Comparative population genomics reveals genetic basis underlying body size of domestic chickens
作者机构：State Key Laboratory of Genetic Resources and EvolutionYunnan Laboratory of Molecular Biology of Domestic AnimalsKunming Institute of ZoologyChinese Academy of SciencesKunming 650223China Kunming College of Life ScienceUniversity of Chinese Academy of SciencesKunming 650204China College of Life ScienceAnhui UniversityHefei 230601China Laboratory for Conservation and Utilization of Bio-ResourceYunnan UniversityKunming 650091China Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences&Yunnan ProvinceKunming Institute of ZoologyKunming 650223China Department of Laboratory Medicine and PathobiologyUniversity of TorontoTorontoOntario M5S 1A8Canada Banting and Best Diabetes CentreUniversity of TorontoTorontoOntario M5G 2C4Canada
出 版 物：《Journal of Molecular Cell Biology》 (分子细胞生物学报（英文版）)
年 卷 期：2016年第8卷第6期
页 面：542-552页
核心收录：
学科分类：0202[经济学-应用经济学] 02[经济学] 1002[医学-临床医学] 020205[经济学-产业经济学]
基 金：supported by grants from the National Natural Science Foundation of China(91331104) the 973 Program(2013CB835200,2013CB835204) Bureau of Science and Technology of Yunnan Province(2015FA026)
主 题：body size artificial selection comparative population genomics domestication
摘 要：Body size is the most important economic trait for animal production and *** hundreds of loci have been reported to be associated with growth trait and body weight in *** loci are mapped to large genomic regions due to the low density and limited number of genetic markers in previous ***,we employed comparative population genomics to identify genetic basis underlying the small body size of Yuanbao chicken(a famous ornamental chicken)based on 89 whole *** most significant signal was mapped to the BMP10 gene,whose expression was upregulated in the Yuanbao *** of BMP10 induced a significant decrease in body length by inhibiting angiogenic vessel development in *** addition,three other loci on chromosomes 1,2,and 24 were also identified to be potentially involved in the development of body *** results provide a paradigm shift in identification of novel loci controlling body size variation,availing a fast and efficient *** loci,particularly BMP10,add insights into ongoing research of the evolution of body size under artificial selection and have important implications for future chicken breeding.
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