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Incidence and Clinical Characteristics of pulmonary Hypertension in Patients with Idiopathic pulmonary Fibrosis

Chinese Medical Journal 2015年第7期128卷 896-901页

作者： Wei yan li-Ying peng Cheng-Jun Ban xue-Feng xu min Zhu yan liu Shu Zhang Zhen-Guo Zhai Chen wang Hua-Ping Dai Department of Respiratory and Critical Care Medicine Beijing Chao-Yang Hospital Capital Medical University Beijing 100020 China Beijing Key Laboratory of Respiratory and pulmonary Circulation Beijing Institute of Respiratory Medicine Beijing 100020 China

Background： pulmonary hypertension （PH） frequently complicates the course of idiopathic pulmonary fibrosis （IPF） patients and is associated with significantly worse outcomes. The aim of the present study was to investigate the incidence of PH in IPF patients and evaluate the correlation between clinical parameters and systolic pulmonary artery pressure （sPAP）. Methods： Hospitalized patients with IPF, who were evaluated for sPAP by Doppler echocardiography from January 2004 to December 2011, were enrolled in our study. Patients were defined as PH by an estimated sPAP 〉 50 mmHg and graded as PH likely, PH possible and PH unlikely, based on the 2009 European Society of Cardiology/European Respiratory Society PH Guidelines. The correlations between clinical parameters and sPAP were analyzed by multiple linear regression. Results： Totally, 119 IPF patients were enrolled in our study and 28 （23.5%）, 20 （16.8%） and 71 （59.7%） patients were PH likely, PH possible and PH unlikely, respectively. Borg dyspnea score was positively correlated with sPAP, r = 0.467, P 〈 0.001. Oxygen saturation was negatively correlated with sPAP, r = -0.416, P 〈 0.001. Diffusing capacity of the lung for carbon monoxide percentage predicted was negatively correlated with sPAP, r = -0.424, P = 0.003. N-terminal fragment of pro-brain natriuretic peptide and pulmonary artery width was positively correlated with sPAP, r = 0.452, P = 0.011 and r= 0.513, P 〈 0.001, respectively. Conclusions： The incidence of PH in IPF patients was 23.5% in a single center of China. PH may worsen the dyspnea, right heart dysfunction and decrease the life quality of the patients with IPF.

关键词： Idiopathic pulmonary Fibrosis: Incidence pulmonary Hypertension

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Charge resolution in the isochronous mass spectrometry and the mass of ^(51)Co

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Nuclear Science and Techniques 2021年第4期32卷 30-37页

作者： xu Zhou Meng wang Yu-Hu Zhang Hu-Shan xu You-Jin Yuan Jian-Cheng yang Yu.A.litvinov S.A.litvinov Bo Mei Xin-liang yan Xing xu peng Shuai Yuan-ming Xing Rui-Jiu Chen Xiang-Cheng Chen Chao-Yi Fu Qi Zeng ming-Ze Sun hong-Fu li Qian wang Tong Bao min Zhang min Si Han-Yu Deng ming-Zheng liu Ting liao Jin-yang Shi Yu-Nan song Institute of Modern Physics Chinese Academy of SciencesLanzhou 730000China School of Nuclear Science and Technology University of Chinese Academy of SciencesBeijing 100049China GSI Helmholtzzentrum fu¨r Schwerionenforschung Planckstraße 164291 DarmstadtGermany Sino-French Institute of Nuclear Engineering and Technology Sun Yat-sen UniversityZhuhai 519082China School of Science Xi’an Jiaotong UniversityXi’an 710049China School of Nuclear Science and Engineering East China University of TechnologyNanchang 330013China CNRS/IN2P3 IJCLabUniversite´Paris-Saclay91405 OrsayFrance

Isochronous mass spectrometry(IMS)of heavyion storage rings is a powerful tool for the mass measurements of short-lived *** IMS experiments,masses are determined through precision measurements of the revolution times of the ions stored in the ***,the revolution times cannot be resolved for particles with nearly the same mass-to-charge(m/q)*** overcome this limitation and to extract the accurate revolution times for such pairs of ion species with very close m/q ratios,in our early work on particle identification,we analyzed the amplitudes of the timing signals from the detector based on the emission of secondary ***,the previous data analysis method is further improved by considering the signal amplitudes,detection efficiencies,and number of stored ions in the ring.A sensitive Z-dependent parameter is introduced in the data analysis,leading to a better resolution of ^(34)Ar^(18+) and ^(51)Co^(27+) with A/Z=17/*** mean revolution times of ^(34)Ar^(18+) and ^(51)Co^(27+) are deduced,although their time difference is merely 1.8 *** uncorrected,overlapped peak of these ions has a full width at half maximum of 7.7 *** mass excess of ^(51)Co was determined to be-27;332e41T keV,which is in agreement with the previous value of-27;342e48T keV.

关键词： Isochronous mass spectrometry Charge resolution Signal amplitude Micro-channel plate ^(51)Co

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Association of Estrogen Receptor Gene Polymorphisms and Primary Biliary Cirrhosis in a Chinese Population： A Case- Control Study

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Chinese Medical Journal 2015年第22期128卷 3008-3014页

作者： liu yang hong Zhang yan-Fang Jiang Qing-Long Jin peng Zhang xu li pu-Jun Gao Jun-Qi Niu Department of Hepatology First Hospital Jilin University Changchun Jilin 130021 China National Clinical Research Center of Kidney Diseases Jinling Hospital Nanjing university School of Medicinel Nanjing Jiangsu 210002 China Phase I Clinical Trials Unit First Hospital Jilin University Changchun Jilin 130021 China

Background： Primary biliary cirrhosis （PBC） is a chronic and slowly progressive cholestatic liver disease characterized by destruction of the interlobular bile ducts and a striking female predominance, The aim of this study was to identity associations between estrogen receptor （ESR） gene polymorphisms with the risk of developing PBC and abnormal serum liver tests in a Chinese population. Methods： Thirty-six patients with PBC （case group） and 35 healthy individuals （control group） from the First Hospital of Jilin University were studied. Whole genomic DNA was extracted from all the participants. Three single-nucleotide polymorphisms （rs2234693~ rs2228480, and rs3798577） from ESR1 and two （rs1256030 and rs1048315） from ESR2 were analyzed by a pyrosequencing method. Demographic data and liver biochemical data were collected. Results： Subjects with the T allele at ESR2 rs1256030 had 1.5 times higher risk of developing PBC than those with the C allele （odds ratio [OR] = 2.1277, 95% confidence interval [CI] = 1.1872-4.5517）. Haplotypes TGC of ESRI rs2234693, rs2228480, and rs3798577 were risk thctors for having PBC. The C allele at ESRI rs2234693 was associated with abnormal alkaline phosphatase （OR 5.2469, 95% CI = 1.3704-20.0895） and gamma-glutamyl transferase （OR = 3.4286, 95% CI = 1.0083-13.6578） levels in PBC patients. Conclusions： ESR2 rs1256030 T allele may be a significant risk factor for the development of PBC. Screening for patients with gene polymorphisms may help to make early diagnoses in patients with PBC.

关键词： Estrogen Receptor Gene Polymorphism Primary Biliary Cirrhosis

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基于白光中子源的^(197)Au中子辐射俘获截面测量及共振参数分析

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物理学报 2024年第7期73卷 104-113页

作者：罗淏天张奇玮栾广源王晓宇邹翀任杰阮锡超贺国珠鲍杰孙琪黄翰雄王朝辉吴鸿毅顾旻皓余滔解立坤陈永浩安琪白怀勇鲍煜曹平陈昊磊陈琪萍陈裕凯陈朕崔增琪樊瑞睿封常青高可庆韩长材韩子杰何泳成洪杨黄蔚玲黄锡汝季筱璐吉旭阳蒋伟江浩雨姜智杰敬罕涛康玲康明涛李波李超李嘉雯李论李强李晓李样刘荣刘树彬刘星言穆奇丽宁常军齐斌斌任智洲宋英鹏宋朝晖孙虹孙康孙晓阳孙志嘉谭志新唐洪庆唐靖宇唐新懿田斌斌王丽娇王鹏程王琦王涛峰文杰温中伟吴青彪吴晓光吴煊羊奕伟易晗于莉于永积张国辉张林浩张显鹏张玉亮张志永赵豫斌周路平周祖英朱丹阳朱科军朱鹏朱兴华中国原子能科学研究院核数据重点实验室北京102413 中国科学院高能物理研究所北京100049 散裂中子源科学中心东莞523803 核探测与核电子学国家重点实验室北京100049 中国科学技术大学近代物理系核探测与核电子学国家重点实验室合肥230026 北京大学物理学院核物理与核技术国家重点实验室北京100871 中国工程物理研究院核物理与化学研究所绵阳621900 西北核技术研究院西安710024 中国科学院大学北京100049 中国科学技术大学工程与应用物理系合肥230026 北京航空航天大学物理学院北京100083 华能山东石岛湾核电有限公司荣成264312

中子辐射俘获反应在反应堆运行、核装置设计及核天体物理研究中起重要的作用.4πBaF_(2)探测装置有着高时间分辨能力、低中子灵敏度、高探测效率等优点,适合开展中子辐射俘获反应截面数据的测量.中国原子能科学研究院核数据重点实验室... 详细信息

中子辐射俘获反应在反应堆运行、核装置设计及核天体物理研究中起重要的作用.4πBaF_(2)探测装置有着高时间分辨能力、低中子灵敏度、高探测效率等优点,适合开展中子辐射俘获反应截面数据的测量.中国原子能科学研究院核数据重点实验室建立了伽马全吸收装置(Gamma total absorption facility,GTAF),该装置用28块六棱BaF_(2)晶体和12块五棱BaF_(2)晶体构成了外径25 cm,内径10 cm的球壳,覆盖了95.2%的立体角.利用GTAF在中国散裂中子源Back-n束线上,测量了197Au(n,γ)的反应截面数据.测量数据通过能量筛选、PSD方法、晶体多重性筛选进行了初步本底扣除,随后结合对^(nat)C及空样品的测量数据对本底进行了分析及扣除,获得了197Au俘获反应的产额,利用SAMMY程序拟合得到了^(197)Au在1—100 e V的共振能量、中子共振宽度和伽马共振宽度参数.实验测量结果与ENDF/B-VIII.0数据库符合良好,其共振参数存在一定差异,分析原因可能与GTAF能量分辨率、Back-n的中子能谱测量精度、以及实验本底扣除方法相关,这也是下一步工作的重点.

关键词：中子辐射俘获截面共振参数白光中子源伽马全吸收装置

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气动快关球阀的故障分析与处理

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阀门 2024年第3期 342-347页

作者：李楠李陆昊路泽鑫胡政玺徐朴方李谦黄立还李宗昌刘彦鹏姬佳怡王晓瑶王佳琦西安航天动力试验技术研究所陕西西安710100

气动快关球阀是流体输送系统中安全可靠运行的关键装置,但是在气动阀门的使用过程中,在各种因素的影响下会发生故障,一旦气动阀门出现故障,将影响整个液体输送的稳定性及压力和流量调节的实时性等,相比传统手动阀门控制,气动快关球阀具... 详细信息

气动快关球阀是流体输送系统中安全可靠运行的关键装置,但是在气动阀门的使用过程中,在各种因素的影响下会发生故障,一旦气动阀门出现故障,将影响整个液体输送的稳定性及压力和流量调节的实时性等,相比传统手动阀门控制,气动快关球阀具有控制简单、可靠性高、响应迅速等优点。本文针对航天液体火箭发动机试验台液体长输管线上的实际案例,基于气动快关球阀的结构及特点分析,对实际应用中的球阀阀座PTFE阀座圈被异常切断,进入输送管道中的过滤器中的问题进行确定和分析,提出具体的解决措施,经过验证和改进后的气动快关球阀满足试验使用要求。

关键词：气动快关球阀故障试验阀座圈解决措施

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Amplitude analysis of the decays D^(0)→π^(+)π^(−)π^(+)π^(−)and D^(0)→π^(+)π^(−)π^(0)π^(0)

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Chinese Physics C 2024年第8期48卷 6-33页

作者： M.Ablikim M.N.Achasov P.Adlarson O.Afedulidis X.C.Ai R.Aliberti A.Amoroso Q.An Y.Bai O.Bakina I.Balossino Y.Ban H.-R.Bao V.Batozskaya K.Begzsuren N.Berger M.Berlowski M.Bertani D.Bettoni F.Bianchi E.Bianco A.Bortone I.Boyko R.A.Briere A.Brueggemann H.Cai X.Cai A.Calcaterra G.F.Cao N.Cao S.A.Cetin J.F.Chang W.L.Chang G.R.Che G.Chelkov C.Chen C.H.Chen Chao Chen G.Chen H.S.Chen M.L.Chen S.J.Chen S.L.Chen S.M.Chen T.Chen X.R.Chen X.T.Chen Y.B.Chen Y.Q.Chen Z.J.Chen Z.Y.Chen S.K.Choi X.Chu G.Cibinetto F.Cossio J.J.Cui H.L.Dai J.P.Dai A.Dbeyssi R.E.de Boer D.Dedovich C.Q.Deng Z.Y.Deng A.Denig I.Denysenko M.Destefanis F.De Mori B.Fang S.S.Fang W.X.Fang Y.Fang Y.Q.Fang R.Farinelli L.Fava F.Feldbauer G.Felici C.Q.Feng J.H.Feng Y.T.Feng K.Fischer M.Fritsch C.D.Fu J.L.Fu Y.W.Fu H.Gao Y.N.Gao yang Gao S.Garbolino I.Garzia P.T.Ge Z.W.Ge C.Geng E.M.Gersabeck B.Ding X.X.Ding Y.Ding Y.Ding J.Dong L.Y.Dong M.Y.Dong X.Dong M.C.Du S.X.Du Z.H.Duan P.Egorov Y.H.Fan J.Fang JA.Gilman K.Goetzen L.Gong W.X.Gong W.Gradl S.Gramigna M.Greco M.H.Gu Y.T.Gu C.Y.Guan Z.L.Guan A.Q.Guo L.B.Guo M.J.Guo R.P.Guo Y.P.Guo A.Guskov J.Gutierrez K.L.Han T.T.Han X.Q.Hao F.A.Harris K.K.He K.L.He F.H.Heinsius C.H.Heinz Y.K.Heng C.Herold T.Holtmann P.C.hong G.Y.Hou X.T.Hou Y.R.Hou Z.L.Hou B.Y.Hu H.M.Hu J.F.Hu T.Hu Y.Hu G.S.Huang K.X.Huang L.Q.Huang X.T.Huang Y.P.Huang T.Hussain F.H\"olzken N.H\"usken N.in der Wiesche M.Irshad J.Jackson S.Janchiv J.H.Jeong Q.Ji Q.P.Ji W.Ji X.B.Ji X.L.Ji Y.Y.Ji X.Q.Jia Z.K.Jia D.Jiang H.B.Jiang P.C.Jiang S.S.Jiang T.J.Jiang X.S.Jiang Y.Jiang J.B.Jiao J.K.Jiao Z.Jiao S.Jin Y.Jin M.Q.Jing X.M.Jing T.Johansson S.Kabana N.Kalantar-Nayestanaki X.L.Kang X.S.Kang M.Kavatsyuk B.C.Ke V.Khachatryan A.Khoukaz R.Kiuchi O.B.Kolcu B.Kopf M.Kuessner X.Kui A.Kupsc W.K\"uhn J.J.Lane P.Larin L.Lavezzi T.T.Lei Z.H.Lei H.Leithoff M.Lellmann T.Lenz C.li C.li C.H.li Cheng li D.M.li F.li G.li H.li H.B.li H.J.li H.N.li Hui li J.R.li J.S.li K.li L.J.li L.K.li Lei li M.H.li P.R.li Q.M.li Q.X.li R.li S.X.li T.li W.D.li W.G.li X.li X.H.li X.L.li X.Y.li Y Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China Beihang University Beijing 100191China Bochum Ruhr-University D-44780 BochumGermany Budker Institute of Nuclear Physics SB RAS(BINP) Novosibirsk 630090Russia Carnegie Mellon University PittsburghPennsylvania 15213USA Central China Normal University Wuhan 430079China Central South University Changsha 410083China China Center of Advanced Science and Technology Beijing 100190China China University of Geosciences Wuhan 430074China Chung-Ang University Seoul06974Republic of Korea COMSATS University Islamabad Lahore CampusDefence RoadOff Raiwind Road54000 LahorePakistan Fudan University Shanghai 200433China GSI Helmholtzcentre for Heavy Ion Research GmbH D-64291 DarmstadtGermany Guangxi Normal University Guilin 541004China Guangxi University Nanning 530004China Hangzhou Normal University Hangzhou 310036China Hebei University Baoding 071002China Helmholtz Institute Mainz Staudinger Weg 18D-55099 MainzGermany Henan Normal University Xinxiang 453007China Henan University Kaifeng 475004China Henan University of Science and Technology Luoyang 471003China Henan University of Technology Zhengzhou 450001China Huangshan College Huangshan 245000China Hunan Normal University Changsha 410081China Hunan University Changsha 410082China Indian Institute of Technology Madras Chennai 600036India Indiana University BloomingtonIndiana 47405USA INFN Laboratori Nazionali di Frascati INFN Laboratori Nazionali di FrascatiI-00044FrascatiItaly INFN Laboratori Nazionali di Frascati INFN Sezione di PerugiaI-06100PerugiaItaly INFN Laboratori Nazionali di Frascati University of PerugiaI-06100PerugiaItaly INFN Sezione di Ferrara INFN Sezione di FerraraI-44122FerraraItaly INFN Sezione di Ferrara University of FerraraI-44122FerraraItaly Inner Mongolia University Hohhot 010021China Institute of Modern Physics Lanzhou 730000China Institute of Physics and Technology Peace Avenue 54BUlaanbaatar 13330Mongolia Instituto de A

Using e^(+)e^(−)annihilation data corresponding to an integrated luminosity of 2.93 fb^(−1)taken at the center-of-mass energy√s=3.773 GeV with the BESIII detector,a joint amplitude analysis is performed on the decays D^(0)→π^(+)π^(−)π^(+)π^(−)and D^(0)→π^(+)π^(−)π^(0)π^(0)(non-η).The fit fractions of individual components are obtained,and large interferences among the dominant components of the decays D^(0)→a_(1)(1260)π,D^(0)→π(1300)π,D^(0)→ρ(770)ρ(770),and D^(0)→2(ππ)_(S)are observed in both *** the obtained amplitude model,the CP-even fractions of D^(0)→π^(+)π^(−)π^(+)π^(−)and D^(0)→π^(+)π^(−)π^(0)π^(0)(non-η)are determined to be(75.2±1.1_(stat).±1.5_(syst.))%and(68.9±1.5_(stat).±2.4_(syst.))%,*** branching fractions of D^(0)→π^(+)π^(−)π^(+)π^(−)and D^(0)→π^(+)π^(−)π^(0)π^(0)(non-η)are measured to be(0.688±0.010_(stat.)±0.010_(syst.))%and(0.951±0.025_(stat.)±0.021_(syst.))%,*** amplitude analysis provides an important model for the binning strategy in measuring the strong phase parameters of D^(0)→4πwhen used to determine the CKM angleγ(ϕ_(3))via the B^(−)→DK^(−)decay.

关键词： BESIII D^(0)meson decays amplitude analysis CP-even fraction

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Pomolic acid and its glucopyranose ester promote apoptosis through autophagy in HT-29 colon cancer cells

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World Journal of Gastrointestinal Oncology 2023年第10期15卷 1756-1770页

作者： li-yan liu Teng-Hua Yu Tie-song liao peng xu Ying wang min Shi Bin li Workstation of Academician Jiangxi University of Chinese MedicineNanchang 330004Jiangxi ProvinceChina Department of Pharmacy Jiangxi Cancer Hospital and Jiangxi Cancer CenterNanchang 330029Jiangxi ProvinceChina Department of Breast Surgery Jiangxi Cancer Hospital and Jiangxi Cancer CenterNanchang 330029Jiangxi ProvinceChina Laboratory Animal Science and Technology Center Jiangxi University of Chinese MedicineNanchang 330004Jiangxi ProvinceChina Department of Pharmacy Shangrao Health SchoolShangrao 334000Jiangxi ProvinceChina

BACKGROUND Colon cancer remains a leading cause of death *** acid(PA)can be separated from the ethyl acetate fraction of achyrocline *** To determine the effects of PA and its glucopyranose ester,pomolic acid-28-O-β-D-glucopyranosyl ester(PAO),on colon cancer HT-29 *** 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide assay was used to measure cell *** was detected via hoechst 33342 *** single staining was identified by flow cytometry to determine the cycle and scratch assay was used to observe the migration of HT-29 *** levels of mRNA and proteins were evaluated by q polymerase chain reaction and western blotting,*** PA and PAO considerably inhibited the growth of the HT-29 cell line in a time and dose-dependent *** the administration of PA and PAO for 24 and 48 h,cell apoptosis was significantly promoted and HT-29 cells were arrested in the G0/G1 *** Bax/Bcl2 ratio was also increased,which activated cysteinyl aspartate specific proteinase 3,leading to apoptosis;it also increased the expression of light chain 3 II/I and Beclin1,which activated autophagy and caused cell *** in turn increased the expression of p62 to promote cell apoptosis,inhibiting the levels of signal transducer and activator of transcription 3(STAT3)and p-STAT3,suppressing the level of Bcl2,and promoting *** Both PA and PAO provide novel therapeutic strategies for treating colorectal cancer.

关键词： Colon cancer Achyrocline satureioides Pomolic acid Pomolic acid-28-O-β-D-glucopyranose

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Comparative population genomics reveals genetic basis underlying body size of domestic chickens

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Journal of Molecular Cell Biology 2016年第6期8卷 542-552页

作者： ming-Shan wang Yong-Xia Huo yan li Newton OOtecko ling-yan Su Hai-Bo xu Shi-Fang Wu min-Sheng peng He-Qun liu lin Zeng David M.Irwin Yong-Gang Yao Dong-Dong Wu Ya-Ping Zhang State Key Laboratory of Genetic Resources and Evolution Yunnan Laboratory of Molecular Biology of Domestic AnimalsKunming Institute of ZoologyChinese Academy of SciencesKunming 650223China Kunming College of life Science University of Chinese Academy of SciencesKunming 650204China College of life Science Anhui UniversityHefei 230601China Laboratory for Conservation and Utilization of Bio-Resource Yunnan UniversityKunming 650091China Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences&Yunnan Province Kunming Institute of ZoologyKunming 650223China Department of Laboratory Medicine and Pathobiology University of TorontoTorontoOntario M5S 1A8Canada Banting and Best Diabetes Centre University of TorontoTorontoOntario M5G 2C4Canada

Body size is the most important economic trait for animal production and *** hundreds of loci have been reported to be associated with growth trait and body weight in *** loci are mapped to large genomic regions due to the low density and limited number of genetic markers in previous ***,we employed comparative population genomics to identify genetic basis underlying the small body size of Yuanbao chicken(a famous ornamental chicken)based on 89 whole *** most significant signal was mapped to the BMP10 gene,whose expression was upregulated in the Yuanbao *** of BMP10 induced a significant decrease in body length by inhibiting angiogenic vessel development in *** addition,three other loci on chromosomes 1,2,and 24 were also identified to be potentially involved in the development of body *** results provide a paradigm shift in identification of novel loci controlling body size variation,availing a fast and efficient *** loci,particularly BMP10,add insights into ongoing research of the evolution of body size under artificial selection and have important implications for future chicken breeding.

关键词： body size artificial selection comparative population genomics domestication

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Data processing and data products from 2017 to 2019 campaign of astronomical site testing at Ali,Daocheng and Muztagh-ata

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Research in Astronomy and Astrophysics 2020年第6期20卷 109-130页

作者： Zi-Huang Cao Jin-Xin Hao Lu Feng Hugh RAJones Jian li Jing xu li-Yong liu Teng-Fei song Jian-Feng wang Hua-lin Chen yan-Jie xue Huang Shen Yong-Heng Zhao Zhao-Xiang Qi Jian-Rong Shi Yuan Tian Zheng wang Xia wang Jin-liang Hou Jin-ming Bai Ji yang xu Zhou Yong-Qiang Yao Jia Yin Ali Esamdin Guang-Xin pu peng Wei Chun-Hai Bai Guo-Jie Feng Lu Ma xuan Zhang Yu liu Chong Pei Zhi-Xia Shen Yun-Ying Jiang Jian-Feng Tian Xian-Qun Zeng Zhi-Gang Hou xu yang Jun-Bo Zhang Shi-Long liao Dong-Wei Fan Yun-Fei xu Jian-Ping Xiong Tai-Sheng yan Xi Zhang Chang-Hua li Yi-Han Tao Si-Cheng Yu Zhi-song Cao hong-Shuai wang National Astronomical Observatories Chinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China Shanghai Astronomical Observatory Chinese Academy of SciencesShanghai 200030China Centre for Astrophysics University of HertfordshireHatfieldUK School of Journalism Communication University of ChinaBeijing 100024China Nanjing Institute of Astronomical Optics&Technology Chinese Academy of SciencesNanjing 210042China Xinjiang Astronomical Observatory Chinese Academy of SciencesUrumqi 830011China Yunnan Observatories Chinese Academy of SciencesKunming 650216China purple Mountain Observatory Chinese Academy of SciencesNanjing 210033China Beijing Kaiyang Space Technology Co. LtdBeijing 100085China

Based on previous site testing and satellite cloud data,Ali,Daocheng and Muztagh-ata have been selected as candidate sites for the Large Optical/Infrared Telescope(LOT) in *** present the data collection,processing,management and quality analysis for our site testing based on using similar *** analyze meteorological data,seeing,background light,cloud and precipitable water vapor data from 2017 March 10 to 2019 March *** also investigated the relative usefulness of our all-sky camera data in comparison to that from the meteorological TERRA satellite data based on a night-by-night comparison of the correlation and consistency between *** find a 6% discrepancy arising from a wide range of factors.

关键词： LOT Site-selection-data processing

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San-Ao Decoction (三拗汤) Regulates Urine Volume on Bronchial Asthma Model Mice

引用

Chinese Journal of Integrative Medicine 2021年第3期27卷 212-219页

作者： wang min SUN yan ZHANG Shu-jing GAO Yu-shan WEI Ya-nan ZHAO peng-na liu Miao yanG Jia-min ZHENG Feng-jie xu hong li Yu-hang School of Chinese Medicine Beijing University of Chinese MedicineBeijing 100029China

Objective To observe the effect of San-Ao Decoction(三拗汤,SAD)on water metabolism of bronchial asthra model *** Forty-five female BALB/c mice were randomly divided into control,model and SAD groups by a random number table,15 mice in each group.A composite method with ovalbumin(OVA)sensitization and challenge was developed to establish bronchial asthma *** in the control group were intraperitoneally injected with distilled water without aerosol inhalation *** day 15–22,0.3 mL SAD was administered via gastric route in SAD group,one time per day,while an equivalent volume of normal saline was used for gastric administration in the control and model *** in airway resistance in the inspiratory phase(RI-R-Area)were detected using an AniRes2005 system,and 5-h urine output was collected by metabolic *** changes in lung and kidney were observed by hematoxylin-eosin *** expressions of aquaporin(AQP)1 and AQP2 in kidney were detected by reverse transcription-polymerase chain reaction,and the protein expressions of AQP1 and AQP2 in kidney were detected by ***-linked immune sorbent assay was used to detect the OVA-specific endothelium-1(ET-1),antidiuretic hormone(ADH),atrial natriuretic peptide(ANP),prostaglandin E_(2)(PGE_(2)),and angiotensin II(Ang II)levels in serum,lung and kidney tissues,*** nitric oxide(NO)contents in serum,lung,and kidney tissues were tested by chemical method,*** Compared with the control group,the serum IgE level in model group increased(P<0.01).Following the pathologic changes in lung tissue,no significant change in kidney tissue was observed among 3 *** with the control group,the mice in the model group showed elevated airway resistance during inhalation phase,higher mRNA and protein expression levels on AQP1 and AQP2 in kidney tissue and higher ET-1 levels in serum,lung and kidney tissues,ADH and ANP in lung and serum,PGE

关键词： regulation of fluid passage urine volume aquaporin San-Ao Decoction bronchial asthma

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