Antidepressant-like effects of albiflorin involved the NO signaling pathway in rats model of chronic restraint stress

作     者：ZHU Ying-Li WANG Lin-Yuan ZHAO Dan-Ping WANG Cheng-Long ZHANG Rui FEI Wen-Ting WANG Jing-Xia ZHANG Jian-Jun ZHU Ying-Li;WANG Lin-Yuan;ZHAO Dan-Ping;WANG Cheng-Long;ZHANG Rui;FEI Wen-Ting;WANG Jing-Xia;ZHANG Jian-Jun

作者机构：School of Chinese Materia MedicaBejing University of Chinese MedicineBejing100029China School of Traditional Chinese MedicineBejing University of Chinese MedicineBeijing100029China 

出 版 物：《Chinese Journal of Natural Medicines》 (中国天然药物（英文版）)

年 卷 期：2020年第18卷第11期

页      面：872-880页

核心收录：

学科分类：1007[医学-药学(可授医学、理学学位)] 1006[医学-中西医结合] 100706[医学-药理学] 100602[医学-中西医结合临床] 10[医学] 

基　　金：supported by the National Nature Science Foundation of China (Nos. 81473370 and 81173569) 

主　　题：Paeonia lactiflora Albiflorin Chronic restraint stress Anti-stress NO-mediated pathway 

摘      要：The depressant-like effects of albiflorin(AF) were studied on stressed chronic restraint stress(CRS) rats. Experimental rats were subjected to immobilization stress for a daily 6 h-restraining in a plastic restrainer for continuous 21 d and were treated with 30 or 15 mg·kg-1 of AF for 21 d. Control rats were maintained in completely non stressed conditions. Behavioral tests and biochemical analysis were applied to investigating a regulatory mechanism of anti-stress of AF. Treatment with AF significantly restored the depressant-like behaviors. Besides, AF increased the levels of 5-hydroxytryptophan(5-HT), 5-hydroxyindoleacetic acid(5-HIAA),noradrenaline(NE) and dopamine(DA) in the hippocampus and increased the level of brain-derived neurotrophic factor(BDNF) in serum and protein expression in hippocampus. In addition, AF decreased the levels of hypothalamo-pituitary-adrenal(HPA) cascade,reduced the level of NO and c GMP in serum and inhibited the overexpression of 5-HT2AR m RNA and protein expression. Taken together, AF can modulate the NO-mediated network pathway in the hippocampus against stress-induced depressive-like *** physiological and behavioral changes allow rats to avoid potential deleterious effects of stress that may result from chronically elevated levels of glucocorticosteroids over days.