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Integrins and their potential roles in mammalian pregnancy

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Journal of Animal Science and Biotechnology 2024年第1期15卷 1-19页

作者： Gregory A.Johnson Robert c.Burghardt Fuller w.Bazer Heewon Seo Joe w.cain Department of Veterinary Integrative Biosciences School of Veterinary Medicine and Biomedical SciencesTexas A&M UniversityCollege StationTX 77843‑4459USA Department of Animal Science College of Agriculture and Life SciencesTexas A&M UniversityCollege StationTX 77843‑2471USA

Integrins are a highly complex family of receptors that, when expressed on the surface of cells, can mediate reciprocal cell-to-cell and cell-to-extracellular matrix(EcM) interactions leading to assembly of integrin adhesion complexes(IAcs) that initiate many signaling functions both at the membrane and deeper within the cytoplasm to coordinate processes including cell adhesion, migration, proliferation, survival, differentiation, and metabolism. All metazoan organisms possess integrins, and it is generally agreed that integrins were associated with the evolution of multicellularity, being essential for the association of cells with their neighbors and surroundings, during embryonic development and many aspects of cellular and molecular biology. Integrins have important roles in many aspects of embryonic development, normal physiology, and disease processes with a multitude of functions discovered and elucidated for integrins that directly influence many areas of biology and medicine, including mammalian pregnancy, in particular implantation of the blastocyst to the uterine wall, subsequent placentation and conceptus(embryo/fetus and associated placental membranes) development. This review provides a succinct overview of integrin structure, ligand binding, and signaling followed with a concise overview of embryonic development, implantation, and early placentation in pigs, sheep, humans, and mice as an example for rodents. A brief timeline of the initial localization of integrin subunits to the uterine luminal epithelium(LE) and conceptus trophoblast is then presented, followed by sequential summaries of integrin expression and function during gestation in pigs, sheep, humans, and rodents. As appropriate for this journal, summaries of integrin expression and function during gestation in pigs and sheep are in depth, whereas summaries for humans and rodents are brief. Because similar models to those illustrated in Fig. 1, 2, 3, 4, 5 and 6 are present throughout the sc

关键词： Humans Implantation Integrins Pigs Pregnancy Rodents Sheep

Elevated brain temperature under severe heat exposure impairs cortical motor activity and executive function

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Journal of Sport and Health Science 2024年第2期13卷 233-244页

作者： Xiang Ren Tan Mary c.Stephenson Sharifah Badriyah Alhadad Kelvin w.Z.Loh Tuck wah Soong Jason K.w.Lee Ivan c.c.Low Health and Social Sciences Singapore Institute of TechnologySingapore 138683Singapore Human Potential Translational Research Programme Yong Loo Lin School of MedicineNational University of SingaporeSingapore 117597Singapore centre for Translational Magnetic Resonance Research Yong Loo Lin School of MedicineNational University of SingaporeSingapore 117549Singapore Department of Physiology Yong Loo Lin School of MedicineNational University of SingaporeSingapore 117593Singapore Heat Resilience and Performance centre Yong Loo Lin School of MedicineNational University of SingaporeSingapore 117510Singapore N.1 Institute for Health National University of SingaporeSingapore 117456Singapore campus for Research Excellence and Technological Enterprise(cREATE) Singapore 138602Singapore

Background:Excessive heat exposure can lead to hyperthermia in humans,which impairs physical performance and disrupts cognitive *** heat is a known physiological stressor,it is unclear how severe heat stress affects brain physiology and ***:Eleven healthy participants were subjected to heat stress from prolonged exercise or warm water immersion until their rectal temperatures(T_(re))attained 39.5℃,inducing exertional or passive hyperthermia,*** a separate trial,blended ice was ingested before and during exercise as a cooling *** were compared to a control condition with seated rest(normothermic).Brain temperature(T_(br)),cerebral perfusion,and task-based brain activity were assessed using magnetic resonance imaging ***:T_(br)in motor cortex was found to be tightly regulated at rest(37.3℃±0.4℃(mean±SD))despite fluctuations in T_(re).with the development of hyperthermia,T_(br)increases and dovetails with the rising T_(re).Bilateral motor cortical activity was suppressed during high-intensity plantarflexion tasks,implying a reduced central motor drive in hyperthermic participants(T_(re)=38.5℃±0.1℃).Global gray matter perfusion and regional perfusion in sensorimotor cortex were reduced with passive *** function was poorer under a passive hyperthermic state,and this could relate to compromised visual processing as indicated by the reduced activation of left lateral-occipital ***,ingestion of blended ice before and during exercise alleviated the rise in both T_(re)and T_(bc)and mitigated heat-related neural ***:Severe heat exposure elevates T_(br),disrupts motor cortical activity and executive function,and this can lead to impairment of physical and cognitive performance.

关键词： Brain functional activity cognition Heat stress Hyperthermia Motor function

Superexchange and charge transfer in the nickelate superconductor La_(3)Ni_(2)O_(7) under pressure

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Science china(Physics,Mechanics & Astronomy) 2024年第11期67卷 1-8页

作者： wéi wú Zhihui Luo Dao-Xin Yao Meng wang center for Neutron Science and Technology Guangdong Provincial Key Laboratory of Magnetoelectric Physics and DevicesSchool of PhysicsSun Yat-sen UniversityGuangzhou 510275China

Recently, a bulk nickelate superconductor La_(3)Ni_(2)O_(7) is discovered at pressures with a remarkable high transition temperature T_(c)~ 80 K. Here, we study a Hubbard model with tight-binding parameters derived from ab initio calculations of La_(3)Ni_(2)O_(7),by employing large scale determinant quantum Monte carlo and cellular dynamical mean-field theory. Our result suggests that the superexchange couplings in this system are comparable to that of cuprates. The system is a charge transfer insulator as the hole concentration becomes four per site at large Hubbard U. Upon hole doping, two low-energy spin-singlet bands emerge in the system exhibiting distinct correlation properties: while the one composed of the out-of-plane Ni-d_(3z^(2)-r^(2)) and O-p_(z) orbitals demonstrates strong antiferromagnetic correlations and narrow effective bandwidth, the in-plane singlet band consisting of the Ni-d_(x^(2)-y^(2)) and O-p_(x)/p_(y) orbitals is in general more itinerant. Over a broad range of hole doping, the doped holes occupy primarily the d_(x^(2)-y^(2)) and p_(x)/p_(y) orbitals, whereas the d_(3z^(2)-r^(2)) and p_(z) orbitals retain underdoped. we propose an effective t-J model to capture the relevant physics and discuss the implications of our result for comprehending the La_(3)Ni_(2)O_(7) superconductivity.

关键词： superconductivity nickelate superconductors Hubbard model superexchange charge transfer insulator quantum Monte carlo

continuous high-efficient water-electricity cogeneration over a hybrid solar-driven water evaporation system and the working mechanism

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Science china Materials 2024年第7期67卷 2371-2372页

作者： Dewei chu School of Materials Science and Engineering University of New South WalesSydneyNSW 2052Australia

with the escalation of industrialization and population growth,energy and clean water shortages pose an unprecedented threat to sustainable ***,it is imperative to develop green and effective strategies to address these *** this context,solar-driven interfacial water evaporation(SIwE)has emerged as a highly promising low-carbon solution to the water-energy nexus[1].By locating the evaporator at airwater interfaces,heat localization can be achieved,leading to high-efficient water evaporation and freshwater *** significantly,taking advantage of the special conditions during SIwE has opened numerous opportunities for generation of extra electrical power[2,3].Throughout the processes of SIwE,various elements such as photons,waves,capillary flow,evaporation,vapor motions,condensation,and droplet sliding can all be harnessed to produce electricity through photovoltaic,thermoelectric,thermogalvanic,pyroelectric,piezoelectric,triboelectricity and hydrovoltaic effects[3].Extensive research efforts have provided valuable insights for the development of water-electricity cogeneration(wEG)hybrid systems.

关键词： mechanism evaporation piezoelectric

Superplasticity of fine-grained Mg-10Li alloy prepared by severe plastic deformation and understanding its deformation mechanisms

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Journal of Magnesium and Alloys 2024年第1期12卷 316-331页

作者： H.T.Jeong S.w.Lee w.J.Kim Department of Materials Science and Engineering Hongik UniversityMapo-guSangsu-dong 72-1Seoul 121-791Republic of Korea

The superplastic behavior and associated deformation mechanisms of a fine-grained Mg-10.1 Li-0.8Al-0.6Zn alloy(LAZ1011)with a grain size of 3.2μm,primarily composed of the Bccβphase and a small amount of the HcPαphase,were examined in a temperature range of 473 K to 623 *** microstructural refinement of this alloy was achieved by employing high-ratio differential speed *** best superplasticity was achieved at 523 K and at strain rates of 10^(-4)-5×10^(-4)s^(-1),where tensile elongations of 550±600%were *** the heating and holding stage of the tensile samples prior to tensile loading,a significant increase in grain size was observed at temperatures above 573 ***,it was important to consider this effect when analyzing and understanding the superplastic deformation behavior and *** the investigated strain rate range,the superplastic flow at low strain rates was governed by lattice diffusion-controlled grain boundary sliding,while at high strain rates,lattice diffusion-controlled dislocation climb creep was the rate-controlling deformation *** was concluded that solute drag creep is unlikely to *** the late stages of deformation at 523 K,it was observed that grain boundary sliding led to the agglomeration of theαphase,resulting in significant strain *** mechanism maps were constructed forβ-Mg-Li alloys in the form of 2D and 3D formats as a function of strain rate,stress,temperature,and grain size,using the constitutive equations for various deformation mechanisms derived based on the data of the current tests.

关键词： Magnesium-lithium alloy Superplasticity Severe plastic deformation Grain size Grain growth

Effects of dust controls on respirable coal mine dust composition and particle sizes:case studies on auxiliary scrubbers and canopy air curtain

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International Journal of coal Science & Technology 2024年第3期11卷 86-101页

作者： F.Animah c.Keles w.R.Reed E.Sarver Department of Mining and Minerals Engineering Virginia Polytechnic Institute&State UniversityBlacksburgVAUSA National Institute of Occupational Safety and Health(NIOSH) PittsburghPAUSA

control of dust in underground coal mines is critical for mitigating both safety and health *** decades,the National Institute of Occupational Safety and Health(NIOSH)has led research to evaluate the effectiveness of various dust control technologies in coal *** studies have included the evaluation of auxiliary scrubbers to reduce respirable dust downstream of active mining and the use of canopy air curtains(cAcs)to reduce respirable dust in key operator *** detailed dust characterization was not a focus of such studies,this is a growing area of *** preserved filter samples from three previous NIOSH studies,the current work aims to explore the effect of two different scrubbers(one wet and one dry)and a roof bolter cAc on respirable dust composition and particle size *** this,the preserved filter samples were analyzed by thermogravimetric analysis and/or scanning electron microscopy with energy dispersive *** indicate that dust composition was not appreciably affected by either scrubber or the ***,the wet scrubber and cAc appeared to decrease the overall particle size *** an effect of the dry scrubber was not consistently observed,but this is probably related to the particular sampling location downstream of the scrubber which allowed for significant mixing of the scrubber exhaust and other return *** from the insights gained with respect to the three specific dust control case studies revisited here,this work demonstrates the value of preserved dust samples for follow-up investigation more broadly.

关键词： Respirable dust Dust control SEM–EDX Scrubber canopy air curtain Silica

Paving the way toward soil safety and health:current status,challenges,and potential solutions

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Frontiers of Environmental Science & Engineering 2024年第6期18卷 63-73页

作者： chiheng chu Lizhong Zhu college of Environmental and Resource Sciences Zhejiang UniversityHangzhou 310058China

Soil is a non-renewable resource,providing a majority of the world’s food and fiber while serving as a vital carbon ***,the health of soil faces global threats from human activities,particularly widespread contamination by industrial *** physical,chemical,and biological remediation approaches encounter challenges in preserving soil structure and function throughout the remediation process,as well as addressing the complexities of soil contamination on a regional *** solutions encompass monitoring and simulating soil processes,with a focus on utilizing big data to bridge micro-scale and macro-scale ***,reducing pollutant emissions to soil is paramount due to the significant challenges associated with removing contaminants once they have entered the soil,coupled with the high economic costs of ***,it is imperative to implement advanced remediation technologies,such as monitored natural attenuation,and embrace holistic soil management approaches that involve regulatory frameworks,soil health indicators,and soil safety monitoring *** the enduring health and resilience of soils necessitates a blend of interdisciplinary research,technological innovation,and collaborative initiatives.

关键词： Soil safety and health Source emission reduction Process monitoring and simulation Green remediation technology Soil health management

TDP-43 is a key molecule accelerating development of Alzheimer’s disease following traumatic brain injury

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Neural Regeneration Research 2024年第5期19卷 955-956页

作者： chu chen Department of cellular and Integrative Physiology Long School of MedicineUniversity of Texas Health Science Center at San AntonioSan AntonioTXUSA

currently,more than 55 million people have dementia worldwide and Alzheimer’s disease(AD)is one of the most common causes of dementia in ***,no effective therapies are currently available for the prevention and treatment of *** is largely due to our limited understanding of the mechanisms underlying the neuropathogenesis of *** has widely been recognized that AD is heterogeneous and that multi-factors are contributing to the pathogenesis of *** evidence suggests that traumatic brain injury(TBI)is an important risk factor for the development of AD and dementia later in life(Guo et al.,2000;Johnson et al.,2010).However,the precise mechanism by which TBI contributes to developing AD has yet to be elucidated.

关键词： Alzheimer traumatic

Pervasive Attentive Neural Network for Intelligent Image classification Based on N-cDE’s

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computers, Materials & continua 2024年第4期79卷 1137-1156页

作者： Anas w.Abulfaraj Department of Information Systems Faculty of Computing and Information TechnologyKing Abdulaziz UniversityRabigh21911Saudi Arabia

The utilization of visual attention enhances the performance of image classification *** attentionbased models have demonstrated notable performance,but many of these models exhibit reduced accuracy when confronted with inter-class and intra-class similarities and ***-controlled Differential Equations(N-cDE’s)and Neural Ordinary Differential Equations(NODE’s)are extensively utilized within this ***’s possesses the capacity to effectively illustrate both inter-class and intra-class similarities and differences with enhanced *** this end,an attentive neural network has been proposed to generate attention maps,which uses two different types of N-cDE’s,one for adopting hidden layers and the other to generate attention *** distinct attention techniques are implemented including time-wise attention,also referred to as bottom N-cDE’s;and element-wise attention,called topN-cDE’***,a trainingmethodology is proposed to guarantee that the training problem is sufficiently *** classification tasks including fine-grained visual classification andmulti-label classification,are utilized to evaluate the *** proposedmethodology is employed on five publicly available datasets,including cUB-200-2011,ImageNet-1K,PAScAL VOc 2007,PAScAL VOc 2012,and MS *** obtained visualizations have demonstrated that N-cDE’s are better appropriate for attention-based activities in comparison to conventional NODE’s.

关键词： Differential equations neural-controlled DE image classification attention maps N-cDE’s