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Curcumin co-treatment ameliorates resistance to gefitinib in drug-resistant NCI-H1975 lung cancer cells

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Journal of Traditional Chinese Medicine 2017年第3期37卷 355-360页

作者： Jin xin wang Jue Shen Huifen Ran Ran Xu Kai Tong Xiangming Zhang Weiping Feng li Institute of Hematology the First Affiliated Hospital of Medical School of Zhejiang University Department of Oncology the Third Affiliated Hospital of Zhejiang Chinese Medical University Institute of Hematology Zhejiang Provincial People's Hospital Traditional Chinese Medicine Department of National Cancer Center/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College

OBJECTIVE: To examine whether a combinative treatment with curcumin enhances the effects of the epidermal growth factor receptor-tyrosine kinase inhibitor(EGFR-TKI) gefitinib on cell proliferation, clonogenic capacity and apoptosis in the drug-resistant lung cancer cell line NCI-H1975, and further investigate the molecular mechanisms ***: NCI-H1975 cells were treated with curcumin and gefitinib alone or in combination, and cell proliferation, clonogenic capacity and apoptosis were examined using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide(MTT) assay, clone forming experiments, and flow cytometry, respectively, while p38, extracellular regulated protein kinase(ERK)1/2, and protein kinase B(AKT)phosphorylation were examined using Western ***: Compared with the effects of either agent alone, the combination of curcumin and gefitinib had a stronger suppressive effect on proliferation and the clonogenic capacity(P lity to promote apoptosis(P lity of gefitinib to inhibit cell proliferation, suppress the clonogenic capacity and enhance apoptosis in NCI-H1975 cells,and these effects are possibly mediated via a decrease in phosphorylation of proteins in downstream pathways of the epidermal growth factor receptor.

关键词： Lung neoplasms Cell line, tumor Cur-cumin Cell proliferation Apoptosis Receptor, epi-dermal growth factor Gefitinib

Revealing Spatial Spillover Effect in High-Tech Industry Agglomeration from a High-Skilled Labor Flow Network Perspective

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Journal of Systems Science & Complexity 2022年第3期35卷 839-859页

作者： wang Chen wang Lu XUE Yanbo li Ruiqi School of Economics and Management University of Science and Technology BeijingBeijing 100083China The Institute of Low Carbon Operations Strategy for Beijing Enterprises University of Science and Technology BeijingBeijing 100083China Career Science Lab Boss ZhipinBeijing 100028China UrbanNet Lab College of Information Science and TechnologyBeijing University of Chemical TechnologyBeijing 100029China

Understanding the high-tech industrial agglomeration from a spatial-spillover perspective is essential for cities to gain economic and technological competitive *** with rapid urbanization and the development of fast transportation networks,socioeconomic interactions between cities have been ever-increasing,traditional spatial metrics are not enough to describe actual inter-city ***-skilled labor flow between cities strongly influences the high-tech industrial agglomeration,yet receives less *** exploiting unique large-scale datasets and tools from complex network and data mining,the authors construct an inter-city high-skilled labor flow network,which was integrated into spatial econometric *** regression results indicate that spatial-spillover effects exist in the development of high-tech industries in the Yangtze River Delta Urban Agglomeration ***,the spatial-spillover effects are stronger among cities with a higher volume of high-skilled labor flows than among cities with just stronger geographic ***,the authors investigate the channels for the spillover effects and discover that inadequate local government expenses on science and technology likely hamper the high-tech industrial agglomeration,so does the inadequate local educational *** increasing foreign direct investments in one city likely encourages the high-tech industrial agglomeration in other cities because of the policy inertia toward traditional industries.

关键词： High-tech industry agglomeration labor flow network spatial econometrics topological space

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(D-Ser2) oxyntomodulin recovers hippocampal synaptic structure and theta rhythm in Alzheimer’s disease transgenic mice

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Neural Regeneration Research 2022年第9期17卷 2072-2078页

作者： Guang-Zhao Yang Qi-Chao Gao Wei-Ran li Hong-Yan Cai Hui-Min Zhao Jian-Ji wang xin-Rui Zhao Jia-xin wang Mei-Na Wu Jun Zhang Christian Hölscher Jin-Shun Qi Zhao-Jun wang Department of Cardiovascular Medicine the First Hospital of Shanxi Medical UniversityTaiyuanShanxi ProvinceChina Department of Physiology Shanxi Medical UniversityKey Laboratory of Cellular PhysiologyMinistry of EducationKey Laboratory of Cellular Physiology in Shanxi ProvinceTaiyuanShanxi ProvinceChina Department of Microbiology and Immunology Shanxi Medical UniversityTaiyuanShanxi ProvinceChina Functional Laboratory Center Shanxi Medical UniversityTaiyuanShanxi ProvinceChina Research and Experimental Center Henan University of Chinese MedicineZhengzhouHenan ProvinceChina

In our previous studies,we have shown that(D-Ser2)oxyntomodulin(Oxm),a glucagon-like peptide 1(GLP-1)receptor(GLP1R)/glucagon receptor(GCGR)dual agonist peptide,protects hippocampal neurons against Aβ1-42-induced cytotoxicity,and stabilizes the calcium homeostasis and mitochondrial membrane potential of hippocampal ***,we have demonstrated that(D-Ser2)Oxm improves cognitive decline and reduces the deposition of amyloid-beta in Alzheimer’s disease model ***,the protective mechanism remains *** this study,we showed that 2 weeks of intraperitoneal administration of(D-Ser2)Oxm ameliorated the working memory and fear memory impairments of 9-month-old 3×Tg Alzheimer’s disease model *** addition,electrophysiological data recorded by a wireless multichannel neural recording system implanted in the hippocampal CA1 region showed that(D-Ser2)Oxm increased the power of the theta *** addition,(D-Ser2)Oxm treatment greatly increased the expression level of synaptic-associated proteins SYP and PSD-95 and increased the number of dendritic spines in 3×Tg Alzheimer’s disease model *** findings suggest that(D-Ser2)Oxm improves the cognitive function of Alzheimer’s disease transgenic mice by recovering hippocampal synaptic function and theta rhythm.

关键词： (D-ser2)oxyntomodulin Alzheimer’s disease cognitive decline glucagon-like peptide-1 hippocampus local field potential synapse theta rhythm

Huangshan population of Chinese Zacco platypus （Teleostei, Cyprinidae） harbors diverse matrilines and high genetic diversity

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Zoological Research 2016年第2期37卷 103-109页

作者： xin ZHENG Tian-Qi ZHOU Tao WAN Anabel PERDICES Jin-Quan YANG xin-Sheng TANG Zheng-Ping wang li-Qun HUANG Song HUANG Shun-Ping HE Key Laboratory of Exploration and Utilization of Aquatic Genetic Resources Shanghai Ocean University Ministry of Education Shanghai201306 China College of life and Environment Sciences Huangshan University Huangshan Anhui 245041 China State Key Laboratory of Genetic Resources and Evolution Kunming Institute of Zoology Chinese Academy of Sciences KunmingYunnan 650223 China Museo Nacional de Ciencias Naturales CSIC C/Jose GutierrezAbascal 2 28006 Madrid Spains College of Foreign Languages Huangshan University Huangshan Anhui 245041 China Landscaping Bureau of Huangshan Scenic Area Huangshan Anhui 245000 China Institute of Hydrobiology Chinese Academy of Sciences Wuhan Hubei 430072 China

Six main mitochondrial DNA （mtDNA） lineages have been described in minnow （Zacco platypus） samples obtained from northern, western and southern China Perdices et al. （2004） predicted that further sampling of other tributaries might discover more lineages of this species. In this study, we collected 26 Zacco platypus individuals in the Huangshan area of eastern China and determined the cytochrome b （cytb） sequence variations. Combined with reported data in GenBank, we identified ten matrilines （Zacco A-J） in a total of 169 samples, with relatively high molecular divergence found among them. The Huangshan population had the greatest genetic variation among all sampled regions and hosted six of the ten matrilines. Our results highlight the significance of the Huangshan area for the conservation of Zacco platypus.

关键词： Zacco platypus Matriline Huangshan Phylogenetics Diversity

On the energy conservation and critical velocities for the propagation of a "steady-shock" wave in a bar made of cellular material

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Acta Mechanica Sinica 2013年第3期29卷 420-428页

作者： li-li wang li-Ming Yang Yuan-Yuan Ding Mechanics and Material Science Research Center Ningbo University

The propagation of shock waves in a cellular bar is systematically studied in the framework of continuum solids by adopting two idealized material models, viz. the dynamic rigid, perfectly plastic, locking （D-R-PP-L） model and the dynamic rigid, linear hardening plastic, locking （D-R-LHP-L） model, both considering the effects of strain-rate on the material properties. The shock wave speed relevant to these two models is derived. Consider the case of a bar made of one of such material with initial length L 0 and initial velocity v i impinging onto a rigid target. The variations of the stress, strain, particle velocity, specific internal energy across the shock wave and the cease distance of shock wave are all determined analytically. In particular the ＂energy conservation condition＂ and the ＂kinematic existence condition＂ as proposed by Tan et al. （2005） is re-examined, showing that the ＂energy conservation condition＂ and the consequent ＂critical velocity＂, i.e. the shock can only be generated and sustained in R-PP-L bars when the impact velocity is above this critical velocity, is incorrect. Instead, with elastic deformation, strain-hardening and strain-rate sensitivity of the cellular materials being considered, it is appropriate to redefine a first and a second critical impact velocity for the existence and propagation of shock waves in cellular solids. Starting from the basic relations for shock wave propagating in D-R-LHP-L cellular materials, a new method for inversely determining the dynamic stress-strain curve for cellular materials is proposed. By using e.g. a combination of Taylor bar and Hopkinson pressure bar impact experimental technique, the dynamic stress-strain curve of aluminum foam could bedetermined. Finally, it is demonstrated that this new formulation of shock theory in this one-dimensional stress state can be generalized to shocks in a one-dimensional strain state, i.e. for the case of plate impact on cellular materials, by simply making proper

关键词： Cellular solids 1D shock theory D-R-PP-L model D-R-SHP-L model Energy conservation across shock Critical velocities

Aqueous K-ion battery incorporating environment-friendly organic compound and Berlin green

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Journal of Energy Chemistry 2020年第9期29卷 14-20,I0002页

作者： Mingtan wang Huaiqing wang Huamin Zhang Xianfeng li Division of Energy Storage Dalian National Laboratory for Clean Energy(DNL)Dalian Institute of Chemical PhysicsChinese Academy of SciencesDalian 116023LiaoningChina University of Chinese Academy of Sciences Beijing 100049China

Aqueous rechargeable metal-ion batteries(ARMBs)hold intrinsic advantages of high safety,low cost and environmental benignity for large scale energy storage ***,the research on aqueous Kion batteries(AKIBs)was hindered by limited ***,a novel AKIB was reported by employing environment-friendly 1,4,5,8-naphthalenetetracarboxylic dianhydride-derived polyimide(PNTCDA)as anode and Berlin green(FeHCF)as *** electrodes have high rate performance and excellent capacity retention during *** researches verify the superior electrochemical property of PNTCDA in saturated KNO3 ***-situ XRD of FeHCF demonstrates the unique shift of peak position and negligible distortion of lattice during the insertion/extraction of K+.The AKIB exhibits an attractive energy density of 46.9 Wh/kg and a high capacity retention of 74%in 300 *** importantly,the battery can reach a super-high power of 2079.1 W/kg with an energy density of 24.2 Wh/kg,ranking relatively high among the *** system extends the use of polyimide and points a way of AKIBs for grid-scale energy storage.

关键词： Polyimide Berlin green Aqueous Potassium Battery

A star identification algorithm for rolling shutter exposure based on Hough transform

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Chinese Journal of Aeronautics 2024年第6期37卷 319-330页

作者： Tao wang Gangyi wang xinguo WEI Yongyong li School of Instrumentation and Optoelectronic Engineering Beihang UniversityBeijing 100191China

The star identification algorithm usually identifies stars by angular distance ***,under high dynamic conditions,the rolling shutter effect distorts the angular distances between the measured and true star positions,leading to plethoric false matches and requiring complex and time-consuming verification for star *** identification rate hinders the application of low-noise and cost-effective rolling shutter image *** this work,we first study a rolling shutter distortion model of angular distances between stars,and then propose a novel three-stage star identification algorithm to identify distorted star images captured by the rolling shutter star *** first stage uses a modified grid algorithm with adaptive error tolerance and an expanded pattern database to efficiently eliminate spurious *** second stage performs angular velocity estimation based on Hough transform to verify the matches that follow the same distortion *** third stage applies a rolling shutter error correction method for further *** the simulation and night sky image test demonstrate the effectiveness and efficiency of our algorithm under high dynamic *** accuracy of angular velocity estimation method by Hough transform is evaluated and the root mean square error is below 0.5(°)/*** algorithm achieves a 95.7% identification rate at an angular velocity of 10(°)/s,which is much higher than traditional algorithms.

关键词： Star trackers Star identification Rolling shutter Angular velocity estimation Hough transform

基于上海市绿地规划的花海景观综合效益评价体系研究

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城市建筑 2025年第1期22卷 228-232页

作者：王艳可李小双上海应用技术大学生态技术与工程学院

花海景观作为城市绿化中重要的植物景观专类,对满足城市居民审美、游憩等生活需求、丰富绿地景观效益具有重要意义。当前缺少花海景观综合效益量化评价方法,不利于景观综合效益提升。文章以草本植物花海作为研究对象,将花海景观纳入研... 详细信息

花海景观作为城市绿化中重要的植物景观专类,对满足城市居民审美、游憩等生活需求、丰富绿地景观效益具有重要意义。当前缺少花海景观综合效益量化评价方法,不利于景观综合效益提升。文章以草本植物花海作为研究对象,将花海景观纳入研究范畴;基于上海市绿地规划,运用层次分析法融合植物应用评价与景观效益评估模型,并邀请专家打分得出各指标的综合权重,构建出花海景观综合效益指标评价体系。选取9个典型花海景观点位进行评价,论证其可行性,并结合评价结果提出相应优化策略;以期为对花海景观进行科学的效益量化评价提供参考基础。

关键词：城市绿地规划层次分析法花海景观综合效益评价

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Numerical Study of Heat Transfer Characteristic for Subcooled Falling Film outside the Shaped Tubes under Rolling Motion

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Journal of Thermal Science 2023年第3期32卷 922-932页

作者： HAN Hui wang Junqi wang Shaowei li Yuxing Provincial Key Laboratory of Oil and Gas Storage and Transportation Safety in Shandong Province China University of Petroleum(Huadong)Qingdao 266580China

The heat transfer performance of spiral wound heat exchanger used in the floating liquefied natural gas(FLNG)may be significantly affected by the sloshing *** this paper,a three-dimensional numerical model combined with the dynamic mesh technology is conducted to study subcooled falling film heat transfer under static and sloshing *** three-dimensional velocity distribution of the liquid film on the shell side is *** effects of cross-section shape of heat exchange tubes,Reynolds numbers and sloshing parameters on heat transfer characteristics are *** results indicate that the heat transfer performance of the egg-shaped tube is superior to that of the elliptical and circular tube under both static and sloshing conditions due to significant heat transfer improvement in the lower half of the *** heat transfer coefficients of three different kinds of tubes decrease under sloshing *** the rolling amplitude is 6°,the average heat transfer coefficients of the circular tube,elliptical tube and egg-shaped tube are reduced by 2.1%,3.7%and 4.9%*** the current sloshing parameters,increasing the rolling amplitude,the heat transfer coefficients of three different tubes are slightly increased,while the sloshing period has little effect on heat *** egg-shaped tube and elliptical tube are greatly affected by sloshing motion at the low Reynolds number,while the effect is relatively small at the high Reynolds number.

关键词： falling film flow sloshing condition spiral wound heat exchanger floating liquefied natural gas