IGF2BPs as novel m^(6)A readers:Diverse roles in regulating cancer cell biological functions,hypoxia adaptation,metabolism,and immunosuppressive tumor microenvironment
作者机构：Department of General SurgeryThe Fourth Affiliated Hospital of China Medical UniversityShenyangLiaoning 110032China Department of GastroendoscopyThe Fourth Affiliated Hospital of China Medical UniversityShenyangLiaoning 110032China Department of Rheumatology and ImmunologyThe First Affiliated Hospital of China Medical UniversityShenyangLiaoning 110002China
出 版 物：《Genes & Diseases》 (基因与疾病（英文）)
年 卷 期：2024年第11卷第2期
页 面：890-920页
核心收录：
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
基 金：supported by grants from the Liaoning Nature Science Foundationof China(No.2022JH2/101300042) The National Natural Science Foundation of China(No.82173194,81672877) the Key Research Project of Liaoning Provincial Department of Education of China(No.ZD2020004) 2018 Youth Backbone Support Program of China Medical University(No.QGZ2018063)
主 题：Cancer IGF2BP Immunosuppressive TME m^(6)A Molecular mechanism Therapy
摘 要：m^(6)A methylation is the most frequent modification of mRNA in eukaryotes and plays a crucial role in cancer progression by regulating biological ***-like growth factor 2 mRNA-binding proteins(IGF2BP)are newly identified m^(6)A‘readers’.They belong to a family of RNA-binding proteins,which bind to the m^(6)A sites on different RNA sequences and stabilize them to promote cancer *** this review,we summarize the mechanisms by which different upstream factors regulate IGF2BP in *** current literature analyzed here reveals that the IGF2BP family proteins promote cancer cell proliferation,survival,and chemoresistance,inhibit apoptosis,and are also associated with cancer glycolysis,angiogenesis,and the immune response in the tumor ***,with the discovery of their role as‘readers’of m^(6)A and the characteristic re-expression of IGF2BPs in cancers,it is important to elucidate their mechanism of action in the immunosuppressive tumor *** also describe in detail the regulatory and interaction network of the IGF2BP family in downstream target RNAs and discuss their potential clinical applications as diagnostic and prognostic markers,as well as recent advances in IGF2BP biology and associated therapeutic value.
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