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Genes & Diseases 2024年第2期11卷 890-920页

作者： Meiqi Duan Haiyang Liu Shasha Xu Zhi Yang Fusheng Zhang Guang wang yutian wang Shan Zhao Xiaofeng Jiang Department of General Surgery The Fourth Affiliated Hospital of China Medical UniversityShenyangLiaoning 110032China Department of Gastroendoscopy The Fourth Affiliated Hospital of China Medical UniversityShenyangLiaoning 110032China Department of Rheumatology and Immunology The First Affiliated Hospital of China Medical UniversityShenyangLiaoning 110002China

m^(6)A methylation is the most frequent modification of mRNA in eukaryotes and plays a crucial role in cancer progression by regulating biological ***-like growth factor 2 mRNA-binding proteins(IGF2BP)are newly identified m^(6)A‘readers’.They belong to a family of RNA-binding proteins,which bind to the m^(6)A sites on different RNA sequences and stabilize them to promote cancer *** this review,we summarize the mechanisms by which different upstream factors regulate IGF2BP in *** current literature analyzed here reveals that the IGF2BP family proteins promote cancer cell proliferation,survival,and chemoresistance,inhibit apoptosis,and are also associated with cancer glycolysis,angiogenesis,and the immune response in the tumor ***,with the discovery of their role as‘readers’of m^(6)A and the characteristic re-expression of IGF2BPs in cancers,it is important to elucidate their mechanism of action in the immunosuppressive tumor *** also describe in detail the regulatory and interaction network of the IGF2BP family in downstream target RNAs and discuss their potential clinical applications as diagnostic and prognostic markers,as well as recent advances in IGF2BP biology and associated therapeutic value.

关键词： Cancer IGF2BP Immunosuppressive TME m^(6)A Molecular mechanism Therapy

Effect of overheating-induced minor addition on Zr-based metallic glasses

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Chinese Physics B 2024年第3期33卷 118-125页

作者：杨福薄振兴黄瑶王雨田孙博阳鲁振孙保安柳延辉汪卫华潘明祥 Institute of Physics Chinese Academy of SciencesBeijing 100190China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing 100049China School of Physical Sciences University of Chinese Academy of SciencesBeijing 100049China Songshan Lake Materials Laboratory Dongguan 523808China

Melt treatment is well known to have an important influence on the properties of metallic glasses(MGs).However,for the MGs quenched from different melt temperatures with a quartz tube,the underlying physical origin responsible for the variation of properties remains poorly *** the present work,we systematically studied the influence of melt treatment on the thermal properties of a Zr50Cu36Al14 glass-forming alloy and unveiled the microscopic ***,we quenched the melt at different temperatures ranging from 1.1Tl to 1.5Tl(Tl is the liquidus temperature)to obtain melt-spun MG ribbons and investigated the variation of thermal properties of the MGs upon *** found that glass transition temperature,Tg,increases by as much as 36 K,and the supercooled liquid region disappears in the curve of differential scanning calorimetry when the melt is quenched at a high temperature up to *** careful chemical analyses indicate that the change in glass transition behavior originates from the incorporation of oxygen and silicon in the molten *** incorporated oxygen and silicon can both enhance the interactions between atoms,which renders the cooperative rearrangements of atoms difficult,and thus enhances the kinetic stability of the MGs.

关键词： metallic glass thermal properties melt treatment overheating oxygen content

基于混沌云量子蝙蝠CNN-GRU大坝变形智能预报方法研究

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哈尔滨工程大学学报 2024年第1期45卷 110-118页

作者：陈以浩李明伟安小刚王宇田徐瑞喆交通运输部水运科学研究院北京100088 哈尔滨工程大学船舶工程学院黑龙江哈尔滨150001

针对大坝变形影响因素复杂、精准预报难度较大问题,为了提高在大坝安全管理过程中大坝变形的预报精度,本文从大坝变形非线性动力系统时间序列的强非线性出发,引入深度卷积神经网络,对大坝变形及其空间影响特性进行挖掘,引入门控循环单元... 详细信息

针对大坝变形影响因素复杂、精准预报难度较大问题,为了提高在大坝安全管理过程中大坝变形的预报精度,本文从大坝变形非线性动力系统时间序列的强非线性出发,引入深度卷积神经网络,对大坝变形及其空间影响特性进行挖掘,引入门控循环单元,对大坝变形的时域特性进行挖掘,构建应用于大坝变形预报的深度卷积神经网络-门控循环单元大坝变形组合深度学习网络;同时,为了获取深度卷积神经网络-门控循环单元组合网络的最佳超参,引入了混沌云量子蝙蝠算法,建立了基于混沌云量子蝙蝠算法算法的深度卷积神经网络-门控循环单元组合网络超参优选方法;最后,提出了深度卷积神经网络-门控循环单元-混沌云量子蝙蝠算法大坝变形组合深度学习智能预报方法。基于实测数据开展预报研究,对比结果表明:与对比模型相比,提出的深度卷积神经网络-门控循环单元-混沌云量子蝙蝠算法预报方法取得了更精确的预报结果,混沌云量子蝙蝠算法算法用于超参优选获得了更佳的超参组合。

关键词：大坝变形预测卷积神经网络门控循环单元蝙蝠算法量子力学混沌理论非线性动力系统模拟与预测深度学习

乡村文化产业赋能乡村振兴的创新路径——以江苏省连云港市灌云县南岗镇A村为例

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南京工程学院学报（社会科学版） 2024年第1期24卷 72-76页

作者：贺龙王宇甜南京传媒学院文化管理学院江苏南京211172 南京传媒学院校长办公室江苏南京211172

2017年10月18日,党的十九大报告提出乡村振兴的战略,强调始终要把“三农”(农业、农村、农民)问题摆在重要发展位置。从党的十九大之后农村发展的内外在优势可见,乡村文化产业建设已成为促进农村经济发展和文化传承的重要途径,这就要求... 详细信息

2017年10月18日,党的十九大报告提出乡村振兴的战略,强调始终要把“三农”(农业、农村、农民)问题摆在重要发展位置。从党的十九大之后农村发展的内外在优势可见,乡村文化产业建设已成为促进农村经济发展和文化传承的重要途径,这就要求我们更加重视乡村文化产业建设,补齐农业农村发展短板。我国现阶段的乡村文化产业发展存在诸多问题。江苏省连云港市灌云县南岗镇A村在乡村文化产业结构、人才发展现状、家庭经济收入、农业发展特色等方面的问题亟待解决。相关职能部门需要重视乡村产业政策扶持、人才培养机制的完善、数字化建设、产学研合作等方面的发展,为我国农村文化产业的建设打下坚实的基础。

关键词：乡村建设文化产业文化管理

回火工艺对铁路用A3车轴钢组织及力学性能的影响

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金属热处理 2024年第1期49卷 202-205页

作者：赵志刚陈建礼张锦文王松伟王育田山西太钢不锈钢股份有限公司技术中心山西太原030003

通过试验探讨了不同回火工艺对铁路车辆用A3车轴钢的显微组织及力学性能的影响。结果表明,在860℃的淬火条件下,回火温度为640~740℃时,A3车轴钢的淬火+回火显微组织均为回火索氏体。在试验的回火温度区间内,随回火温度的逐渐升高,A3车... 详细信息

通过试验探讨了不同回火工艺对铁路车辆用A3车轴钢的显微组织及力学性能的影响。结果表明,在860℃的淬火条件下,回火温度为640~740℃时,A3车轴钢的淬火+回火显微组织均为回火索氏体。在试验的回火温度区间内,随回火温度的逐渐升高,A3车轴钢在常温下的抗拉强度、屈服强度呈下降趋势,而其冲击吸收能量、断后伸长率以及断面收缩率呈上升趋势。在640~680℃范围内回火温度逐渐升高时,冲击吸收能量有显著的提高;但在680~740℃范围内回火温度逐渐升高时,冲击吸收能量逐渐增加,但增幅较小。在860℃淬火的工艺条件下,为满足A3车轴钢的各项性能,其回火温度应该控制在680~720℃。

关键词： A3车轴钢回火温度组织力学性能

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一种新型四极杆质谱仪数据采集系统的研制

实验与分析 2024年第2期2卷 53-59页

作者：王愉天陈吉文北方工业大学北京100144

电子倍增器是目前大多数四极杆质谱仪采用的检测器方案,这种检测器输出的是微弱电流信号,这种微弱电流信号在后续的处理、采集过程中容易被噪声信号干扰,导致仪器信噪比降低。针对传统四极杆质谱仪数据采集系统易受干扰且信噪比较低的问... 详细信息

电子倍增器是目前大多数四极杆质谱仪采用的检测器方案,这种检测器输出的是微弱电流信号,这种微弱电流信号在后续的处理、采集过程中容易被噪声信号干扰,导致仪器信噪比降低。针对传统四极杆质谱仪数据采集系统易受干扰且信噪比较低的问题,研制了一种新型数据采集系统,对于模拟模式,使用VFC(电压-频率转换Voltage-Frequency Conversion)方案替代了传统的ADC方案;对于脉冲模式,研制了一种新型脉冲信号调理电路,可将脉冲模式输出的不规则电流脉冲信号转换为幅值、脉宽信号一致的电压脉冲以方便采集。在本团队自制的ICP-MS样机平台上利用本套系统测试含有9Be、59Co、89Y、115In、140Ce、209Bi的梯度浓度标准溶液,实验结果表明,在ICP源强烈的电磁干扰影响下,新型数据采集系统的稳定性、精度等关键指标满足仪器需求。

关键词：四极杆质谱仪数据采集系统 VFC 脉冲信号调理

Design and development of a five-axis machine tool with high accuracy,stiffness and efficiency for aero-engine casing manufacturing

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Chinese Journal of Aeronautics 2022年第4期35卷 485-496页

作者： yutian wang Dong wang Shizhen ZHANG Zihan TANG Liping wang Yanmin LIU State Key Laboratory of Tribology and Institute of Manufacturing Engineering Department of Mechanical EngineeringTsinghua UniversityBeijing 100084China Beijing Key Lab of Precision Ultraprecision Manufacturing Equipment and Control Beijing 100084China Beijing Precision Machinery&Engineering Research Co.LTD Beijing 101312China Beijing Institute of Control Engineering Beijing 100094China

In order to satisfy the machining requirements of aero-engine casing in modern aviation industry, this paper investigates three main issues during the design and development process of a five-axis machine tool with high accuracy, stiffness and efficiency, including whole structure design,key components design, and supporting stiffness design. First, an appropriate structure of five-axis machine tool is determined considering the processing characteristics of aero-engine casing. Then, a dual drive swing head and a compact motorized spindle are designed with enough drive capability and stiffness, and related structure, assembly method, cooling technology, and performance simulation are given in detail. Next, a design method of supporting stiffness of guide is proposed through the deformation prediction of the spindle end. Based on above work, a prototype of machine tool is developed, and some experiments are carried out, including performance tests of swing head and motorized spindle, and machining of a simulated workpiece of aero-engine casing. All experimental results show that the machine tool has satisfactory accuracy, stiffness and efficiency, which meets the machining requirements of aero-engine casing. The main work can be used as references for engineers and technicians, which are meaningful in practice.

关键词： Aero-engine casing manufacturing Compact motorized spindle Dual drive swing head Five-axis machine tool Supporting stiffness

银杏叶及其提取物中33种禁用农药残留检测分析及风险评估

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中国现代应用药学 2024年第4期41卷 476-488页

作者：刘丹丹印晓红黄婷丁楠王玉田王芳芳吴萍姚建标浙江康恩贝制药股份有限公司杭州310052 浙江省中药制药技术重点实验室杭州310052

目的建立银杏叶及其提取物中33种禁用农药残留的分析方法,并开展风险评估研究。方法采用液相色谱-串联质谱法及气相色谱-串联质谱法对136批银杏叶及58批银杏叶提取物进行检测,采用点评估方式计算样品中农药残留的急性和慢性摄入风险,采... 详细信息

目的建立银杏叶及其提取物中33种禁用农药残留的分析方法,并开展风险评估研究。方法采用液相色谱-串联质谱法及气相色谱-串联质谱法对136批银杏叶及58批银杏叶提取物进行检测,采用点评估方式计算样品中农药残留的急性和慢性摄入风险,采用英国兽药残留风险排序矩阵计算各农药的风险得分。结果136批银杏叶中共检出6种禁用农药,总检出率为35.29%,农药检出量为0.002~0.210 mg·kg^(-1);检出农药的慢性膳食摄入风险为0.018%~0.620%,急性膳食摄入风险为0.0001%~0.0140%,表明银杏叶中农药的膳食暴露风险处于较低水平。58批银杏叶提取物中共检出2种禁用农药,检出率为55.17%,农药检出量为0.002~1.788 mg·kg^(-1);检出农药的慢性膳食摄入风险为0.003%~0.143%,急性膳食摄入风险为0.0024%,其膳食暴露风险也处于较低水平。风险排序结果表明,银杏叶中甲拌磷风险最高,应在生产和安全监管中重点关注。结论该方法准确,重复性好,可用于银杏叶及其提取物中33种禁用农药的检测。测定结果显示,银杏叶及其提取物中禁用农药残留量极低,无重大健康风险。

关键词：银杏叶银杏叶提取物禁用农药残留风险评估风险排序

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极性可控的激光加工氧化石墨烯基忆阻器(特邀)

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激光与光电子学进展 2024年第3期61卷 233-239页

作者：刘素玲万正芬王雨田顾敏张启明上海理工大学光子芯片研究院上海200093 上海理工大学光电信息与计算机工程学院上海200093

近年来,受生物神经系统结构和功能的启发,神经形态计算引起广泛兴趣。忆阻器可以通过其电荷或磁通量调节电导,与人脑突触作用机制相似,是神经形态计算最有前途的候选器件之一。提出一种基于飞秒激光加工氧化石墨烯基忆阻器的方法,通过... 详细信息

近年来,受生物神经系统结构和功能的启发,神经形态计算引起广泛兴趣。忆阻器可以通过其电荷或磁通量调节电导,与人脑突触作用机制相似,是神经形态计算最有前途的候选器件之一。提出一种基于飞秒激光加工氧化石墨烯基忆阻器的方法,通过调整器件两端扫描电压,实现了极性可控的电阻开关:低电压下,器件表现出单极性电阻开关特性,在150个循环扫描中呈现高度稳定性,且功耗仅有0.75 nW;高电压下,器件呈现双极性开关特性。伴随测试次数的增加,器件整体电导逐步增加,同时分别讨论了两种电压下器件的开关机制。

关键词：极性可控激光加工氧化石墨烯忆阻器

Reliability of dermatomal somatosensory-evoked potential in the evaluation of lumbosacral nerve root injury A concurrent case-control study

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Neural Regeneration Research 2008年第1期3卷 57-60页

作者： Ningjiang Shen Jian Chen Guangji wang Xiaoli Wu yutian wang Department of Orthopaedic Surgery Hainan Provincial People＇s Hospital Haikou 570311 Hainan Province China

BACKGROUND： It has been reported that dermatomal somatosensory evoked potential （DSEP） can be used for diagnosing nerve root injury in patients with lumbar disc herniation （LDH）, and that 83% 95% of patients suffer from the disease. Body height correction is not performed prior to determinations of latency and latency difference between the healthy and affected sides. However, latency noticeably correlates to body height. OBJECTIVE： This study aims to determine the lumbosacral nerve root injury in patients with LDH by DSEP, and to evaluate the sensitivity of the DSEP difference between the healthy and affected sides using a diagnostic index following body height correction. DESIGN： A case-control observation. SETTING： Department of Orthopedic Surgery, Hainan Provincial People＇s Hospital. PARTICIPANTS： Ninety-six patients, comprised of 67 males and 29 females, with an average age of 43 years and a mean body height of 1.65 m （range 1.48-1.81 m）, were recruited for this study. These patients suffered from unilateral lower limb radiation pain and received treatment at the Department of Orthopedic Surgery, Hainan Provincial People＇s Hospital between January 2004 and December 2006. All patients were confirmed to suffer from LDH at the L3-4, L-5, and/or Ls-SI by CT and/or MRI examinations. Central nervous system diseases were excluded. In order to obtain a normal reference value, DSEP was determined for a group of 50 subjects, who concurrently received health examinations in the same department. The subjects had no previous history of back leg pain or nervous system disease. The group of healthy controls included 26 males and 24 females, with an average age of 37 years and a mean body height of 1.63 m （range 1.50-1.80 m）. Written informed consent was obtained from all subjects for laboratory samples. The protocol was approved by the Hospital＇s Ethics Committees. DSEP was determined with myoelectricity-evoked potential equipment （Keypoint, Batch No. 9020A0042591, Dantec Com

关键词： dermatomal somatosensory evoked potential lumbar disc herniation nerve root injury