Atorvastatin combined with low-dose dexamethasone for vascular endothelial cell dysfunction induced by chronic subdural hematoma

作     者：Yue-Shan Fan Bo Wang Dong Wang Xin Xu Chuang Gao Ying Li Shu Zhang Gui-Li Yang Xiao Liu Rong-Cai Jiang Jian-Ning Zhang Yue-Shan Fan;Bo Wang;Dong Wang;Xin Xu;Chuang Gao;Ying Li;Shu Zhang;Gui-Li Yang;Xiao Liu;Rong-Cai Jiang;Jian-Ning Zhang

作者机构：Department of NeurosurgeryGeneral Hospital of Tianjin Medical UniversityTianjinChina Tianjin Neurological InstituteKey Laboratory of Post-Neuroinjury Neuro-repair and Regeneration in Central Nervous SystemMinistry of Education and Tianjin CityTianjinChina Graduate SchoolTianjin Medical UniversityTianjinChina Department of NeurosurgeryXuanwu HospitalCapital Medical UniversityBeijingChina 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2021年第16卷第3期

页      面：523-530页

核心收录：

学科分类：1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 1010[医学-医学技术（可授医学、理学学位）] 100104[医学-病理学与病理生理学] 100215[医学-康复医学与理疗学] 10[医学] 

基　　金：supported by the National Natural Science Foundation of China,Nos.81671380(to DW),81720108015(to JNZ),81930031(to JNZ),81771221(to YL),and 81901525(to SZ) the Clinical Study of Tianjin Medical University of China,No.2017kylc007(to RCJ) the Natural Science Foundation of Tianjin of China,No.17JCZDJC35900(to DW) the Tianjin Science and Technology Plan Program of China,No.19YFZCSY00650(to RCJ) 

主　　题：brain brain trauma cells central nervous system inflammation plasticity protein repair 

摘      要：Atorvastatin has been shown to be a safe and effective non-surgical treatment option for patients with chronic subdural ***,treatment with atorvastatin is not effective in some patients,who must undergo further surgical *** has anti-inflammatory and immunomodulatory effects,and low dosages are safe and effective for the treatment of many diseases,such as ankylosing spondylitis and community-acquired ***,the effects of atorvastatin and low-dose dexamethasone for the treatment of chronic subdural hematoma remain poorly *** samples of patients with chronic subdural hematoma admitted to the General Hospital of Tianjin Medical University of China were collected and diluted in endothelial cell medium at 1:1 as the hematoma ***,dexamethasone,or their combination was added to the culture *** main results were as follows:hopping probe ion conductance microscopy and permeability detection revealed that the best dosages to improve endothelial cell permeability were 0.1μM atorvastatin and 0.1μM ***,dexamethasone,or their combination could markedly improve the recovery of injured endothelial *** subcutaneously injected with diluted hematoma solution and then treated with atorvastatin,dexamethasone,or their combination exhibited varying levels of rescue of endothelial cell *** probe ion conductance microscopy,western blot assay,and polymerase chain reaction to evaluate the status of human cerebral endothelial cell status and expression level of tight junction protein indicated that atorvastatin,dexamethasone,or their combination could reduce subcutaneous vascular leakage caused by hematoma ***,the curative effect of the combined treatment was significantly better than that of either single *** of Krüppel-like factor 2 protein in human cerebral endothelial cells was significantly increased,as was expression of the tight junctio