Triterpenoids and phenolics from the fruiting bodies of Inonotus hispidus and their activations of melanogenesis and tyrosinase

作     者：Qing Ren Xue-Ying Lu Jian-Xin Han Haji Akber Aisa Tao Yuan 

作者机构：The Key Laboratory of Plant Resources and Chemistry of Arid ZoneChinese Academy of SciencesState Key Laboratory of Xinjiang Indigenous Medicinal Plants Resource UtilizationXinjiang Technical Institute of Physics and ChemistryChinese Academy of SciencesUrumqi 830011China University of Chinese Academy of SciencesBeijing 100049China 

出 版 物：《Chinese Chemical Letters》 (中国化学快报（英文版）)

年 卷 期：2017年第28卷第5期

页      面：1052-1056页

核心收录：

学科分类：1007[医学-药学(可授医学、理学学位)] 10[医学] 

基　　金：supported by the Recruitment Program of Global Experts(to Tao Yuan),China the Xinjiang Key Research and Development Program(No.2016B03038-3) 

主　　题：Inonotus hispidus Lanostane triterpenoids Phenolic compound Melanogenesis Tyrosinase 

摘      要：Two new 24-methyl lanostane triterpenoids,hispindic acids A and B（1 and 2）,and a new phenolic compound,hispinine（7）,along with nine known compounds（3-6,and 8-12）,were isolated from the fruiting bodies of Inonotus *** structures were elucidated based on the extensive analysis of spectroscopic data（NMR and HRMS）.Hispindic acid A（1） possesses an unusual formyl group at *** 1,3-4,and 8 showed stronger activate abilities of melanogenesis and tyrosinase in B16 melanoma cells than those of positive control,8-methoxypsoralen,at 50 μmol/L