(D-Ser2) oxyntomodulin recovers hippocampal synaptic structure and theta rhythm in Alzheimer’s disease transgenic mice

作     者：Guang-Zhao Yang Qi-Chao Gao Wei-Ran Li Hong-Yan Cai Hui-Min Zhao Jian-Ji Wang Xin-Rui Zhao Jia-Xin Wang Mei-Na Wu Jun Zhang Christian Hölscher Jin-Shun Qi Zhao-Jun Wang Guang-Zhao Yang;Qi-Chao Gao;Wei-Ran Li;Hong-Yan Cai;Hui-Min Zhao;Jian-Ji Wang;Xin-Rui Zhao;Jia-Xin Wang;Mei-Na Wu;Jun Zhang;Christian H(o)lscher;Jin-Shun Qi;Zhao-Jun Wang

作者机构：Department of Cardiovascular Medicinethe First Hospital of Shanxi Medical UniversityTaiyuanShanxi ProvinceChina Department of PhysiologyShanxi Medical UniversityKey Laboratory of Cellular PhysiologyMinistry of EducationKey Laboratory of Cellular Physiology in Shanxi ProvinceTaiyuanShanxi ProvinceChina Department of Microbiology and ImmunologyShanxi Medical UniversityTaiyuanShanxi ProvinceChina Functional Laboratory CenterShanxi Medical UniversityTaiyuanShanxi ProvinceChina Research and Experimental CenterHenan University of Chinese MedicineZhengzhouHenan ProvinceChina 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2022年第17卷第9期

页      面：2072-2078页

核心收录：

学科分类：1002[医学-临床医学] 100203[医学-老年医学] 10[医学] 

基　　金：supported by the National Natural Science Foundation of China,No.31600865(to ZJW) “Sanjin Scholars”of Shanxi Province of China,No.7(to MNW) Shanxi Province Science Foundation for Excellent Young Scholars of China,No.201801D211005(to MNW) the Applied Basic Research Program of Shanxi Province of China,No.201901D111358(to GZY) the Doctoral Startup Research Fund of Shanxi Medical University of China,No.03201536(to GZY) the Doctoral Startup Research Fund of the First Hospital of Shanxi Medical University of China,No.YJ1507(to GZY) the National Undergraduate Innovation Program of China,No.201910114019(to JXW) the Undergraduate Innovation Program of Shanxi Province of China,No.2020189(to XRZ) 

主　　题：(D-ser2)oxyntomodulin Alzheimer’s disease cognitive decline glucagon-like peptide-1 hippocampus local field potential synapse theta rhythm 

摘      要：In our previous studies,we have shown that(D-Ser2)oxyntomodulin(Oxm),a glucagon-like peptide 1(GLP-1)receptor(GLP1R)/glucagon receptor(GCGR)dual agonist peptide,protects hippocampal neurons against Aβ1-42-induced cytotoxicity,and stabilizes the calcium homeostasis and mitochondrial membrane potential of hippocampal ***,we have demonstrated that(D-Ser2)Oxm improves cognitive decline and reduces the deposition of amyloid-beta in Alzheimer’s disease model ***,the protective mechanism remains *** this study,we showed that 2 weeks of intraperitoneal administration of(D-Ser2)Oxm ameliorated the working memory and fear memory impairments of 9-month-old 3×Tg Alzheimer’s disease model *** addition,electrophysiological data recorded by a wireless multichannel neural recording system implanted in the hippocampal CA1 region showed that(D-Ser2)Oxm increased the power of the theta *** addition,(D-Ser2)Oxm treatment greatly increased the expression level of synaptic-associated proteins SYP and PSD-95 and increased the number of dendritic spines in 3×Tg Alzheimer’s disease model *** findings suggest that(D-Ser2)Oxm improves the cognitive function of Alzheimer’s disease transgenic mice by recovering hippocampal synaptic function and theta rhythm.