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Genome-wide CRISPR screening identifies critical role of phosphatase and tensin homologous (PTEN) in sensitivity of acute myeloid leukemia to chemotherapy

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2024年第8期25卷 700-710页

作者： liming liN Jingjing TAO ying MENG Yichao GAN Xin HE Shu li Jiawei zhang Feiqiong gao Dijia XIN Luyao wang Yili fan Boxiao CHEN Zhimin LU yang XU Department of Hematology the Second Affiliated HospitalZhejiang University School of MedicineHangzhou 310009China Zhejiang Provincial Key Laboratory of Pancreatic Disease the First Affiliated Hospital and Institute of Translational MedicineCancer CenterZhejiang University School of MedicineHangzhou 310029China Institute of Genetics Zhejiang UniversityHangzhou 310058China Division of Hematopoietic Stem Cell&Leukemia Research Beckman Research Institute of City of HopeDuarteCA 91010USA Department of Hematology Shanghai General HospitalShanghai Jiao Tong University School of MedicineShanghai 200025China

Although significant progress has been made in the development of novel targeted drugs for the treatment of acute myeloid leukemia(AML)in recent years,chemotherapy still remains the mainstay of treatment and the overall survival is poor in most ***,we demonstrated the antileukemia activity of a novel small molecular compound NL101,which is formed through the modification on bendamustine with a suberanilohydroxamic acid(SAHA)***101 suppresses the proliferation of myeloid malignancy cells and primary AML *** induces DNA damage and caspase 3-mediated apoptosis.A genome-wide clustered regularly interspaced short palindromic repeats(CRISPR)library screen revealed that phosphatase and tensin homologous(PTEN)gene is critical for the regulation of cell survival upon NL101 *** knockout or inhibition of PTEN significantly reduced NL101-induced apoptosis in AML and myelodysplastic syndrome(MDS)cells,accompanied by the activation of protein kinase B(AKT)signaling *** inhibition of mammalian target of rapamycin(mTOR)by rapamycin enhanced the sensitivity of AML cells to NL101-induced cell *** findings uncover PTEN protein expression as a major determinant of chemosensitivity to NL101 and provide a novel strategy to treat AML with the combination of NL101 and rapamycin.

关键词： Genome-wide clustered regularly interspaced short palindromic repeats(CRISPR)library Phosphatase and tensin homologous(PTEN) Rapamycin Acute myeloid leukemia(AML) Chemotherapy

Space advanced technology demonstration satellite

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Science China(Technological Sciences) 2024年第1期67卷 240-258页

作者： zhang XiaoFeng CHEN Wen ZHU XiaoCheng MENG Na HE Junwang BI XingZi zhang YongHe SHI Qi li Fei liU Rui FENG ZhengGong liU liu li JinSong WU HaiChen XU DongXiao li TaiJie HUANG JiangJiang liU Shuo li TianTong YU XianSheng gao yang ZHOU Heng BAN HanYu zhang Yanli zhang YueTing yang yingQuan HE Tao DUAN Xuliang CHEN Xin wang YaMin SUN AnTai zhang KuoXiang SUN ying wang YaoBin fan ChengCheng XIONG Shaolin li XinQiao WEN Xiangyang liNG ZhiXing SUN XiaoJin zhang Chen BAI XianYong wang ZhanShan DENG YuanYong TIAN hui yang JianFeng XUE HongBo SANG Peng liU JinGuo ZHENG huiLong ZHU Xiang HE JianWu li hui XU LuXiang XU ShuYan CHEN WenWu liU ZhenDong wang Zhaoli MAO XiangLong gao Rong li ZongXuan DING GuoPeng wang XinYu DOU RunJiang WENG LuBin LUO Hao wang YaPing liANG XianFeng fanG ZiRuo Innovation Academy for Microsatellites Chinese Academy of SciencesShanghai 201203China Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China National Astronomical Observatory of China Beijing 100101China Shanghai Institute of Technical Physics Chinese Academy of SciencesShanghai 200083China Institute of Precision Optical Engineering School of Physics Science and EngineeringTongji UniversityShanghai 200092China School of Earth and Space Sciences Peking UniversityBeijing 100871China Xi’an Institute of Optics and Precision Mechanics Chinese Academy of SciencesXi’an 710119China National Space Science Center Chinese Academy of SciencesBeijing 100190China Shenyang Institute of Automation Chinese Academy of SciencesShenyang 110016China Institute of Engineering Thermophysics Chinese Academy of SciencesBeijing 100190China Institute of Mechanics Chinese Academy of SciencesBeijing 100190China Shanghai Institute of Organic Chemistry Chinese Academy of SciencesShanghai 200032China Hangzhou Institute for Advanced Study University of Chinese Academy of SciencesHangzhou 310024China Nanyang Technological University Singapore 569830Singapore Dalian Institute of Chemical Physics Chinese Academy of SciencesDalian 116023China Technical Institute of Physics and Chemistry Chinese Academy of SciencesBeijing 100049China Changchun Institute of Optics Fine Mechanics and PhysicsChinese Academy of SciencesChangchun 130033China Institute of Semiconductors Chinese Academy of SciencesBeijing 100083China Institute of Automation Chinese Academy of SciencesBeijing 100190China School of Aeronautics and Astronautics Zhejiang UniversityHangzhou 310058China

The Space Advanced Technology demonstration satellite(SATech-01),a mission for low-cost space science and new technology experiments,organized by Chinese Academy of Sciences(CAS),was successfully launched into a Sun-synchronous orbit at an altitude of~500 km on July 27,2022,from the jiuquan Satellite Launch *** as an experimental platform for space science exploration and the demonstration of advanced common technologies in orbit,SATech-01 is equipped with 16 experimental payloads,including the solar upper transition region imager(SUTRI),the lobster eye imager for astronomy(LEIA),the high energy burst searcher(HEBS),and a High Precision Magnetic Field Measurement System based on a CPT Magnetometer(CPT).It also incorporates an imager with freeform optics,an integrated thermal imaging sensor,and a multi-functional integrated imager,*** paper provides an overview of SATech-01,including a technical description of the satellite and its scientific payloads,along with their on-orbit performance.

关键词： SATech-01 spacecraft design scientific instruments on-orbit performance

The In-Flight Realtime Trigger and Localization Software of GECAM

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Research in Astronomy and Astrophysics 2024年第10期24卷 11-24页

作者： Xiao-Yun Zhao Shao-lin Xiong Xiang-yang Wen Xin-Qiao li Ce Cai Shuo Xiao Qi Luo Wen-Xi Peng Dong-Ya Guo Zheng-Hua An Ke Gong Jin-Yuan liao Yan-Qiu zhang Yue Huang Lu li Xing Wen Fei zhang Jing Duan Chen-Wei wang Dong-li Shi Peng zhang Qi-Bin Yi chao-yang li Yan-Bing Xu Xiao-Hua liang Ya-Qing liu Da-li zhang Xi-Lei Sun fan zhang Gang Chen Huan-Yu wang Sheng yang Xiao-Jing liu Min gao Mao-Shun li Jin-Zhou wang Xing Zhou Yi Zhao wang-Chen Xue chao Zheng Jia-Cong liu Xing-Bo Han Jin-ling Qi Jia Huang Ke-Ke zhang Can Chen Xiong-Tao yang Dong-Jie Hou Yu-Sa wang Rui Qiao Xiang Ma Xiao-Bo li Ping wang Xin-ying Song li-Ming Song Shi-Jie Zheng Bing li Hong-Mei zhang Yue Zhu Wei Chen Jian-Jian He Zhen zhang Jin Hou Hong-Jun wang Yan-chao Hao Xiang-Yu wang Zong-Yuan yang Zhi-Long Wen Zhi Chang Yuan-Yuan Du Rui gao Xiao-Fei Lan Yan-Guo li Gang li Xu-fang li fang-Jun Lu Hong Lu Bin Meng Feng Shi hui wang hui-Zhen wang Yu-Peng Xu Jia-Wei yang Xue-Juan yang Shuang-Nan zhang chao-Yue zhang Cheng-Mo zhang Zhi-Cheng Tang Cheng Cheng Key Laboratory of Particle Astrophysics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China University of Chinese Academy of Sciences Chinese Academy of SciencesBeijing 100049China School of Information Science and Technology Southwest Jiaotong UniversityChengdu 611756China Key Laboratory of Stellar and Interstellar Physics and Department of Physics Xiangtan UniversityXiangtan 411105China Physics and Space Science College China West Normal UniversityNanchong 637002China Department of Astronomy Beijing Normal UniversityBeijing 100875China Innovation Academy for Microsatellites of CAS Shanghai 201203China Changchun University of Science and Technology Changchun 130022China Chinese Academy of Sciences South America Center for Astronomy National Astronomical ObservatoriesCASBeijing 100101China

Realtime trigger and localization of bursts are the key functions of GECAM,an all-sky gamma-ray monitor launched on 2020 December *** developed a multifunctional trigger and localization software operating in the CPU of the GECAM Electronic *** onboard software has the following features:high trigger efficiency for real celestial bursts with a suppression of false triggers caused by charged particle bursts and background fluctuation,dedicated localization algorithm optimized for both short and long bursts,and low time latency of the trigger information which is downlinked through the Global Short Message Communication service of the global BeiDou navigation *** paper provides a detailed description of the design and development of the trigger and localization software system for *** covers the general design,workflow,the main functions,and the algorithms used in the *** paper also includes on-ground trigger tests using simulated gamma-ray bursts generated by a dedicated X-ray tube,as well as an overview of the performance for real celestial bursts during its in-orbit operation.

关键词： telescopes instrumentation:detectors methods:observational

Synthesis of Codon-optimized Human Interleukin-18 Gene by Combination of Chemical and Enzymatic Method

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Chemical Research in Chinese Universities 2008年第4期24卷 487-490页

作者： gao chao-hui SHI Xiao-yue HOU Xin-tong MENG Qing-fan zhang ying-jiu TENG li-rong College of life Science Jilin University Changehun 130012 P. R. China Key Laboratory for Molecular Enzymology and Engineering of Ministry of Education Jilin University Changehun 130021 P. R. China Changehun Diseases Control and Prevention Center Changehun 130033 P. R. China College of Animal Science and Veterinary Medicine Jilin University Changehun 130062 P. R. China

According to the amino acid sequence and codon preference of E. coli, the human interleukin-18（IL-18） gene was optimized to avoid the rare codons. The total length of the synthesized gene is 571 bp; 18 oligonucleotides, DNA fragments were designed and synthesized by the phosphoramidite four-step chemical method. The whole DNA sequence was synthesized by a one-step total gene synthesis method, and then inserted in pUC18 vector. Five positive clones identified by blue-white colony screening were sent to Shanghai Sangon Biological Engineering Technology and Service Co., Ltd. for sequencing. The sequencing result shows that one clone contained the complete correct gene in all the five positive clones.

关键词： Human IL-18 Gene synthesis One-step method Oligodeoxynucleotide synthesis

接种根瘤菌对‘蒙农三叶草1号’根部转录水平的影响

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草地学报 2024年第9期32卷 2759-2768页

作者：曹克璠索荣臻张慧敏马一鸣吴倩包立高王明玖内蒙古农业大学草原与资源环境学院/草地资源教育部重点实验室内蒙古呼和浩特010018 内蒙古自治区农牧业技术推广中心内蒙古呼和浩特010030

为探究‘蒙农三叶草1号’(Trifolium ambiguum Bieb.‘Mengnong No.1’)与根瘤菌共生过程中相关基因的分子机制及代谢通路,本研究选取了接种根瘤菌的‘蒙农三叶草1号’以及未接种的对照组为研究对象,通过转录组测序,比较了共生与非共生... 详细信息

为探究‘蒙农三叶草1号’(Trifolium ambiguum Bieb.‘Mengnong No.1’)与根瘤菌共生过程中相关基因的分子机制及代谢通路,本研究选取了接种根瘤菌的‘蒙农三叶草1号’以及未接种的对照组为研究对象,通过转录组测序,比较了共生与非共生状态下的转录组差异。结果表明,与未接种组相比,接种组共筛选出1105个差异表达基因(Differentially expressed genes,DEGs)。进一步分析发现,这些DEGs涉及多个代谢通路和生物学过程,包括苯丙烷生物合成、氨基糖和核苷酸糖代谢、半胱氨酸和甲硫氨酸代谢等。其中,677个基因上调,428个基因下调。通过实时荧光定量PCR(qRT-PCR)对部分基因进行验证,证实了转录组测序的可靠性。本研究揭示了‘蒙农三叶草1号’在根瘤菌共生状态下的转录组特征,为深入理解植物与根瘤菌共生机制提供了重要参考。

关键词： ‘蒙农三叶草1号’ 接种根瘤菌差异表达基因转录组学

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CEPC Technical Design Report

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Radiation Detection Technology and Methods 2024年第1期8卷 I0003-I0016,1-1091页

作者： Waleed Abdallah Tiago Carlos Adorno de Freitas Konstantin Afanaciev Shakeel Ahmad Ijaz Ahmed Xiaocong Ai Abid Aleem Wolfgang Altmannshofer Fabio Alves Weiming An Rui An Daniele Paolo Anderle Stefan Antusch Yasuo Arai Andrej Arbuzov Abdesslam Arhrib Mustafa Ashry Sha Bai Yu Bai yang Bai Vipul Bairathi Csaba Balazs Philip Bambade Yong Ban Tripamo Bandyopadhyay Shou-Shan Bao Desmond P.Barber Ayse Bat Varvara Batozskaya Subash Chandra Behera Alexander Belyaev Michele Bertucci Xiao-Jun Bi Yuanjie Bi Tianjian Bian Fabrizio Bianchi Thomas Biekotter Michela Biglietti Shalva Bilanishvili Deng Binglin Denis Bodrov Anton Bogomyagkov Serge Bondarenko Stewart Boogert Maarten Boonekamp Marcello Borri Angelo Bosotti Vincent Boudry Mohammed Boukidi Igor Boyko Ivanka Bozovic Giuseppe Bozzi Jean-Claude Brient Anastasiia Budzinskaya Masroor Bukhari Vladimir Bytev Giacomo Cacciapaglia Hua Cai Wenyong Cai Wujun Cai Yijian Cai Yizhou Cai Yuchen Cai Haiying Cai Huacheng Cai Lorenzo Calibbi Junsong Cang Guofu Cao Jianshe Cao Antoine Chance Xuejun Chang Yue Chang Zhe Chang Xinyuan Chang Wei chao Auttakit Chatrabhuti Yimin Che Yuzhi Che Bin Chen Danping Chen Fuqing Chen Fusan Chen Gang Chen Guoming Chen Hua-Xing Chen huirun Chen Jinhui Chen Ji-Yuan Chen Kai Chen Mali Chen Mingjun Chen Mingshui Chen Ning Chen Shanhong Chen Shanzhen Chen Shao-Long Chen Shaomin Chen Shiqiang Chen Tianlu Chen Wei Chen Xiang Chen Xiaoyu Chen Xin Chen Xun Chen Xurong Chen Ye Chen ying Chen Yukai Chen Zelin Chen Zilin Chen Gang Chen Boping Chen Chunhui Chen Hok Chuen Cheng Huajie Cheng Shan Cheng Tongguang Cheng Yunlong Chi Pietro Chimenti Wen Han Chiu Guk Cho Ming-Chung Chu Xiaotong Chu Ziliang Chu Guglielmo Coloretti Andreas Crivellin Hanhua Cui Xiaohao Cui Zhaoyuan Cui Brunella D'Anzi ling-Yun Dai Xinchen Dai Xuwen Dai Antonio De Maria Nicola De Filippis Christophe De La Taille Francesca De Mori Chiara De Sio Elisa Del Core Shuangxue Deng Wei-Tian Deng Zhi Deng Ziyan Deng Bhupal Dev Tang Dewen Biagio Di Micco Ran Ding Siqin Dingl Yadong Ding Haiyi Dong Jianin AGH University of Science and Technology Faculty of Physics and Applied Computer ScienceKrakow Anhui University HefeiAnhui Applied Physics Department Federal Urdu University of ArtsScience and TechnologyIslamabad Banaras Hindu University Institute of ScienceVaranasi Bandirma Onyedi Eylul University Bandirma Beihang University Beijing Beijing Computational Science Research Center Beijing Beijing Conveyi LTD Beijing Beijing Glass Research Institute Co. LtdBeijing Beijing Institute of Technology Beijing Beijing Normal University Beijing Brown University ProvidenceRI Budker Institute of Nuclear Physics Novosibirsk Cadi Ayyad University Laboratory of Fundamental and Applied PhysicsPolydisciplinary FacultyMarrakech Cairo University Giza Center for Theory and Computation National Tsing Hua UniversityHsinchu Central China Normal University WuhanHubei Central South University ChangshaHunan Centro de Fisica Teorica de Particulas Universidade Tecnica de LisboaLisboa Chengdu KaitengSifang Digital Radio&TV Equipment Co. LtdChengduSichuan China academy of engineering physics MianyangSichuan China building materials academy Beijing China Center of Advanced Science and Technology Beijing China Institute of Atomic Energy Beijing China Jiliang University HangzhouZhejiang China Nuclear Instrument CO. LTDBeijing China University of Geosciences Beijing China University of Geosciences WuhanHubei China University of Mining and Technology XuzhouJiangsu China West Normal University NanchongSichuan Chongqing University Department of PhysicsChongqing Chulalongkorn University Bangkok City University of Hong Kong Department of PhysicsHong Kong Cockcroft Institute Daresbury Cornell University IthacaNY CPPM(AMU/IPhU&CNRS/INP) Marseille Dalian Minzu University DalianLiaoning Dalian University of Technology Department of PhysicsDalian Deutsches Elektronen-Synchrotron DESY Hamburg Dzhelepov Laboratory of Nuclear Problems of Joint Institute for Nuclear Research(DLNP JINR) Dubna East China University Of Science And Technol

The Circular Electron Positron Collider(CEPC)is a large scientific project initiated and hosted by China,fostered through extensive collaboration with international *** complex comprises four accelerators:a 30 GeV linac,a 1.1 GeV Damping Ring,a Booster capable of achieving energies up to 180 GeV,and a Collider operating at varying energy modes(Z,W,H,and tt).The linac and Damping Ring are situated on the surface,while the subterranean Booster and Collider are housed in a 100 km circumference underground tunnel,strategically accommodating future expansion with provisions for a potential Super Proton Proton Collider(SPPC).The CEPC primarily serves as a Higgs *** its baseline design with synchrotron radiation(SR)power of 30 MW per beam,it can achieve a luminosity of 5×10^(34)cm^(-2)s^(-1)per interaction point(IP),resulting in an integrated luminosity of 13 ab^(-1)for two IPs over a decade,producing 2.6 million Higgs *** the SR power to 50 MW per beam expands the CEPC's capability to generate 4.3 million Higgs bosons,facilitating precise measurements of Higgs coupling at sub-percent levels,exceeding the precision expected from the HL-LHC by an order of *** Technical Design Report(TDR)follows the Preliminary Conceptual Design Report(Pre-CDR,2015)and the Conceptual Design Report(CDR,2018),comprehensively detailing the machine's layout,performance metrics,physical design and analysis,technical systems design,R&D and prototyping efforts,and associated civil engineering ***,it includes a cost estimate and a preliminary construction timeline,establishing a framework for forthcoming engineering design phase and site selection *** is anticipated to begin around 2027-2028,pending government approval,with an estimated duration of 8 *** commencement of experiments and data collection could potentially be initiated in the mid-2030s.

关键词： initiated exceeding precise

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板栗全生长季树干液流及蒸腾耗水特征

中国农业科学 2024年第9期57卷 1794-1806页

作者：郭燕张树航张馨方李颖刘金雨范丽颖刘师源高倩王广鹏河北省农林科学院昌黎果树研究所

【目的】明确板栗（Castanea mollissima Bl.）蒸腾耗水特征，为板栗园制定科学合理的水分管理措施提供理论参考。【方法】采用热扩散探针法，对‘大板红’板栗植株全生长季树干液流速率进行连续监测，并同步观测7个相关环境因子：太阳... 详细信息

【目的】明确板栗（Castanea mollissima Bl.）蒸腾耗水特征，为板栗园制定科学合理的水分管理措施提供理论参考。【方法】采用热扩散探针法，对‘大板红’板栗植株全生长季树干液流速率进行连续监测，并同步观测7个相关环境因子：太阳辐射（solar radiation,SR）、水汽压亏缺（vapor pressure deficit,VPD）、空气温度（air temperature,AT）、空气相对湿度（air relative humidity,ARH）、风速（wind speed,WS）、土壤温度（soil temperature,ST）和土壤湿度（soil relative humidity,SRH），解析板栗树干液流规律和耗水特征及其与环境因子间的关联性。【结果】板栗树干明显液流启动于5月3日，结束于10月26日，前后历时176 d。板栗全生长季晴天树干液流速率日变化呈单峰“几”字形曲线，其在6、7、8月每日启动到达峰值时间早于5、9、10月，而下降时间晚于5、9、10月，致6、7、8月份液流速率峰值持续时间长于5、9、10月。板栗全生长季液流速率日均值、日均耗水量和月耗水量由高到低排序均为8月>7月>6月>9月>5月>10月，其中显著性检验表明7月和8月之间无显著差异，但显著高于其他月份。夜间液流量占比由高到低排序为10月>9月>5月>6月>7月>8月，其中显著性检验表明10月、9月和5月显著高于6月、7月和8月。板栗全生长季树干液流速率与太阳辐射、水汽压亏缺、空气温度和风速均呈极显著正相关，而与空气相对湿度均呈极显著负相关。分别建立了5—10月板栗树干液流速率与7个环境因子的6个回归模型。【结论】板栗树干有明显液流始于5月初、终于10月末；7—8月是板栗的关键需水期；建立的板栗植株液流速率与环境因子的回归模型，可用于通过环境因子估测不同月份及整个生长季的植株耗水量。

关键词：板栗液流速率耗水量环境因子特征

桔梗特异DNA条形码筛选、种质资源鉴定及遗传多样性分析

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药学学报 2024年第1期59卷 243-252页

作者：王馨石玥满金辉黄钰莹张晓芹安克露何高洁刘子齐关范圆郑语嫣王晓晖魏胜利北京中医药大学中药学院北京102488 北京中医药大学北京中医药研究院中药现代研究中心北京102488 北京中医药大学生命科学院北京102488 黑龙江诺初中药材种植有限公司黑龙江哈尔滨150600

中药材桔梗为桔梗科植物桔梗的干燥根,具有多种药理作用,是常用的大宗中药材。本研究利用Illumina HiSeq X Ten平台对6份来自不同产地的桔梗进行叶绿体基因组测序,筛选特异性DNA条形码,基于特异性DNA条形码对不同产区的桔梗样品的种质... 详细信息

中药材桔梗为桔梗科植物桔梗的干燥根,具有多种药理作用,是常用的大宗中药材。本研究利用Illumina HiSeq X Ten平台对6份来自不同产地的桔梗进行叶绿体基因组测序,筛选特异性DNA条形码,基于特异性DNA条形码对不同产区的桔梗样品的种质资源和遗传多样性进行分析。6份桔梗叶绿体基因组全长为172260~172275 bp,均呈现典型的环状四分体结构,编码141个基因。根据比较基因组学分析和扩增效率分析发现trnG-UCC和ndhG_ndhF可作为潜在的桔梗种内种质资源鉴定的特异性DNA条形码。对来自9省15个产地305份桔梗样品的trnG-UCC和ndhG_ndhF进行PCR扩增和序列分析,结果表明trnG-UCC和ndhG_ndhF分别有5和11个变异位点,分别鉴定到5和7个单倍型;两段序列联合分析鉴定13个单倍型(Hap1~Hap13),其中占比最多的是Hap4,其次是Hap1。3个产地拥有的特异单倍型,可作为该产地的DNA分子标签与其他产地的桔梗种质资源进行区分。单倍型多样性、核苷酸多样性和遗传距离分别为0.94、4.79×10^(-3)和0.0000~0.0203,表明桔梗在物种水平上有较高的遗传多样性,种内各单倍型之间亲缘关系比较接近。本研究为桔梗产地鉴定、种质资源保护利用和分子育种等工作奠定基础。

关键词：桔梗叶绿体基因组 DNA条形码种质资源遗传多样性

Atorvastatin combined with low-dose dexamethasone for vascular endothelial cell dysfunction induced by chronic subdural hematoma

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Neural Regeneration Research 2021年第3期16卷 523-530页

作者： Yue-Shan fan Bo wang Dong wang Xin Xu Chuang gao ying li Shu zhang Gui-li yang Xiao liu Rong-Cai Jiang Jian-Ning zhang Department of Neurosurgery General Hospital of Tianjin Medical UniversityTianjinChina Tianjin Neurological Institute Key Laboratory of Post-Neuroinjury Neuro-repair and Regeneration in Central Nervous SystemMinistry of Education and Tianjin CityTianjinChina Graduate School Tianjin Medical UniversityTianjinChina Department of Neurosurgery Xuanwu HospitalCapital Medical UniversityBeijingChina

Atorvastatin has been shown to be a safe and effective non-surgical treatment option for patients with chronic subdural ***,treatment with atorvastatin is not effective in some patients,who must undergo further surgical *** has anti-inflammatory and immunomodulatory effects,and low dosages are safe and effective for the treatment of many diseases,such as ankylosing spondylitis and community-acquired ***,the effects of atorvastatin and low-dose dexamethasone for the treatment of chronic subdural hematoma remain poorly *** samples of patients with chronic subdural hematoma admitted to the General Hospital of Tianjin Medical University of China were collected and diluted in endothelial cell medium at 1:1 as the hematoma ***,dexamethasone,or their combination was added to the culture *** main results were as follows:hopping probe ion conductance microscopy and permeability detection revealed that the best dosages to improve endothelial cell permeability were 0.1μM atorvastatin and 0.1μM ***,dexamethasone,or their combination could markedly improve the recovery of injured endothelial *** subcutaneously injected with diluted hematoma solution and then treated with atorvastatin,dexamethasone,or their combination exhibited varying levels of rescue of endothelial cell *** probe ion conductance microscopy,western blot assay,and polymerase chain reaction to evaluate the status of human cerebral endothelial cell status and expression level of tight junction protein indicated that atorvastatin,dexamethasone,or their combination could reduce subcutaneous vascular leakage caused by hematoma ***,the curative effect of the combined treatment was significantly better than that of either single *** of Krüppel-like factor 2 protein in human cerebral endothelial cells was significantly increased,as was expression of the tight junctio

关键词： brain brain trauma cells central nervous system inflammation plasticity protein repair