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Chinese Science Bulletin 2013年第19期58卷 2379-2386页

作者： CHEN YuQi CAO Jie ZHU HongYan CUI SiSi wang aqin QIAN ZhiYu GU YueQing Department of Biomedical Engineering School of Life Science and TechnologyChina Pharmaceutical University Department of Biomedical Engineering School of AutomationNanjing University of Aeronautics and Astronautics

In this study, an amphiphilic copolymer folate-succinyl-methionine-chitosan-octyl (FSMCO) was successfully synthesized step by step for self-assembling polymeric micelles. The copolymers formed micelle-like nanoparticles by their amphiphilic characteristics and structures were examined by UV-Vis absorption and Fourier transform spectroscopy. The sizes of blank and ICG derivativeloaded micelles measured by dynamic light scattering were about 170 and 140 nm, respectively, which were spherical in shape with an average zeta potential of 10 mV. Further studies on the stability showed that the micellar solutions maintain their sizes at room temperature for 1 month without distinct aggregation or dissociation. ICG derivative was much better photostable after being entrapped by the new carrier. The prepared FSMCO micelles displayed a good drug loading content (11.7%), entrapment efficiency (66.5%) and sustained release rate for the model drug fluorescein. The copolymers demonstrated weeny cytotoxicity toward Bel-7402, L02 and A549 cells when incubated for 2 d. Ligands modified micelles endowed preferable cell targeting capability and beautiful cell inhibition of HCPT-FSMCO on Bel-7402 tumor cells. This kind of polymeric micelles may be a promising nanovehicle in delivering near-infrared dyes for tumors imaging and chemotherapeutic drugs for cancer therapeutics.

关键词：聚合物胶束化疗药物输送系统合成叶酸两亲性共聚物疏水性组装体

基于聚类分析的胃癌术后化疗患者症状群的分类研究

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中国实用护理杂志 2019年第17期35卷 1281-1286页

作者：王潇段培蓓王阿芹夏超南京中医药大学护理学院 210023 南京中医药大学附属医院肿瘤内科 210029 南京中医药大学附属医院护理部 210029

目的从胃癌术后化疗患者对疼痛-疲乏-睡眠障碍症状群的体验角度,分析该症状群患者可能的类型,并探讨不同类型症状群患者的影响因素及与生命质量的关系。方法采用一般资料调查表、数字疼痛评估表(NRS)、简易疲乏量表(BFI)、匹兹堡睡眠质... 详细信息

目的从胃癌术后化疗患者对疼痛-疲乏-睡眠障碍症状群的体验角度,分析该症状群患者可能的类型,并探讨不同类型症状群患者的影响因素及与生命质量的关系。方法采用一般资料调查表、数字疼痛评估表(NRS)、简易疲乏量表(BFI)、匹兹堡睡眠质量指数量表(PSQI)、卡诺夫斯基功能状态量表(KPS)、胃癌患者生命质量量表(QLICP-ST)对161例胃癌术后化疗患者进行调查,通过SPSS 22.0中的聚类分析方法进行分类,并根据分类结果分析其影响因素及与生命质量的关系。结果161例胃癌术后化疗患者可分为Ⅰ类(症状均低组)23例占14.3%,Ⅱ类(低疼痛、中疲乏组)43例占26.7%,Ⅲ类(低疼痛、高疲乏组)62例占38.5%,Ⅳ类(症状中高组)33例占20.5%。文化程度、化疗周期及KPS得分是胃癌术后化疗患者疼痛-疲乏-睡眠障碍症状群分类的主要影响因素(χ2=13.873、26.442,F=3.193,P <0.05或0.01)。其中文化程度较高,化疗处于后期,KPS评分较低患者更倾向于"症状中高组"。且"症状中高组"患者的生命质量总得分显著低于其余3组(F=10.552,P <0.01)。结论胃癌术后化疗患者基于疼痛-疲乏-睡眠障碍症状群的体验状况可分为4种不同类型,如医护人员有效甄别,并制定有针对性的干预措施,将更大程度地提高患者生命质量。

关键词：胃肿瘤生活质量症状群聚类分析

降钙素原在慢性阻塞性肺疾病急性加重期抗感染治疗中的临床应用

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当代医学 2020年第5期26卷 74-76页

作者：王阿琴江西省鹰潭市人民医院铁路分院呼吸内科

目的探究降钙素原(PTC)在慢性阻塞性肺疾病急性加重期(AECOPD)抗感染治疗中的临床应用价值。方法选取2015年2月至2018年1月本院收治的98例AECOPD患者作为研究对象,随机分为对照组和观察组,各49例,对照组根据患者临床症状、相关指南及医... 详细信息

目的探究降钙素原(PTC)在慢性阻塞性肺疾病急性加重期(AECOPD)抗感染治疗中的临床应用价值。方法选取2015年2月至2018年1月本院收治的98例AECOPD患者作为研究对象,随机分为对照组和观察组,各49例,对照组根据患者临床症状、相关指南及医师经验应用抗菌药物,观察组根据患者血清PTC值应用抗菌药物治疗,比较两组患者的临床治疗效果。结果两组患者治疗后PCT水平、白细胞计数、C反应蛋白指标的比较差异无统计学意义;观察组患者抗生素使用率、平均抗生素疗程、人均抗生素费用、住院天数、总住院费用均优于对照组(P<0.05);两组患者治疗有效率、病情加重率、病死率比较差异无统计学意义。结论在慢性阻塞性肺疾病急性加重期抗感染治疗中监测血清PTC能减少抗生素的使用率、平均抗生素疗程及人均抗生素费用,缩短患者住院时间及住院费用,临床应用价值较高。

关键词：降钙素原慢性阻塞性肺疾病急性加重期抗感染应用

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癌症症状群识别方法研究进展

中国护理管理 2018年第9期18卷 1274-1279页

作者：王潇段培蓓王阿芹胡月张敏夏超南京中医药大学附属医院肿瘤外科 210029 江苏省中医院护理部南京中医药大学附属医院刮痧门诊 210029 南京中医药大学附属医院肿瘤内科 210029 南京中医药大学附属医院ICU 210029

本文就癌症症状群的定义、理论基础、识别方法及识别中存在的难点和展望进行综述,提出我国癌症症状管理者及研究者应以成熟的理论作为基础,采用科学的症状群识别方法,从而探索出具有临床共识的症状群,促进未来临床实践中癌症症状的管理... 详细信息

本文就癌症症状群的定义、理论基础、识别方法及识别中存在的难点和展望进行综述,提出我国癌症症状管理者及研究者应以成熟的理论作为基础,采用科学的症状群识别方法,从而探索出具有临床共识的症状群,促进未来临床实践中癌症症状的管理,真正减轻癌症患者的症状负担。

关键词：肿瘤症状群症状管理研究方法

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含铁牛血肽改善大鼠缺铁性贫血的效果评价

食品与生物技术学报 2023年第11期42卷 27-33页

作者：鲍正好王阿琴许月新刘菲菲余钧何红鹏天津科技大学生物工程学院天津300457 杭州佰倍优生物科技有限公司浙江杭州310020 北京市门头沟区医院北京102300

为开发牛血肽相关功能性产品提供理论依据,作者研究了含铁牛血肽对于大鼠缺铁性贫血的治疗效果。以低铁鼠粮饲喂初离乳雌性SD大鼠3周,建立缺铁性贫血模型。以含铁鼠粮为正常对照,以生血宁为阳性对照,用含铁牛血肽灌胃至血红蛋白质质量... 详细信息

为开发牛血肽相关功能性产品提供理论依据,作者研究了含铁牛血肽对于大鼠缺铁性贫血的治疗效果。以低铁鼠粮饲喂初离乳雌性SD大鼠3周,建立缺铁性贫血模型。以含铁鼠粮为正常对照,以生血宁为阳性对照,用含铁牛血肽灌胃至血红蛋白质质量浓度达到100 g/L以上。结果表明:含铁牛血肽显著地改善了缺铁性贫血引起的大鼠体质量以及白细胞、红细胞、血红蛋白和红细胞压积等血常规指标的下降,同时改善铁代谢指标血清铁和血清铁蛋白。低剂量牛血肽效果相当于生血宁,中高剂量牛血肽效果优于生血宁,证明饲喂含铁牛血肽可以改善大鼠缺铁性贫血。

关键词：含铁牛血肽血红素铁缺铁性贫血大鼠

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Constraints on holographic QCD phase transitions from PTA observations

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 71-78页

作者： Song He Li Li Sai wang Shao-Jiang wang Center for Theoretical Physics and College of Physics Jilin University School of Physical Science and Technology Ningbo University Max Planck Institute for Gravitational Physics (Albert Einstein Institute) CAS Key Laboratory of Theoretical Physics Institute of Theoretical Physics Chinese Academy of Sciences School of Fundamental Physics and Mathematical Sciences Hangzhou Institute for Advanced StudyUniversity of Chinese Academy of Sciences (UCAS) School of Physical Sciences University of Chinese Academy of Sciences (UCAS) Theoretical Physics Division Institute of High Energy Physics Chinese Academy of Sciences

The underlying physics of QCD phase transition in the early Universe remains largely unknown due to its strong-coupling nature during the quark-gluon plasma/hadron gas transition, yet a holographic model has been proposed to quantitatively fit the lattice QCD data while with its duration of the first-order phase transition(FoPT) left undetermined. At specific baryon chemical potential, the first-order QCD phase transition agrees with the observational constraint of baryon asymmetry. It, therefore, provides a scenario for phase transition gravitational waves(GWs) within the standard model of particle physics. If these background GWs could contribute dominantly to the recently claimed common-spectrum red noise from pulsar timing array(PTA) observations, the duration of this FoPT can be well constrained, and the associated primordial black holes are still allowed by current observations.

关键词： pulsar timing array QCD phase transition gravitational waves primordial black holes

Role of iron ore in enhancing gasification of iron coke:Structural evolution,influence mechanism and kinetic analysis

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 58-69页

作者： Jie wang Wei wang Xuheng Chen Junfang Bao Qiuyue Hao Heng Zheng Runsheng Xu School of Chemistry and Materials Science Hubei Engineering UniversityXiaogan 432000China Key Laboratory for Ferrous Metallurgy and Resources Utilization of Ministry of Education Wuhan University of Science and TechnologyWuhan 430081China Institue of Ironmaking Technology Baosteel Central Research InstituteShanghai 201999China State Key Laboratory of Advanced Metallurgy University of Science and Technology BeijingBeijing 100083China

The utilization of iron coke provides a green pathway for low-carbon *** uncover the influence mechanism of iron ore on the behavior and kinetics of iron coke gasification,the effect of iron ore on the microstructure of iron coke was ***,a comparative study of the gasification reactions between iron coke and coke was conducted through non-isothermal thermogravimetric *** findings indicate that compared to coke,iron coke exhibits an augmentation in micropores and specific surface area,and the micropores further extend and *** provides more adsorption sites for CO_(2) molecules during the gasification process,resulting in a reduction in the initial gasification temperature of iron *** the heating rate in non-isothermal gasification can enhance the reactivity of iron *** metallic iron reduced from iron ore is embedded in the carbon matrix,reducing the orderliness of the carbon structure,which is primarily responsible for the heightened reactivity of the carbon *** kinetic study indicates that the random pore model can effectively represent the gasification process of iron coke due to its rich pore ***,as the proportion of iron ore increases,the activation energy for the carbon gasification gradually decreases,from 246.2 kJ/mol for coke to 192.5 kJ/mol for iron coke 15wt%.

关键词： low-carbon ironmaking iron coke gasification structural evolution kinetic model

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滤膜吸附对克拉霉素片溶出度的干扰试验

中国药师 2014年第5期17卷 875-878页

作者：迟雪梅王阿琴王新月鄢丰姚忠立张洪记杭州中美华东制药有限公司杭州310011

目的:查找克拉霉素片溶出度偏低的原因,研究滤膜吸附对克拉霉素片不同时间点的溶出度结果的干扰程度,探索克拉霉素片溶出液合适的处理方法。方法:选择两种不同厂家的克拉霉素片剂,按照日本橘皮书溶出度方法制备溶出液,经不同方式处理后... 详细信息

目的:查找克拉霉素片溶出度偏低的原因,研究滤膜吸附对克拉霉素片不同时间点的溶出度结果的干扰程度,探索克拉霉素片溶出液合适的处理方法。方法:选择两种不同厂家的克拉霉素片剂,按照日本橘皮书溶出度方法制备溶出液,经不同方式处理后,检测其溶出度计算滤膜吸附率。结果:14种微孔滤膜对两个厂家的克拉霉素均有不同的吸附作用,且有的滤膜其吸附率超过了规定限度。结论:通过蒸煮滤膜和更换美国进口膜均能降低克拉霉素的吸附率;弃去初滤液的体积>5ml或者离心处理溶出液均能有效减少和防止滤膜对药物吸附产生的干扰。

关键词：克拉霉素溶出度微孔滤膜吸附率干扰试验

Interplay between creeping fat and gut microbiota: A brand-new perspective on fecal microbiota transplantation in Crohn's disease

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World Journal of Gastroenterology 2025年第2期31卷 138-143页

作者： Ying wang Jie Liu Department of Life Sciences and Medicine South District of Endoscopic CenterThe First Affiliated Hospital of University of Science and Technology of ChinaUniversity of Science and Technology of ChinaHefei 230001Anhui ProvinceChina Department of Gastroenterology The First Affiliated Hospital of University of Science and Technology of ChinaHefei 230001Anhui ProvinceChina

Inflammatory bowel disease,particularly Crohn's disease(CD),has been linked to modifications in mesenteric adipose tissue(MAT)and the phenomenon known as"creeping fat"(CrF).The presence of CrF is believed to serve as a predictor for early clinical recurrence following surgical intervention in patients with ***,the incorporation of the mesentery during ileocolic resection for CD has been correlated with a decrease in surgical recurrence,indicating the significant role of MAT in the pathogenesis of *** numerous studies have indicated that dysbiosis of the gut microbiota is a critical factor in the development of CD,the functional implications of translocated microbiota within the MAT of CD patients remain *** manuscript commentary discusses a recent basic research conducted by Wu et *** their study,intestinal bacteria from individuals were transplanted into CD model mice,revealing that fecal microbiota trans-plantation(FMT)from healthy donors alleviated CD symptoms,whereas FMT from CD patients exacerbated these ***,FMT was found to affect intestinal permeability,barrier function,and the levels of proinflammatory factors and ***,these findings suggest that targeting MAT and CrF may hold therapeutic potential for patients with ***,the study did not evaluate the composition of the intestinal microbiota of the donors or the subsequent alterations in the gut ***,the gut microbiota plays a crucial role in the histopathology of CD,and thus,targeting MAT and CrF may represent a promising avenue for treatment in this patient population.

关键词： Crohn's disease Mesenteric adipose tissue Creeping fat Fecal microbiota transplantation Gut microbiota

EZH2-dependent myelination following sciatic nerve injury

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Neural Regeneration Research 2025年第8期20卷 2382-2394页

作者： Hui Zhu Li Mu Xi Xu Tianyi Huang Ying wang Siyuan Xu Yiting wang Wencong wang Zhiping wang Hongkui wang Chengbin Xue Research Center of Clinical Medicine Affiliated Hospital of Nantong UniversityKey Laboratory of Neuroregeneration of Jiangsu and Ministry of EducationCo-innovation Center of NeuroregenerationNMPA Key Laboratory for Research and Evaluation of Tissue Engineering Technology ProductsNantong UniversityNantongJiangsu ProvinceChina Medical School of Nantong University NantongJiangsu ProvinceChina Department of Neurology Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina Department of Rehabilitation Medicine Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina Department of Critical Care Medicine Nantong Fourth People’s HospitalNantongJiangsu ProvinceChina

Demyelination and remyelination have been major focal points in the study of peripheral nerve regeneration following peripheral nerve ***,the gene regulatory network of regenerated myelin differs from that of native *** of enhancer of zeste homolog 2(EZH2)hinders the differentiation,maturation,and myelination of Schwann cells in *** further determine the role of EZH2 in myelination and recovery post-peripheral nerve injury,conditional knockout mice lacking Ezh2 in Schwann cells(Ezh2^(fl/fl);Dhh-Cre and Ezh2^(fl/fl);Mpz-Cre)were *** results show that a significant proportion of axons in the sciatic nerve of Ezh2-depleted mice remain *** highlights the crucial role of Ezh2 in initiating Schwann cell ***,we observed that 21 days after inducing a sciatic nerve crush injury in these mice,most axons had remyelinated at the injury site in the control nerve,while Ezh2^(fl/fl);Mpz-Cre mice had significantly fewer remyelinated axons compared with their wild-type *** suggests that the absence of Ezh2 in Schwann cells impairs myelin formation and *** conclusion,EZH2 has emerged as a pivotal regulatory factor in the process of demyelination and myelin regeneration following peripheral nerve *** EZH2 activity during these processes may offer a promising therapeutic target for the treatment of peripheral nerve injuries.

关键词： demyelination EZH2 myelination peripheral nerve injury PRC2 remyelination Schwann cells sciatic nerve crush sciatic nerve transection