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Ontogeny of the Traumatocrinus hsui

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Acta Geologica Sinica(English Edition) 2011年第3期85卷 544-548页

作者： wang Chuanshang CHEN Xiaohong wang Xiaofeng cheng long Wuhan Institute of Geology and Mineral Resources CGS Wuhan 430223 China

It is suggested that the characters of Traumatocrinus hsui Mu infants change remarkably in different ages;however,the characters of adult individuals are comparatively *** present study examined specimens of infant and adult individuals of *** on these observations,the authors divided the ontogeny of *** into four infant stages（infant stageⅠ-Ⅳ）and one adult *** addition,the characters of the anal pyramid are supplemented and the infrabasal plates of *** are confirmed in the present paper for the first time.

关键词： Traumatocrinus hsui ontogeny infant individual

Dynamic Behavior of Gravity Retaining Walls with Coral Sand Backfill Under Earthquakes:Shaking Table Tests

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China Ocean Engineering 2022年第6期36卷 839-848页

作者： ZHANG Yan-ling wang cheng-long DING Xuan-ming WU Qi College of Civil Engineering Taiyuan University of TechnologyTaiyuan 030024China Key Laboratory of New Technology for Construction of Cities in Mountain Area School of Civil EngineeringChongqing UniversityChongqing 400045China

The retaining walls in coral sand sites are inevitably threatened by earthquakes. A series of shaking table tests were carried out to study the seismic stability of gravity retaining walls with coral sand backfill. Parallel tests with quartz sand were performed to compare and discuss the special dynamic properties of coral sand sites. The results show that the acceleration difference between the retaining wall and the coral sand backfill is 76%-92% that of the quartz sand,which corresponds to the larger liquefaction resistance of coral sand compared with the quartz sand. However, the horizontal displacement of the retaining walls with coral sand backfill reaches 79% of its own width under 0.4g vibration intensity. The risk of instability and damage of the retaining walls with coral sand backfill under strong earthquakes needs attention.

关键词： coral sand seismic response liquefaction shaking table test gravity retaining walls

Seismic responses of slopes with different angles in coral sand

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Journal of Mountain Science 2021年第9期18卷 2475-2485页

作者： ZHANG Yan-ling DING Xuan-ming CHEN Zhi-xiong WU Qi wang cheng-long College of Civil Engineering Taiyuan University of TechnologyTaiyuan 030024China College of Civil Engineering Chongqing UniversityChongqing400045China Key Laboratory of New Technology for Construction of Cities in Mountain Area Chongqing UniversityChongqing400045China

This paper investigates the seismic responses of slopes in coral sand taken from a reef island in the South China Sea.A series of shaking table model tests were conducted to explore the responses of soil acceleration,excess pore pressure,and slope displacement for three slope angles(5°,10°,and 15°).The results show that the excess pore pressure ratio of the slope decreases due to an increase in the initial shear stress when the slope angle *** acceleration response of the soil increases with the increase of the slope *** slope displacement presents substantial increments as the excess pore pressure ratio *** addition,the lateral movement,and slope settlement present substantial increments as the slope angle *** liquefaction is observed under a dynamic excitation of 0.2 g in the coral sand *** a dynamic excitation of 0.4 g,the site liquefies quickly,the acceleration amplification factor decreases,and the lateral movement and the settlement of the slope surface both increase compared with that under 0.2 g *** the slope with an angle of 15°at 0.4 g,the flow distance of the sand strip increase by 289.47%compared with that in the 5°*** lateral movement of the slope surface near the water level line is substantially larger than that away from the water *** largest settlement is observed near the middle section of the slope(below the water level)under a dynamic excitation of 0.2 *** contrast,the largest settlement under a dynamic excitation of 0.4 g occurs at the top of the slope.

关键词： Coral sand Slope angle Shaking table tests Seismic response Liquefaction

Treatment of End-Stage Coronary Artery Disease with the Mode of Combination of Disease and Syndrome:A Case Report

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Chinese Journal of Integrative Medicine 2021年第6期27卷 461-464页

作者： BAI Rui-na wang Pei-li GU Feng TAN Juan wang cheng-long CHEN Ke-ji Cardiovascular Diseases Center Xiyuan HospitalChina Academy of Chinese Medical SciencesNational Clinical Research Center for Chinese Medicine CardiologyBeijing(100091)China

Coronary artery disease(CAD)remains the leading cause of mortality *** advanced pharmacologic development and invasive revascularization therapy,a small but not insignificant number of patients show progression to end... 详细信息

关键词： Coronary mortality therapy

Protective effects of paeoniflorin and albiflorin on chemotherapy-induced myelosuppression in mice

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Chinese Journal of Natural Medicines 2016年第8期14卷 599-606页

作者： ZHU Ying-Li wang Lin-Yuan wang Jing-Xia wang Chun wang cheng-long ZHAO Dan-Ping wang Zi-Chen ZHANG Jian-Jun School of Preclinical Medicine Beijing University of Chinese Medicine School of Chinese Materia Medica Beijing University of Chinese Medicine

Paeonia lactiflora root(baishao in Chinese) is a commonly used herb in traditional Chinese medicines(TCM). Two isomers, paeoniflorin(PF) and albiflorin(AF), are isolated from P. lactiflora. The present study aimed to investigate the protective effects of PF and AF on myelosuppression induced by chemotherapy in mice and to explore the underlying mechanisms. The mouse myelosuppression model was established by intraperitoneal(i.p.) injection of cyclophosphamide(CP, 200 mg×kg^(–1)). The blood cell counts were performed. The thymus index and spleen index were also determined and bone morrow histological examination was performed. The levels of tumor necrosis factor-α(TNF-α) in serum and colony-stimulating factor(G-CSF) in plasma were measured by Enzyme-Linked Immunosorbent Assays(ELISA) and the serum levels of interleukin-3(IL-3), granulocyte-macrophagecolony- stimulatingfactor(GM-CSF), and interleukin-6(IL-6) were measured by radioimmunoassay(RIA). The levels of m RNA expression protein of IL-3, GM-CSF and G-CSF in spleen and bone marrow cells were determined respectively. PF and AF significantly increased the white blood cell(WBC) counts and reversed the atrophy of thymus. They also increased the serum levels of GM-CSF and IL-3 and the plasma level of G-CSF and reduced the level of TNF-α in serum.. PF enhanced the m RNA level of IL-3 and AF enhanced the m RNA levels of GM-CSF and G-CSF in the spleen. PF and AF both increased the protein levels of GM-CSF and G-CSF in bone marrow cells. In conclusion, our results demonstrated that PF and AF promoted the recovery of bone marrow hemopoietic function in the mouse myelosuppression model.

关键词： Albiflorin Paeoniflorin Chemotherapy Myelosuppression

Panax quinquefolium saponin Optimizes Energy Homeostasis by Modulating AMPK-Activated Metabolic Pathways in Hypoxia-Reperfusion Induced Cardiomyocytes

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Chinese Journal of Integrative Medicine 2021年第8期27卷 613-620页

作者： YU Yong-hui ZHANG Pei wang cheng-long LIU Jian-gang LI Peng ZHANG Da-wu Department of Traditional Chinese Medicine China-Japan Friendship HospitalBeijing100029China Graduate Shcool Beijing University of Chinese MedicineBeijing100029China Department of Cardiovascular Disease Mongolian Hospital of Traditional Chinese MedicineWuhaiInner Mongolia Autonomous Region016000China Center for Cardiovascular Diseases Xiyuan HospitalChina Academy of Chinese Medical SciencesBeijing100091China

Objective To investigate the effects and underlying mechanisms of Panax quinquefolium saponin(PQS)on energy deficiency in hypoxia-reperfusion(H/R)induced *** The H/R injury involved hypoxia for 3 h and then reperfusion for 2 *** recruited from neonatal rat ventricular myocytes(NRVMs)were randomly divided into control,H/R,H/R+compound C(C.C),H/R+PQS,and H/R+C.C+PQS *** assay,lactase dehydrogenase(LDH)leakage and early apoptosis rate were evaluated to assess cell *** of high energy phosphate compounds were conducted to detect the energy *** expression levels of adenosine monophosphate-activated protein kinase a(AMPKα),glucose transporter 4(GLUT4),phosphate fructose kinase 2(PFK2),fatty acid translocase/cluster of differentiation 36(FAT/CD36),and acetyl CoA carboxylase 2(ACC2)in the regulatory pathways were measured by Western *** staining of GLUT4 and FAT/CD36 was used to observe the mobilization of metabolic *** PQS(50 mg/L)pretreatment significantly alleviated H/R-induced inhibition of NRVMs viability,up-regulation of LDH leakage,acceleration of early apoptosis,and reduction of energy production(P<0.05).Compared with the H/R group,up-regulated expression of AMPKα,GLUT4,PFK2,FAT/CD36 and ACC2 were observed,and more GLUT4 and FAT/CD36 expressions were detected on the membrane in the H/R+PQS group(P<0.05).These effects of PQS on H/R-induced NRVMs were eliminated in the H/R+C.C+PQS group(P<0.05).Conclusion PQS has prominent advantages in protecting NRVMs from H/R-induced cell damages and energy metabolic disorders,by activation of AMPKα-mediated GLUT4-PFK2 and FAT/CD36-ACC2 pathways.

关键词： Panax quinquefolium saponin Chinese medicine neonatal rat ventricular myocytes hypoxia-reperfusion energy metabolism adenosine monophosphate-activated protein kinaseαpathways

Antidepressant-like effects of albiflorin involved the NO signaling pathway in rats model of chronic restraint stress

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Chinese Journal of Natural Medicines 2020年第11期18卷 872-880页

作者： ZHU Ying-Li wang Lin-Yuan ZHAO Dan-Ping wang cheng-long ZHANG Rui FEI Wen-Ting wang Jing-Xia ZHANG Jian-Jun School of Chinese Materia Medica Bejing University of Chinese MedicineBejing100029China School of Traditional Chinese Medicine Bejing University of Chinese MedicineBeijing100029China

The depressant-like effects of albiflorin(AF) were studied on stressed chronic restraint stress(CRS) rats. Experimental rats were subjected to immobilization stress for a daily 6 h-restraining in a plastic restrainer for continuous 21 d and were treated with 30 or 15 mg·kg-1 of AF for 21 d. Control rats were maintained in completely non stressed conditions. Behavioral tests and biochemical analysis were applied to investigating a regulatory mechanism of anti-stress of AF. Treatment with AF significantly restored the depressant-like behaviors. Besides, AF increased the levels of 5-hydroxytryptophan(5-HT), 5-hydroxyindoleacetic acid(5-HIAA),noradrenaline(NE) and dopamine(DA) in the hippocampus and increased the level of brain-derived neurotrophic factor(BDNF) in serum and protein expression in hippocampus. In addition, AF decreased the levels of hypothalamo-pituitary-adrenal(HPA) cascade,reduced the level of NO and c GMP in serum and inhibited the overexpression of 5-HT2AR m RNA and protein expression. Taken together, AF can modulate the NO-mediated network pathway in the hippocampus against stress-induced depressive-like *** physiological and behavioral changes allow rats to avoid potential deleterious effects of stress that may result from chronically elevated levels of glucocorticosteroids over days.

关键词： Paeonia lactiflora Albiflorin Chronic restraint stress Anti-stress NO-mediated pathway

long-Term Follow-Up of Chinese Herbal Medicines Combined with Conventional Treatment in Patients with Acute Coronary Syndrome after Percutaneous Coronary Intervention: A Multicenter Randomized Controlled Trial

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Chinese Journal of Integrative Medicine 2017年第10期23卷 740-746页

作者： wang Pei-li ZHANG Lei wang Shao-li YANG Qiao-ning GAO Zhu-ye DU Jian-peng ZHANG Da-wu FU Chang-geng GU Feng XU Hao Li Li-zhi wang cheng-long SHI Da-zhuo Institute of Cardiovascular Diseases Xiyuan Hospital China Academy of Chinese Medical Sciences Department of Gastroenterology Guang'anmen Hospital China Academy of Chinese Medical Sciences

Objective： To evaluate the prognosis effect of Chinese herbal medicines（CHMs） for benefiting qi and activating blood circulation adjunctive to conventional treatment in patients with acute coronary syndrome（ACS） after percutaneous coronary intervention（PCI）. Methods： A total of 702 patients with ACS who underwent PCI were enrolled and randomly assigned to receive conventional treatment plus CHMs for benefiting qi and activating blood circulation（treatment group, 351 cases） or conventional treatment alone（control group, 351 cases） for 6 months. Six months later, all patients received conventional treatment alone. Follow-ups were scheduled at 6th, 12 th, 18 th, 24 th month after enrollment in April 2008, and the final follow-up visit was during September 2011 and November 2011. The primary endpoint was the composite of cardiac death, nonfatal myocardial infarction or revascularization（PCI or coronary artery bypass grafting）; and the secondary endpoint was the composite of re-admission for ACS, congestive heart failure, nonfatal stroke or other thrombus events. Results： A total of 621（88.59%） patients completed 35.4±3.8 months follow-up, while 80（11.41%） patients withdrew from the trial（41 in the treatment group and 39 in the control group）. The incidence of primary endpoint was 5.7%（20 patients） in the treatment group versus 10.86%（38 patients） in the control group [relative risk（RR）： 0.53; 95% confidence interval（CI）： 0.30, 0.88; P=0.013; absolute risk reduction（ARR）： –0.052, 95% CI： –0.06, 0.01]. The incidence of secondary endpoint was 5.98%（21 patients） in the treatment group versus 10.28%（36 patients） in control group（RR： 0.58, 95% CI： 0.33, 0.97, P=0.037; ARR： –0.043, 95% CI： 0.06, 0.01）. Most of the primary and secondary endpoints were occurred in 18 months（84.50% in the treatment group versus 78.10% in the control group）. Conclusion： CHMs for benefiting qi and activating blood circulation adjunctive to conventional treatment improved clinical outcomes for patie

关键词： long-term follow-up Chinese medicine benefit qi and activate blood circulation acute coronary syndrome percutaneous coronary intervention

Comparative study of shaking table model tests on seismic behavior of underground structures in coral sand and quartz sand sites

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Yantu Lixue/Rock and Soil Mechanics 2020年 41卷 357-366页

作者： Zhang, Yan-Ling Ding, Xuan-Ming Wu, Qi wang, cheng-long Chen, Zhi-Xiong Key Laboratory of New Technology for Construction of Cities in Mountain Area Chongqing University Chongqing 400045 China College of Civil Engineering Chongqing University Chongqing 400045 China

In order to reveal the seismic performance of underground structures in coral sand site, shaking table tests of the dynamic response of underground structures in the coral sand site under two excitation intensities were carried out and compared with the quartz sand site. The results show that with the increase of ground motion intensity, the excess pore pressure ratio, horizontal dynamic earth pressure and strain response of the two sites increase, and the separation between the structure and the surrounding soil is more obvious. The coral sand site has a lower excess pore pressure ratio than that in the quartz sand site, about 42.61%-67.35% of the quartz sand site. The peak acceleration of coral sand site is less than quartz sand site. The horizontal dynamic soil pressure response of the two kinds of sand sites shows a "Z" shaped distribution along the depth, and the horizontal dynamic soil pressure of the coral sand site is less than that of the quartz sand site. On the inner and outer surface of the same wallboard of the underground structure, the strain appears to be large at the corners and small at the midpoints. The strain in the coral sand site is smaller than that of the quartz sand site. With the increase of shaking input intensity, the uneven ground settlement is more obvious, the uneven ground settlement of quartz sand site is higher than that of coral sand site. © 2020, Science Press. All right reserved.

关键词： Sand