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Successful treatment of patients with refractory idiopathic membranous nephropathy with low-dose Rituximab:A single-center experience

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World Journal of Clinical Cases 2023年第3期11卷 566-575页

作者： Yao-Wei wang xin-Hui wang Hong-Xia wang Ren-Huan Yu China Department of Nephrology Xiyuan Hospital of China Academy of Chinese Medical SciencesBeijing 100091China

BACKGROUND The recognition of idiopathic membranous nephropathy(IMN)as an autoimmune disease has paved the way for the use of B-cell-depleting agents,such as Rituximab(RTX),which is now a first-line drug for treating IMN with proven safety and ***,the usage of RTX for the treatment of refractory IMN remains controversial and *** To evaluate the efficacy and safety of a new low-dose RTX regimen for the treatment of patients with refractory *** A retrospective study was performed on refractory IMN patients that accepted a low-dose RTX regimen(RTX,200 mg,once a month for five months)in the Xiyuan Hospital of Chinese Academy of Chinese Medical Sciences’Department of Nephrology from October 2019 to December *** assess the clinical and immune remission data,we performed a 24 h urinary protein quantification(UTP)test and measured the serum albumin(ALB)and serum creatinine(SCr)levels,phospholipase A2 receptor(PLA2R)antibody titer,and CD19+B-cell count every three *** A total of nine refractory IMN patients were *** follow-up conducted twelve months later,the results from the 24 h UTP decreased from baseline[8.14±6.05 g/d to 1.24±1.34 g/d(P<0.05)]and the ALB levels increased from baseline[28.06±8.42 g/L to 40.93±5.85 g/L(P<0.01)].Notably,after administering RTX for six months,the SCr decreased from 78.13±16.49μmol/L to 109.67±40.87μmol/L(P<0.05).All of the nine patients were positive for serum anti-PLA2R at the beginning,and four patients had normal anti-PLA2R titer levels at six *** level of CD19+B-cells decreased to 0 at three months,and CD19+B-cell count remained at 0 up until six months of *** Our low-dose RTX regimen appears to be a promising treatment strategy for refractory IMN.

关键词： Refractory nephrotic syndrome Idiopathic membranous nephropathy Low-dose rituximab

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Usefulness of tumor traction with a snare and endoclips in gastric submucosal tumor resection:a propensity-score-matching analysis

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Gastroenterology Report 2021年第2期9卷 125-132,I0001,I0002页

作者： Qiang Zhang jian-Qun Cai Zhen wang Guangdong Provincial Key Laboratory of Gastroenterology Department of GastroenterologyNanfang HospitalSouthern Medical UniversityGuangzhouGuangdongP.R.China

Background:Endoscopic resection,including endoscopic submucosal dissection(ESD)and endoscopic full-thickness resection(EFR),was used to resect small gastric submucosal tumors(SMTs).Our team explored a method of tumor traction using a snare combined with endoclips to assist in the resection of *** study aims to explore the safety and effectiveness of the ***:This research performed a propensity-score-matching(PSM)analysis to compare ESD/EFR assisted by a snare combined with endoclips(ESD/EFR with snare traction)with conventional ESD/EFR for the resection of gastric *** were made between the two groups,including operative time,en bloc resection rate,perioperative complications,and operation-related ***:A total of 253 patients with gastric SMTs resected between January 2012 and March 2019 were included in this *** yielded 51 matched *** significant differences were identified between the two groups in perioperative complications or the costs of disposable endoscopic surgical ***,the ESD/EFR-with-snare-traction group had a shorter median operative time(39 vs 60 min,P=0.005)and lower rate of en bloc resection(88.2%vs 100%,P¼0.027).Conclusions:ESD/EFR with snare traction demonstrated a higher efficiency and en bloc resection rate for gastric SMTs,with no increases in perioperative complications and the costs of endoscopic surgical ***,the method seems an appropriate choice for the resection of gastric SMTs.

关键词： endoscopic submucosal dissection endoscopic full-thickness resection gastric submucosal tumor snare endoclip

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Transcriptomic response to ammonia-N stress in the hepatopancreas of swimming crab Portunus trituberculatus

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Marine Life Science & Technology 2020年第2期2卷 135-145页

作者： Lingjun Si Luqing Pan Hongdan wang xin Zhang Key Laboratory of Mariculture Ministry of EducationFisheries CollegeOcean University of ChinaQingdao 266003China

The swimming crab Portunus trituberculatus is an important farmed species in ***-N represents a major physiological challenge for crab culture and the hepatopancreas plays a major role in physiological adaptation *** better understand the molecular mechanism of the crab in response to ammonia-N stress,we performed a transcriptome analysis in the hepatopancreas of *** challenged with ammonia-N stress(5 mg/L),using the high-throughput sequencing *** total,52,280 unigenes were obtained from the hepatopancreas of ***,with an average length of 678 *** categorization and pathways showed some diiferentially expressed genes were involved in amino acid and nucleobase metabolism,energy metabolism,antioxidation,immune response,reproduction,moulting and material *** differential expression patterns of eight randomly selected annotated genes were validated by quantitative real-time PCR(qPCR).Results revealed a substantial number of genes modified by ammonia-N stress and a few significant ammonia acclimation pathways,which will serve as an invaluable resource for revealing the molecular basis of physiological adaptation mechanism in ***.

关键词： Portunus trituberculatus Molecular mechanism Digital gene expression Ammonia-N Hepatopancreas

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Semen microbiota in normal and leukocytospermic males

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Asian Journal of Andrology 2022年第4期24卷 398-405页

作者： Ye Yao xin-jian Qiu Dong-Sheng wang Jie-Kun Luo Tao Tang Yun-Hui Li Chun-Hu Zhang Hao Liu Lu Zhou Lin-Lin Zhao Health Management Center The Third Xiangya HospitalCentral South UniversityChangsha 410013China Institute of Integrated Traditional Chinese and Western Medicine Xiangya HospitalCentral South UniversityChangsha 410005China Department of Nephrology Integrated Hospital of Traditional Chinese and Western MedicineSouthern Medical UniversityGuangzhou 510220China Department of Traditional Chinese Medicine Guangdong Second Provincial General HospitalGuangzhou 510220China

Large numbers of microbes can be present in seminal fluid,and there are differences in the semen microbiota between normal and abnormal semen *** evaluate the semen microbiota in patients with leukocytospermia,87 seminal fluid samples,including 33 samples with a normal seminal leukocyte count and 54 samples with leukocytospermia,were obtained for a cross-sectional *** samples with a normal seminal leukocyte count had normal sperm parameters(Control group),and 13 samples with a normal seminal leukocyte count were from asthenozoospermia patients(Ast group).However,32 samples with leukocytospermia were from asthenozoospermia patients(LA group),and only 22 samples with leukocytospermia had normal sperm parameters(Leu group).The 16S ribosomal RNA(rRNA)gene sequencing method was used to sequence the microbiota in the seminal fluid,and multiple bioinformatics methods were utilized to analyze the ***,the results showed that the worse sperm parameters were observed in the leukocytospermia-related *** microbiota analysis found that there was increased alpha diversity in the leukocytospermia-related ***,Proteobacteria,Actinobacteria,and Bacteroidetes were the primary phyla in the seminal *** microbiota profiles,namely,Lactobacillus-enriched and Streptococcus-enriched groups,were identified in this *** majority of the samples in the groups with a normal seminal leukocyte count could be categorized as Lactobacillus-enriched,whereas the majority of the leukocytospermia samples could be categorized as *** study indicated that males with leukocytospermia have worse sperm parameters and a different semen microbiota composition compared to males with a normal seminal leukocyte count.

关键词： 16S rRNA gene sequencing asthenozoospermia leukocytospermia semen microbiota sperm motility

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Broadband Terahertz Transmission Modulation Based on Hybrid Graphene-Metal Metamaterial

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Journal of Electronic Science and Technology 2018年第2期16卷 98-104页

作者： Lan-Ju Liang Zhang Zhang xin Yan xin Ding De-Quan Wei Qi-Li Yang Zhen-Hua Li jian-Quan Yao College of Precision Instrument and Opto-Electronics Engineering Tianjin UniversityTianjin 300072 School of Opto-Electronic Engineering Zaozhuang UniversityZaozhuang 277160

A novel patterned metamaterial,composed of graphene layer and metal periodic array of split ring resonators （SRRs） and cross-shapedresonators （CSRs）, with broadband terahertz （THz） wave modulation was proposed and theoretically studied. It demonstrated that a broad passband high transmission of over 96.1% in the frequency range from 1.02 THz to 1.66 THz and two narrow band resonance frequencies f1 and f2 could be generated. The modulation depth of transmission was 29.2% when the graphene layer was covered on the metal metamaterial surface, and the modulation depth could be further increased by increasing the Fermi energy of graphene layer and reached approximately 79.5% at 1.0 eV in a broadband THz frequency range. The resonance frequencies of f1 and f2 were blue-shifted, and their modulation depths reached about 63.2% and 18%, respectively. These results show that the ultrathin graphene-metal metamaterial exhibits potential to achieve highperformance active THz devices and may offer widespread applications.

关键词： Graphene metamaterial modulator terahertz

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An updated classification for the hyper-diverse genus Corydalis(Papaveraceae: Fumarioideae)based on phylogenomic and morphological evidence

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Journal of Integrative Plant Biology 2023年第9期65卷 2138-2156页

作者： Jun‐Tong Chen Magnus Lidén Xian‐Han Huang Liang Zhang xin‐jian Zhang Tian‐Hui Kuang Jacob BLandis Dong wang Tao Deng Hang Sun CAS Key Laboratory for Plant Diversity and Biogeography of East Asia Kunming Institute of BotanyChinese Academy of SciencesKunming 650201China University of Chinese Academy of Sciences Beijing 100049China Evolutionary Biology Centre Systematic BiologyUppsala UniversityUppsala 75236Sweden School of Integrative Plant Science Section of Plant Biology and the L.H.Bailey HortoriumCornell UniversityIthacaNew York 14853USA BTI Computational Biology Center Boyce Thompson InstituteIthacaNew York 14853USA School of Life Sciences Central China Normal UniversityWuhan 430079China

The genus Corydalis, with ca. 530 species, has long been considered taxonomically challenging because of its great variability. Previous molecular analyses,based on a few molecular markers and incomplete taxonomic sampling, were clearly inadequate to delimit sections and subgenera. We have performed phylogenetic analyses of Corydalis and related taxa,using 65 shared protein-coding plastid genes from313 accessions(including 280 samples of ca. 226species of Corydalis) and 152 universal low-copy nuclear genes from 296 accessions(including 271samples of Corydalis) covering all 42 previously recognized sections and five independent “series”.Phylogenetic trees were inferred using Bayesian Inference and Maximum Likelihood. Eight selected morphological characters were estimated using ancestral state reconstructions. Results include:(i) of the three subgenera of Corydalis, two are fully supported by both the plastid and nuclear data;the third,subg. Cremnocapnos, is weakly supported by plastid DNA only, whereas in the nuclear data the two included sections form successive outgroups to the rest of the genus;(ii) among all 42 sections and five“series”, 25 sections and one “series” are resolved as monophyletic in both data sets;(iii) the common ancestor of Corydalis is likely to be a perennial plant with a taproot, yellow flowers with a short saccate spur, linear fruits with recurved fruiting pedicels, and seeds with elaiosomes;(iv) we provide a new classification of Corydalis with four subgenera(of which subg. Bipapillatae is here newly described), 39 sections, 16 of which are consistent with the previous classification, 16 sections have been recircumscribed, one section has been reinstated and six new sections are established. Characters associated with lifespan, underground structures, floral spur, fruit and elaiosomes are important for the recognition of subgenera and sections. These new phylogenetic analyses combined with ancestral character reconstructions uncovered previo

关键词： character evolution Corydalis genome skimming Papaveraceae phylogeny

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Analysis of clinical and pathological features of ciliary body medulloepithelioma

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International Journal of Ophthalmology(English edition) 2023年第3期16卷 382-387页

作者： Jing He Cheng Pei xin Ge jian-Min Ma Ya-Guang Hu Department of Ophthalmology the First Affiliated Hospital of Xi’an Jiaotong UniversityXi’an 710061Shaanxi ProvinceChina Beijing Ophthalmology and Visual Sciences Key Laboratory Beijing Tongren Eye CenterBeijing Tongren HospitalCapital Medical UniversityBeijing 100730China

AIM:To analyze and summarize the clinical and pathological features of ciliary body ***:The clinical and pathological data of 11 patients(11 eyes) who were diagnosed with ciliary body medulloepithelioma at Beijing Tongren Hospital,Capital Medical University,from 2007 to 2021 were retrospectively ***:The initial symptoms of 11 patients included vision loss(6 eyes),atrophia bulbi(1 eye),proptosis(2 eyes),and leukocoria(2 eyes).Most patients suffered with corneal opacity,anterior chamber flare and *** neovascularization and synechia,complicated cataract,and secondar y glaucoma occurred in several *** patients even had lens subluxation and retinal detachment.B-scan ultrasonography showed vitreous opacity and a medium-high uneven echo mass in the *** biomicroscopy examination showed a spherical or hemispherical ciliary body mass with uneven internal echoes and irregular cystic *** of the 11 patients were diagnosed with malignant ciliary body medulloepithelioma by pathological *** this study,6 patients had enucleation(2 patients had systemic chemotherapy after surgery),and the other 5 patients had local tumor resection(1 patient had plaque radiotherapy after surgery).CONCLUSION:Ciliary body medulloepithelioma is a rare intraocular tumor and may be easily confused with *** the clinical and pathological features of ciliary body medulloepithelioma is useful to further understand ciliary body medulloepithelioma,and can make an accurate diagnosis and better treatment.

关键词： medulloepithelioma ciliary body intraocular tumor retrospective study

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Triterpenoids and phenolics from the fruiting bodies of Inonotus hispidus and their activations of melanogenesis and tyrosinase

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Chinese Chemical Letters 2017年第5期28卷 1052-1056页

作者： Qing Ren Xue-Ying Lu jian-xin Han Haji Akber Aisa Tao Yuan The Key Laboratory of Plant Resources and Chemistry of Arid Zone Chinese Academy of SciencesState Key Laboratory of Xinjiang Indigenous Medicinal Plants Resource UtilizationXinjiang Technical Institute of Physics and ChemistryChinese Academy of SciencesUrumqi 830011China University of Chinese Academy of Sciences Beijing 100049China

Two new 24-methyl lanostane triterpenoids,hispindic acids A and B（1 and 2）,and a new phenolic compound,hispinine（7）,along with nine known compounds（3-6,and 8-12）,were isolated from the fruiting bodies of Inonotus *** structures were elucidated based on the extensive analysis of spectroscopic data（NMR and HRMS）.Hispindic acid A（1） possesses an unusual formyl group at *** 1,3-4,and 8 showed stronger activate abilities of melanogenesis and tyrosinase in B16 melanoma cells than those of positive control,8-methoxypsoralen,at 50 μmol/L

关键词： Inonotus hispidus Lanostane triterpenoids Phenolic compound Melanogenesis Tyrosinase

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Online Detection of Broken Rotor Bar Fault in Induction Motors by Combining Estimation of Signal Parameters via Min-norm Algorithm and Least Square Method

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Chinese Journal of Mechanical Engineering 2017年第6期30卷 1285-1295页

作者： Pan-Pan wang Qiang Yu Yong-Jun Hu Chang-xin Miao School of Electrical and Power Engineering ChinaUniversity of Mining and Technology Xuzhou 221116China

Current research in broken rotor bar （BRB） fault detection in induction motors is primarily focused on a high-frequency resolution analysis of the stator current. Compared with a discrete Fourier transformation, the parametric spectrum estimation technique has a higher frequency accuracy and resolution. However, the existing detection methods based on parametric spectrum estima- tion cannot realize online detection, owing to the large computational cost. To improve the efficiency of BRB fault detection, a new detection method based on the min-norm algorithm and least square estimation is proposed in this paper. First, the stator current is filtered using a band-pass filter and divided into short overlapped data windows. The min-norm algorithm is then applied to determine the fre- quencies of the fundamental and fault characteristic com- ponents with each overlapped data window. Next, based on the frequency values obtained, a model of the fault current signal is constructed. Subsequently, a linear least squares problem solved through singular value decomposition is designed to estimate the amplitudes and phases of the related components. Finally, the proposed method is applied to a simulated current and an actual motor, the results of which indicate that, not only parametric spectrum estimation technique.

关键词： Fault detection Broken rotor bars Min-norm Least squares method Induction motors

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Self-healing hyperbranched polytriazoles prepared by metal-free click polymerization of propiolate and azide monomers

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Science China Chemistry 2016年第12期59卷 1554-1560页

作者： xin wang Rongrong Hu Zujin Zhao Anjun Qin Ben Zhong Tang Guangdong Innovative Research Team State Key Laboratory of Luminescent Materials and Devices South China University of Technology Department of Chemistry Hong Kong Branch of National Engineering Research Center for Tissue Restoration & ReconstructionThe Hong Kong University of Science & Technology Clear Water Bay

The last decade has witnessed the quick develop of self-healing materials. As a newborn strategy, the alternative of irreversible covalent bond formation is, however, to be further developed. In this paper, self-healing hyperbranched poly(aroxycarbonyltriazole)based on such mechanism were prepared by our developed metal-free click polymerization of simplified dipropiolate and triazide. Thanks to their excellent processability and film-forming ability, high quality homogeneous films free from defects were obtained by casting. The cut films could be healed by stacking or pressing the halves together at room temperature and elevated temperature. Thus, this design concept for self-healing materials should be generally applicable to other hyperbranched polymers with reactive groups on their peripheries.

关键词： self-healing hyperbranched polytriazole metal-free click polymerization film

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