。尽管多数患者接受伊马替尼治疗后获益,但仍有部分患者会发生继发性耐药。本例GIST患者接受伊马替... 详细信息

胃肠间质瘤(gastrointestinal stromal tumor,GIST)是消化道最常见的间叶源性肿瘤。随着伊马替尼的应用,晚期GIST的疗效得到了显著改善。尽管多数患者接受伊马替尼治疗后获益,但仍有部分患者会发生继发性耐药。本例GIST患者接受伊马替尼治疗15个月后出现了耐药及肿瘤进展,镜下示部分肿瘤细胞出现明显的多形性,免疫组织化学染色示伴横纹肌细胞分化。在进展的病灶中未发现c-Kit、PDGFRA基因的继发突变。由于GIST横纹肌肉瘤去分化罕见,本病例的报道将有助于伊马替尼治疗后GIST的诊断,避免误诊及漏诊。

关键词：胃肠间质瘤伊马替尼横纹肌肉瘤分化

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肺癌患者外周血循环肿瘤细胞与肿瘤转移及新辅助化疗疗效的关系

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癌症进展 2024年第17期22卷 1943-1946页

作者：郑庆凯程文静郑红陈苗赵晓光焦作市人民医院呼吸与危重症医学科河南焦作4540000 焦作市人民医院健康体检中心河南焦作4540000 焦作市人民医院肿瘤内科河南焦作4540000

目的探讨肺癌患者外周血循环肿瘤细胞(CTC)与肿瘤转移及新辅助化疗(NCT)疗效的关系。方法将106例肺癌患者按外周血CTC水平的不同分为阳性组(CTC≥5/7.5 ml)48例和阴性组(CTC﹤5/7.5 ml)58例。比较两组患者肿瘤转移情况、NCT疗效,采用Log... 详细信息

目的探讨肺癌患者外周血循环肿瘤细胞(CTC)与肿瘤转移及新辅助化疗(NCT)疗效的关系。方法将106例肺癌患者按外周血CTC水平的不同分为阳性组(CTC≥5/7.5 ml)48例和阴性组(CTC﹤5/7.5 ml)58例。比较两组患者肿瘤转移情况、NCT疗效,采用Logistic回归模型分析肺癌患者外周血CTC水平的影响因素。结果阳性组患者淋巴结转移率、远处转移率均高于阴性组,疾病控制率低于阴性组,差异均有统计学意义(P﹤0.05)。多因素Logistic回归分析结果显示,淋巴结转移情况、远处转移情况、疗效均是肺癌患者外周血CTC水平的独立影响因素(P﹤0.05)。结论肺癌患者外周血CTC水平与肿瘤转移情况和NCT疗效有关,对肺癌患者的预后预测有着一定的参考价值。

关键词：肺癌循环肿瘤细胞肿瘤转移新辅助化疗

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Simulating the resonance-mediated(1+2)-three-photon absorption enhancement in Pr3+ions by a rectangle phase modulation

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Chinese Physics B 2022年第6期31卷 285-290页

作者： wenjing cheng Yuan Li Hongzhen Qiao Meng Wang Shaoshuo Ma Fangjie Shu Chuanqi Xie and Guo Liang Henan Province Engineering Research Center of Microcavity and Photoelectric Intelligent Sensing School of Electronics and Electrical EngineeringShangqiu Normal UniversityShangqiu 476000China Department of Ophthalmology First People’s Hospital of ShangqiuShangqiu 476000China The Key Laboratory of Weak Light Nonlinear Photonics Nankai University of Ministry of Education Tianjin 300457China

Enhancing the upconversion luminescence of rare earth ions is crucial for their applications in the laser sources,fiber optic communications,color displays,biolabeling,and biomedical *** this paper,we theoretically study the resonance-mediated(1+2)-three-photon absorption in Pr^(3+) ions by a rectangle phase *** results show that the resonance-mediated(1+2)-three-photon absorption can be effectively enhanced by properly designing the depth and width of the rectangle phase modulation,which can be attributed to the constructive interference between on-resonant and near-resonant three-photon excitation ***,the enhancement efficiency of resonance-mediated(1+2)-threephoton absorption can be affected by the pulse width(or spectral bandwidth)of femtosecond laser field,final state transition frequency,and absorption *** research can provide a clear physical picture for understanding and controlling the multi-photon absorption in rare-earth ions,and also can provide theoretical guidance for improving the up-conversion luminescence.

关键词： coherent quantum control femtosecond pulse shaping three-photon absorption rare-earth ions

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Weighted Wavelet Estimate in Semiparametric Models with Heteroscedastic Errors

Weighted Wavelet Estimate in Semiparametric Models with Hete...

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2012年计算机应用与系统建模国际会议

作者： wenjing cheng School of Mathematics and Statistics Hubei Normal University

Using wavelet smoothing method, we consider the semiparametric regression model with independent heteroscedastic errors. We investigate the asymptotic normality and weak consistence rates of wavelet estimators.

关键词： Semiparametric regression model Wavelet estimate Asymptotic normality Weak consistence rates Heteroscedastic error

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Amine-functionalized metal organic framework@graphene oxide as filler in PAEK-containing carboxyl group membrane for ultrafiltration with ultra-high permeability and strong fouling resistance

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Chinese Journal of Chemical Engineering 2024年第6期70卷 93-103页

作者： Zhaoli Wang wenjing Li Yi Zhang Yanyin cheng Junjian Yu Tianming Dong Xiaoyu Chi Di Liu Zhe Wang School of Chemistry and Life Science Changchun University of TechnologyChangchun 130012China Advanced Institute of Materials Science Changchun University of TechnologyChangchun 130012China Key Laboratory of Advanced Functional Polymer Membrane Materials of Jilin Province Changchun 130012China

Achieving high fouling resistance and permeability using membrane separation technology in water treatment processes remains a *** this work,a novel mixed-matrix membrane(MMM)(poly(arylene ether ketone)[PAEK]-containing carboxyl groups[PAEK-COOH]/UiO-66-NH_(2)@graphene oxide[GO])with superb fouling resistance and high permeability was prepared by the nonsolvent-induced phase separation method,by in-situ growth of UiO-66-NH_(2) on the GO layer,and by preparing hydrophilic *** the basis of the structure and performance analysis of the MMM,the maximum water flux reached 591.25 L·m^(-2)·h^(-1) for PAEK-COOH/UiO-66-NH_(2)@GO,whereas the retention rate for bovine serum albumin increased from 85.40%to 94.87%.As the loading gradually increased,the hydrophilicity of the MMMs increased,significantly enhancing their fouling *** strongest anti-fouling ability observed was 94.74%,which was 2.02 times greater than that of the pure *** the same time,the MMMs contained internal amide and hydrogen bonds during the preparation process,forming a cross-linked structure,which further enhanced the mechanical strength and chemical *** summary,the MMMs with high retention rate,strong permeability,and anti-fouling ability were successfully prepared.

关键词： Poly(arylene ether ketone)-containing Carboxyl groups(PAEK-COOH) UiO-66-NH_(2)@graphene oxide Hydrophilic modification Ultra-high selectivity Strong anti-fouling

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Amino-functionalized UiO-66-doped mixed matrix membranes with high permeation performance and fouling resistance

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Chinese Journal of Chemical Engineering 2024年第3期67卷 68-77页

作者： Yi Zhang Di Liu Zhaoli Wang Junjian Yu Yanyin cheng wenjing Li Zhe Wang Hongzhe Ni Yuchao Wang School of Chemical Engineering Changchun University of TechnologyChangchun 130012China Advanced Institute of Materials Science Changchun University of TechnologyChangchun 130012China Key Laboratory of Advanced Functional Polymer Membrane Materials of Jilin Province Changchun 130012China School of Chemistry and Life Science Changchun University of TechnologyChangchun 130012China

For the reduction of bovine serum proteins from wastewater,a novel mixed matrix membrane was prepared by functionalizing the substrate material polyaryletherketone(PAEK),followed by carboxyl groups(C-SPAEKS),and then adding amino-functionalized UiO-66-NH_(2)(Am-UiO-66-NH_(2)).Aminofunctionalization of UiO-66 was accomplished by melamine,followed by an amidation reaction to immobilize Am-UiO-66-NH_(2),which was immobilized on the surface of the membrane as well as in the pore channels,which enhanced the hydrophilicity of the membrane surface while increasing the negative potential of the membrane *** nanoparticle-loaded ultrafiltration membrane has good permeation performance,with a pure water flux of up to 482.3 L·m^(-2)·h^(-1) for C-SPAEKS/AmUiO-66-NH_(2) and a retention rate of up to 98.7%for bovine serum albumin(BSA)-contaminated ***,after several hydrophilic modifications,the flux recovery of BSA contaminants by this series of membranes increased from 56.2%to 80.55%of pure *** results of ultra-filtration flux time tests performed at room temperature showed that the series of ultrafiltration membranes remained relatively stable over a test time of 300 ***,the newly developed mixed matrix membrane showed potential for high efficiency and stability in wastewater treatment containing bovine serum proteins.

关键词： Ultrafiltration Mixed matrix membranes Amino functionalization Hydrophilic modification Negatively charged

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Spectral purification improves monitoring accuracy of the comprehensive growth evaluation index for film-mulched winter wheat

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Journal of Integrative Agriculture 2024年第5期23卷 1523-1540页

作者： Zhikai cheng Xiaobo Gu Yadan Du Zhihui Zhou Wenlong Li Xiaobo Zheng wenjing Cai Tian Chang Key Laboratory of Agricultural Soil and Water Engineering in Arid and Semiarid AreasMinistry of Education/Northwest A&F University Yangling712100China

In order to further improve the utility of unmanned aerial vehicle(UAV)remote-sensing for quickly and accurately monitoring the growth of winter wheat under film mulching, this study examined the treatments of ridge mulching,ridge–furrow full mulching, and flat cropping full mulching in winter *** on the fuzzy comprehensive evaluation (FCE) method, four agronomic parameters (leaf area index, above-ground biomass, plant height, and leaf chlorophyll content) were used to calculate the comprehensive growth evaluation index (CGEI) of the winter wheat, and 14 visible and near-infrared spectral indices were calculated using spectral purification technology to process the remote-sensing image data of winter wheat obtained by multispectral *** machine learning algorithms, partial least squares, support vector machines, random forests, and artificial neural network networks(ANN), were used to build the winter wheat growth monitoring model under film mulching, and accuracy evaluation and mapping of the spatial and temporal distribution of winter wheat growth status were carried *** results showed that the CGEI of winter wheat under film mulching constructed using the FCE method could objectively and comprehensively evaluate the crop growth *** accuracy of remote-sensing inversion of the CGEI based on the ANN model was higher than for the individual agronomic parameters, with a coefficient of determination of 0.75,a root mean square error of 8.40, and a mean absolute value error of *** purification could eliminate the interference of background effects caused by mulching and soil, effectively improving the accuracy of the remotesensing inversion of winter wheat under film mulching, with the best inversion effect achieved on the ridge–furrow full mulching area after spectral *** results of this study provide a theoretical reference for the use of UAV remote-sensing to monitor the growth status of winter wheat with film mulching.

关键词： mulched winter wheat machine learning fuzzy comprehensive evaluation comprehensive growth evaluation index unmanned aerial vehicle

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Gapless Genome Assembly of ZH8015 and Preliminary Multi-Omics Analysis to Investigate ZH8015's Responses Against Brown Planthopper Infestation

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Rice science 2024年第3期31卷 317-327,I0042-I0045页

作者： LI Dian DUAN wenjing LIU Qun’en WU Weixun ZHAN Xiaodeng SUN Lianping ZHANG Yingxin cheng Shihua State Key Laboratory of Rice Biology and Breeding China National Rice Research InstituteHangzhou 310006China

Accurate genomic information is essential for advancing genetic breeding research in specific rice *** study presented a gapless genome assembly of the indica rice cultivar Zhonghui 8015(ZH8015)using Pac Bio HiFi,Hi-C,and ONT(Oxford Nanopore Technologies)ultra-long sequencing technologies,annotating 43037 gene ***,utilizing this genome along with transcriptomic and metabolomic techniques,we explored ZH8015's response to brown planthopper(BPH)*** transcriptomic sampling indicated significant changes in gene expression levels around 48 h after BPH *** analysis revealed particularly significant alterations in genes related to reactive oxygen species scavenging and cell wall *** results demonstrated marked increases in levels of several monosaccharides,which are components of the cell wall and dramatic changes in flavonoid *** association analysis identified differentially expressed genes associated with key metabolites,shedding light on ZH8015's response to BPH *** summary,this study constructed a reliable genome sequence resource for ZH8015,and the preliminary multi-omics results will guide future insect-resistant breeding research.

关键词： brown planthopper gapless genome genome assembly multi-omics Nilaparvata lugens rice

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皮肤血管周上皮样细胞肿瘤1例

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中华皮肤科杂志 2023年第4期56卷 349-350页

作者：成文静王雷第四军医大学西京皮肤医院西安710032

患者女,64岁,因右大腿红色结节1年余于2020年10月19日就诊。1年前无明显诱因出现右大腿红色结节,渐增大,无瘙痒及疼痛,未治疗。既往有高血压病史3年,“双黄连”药物过敏史,无结节性硬化症病史,无糖尿病、心脏病等慢性病病史,否认外伤手... 详细信息

患者女,64岁,因右大腿红色结节1年余于2020年10月19日就诊。1年前无明显诱因出现右大腿红色结节,渐增大,无瘙痒及疼痛,未治疗。既往有高血压病史3年,“双黄连”药物过敏史,无结节性硬化症病史,无糖尿病、心脏病等慢性病病史,否认外伤手术史.

关键词：红色结节结节性硬化症外伤手术血管周上皮样细胞肿瘤双黄连药物过敏史慢性病心脏病

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