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Alter fecal microbiota composition and relieve symptom in depression-like rats after treatment by inulin-type fructo-oligosaccharides in Morinda Officinalis

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Alter fecal microbiota composition and relieve symptom in de...

Mushroom polysaccharides and jiaogulan saponins exert cancer preventive effects by shaping the gut microbiota and the microenvironment in ApcMin/+ mice

2018年第十二届中国药物制剂大会

作者：池连娣 Zibei lin Guoxing Huang w.l.wendy hsiao Jiwen Zhang Ying Zheng State Key laboratory of Quality Research in Chinese Medicine Institute of Chinese Medical Sciences University of Macau State Key laboratory of Quality Research in Chinese Medicine Macau University of Science and Technology Center for Drug Delivery System Shanghai Institute of Materia Medica Chinese Academy of Sciences

Inulin-type fructooligosaccharides（FOS） purified from Morinda officinalis,with degrees of polymerization（DP） from 3 to 9, has been approved as the prescribed oral drug by CFDA in 2012 with the indications for mild and moderate depressive episode, while the bioprocess of this FOS mixtures are largely unknown. This work aimed to illustrate this bioprocess related to gut microbiota and intestine construction. The depression-like rat model was built by chronic unpredictable mild stress（CUMS） procedure for seven weeks, then verified by open field test（OFT） and sucrose preference test（SPT）. Under the three weeks’ treatment period, the fecal sample were collected at day 0, 15 and 22, and further analyzed the microbiota DNA composition using ERIC-PCR method. Hematoxylin and eosin（H＆E） staining was applied to investigate the gut epithelial morphology. Results showed that, rats with depression-like behaviors presented low SPT value（＜50%, p＜0.01） and low total travel distance in OFT test（p＜0.01）. Conversely, SPT value was increased（＞65%, p＜0.05） after treatments with FOS, indicating recovering the pleasant sensation. Meanwhile, in partial least square data analysis（PlS-DA） plot, differential modulations of normal and depressive rat model were observed at 0-day microbiota composition. Furthermore, while compared the 22-day plot, there were greatly changed the microbiota composition after treatments（fluoxetine, FOS-DP5 and FOS mixture）. In other side, the colon mucosa, intestinal villus（height and integrity） were severe damaged in intestine of depressive rat model. It was the intestinal inflammatory and severe damage happened in depression-like rats. However, intestinal micro-architecture abnormalities were restored and reversed by FOS treatment. Inferior to FOS, fluoxetine aroused intestinal irritation（cell necrosis, exfoliation and deep staining） on parts of treated rats. On balance, depression-like rat model has significant influence in behavior, intestine structure and micro

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Mushroom polysaccharides and jiaogulan saponins exert cancer...

Antibiotic Resistance and Heavy Metals Tolerance in Gram-Negative Bacteria from Diseased American Bullfrog (Rana catesbeiana) Cultured in Malaysia

2019年海峡两岸暨港澳青年科学家毒理学学术交流会

作者： Imran Khan 黄国鑫 Xiao-ang li weilin liao wai Kit leong wenrui Xia Xiqing Bian Jianlin wu w.l.wendy hsiao State Key laboratory of Quality Research in Chinese Medicine Macau University of Science and Technology 澳门科技大学-中药质量研究国家重点实验室

The incidence of colorectal cancer(CRC) is alarming among younger *** no effective chemopreventive drug available in the market,researchers have been searching for alternative strategies against CRC that are in ***,we tested the cancer-preventive properties of Ganoderma lucidum(lingzhi) polysaccharides(GlP),along with the saponins extracted from Gynostemma pentaphyllum(GpS),an herbal tea with prebiotic-like ***,we report that saponins from Gynostemma pentaphyllum(GpS) and polysaccharides from Ganoderma lucidum(GlP together with GpS) profoundly improved the inflamed gut barrier of Apc mice by reducing polyps,shifting colonic M1 to M2 macrophages,positively reverting E-cadherin/N-cadherin ratio,and downregulating oncogenic signaling *** treatments also markedly promoted short-chain fatty acids(SCFAs)-producing bacteria and abridged sulfate-reducing bacteria in a time-dependent manner.G-protein coupled-receptors were significantly stimulated in the treated mice,accompanied by the modulated expressions of histone deacetylases,anti-cancer gut hormone PYY,and PPAPγ.These findings suggest that some of the herbal medicinal foods could modulate the relationship between the host and the GM to exert their beneficial properties to the *** study also implicates that these dietary mushroom polysaccharides and the Gp saponins have the potential to be developed as new preventive medicines against CRC.

关键词： Gut microbiota Saponins Polysaccharides SCFAs GPCRs ApcMin/+ mice

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Agricultural Sciences in China 2009年第10期8卷 1270-1275页

作者： M Najiah S w lee w wendy l w Tee M Nadirah S H Faizah Department of Fisheries Science and Aquaculture Faculty of Agrotechnology and Food Science Universiti Malaysia Terengganu Institute of Tropical Aquaculture Universiti Malaysia Terengganu Faculty of Agro Industry and Natural Resources Universiti Malaysia Kelantan

A total of 140 bacterial isolates have been successfully isolated from various organs of diseased American bullfrog （Rana catesbeiana） cultured in Malaysia. The most frequently isolated bacteria was Edwardsiella spp. （46 isolates） followed by Aeromonas spp. （33 isolates）, Flavobacterium spp. （31 isolates）, and Vibrio spp. （30 isolates）. Majority of the bacterial isolates were found sensitive to furazolidone （85.0%）, chloramphenicol （85.0%）, oxolinic acid （90.0%）, florfenicol （95.0%）, and flumequine （97.5%）. On the other hand, most of the bacterial isolates were resistant to oleandomycin （77.5%） and lincomycin （87.5%）. Nitrofurantoin and flumequine can be inhibited the growth of all of Vibrio spp. whereas all isolates of Edwardsiella spp. were found sensitive to florfenicol and flumequine. Multiple antibiotic resistance （MAR） index were in range of 0.30-0.40, indicating that bacterial isolates from cultured bullfrogs may have received high risk exposure to the tested antibiotics. In addition, 90-100% of the isolates were resistant to copper, cadmium, and chromium. These results provided insight information on tolerance level of bacterial isolates from cultured bullfrogs to 21 antibiotics as well as heavy metals.

关键词： Rana catesbeiana MAR index Edwardsiella Aeromonas Flavobaeterium Vibrio antibiotic resistance,heavy metal tolerance

EFFECT OF A PROPEllER AND GAS DIFFUSION ON BUBBlE NUClEI DISTRIBUTION IN A lIQUID

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Journal of Hydrodynamics 2012年第6期24卷 809-822页

作者： hsiao Chao-Tsung CHAHINE Georges l. DYNAFlOw INC.

A multi-bubble dynamics code accounting for gas diffusion in the liquid and through the bubble wall was developed and used to study the modification of a bubble nuclei population dynamics by a propeller. The propeller flow field was obtained using a Reynolds-Averaged Navier-Stokes （RANS） solver and bubble nuclei populations were propagated in this field. The numerical procedure enabled establishment of the possibility of production behind the propeller of relatively large visible bubbles starting from typical ocean nuclei size distributions. The resulting larger bubbles are seen to cluster in the blade wakes and tip vortices. Parametric investigations of the initial nuclei size distribution, the dissolved gas concentration, and the cavitation number were conducted to ide- ntify their effects on bubble entrainment and the resultant void fractions and bubble distribution modifications downstream from the propeller. Imposed synthetic turbulence-like fluctuations unto the average RANS flow field were also used to study the effect averaging in the RANS procedure has on the results.

关键词： gas diffusion bubble entrainment propeller

MODElING MICROBUBBlE DYNAMICS IN BIOMEDICAl APPlICATIONS

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Journal of Hydrodynamics 2012年第2期24卷 169-183页

作者： CHAHINE Georges l. hsiao Chao-Tsung Dynaflow Inc.JessupMaryland 20794USA

Controlling microbubble dynamics to produce desirable biomedical outcomes when and where necessary and avoid deleterious effects requires advanced knowledge, which can be achieved only through a combination of experimental and numerical/ analytical techniques. The present communication presents a multi-physics approach to study the dynamics combining viscous- inviscid effects, liquid and structure dynamics, and multi bubble interaction. while complex numerical tools are developed and used, the study aims at identifying the key parameters influencing the dynamics, which need to be included in simpler models.

关键词： microbubble biological contrast agents thick shell ultrasound

A novel method for clustering cellular data to improve classification

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Neural Regeneration Research 2025年第9期20卷 2697-2705页

作者： Diek w.wheeler Giorgio A.Ascoli Center for Neural Informatics Structures&PlasticityKrasnow Institute for Advanced Study Bioengineering Department Volgenau School of Engineering George Mason University FairfaxVAUSA

Many fields,such as neuroscience,are experiencing the vast prolife ration of cellular data,underscoring the need fo r organizing and interpreting large datasets.A popular approach partitions data into manageable subsets via hierarchical clustering,but objective methods to determine the appropriate classification granularity are *** recently introduced a technique to systematically identify when to stop subdividing clusters based on the fundamental principle that cells must differ more between than within *** we present the corresponding protocol to classify cellular datasets by combining datadriven unsupervised hierarchical clustering with statistical *** general-purpose functions are applicable to any cellular dataset that can be organized as two-dimensional matrices of numerical values,including molecula r,physiological,and anatomical *** demonstrate the protocol using cellular data from the Janelia Mouselight project to chara cterize morphological aspects of neurons.

关键词： cellular data clustering dendrogram data classification levene's one-tailed statistical test unsupervised hierarchical clustering

Multiple Antibiotic Resistance and Heavy Metal Resistance Profile of Bacteria Isolated from Giant Freshwater Prawn (Macrobrachium rosenbergii) Hatchery

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Agricultural Sciences in China 2009年第6期8卷 740-745页

作者： S w lee M Najiah w wendy A Zahrol M Nadirah Department of Fishery and Aquaculture Faculty of Agrotechnology and Food Science Universiti Malaysia Terengganu

In this article, antibiogram and heavy metal resistance profile of bacteria isolated from giant freshwater prawn （Macrobrachium rosenbergii） hatchery in Malaysia are described. Although giant freshwater prawn was introduced into Malaysia since the 1980s, there was no database information on antibiogram and heavy metal resistance profile of bacteria from giant freshwater prawn （34. rosenbergii） hatchery in Malaysia. Therefore, this study was carried out to determine the effectiveness of antibiotic and heavy metal resistance profile to control bacterial diseases in M. rosenbergii hatchery. The results can provide valuable information for local M. rosenbergii post-larval producer. Antibiotic sensitivity test was carried out by disk-diffusion method against 15 types of antibiotics as follows： oxolinic acid （2 μg）, ampicillin （10μg）, erythromycin （15μg）, furazolidone （15 μg）, lincomycin （15μg）, amoxicillin （25 μg）, colistin sulphate （25 μg）, doxycycline （30μg）, florfenicol （30 μg）, flumequine （30 lag）, nalidixic acid （30μg）, tetracycline （30μg）, oleandomycin （15μg）, fosfomycin （50μg）, and spiramycin （100 μg）, whereas heavy metal resistance profile of the present bacterial isolates was determined by 2-fold agar dilution technique. In this study, 5 types of bacteria were successfully isolated; they were Aeromonas spp. （n = 77）, Escherichia coli （n = 73）, Edwardsiella spp. （n = 62）, Salmonella spp. （n = 75）, and Vibrio spp. （n = 43）. The result showed that furazolidone was the most effective antibiotic to control the bacteria isolated in this study, approximately 89.7% of the bacterial isolates were sensitive to this antibiotic. Multiple antibiotic resistance （MAR） index indicated that the hatchery water source and M. rosenbergii post-larval and sediment tanks were at high-risk exposure to the tested antibiotic. Furthermore, all the tested heavy metals （Cd2＋, Cr6＋, Hg2＋, and Cu2＋） failed to inhibit the growth of the bacterial isolates. Therefore, it indicated that the water

关键词： Macrobrachium rosenbergii hatchery antibiotic heavy metal MAR index

Genistein:a possible solution for the treatment of Alzheimer’s disease

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Neural Regeneration Research 2025年第10期20卷 2903-2905页

作者： Karolina Pierzynowska Bartosz Karaszewski Grzegorz węgrzyn Department of Molecular Biology University of GdanskGdanskPoland Gdansk Polandand Department of Adult NeurologyFaculty of MedicineMedical University of GdanskGdanskPoland

Neurodegenerative diseases are defined as disorders resulting from the slow and progressive loss of function and eventual death of neural cells that result from the primary pathology of nervous *** can lead to severe nervous system dysfunction,eventually affecting multiple organs and *** hundred neurodegenerative diseases have been described,and owing to their prevalence,severity.

关键词： organs Alzheimer death

large anisotropic negative thermal expansion in Cu-TDPAT metalorganic framework:A combined in situ X-ray diffraction and DRIFTS study

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Nano Research 2021年第2期14卷 404-410页

作者： Mehrdad Asgari lia Kochetygov Hassan Abedini wendy l.Queen Institut des Sciences et Ingenierie Chimiques Ecole Polytechnique Federale de Lausanne(EPFL)-Valais WallisCH-1951 SionSwitzerland Gas Engineering Department Faculty of PetroleumPetroleum University of Technology(PUT)Ahwaz 61991-71183Iran

Cu-TDPAT(H_(6)TDPAT=2,4,6-tris(3,5-dicarboxylphenylamino)-1,3,5-triazine),a stable nanoporous metal-organic framework with rht topology,has sparked broad interest as an adsorbent for several chemical separation *** this work,in situ synchrotron diffraction experiments followed by sequential leBail refinements reveal that Cu-TDPAT shows unusually large anisotropic negative thermal expansion(NTE).The PASCal crystallography tool,used to analyze the magnitude of the NTE,reveals an average volumetric thermal expansion coefficientαv=-20.3 MK^(-1).This value is significantly higher than the one reported for Cu-BTC(also known as HKUST-1),which contains the same Cu-paddlewheel building unit,αv=-12 MK^(-1).In situ synchrotron single crystal X-ray diffraction and in situ diffuse reflectance infrared Fourier transform spectroscopy(DRIFTS)were employed to shed light on the NTE *** these two methods,we were able to elucidate the three main structural motions that are responsible for the NTE *** more pronounced NTE behavior of Cu-TDPAT is attributed to the lower symmetry combined with the more complex ligand structure when compared to *** knowledge obtained in this work is important for understanding the behavior of the adsorbent under transient variable temperature conditions in fixed adsorption beds.

关键词： negative thermal expansion metal-organic frameworks Cu-TDPAT in situ diffraction in situ diffuse reflectance infrared Fourier transform spectroscopy(DRIFTS)